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Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R)

 GLP2R_HUMAN             Reviewed;         553 AA.
O95838; Q4VAT3;
11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
12-SEP-2018, entry version 137.
RecName: Full=Glucagon-like peptide 2 receptor;
Short=GLP-2 receptor;
Short=GLP-2-R;
Short=GLP-2R;
Name=GLP2R;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Stomach;
PubMed=9990065; DOI=10.1073/pnas.96.4.1569;
Munroe D.G., Gupta A.K., Kooshesh F., Vyas T.B., Rizkalla G., Wang H.,
Demchyshyn L., Yang Z.-H., Kamboj R.K., Chen H., McCallum K.,
Sumner-Smith M., Drucker D.J., Crivici A.;
"Prototypic G protein-coupled receptor for the intestinotrophic factor
glucagon-like peptide 2.";
Proc. Natl. Acad. Sci. U.S.A. 96:1569-1573(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-470.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: This is a receptor for glucagon-like peptide 2. The
activity of this receptor is mediated by G proteins which activate
adenylyl cyclase.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
{ECO:0000305}.
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EMBL; AF105367; AAD16895.1; -; mRNA.
EMBL; BC096262; AAH96262.1; -; mRNA.
CCDS; CCDS11150.1; -.
RefSeq; NP_004237.1; NM_004246.2.
UniGene; Hs.248202; -.
ProteinModelPortal; O95838; -.
MINT; O95838; -.
STRING; 9606.ENSP00000262441; -.
BindingDB; O95838; -.
ChEMBL; CHEMBL5844; -.
DrugBank; DB00040; Glucagon recombinant.
DrugBank; DB08900; Teduglutide.
GuidetoPHARMACOLOGY; 250; -.
iPTMnet; O95838; -.
PhosphoSitePlus; O95838; -.
BioMuta; GLP2R; -.
PaxDb; O95838; -.
PRIDE; O95838; -.
ProteomicsDB; 51084; -.
Ensembl; ENST00000262441; ENSP00000262441; ENSG00000065325.
GeneID; 9340; -.
KEGG; hsa:9340; -.
UCSC; uc002gmd.2; human.
CTD; 9340; -.
DisGeNET; 9340; -.
EuPathDB; HostDB:ENSG00000065325.12; -.
GeneCards; GLP2R; -.
HGNC; HGNC:4325; GLP2R.
HPA; CAB022690; -.
HPA; HPA049244; -.
MIM; 603659; gene.
neXtProt; NX_O95838; -.
OpenTargets; ENSG00000065325; -.
PharmGKB; PA28726; -.
eggNOG; KOG4564; Eukaryota.
eggNOG; ENOG410XRS2; LUCA.
GeneTree; ENSGT00760000118800; -.
HOGENOM; HOG000008250; -.
HOVERGEN; HBG008318; -.
InParanoid; O95838; -.
KO; K04582; -.
OMA; HEILFSF; -.
OrthoDB; EOG091G0NF8; -.
PhylomeDB; O95838; -.
TreeFam; TF315710; -.
Reactome; R-HSA-418555; G alpha (s) signalling events.
Reactome; R-HSA-420092; Glucagon-type ligand receptors.
GeneWiki; Glucagon-like_peptide_2_receptor; -.
GenomeRNAi; 9340; -.
PRO; PR:O95838; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000065325; Expressed in 78 organ(s), highest expression level in muscle layer of sigmoid colon.
CleanEx; HS_GLP2R; -.
ExpressionAtlas; O95838; baseline and differential.
Genevisible; O95838; HS.
GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO; GO:0004967; F:glucagon receptor activity; IEA:Ensembl.
GO; GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
Gene3D; 4.10.1240.10; -; 1.
InterPro; IPR039125; GLP2R.
InterPro; IPR017981; GPCR_2-like.
InterPro; IPR036445; GPCR_2_extracell_dom_sf.
InterPro; IPR001879; GPCR_2_extracellular_dom.
InterPro; IPR000832; GPCR_2_secretin-like.
InterPro; IPR017983; GPCR_2_secretin-like_CS.
PANTHER; PTHR12011:SF269; PTHR12011:SF269; 1.
Pfam; PF00002; 7tm_2; 1.
Pfam; PF02793; HRM; 1.
PRINTS; PR00249; GPCRSECRETIN.
SMART; SM00008; HormR; 1.
SUPFAM; SSF111418; SSF111418; 1.
PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism;
Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 553 Glucagon-like peptide 2 receptor.
/FTId=PRO_0000012838.
TOPO_DOM 1 173 Extracellular. {ECO:0000250}.
TRANSMEM 174 198 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 199 210 Cytoplasmic. {ECO:0000250}.
TRANSMEM 211 235 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 236 261 Extracellular. {ECO:0000250}.
TRANSMEM 262 285 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 286 299 Cytoplasmic. {ECO:0000250}.
TRANSMEM 300 321 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 322 339 Extracellular. {ECO:0000250}.
TRANSMEM 340 362 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 363 386 Cytoplasmic. {ECO:0000250}.
TRANSMEM 387 405 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 406 417 Extracellular. {ECO:0000250}.
TRANSMEM 418 438 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 439 550 Cytoplasmic. {ECO:0000250}.
CARBOHYD 97 97 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 113 113 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 148 148 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 162 162 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 83 105 {ECO:0000250}.
DISULFID 96 137 {ECO:0000250}.
DISULFID 118 159 {ECO:0000250}.
VARIANT 22 22 H -> L (in dbSNP:rs8072568).
/FTId=VAR_033967.
VARIANT 470 470 D -> N (in dbSNP:rs17681684).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_033968.
VARIANT 523 523 R -> H (in dbSNP:rs16958918).
/FTId=VAR_033969.
SEQUENCE 553 AA; 63001 MW; DA37379DF774A8F4 CRC64;
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR PFLTLVLLVS
IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF DQYVCWPHSS PGNVSVPCPS
YLPWWSEESS GRAYRHCLAQ GTWQTIENAT DIWQDDSECS ENHSFKQNVD RYALLSTLQL
MYTVGYSFSL ISLFLALTLL LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS
KRPDNENGWM SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC VTVNFFIFLK
ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL FSFITDDQVE GFAKLIRLFI
QLTLSSFHGF LVALQYGFAN GEVKAELRKY WVRFLLARHS GCRACVLGKD FRFLGKCPKK
LSEGDGAEKL RKLQPSLNSG RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM
ANTMEEILEE SEI


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