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Glucagon family neuropeptides [Cleaved into: Growth hormone-releasing factor (GRF) (Growth hormone-releasing hormone) (GHRH); Pituitary adenylate cyclase-activating polypeptide (PACAP)]

 PACA_ONCNE              Reviewed;         173 AA.
P41585;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
10-MAY-2017, entry version 63.
RecName: Full=Glucagon family neuropeptides;
Contains:
RecName: Full=Growth hormone-releasing factor;
Short=GRF;
AltName: Full=Growth hormone-releasing hormone;
Short=GHRH;
Contains:
RecName: Full=Pituitary adenylate cyclase-activating polypeptide;
Short=PACAP;
Flags: Precursor;
Oncorhynchus nerka (Sockeye salmon) (Salmo nerka).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus.
NCBI_TaxID=8023;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
TISSUE=Brain;
PubMed=8344311; DOI=10.1111/j.1432-1033.1993.tb18051.x;
Parker D.B., Coe I.R., Dixon G.H., Sherwood N.M.;
"Two salmon neuropeptides encoded by one brain cDNA are structurally
related to members of the glucagon superfamily.";
Eur. J. Biochem. 215:439-448(1993).
-!- FUNCTION: Primary role of GHRH is to release GH from the
pituitary.
-!- FUNCTION: PACAP plays pivotal roles as a neurotransmitter and/or a
neuromodulator.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Long;
IsoId=P41585-1; Sequence=Displayed;
Name=Short;
IsoId=P41585-2; Sequence=VSP_001762, VSP_001763;
Note=Lacks the GHRH-like sequence.;
-!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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EMBL; X73233; CAA51705.1; ALT_SEQ; mRNA.
PIR; S34767; S34767.
SMR; P41585; -.
HOVERGEN; HBG018069; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
Pfam; PF00123; Hormone_2; 2.
PRINTS; PR00275; GLUCAGON.
SMART; SM00070; GLUCA; 2.
PROSITE; PS00260; GLUCAGON; 2.
2: Evidence at transcript level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Hormone; Polymorphism; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
PROPEP 23 80
/FTId=PRO_0000011525.
PEPTIDE 82 126 Growth hormone-releasing factor.
/FTId=PRO_0000011526.
PEPTIDE 129 166 Pituitary adenylate cyclase-activating
polypeptide.
/FTId=PRO_0000011527.
PROPEP 170 173
/FTId=PRO_0000011528.
MOD_RES 166 166 Lysine amide. {ECO:0000255}.
VAR_SEQ 78 78 G -> S (in isoform Short). {ECO:0000305}.
/FTId=VSP_001762.
VAR_SEQ 79 113 Missing (in isoform Short).
{ECO:0000305}.
/FTId=VSP_001763.
VARIANT 22 22 S -> C.
VARIANT 61 61 P -> S.
VARIANT 78 78 G -> R.
VARIANT 122 122 T -> S.
VARIANT 165 165 N -> S.
VARIANT 171 171 G -> A.
SEQUENCE 173 AA; 19704 MW; 2B0B554F43C738F2 CRC64;
MSSKATLALL IYGIIMHYSV YSSPLGLNYP NLRLENEVYD EDGNSLPALA FDSDQIAIRS
PPSVADDLYT LYYPPEKGTE RHADGMFNKA YRKALGQLSA RKYLHSLMAK RVGGGSTMED
DTEPLSKRHS DGIFTDSYSR YRKQMAVKKY LAAVLGKRYR QRYRNKGRRL GYL


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