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Glucagon family neuropeptides (Pituitary adenylate cyclase-activating polypeptide)

 Q58FG9_CHICK            Unreviewed;       172 AA.
Q58FG9; E1C6B6;
26-APR-2005, integrated into UniProtKB/TrEMBL.
26-APR-2005, sequence version 1.
18-JUL-2018, entry version 64.
SubName: Full=Glucagon family neuropeptides {ECO:0000313|Ensembl:ENSGALP00000023931};
SubName: Full=Pituitary adenylate cyclase-activating polypeptide {ECO:0000313|EMBL:AAX56089.1};
Name=PACAP {ECO:0000313|EMBL:AAX56089.1};
Synonyms=ADCYAP1 {ECO:0000313|Ensembl:ENSGALP00000023931};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031 {ECO:0000313|EMBL:AAX56089.1};
[1] {ECO:0000313|Ensembl:ENSGALP00000023931, ECO:0000313|Proteomes:UP000000539}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000023931,
ECO:0000313|Proteomes:UP000000539};
PubMed=15592404; DOI=10.1038/nature03154;
International Chicken Genome Sequencing Consortium;
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
Mardis E.R., Wilson R.K.;
"Sequence and comparative analysis of the chicken genome provide
unique perspectives on vertebrate evolution.";
Nature 432:695-716(2004).
[2] {ECO:0000313|EMBL:AAX56089.1}
NUCLEOTIDE SEQUENCE.
PubMed=16553291;
Wang C.Y., Wang Y., Li J., Leung F.C.;
"Expression profiles of growth hormone-releasing hormone and growth
hormone-releasing hormone receptor during chicken embryonic pituitary
development.";
Poult. Sci. 85:569-576(2006).
[3] {ECO:0000313|Ensembl:ENSGALP00000023931}
IDENTIFICATION.
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000023931};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00408389}.
-!- SIMILARITY: Belongs to the glucagon family.
{ECO:0000256|SAAS:SAAS00593530}.
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EMBL; AADN04000186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY956323; AAX56089.1; -; mRNA.
RefSeq; NP_001001291.2; NM_001001291.2.
UniGene; Gga.51518; -.
UniGene; Gga.52384; -.
UniGene; Gga.616; -.
Ensembl; ENSGALT00000023977; ENSGALP00000023931; ENSGALG00000014858.
GeneID; 408251; -.
KEGG; gga:408251; -.
CTD; 116; -.
GeneTree; ENSGT00530000063592; -.
HOVERGEN; HBG018069; -.
KO; K05262; -.
OrthoDB; EOG091G0J1P; -.
TreeFam; TF332804; -.
Reactome; R-GGA-418555; G alpha (s) signalling events.
Reactome; R-GGA-420092; Glucagon-type ligand receptors.
Proteomes; UP000000539; Chromosome 2.
Bgee; ENSGALG00000014858; -.
ExpressionAtlas; Q58FG9; baseline and differential.
GO; GO:0044297; C:cell body; IDA:AgBase.
GO; GO:0070852; C:cell body fiber; IDA:AgBase.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0043005; C:neuron projection; IDA:AgBase.
GO; GO:0043204; C:perikaryon; IDA:AgBase.
GO; GO:0005184; F:neuropeptide hormone activity; IEA:Ensembl.
GO; GO:0051428; F:peptide hormone receptor binding; IEA:Ensembl.
GO; GO:0016521; F:pituitary adenylate cyclase activating polypeptide activity; IEA:Ensembl.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
GO; GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:Ensembl.
GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
GO; GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:Ensembl.
GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
InterPro; IPR039080; PACAP.
PANTHER; PTHR11213:SF1; PTHR11213:SF1; 1.
Pfam; PF00123; Hormone_2; 2.
SMART; SM00070; GLUCA; 2.
PROSITE; PS00260; GLUCAGON; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000539};
Reference proteome {ECO:0000313|Proteomes:UP000000539};
Secreted {ECO:0000256|SAAS:SAAS00486903};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 22 {ECO:0000256|SAM:SignalP}.
CHAIN 23 172 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014309703.
DOMAIN 128 150 GLUCAGON. {ECO:0000259|PROSITE:PS00260}.
SEQUENCE 172 AA; 19172 MW; 159423DA5533FD4B CRC64;
MCSKALLALL VYGIIMHCSV YCSPAVGLQY PALRLEEEVY DEDGNTLQDF AYEQEPLGVA
GPPSALGEVY ALYYPPGKRH ADGIFSKAYR KLLGQLSARK YLHSLMAKRV GGASSGLGDE
AEPLSKRHID GIFTDSYSRY RKQMAVKKYL AAVLGKRYKQ RVKNKGRRVA YL


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