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Glucagon-1 (Glucagon I) [Cleaved into: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2)]

 GLUC1_ONCMY             Reviewed;         178 AA.
Q91971; Q91188; Q91408; Q92169;
16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 68.
RecName: Full=Glucagon-1;
AltName: Full=Glucagon I;
Contains:
RecName: Full=Glicentin-related polypeptide 1;
Short=GRPP 1;
Contains:
RecName: Full=Glucagon-1;
Contains:
RecName: Full=Glucagon-like peptide 1-1;
Short=GLP 1-1;
Contains:
RecName: Full=Glucagon-like peptide 2;
Short=GLP 2;
Flags: Precursor;
Name=gcg1;
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus.
NCBI_TaxID=8022;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND ALTERNATIVE SPLICING.
TISSUE=Distal small intestine, and Pancreas;
PubMed=7776976; DOI=10.1210/mend.9.3.7776976;
Irwin D.M., Wong J.;
"Trout and chicken proglucagon: alternative splicing generates mRNA
transcripts encoding glucagon-like peptide 2.";
Mol. Endocrinol. 9:267-277(1995).
-!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises
the blood sugar level. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Intestinal;
IsoId=Q91971-1; Sequence=Displayed;
Name=Pancreatic;
IsoId=Q91971-2; Sequence=VSP_050470;
-!- INDUCTION: Produced in the A cells of the islets of Langerhans in
response to a drop in blood sugar concentration.
-!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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EMBL; U19913; AAC59667.1; -; mRNA.
EMBL; U19917; AAC59669.1; -; mRNA.
EMBL; U19918; AAC60212.1; -; Genomic_DNA.
EMBL; U19919; AAC60213.1; -; Genomic_DNA.
EMBL; U19918; AAC60213.1; JOINED; Genomic_DNA.
EMBL; S78475; AAB34505.1; -; mRNA.
EMBL; S78473; AAB34504.2; -; mRNA.
PIR; I51058; I51058.
RefSeq; NP_001118170.1; NM_001124698.1. [Q91971-1]
UniGene; Omy.33144; -.
ProteinModelPortal; Q91971; -.
SMR; Q91971; -.
GeneID; 100136745; -.
CTD; 100136745; -.
HOVERGEN; HBG003010; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR015550; Glucagon.
InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
InterPro; IPR006162; Ppantetheine_attach_site.
PANTHER; PTHR11418; PTHR11418; 1.
Pfam; PF00123; Hormone_2; 3.
SMART; SM00070; GLUCA; 3.
PROSITE; PS00260; GLUCAGON; 3.
2: Evidence at transcript level;
Alternative splicing; Cleavage on pair of basic residues; Hormone;
Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
PEPTIDE 22 49 Glicentin-related polypeptide 1.
/FTId=PRO_0000011357.
PEPTIDE 52 80 Glucagon-1.
/FTId=PRO_0000011358.
PROPEP 83 87 {ECO:0000250}.
/FTId=PRO_0000011359.
PEPTIDE 90 120 Glucagon-like peptide 1-1. {ECO:0000250}.
/FTId=PRO_0000011360.
PROPEP 123 134
/FTId=PRO_0000011361.
PEPTIDE 137 169 Glucagon-like peptide 2.
/FTId=PRO_0000011362.
PROPEP 171 178
/FTId=PRO_0000011363.
VAR_SEQ 124 178 Missing (in isoform Pancreatic).
{ECO:0000305}.
/FTId=VSP_050470.
SEQUENCE 178 AA; 20034 MW; 5CF6980CF2A9D58E CRC64;
MFGIHSLAGV LLLVIVQRQL ASPLQEAEDN SSLETTDPLL EDLMGVSNVK RHSEGTFSND
YSKYQEERMA QDFVQWLMNS KRSGAPSKRH ADGTYTSDVS TYLQDQAAKD FVSWLKSGRA
RRESAEESRN GPMSRRHVDG SFTSDVNKVL DSLAAKEYLL WVMTSKTSGK SNKRQEDH


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