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Glutamyl-tRNA reductase-binding protein, chloroplastic (AtGluTRBP) (GluTR-binding protein) (Protein PROTON GRADIENT REGULATION 7)

 GLUBP_ARATH             Reviewed;         317 AA.
Q9LU39; Q8LAE4;
26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-APR-2018, entry version 115.
RecName: Full=Glutamyl-tRNA reductase-binding protein, chloroplastic {ECO:0000303|PubMed:22180625};
Short=AtGluTRBP {ECO:0000303|PubMed:22180625};
Short=GluTR-binding protein {ECO:0000303|PubMed:22180625};
AltName: Full=Protein PROTON GRADIENT REGULATION 7 {ECO:0000303|PubMed:20657737};
Flags: Precursor;
Name=GLUTRBP {ECO:0000303|PubMed:22180625};
Synonyms=PGR7 {ECO:0000303|PubMed:20657737};
OrderedLocusNames=At3g21200 {ECO:0000312|Araport:AT3G21200};
ORFNames=MXL8.5 {ECO:0000312|EMBL:AAL32732.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10819329; DOI=10.1093/dnares/7.2.131;
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
features of the regions of 4,504,864 bp covered by sixty P1 and TAC
clones.";
DNA Res. 7:131-135(2000).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[5]
FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
PubMed=20657737; DOI=10.1371/journal.pone.0011688;
Jung H.S., Okegawa Y., Shih P.M., Kellogg E., Abdel-Ghany S.E.,
Pilon M., Sjolander K., Shikanai T., Niyogi K.K.;
"Arabidopsis thaliana PGR7 encodes a conserved chloroplast protein
that is necessary for efficient photosynthetic electron transport.";
PLoS ONE 5:E11688-E11688(2010).
[6]
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH HEMA1, AND DISRUPTION
PHENOTYPE.
PubMed=22180625; DOI=10.1105/tpc.111.086421;
Czarnecki O., Hedtke B., Melzer M., Rothbart M., Richter A.,
Schroter Y., Pfannschmidt T., Grimm B.;
"An Arabidopsis GluTR binding protein mediates spatial separation of
5-aminolevulinic acid synthesis in chloroplasts.";
Plant Cell 23:4476-4491(2011).
[7]
X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 42-317, FUNCTION, AND
SUBUNIT.
PubMed=24753615; DOI=10.1073/pnas.1400166111;
Zhao A., Fang Y., Chen X., Zhao S., Dong W., Lin Y., Gong W., Liu L.;
"Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex
with its stimulator protein.";
Proc. Natl. Acad. Sci. U.S.A. 111:6630-6635(2014).
-!- FUNCTION: Involved in the regulation of glutamyl-tRNA reductase
(GluTR) which is important for the synthesis and distribution of
5-aminolevulinate, a precursor in heme and chlorophyll
biosynthesis (PubMed:22180625). Stimulates GluTR activity and
regulates glutamate-1-semialdehyde release. May play a role in
heme metabolism (PubMed:24753615). Necessary for efficient
photosynthetic electron transport in chloroplasts
(PubMed:20657737).
-!- SUBUNIT: Interacts with HEMA1 (PubMed:22180625, PubMed:24753615)
and forms a heterotetramer of two GLUTRBP and two HEMA1 subunits
(PubMed:24753615). {ECO:0000269|PubMed:22180625,
ECO:0000269|PubMed:24753615}.
-!- SUBCELLULAR LOCATION: Plastid, chloroplast stroma
{ECO:0000269|PubMed:20657737, ECO:0000269|PubMed:22180625}.
Note=Detected at low levels in thylakoids.
{ECO:0000269|PubMed:20657737, ECO:0000269|PubMed:22180625}.
-!- DISRUPTION PHENOTYPE: Reduced growth, slightly pale green leaves,
reduced levels of chlorophyll and heme, and low non-photochemical
quenching (NPQ). {ECO:0000269|PubMed:20657737,
ECO:0000269|PubMed:22180625}.
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EMBL; AB023045; BAB01711.1; -; Genomic_DNA.
EMBL; CP002686; AEE76475.1; -; Genomic_DNA.
EMBL; AY062654; AAL32732.1; -; mRNA.
EMBL; BT002574; AAO00934.1; -; mRNA.
EMBL; AY087867; AAM65419.1; -; mRNA.
RefSeq; NP_566678.1; NM_113015.3.
UniGene; At.70384; -.
UniGene; At.8075; -.
PDB; 4N7R; X-ray; 2.80 A; C/D=42-317.
PDB; 5CHE; X-ray; 3.20 A; C/D=42-317.
PDBsum; 4N7R; -.
PDBsum; 5CHE; -.
ProteinModelPortal; Q9LU39; -.
SMR; Q9LU39; -.
BioGrid; 7005; 1.
IntAct; Q9LU39; 1.
STRING; 3702.AT3G21200.1; -.
PaxDb; Q9LU39; -.
EnsemblPlants; AT3G21200.1; AT3G21200.1; AT3G21200.
GeneID; 821673; -.
Gramene; AT3G21200.1; AT3G21200.1; AT3G21200.
KEGG; ath:AT3G21200; -.
Araport; AT3G21200; -.
TAIR; locus:2094741; AT3G21200.
eggNOG; ENOG410IJ42; Eukaryota.
eggNOG; ENOG410XX7U; LUCA.
HOGENOM; HOG000030673; -.
InParanoid; Q9LU39; -.
OMA; QCTIQGT; -.
OrthoDB; EOG09360J0T; -.
PhylomeDB; Q9LU39; -.
PRO; PR:Q9LU39; -.
Proteomes; UP000006548; Chromosome 3.
ExpressionAtlas; Q9LU39; baseline and differential.
Genevisible; Q9LU39; AT.
GO; GO:0009507; C:chloroplast; IDA:TAIR.
GO; GO:0009570; C:chloroplast stroma; IDA:TAIR.
GO; GO:0009534; C:chloroplast thylakoid; IDA:TAIR.
GO; GO:0048037; F:cofactor binding; IEA:InterPro.
GO; GO:0043495; F:protein membrane anchor; IDA:TAIR.
GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0009767; P:photosynthetic electron transport chain; IMP:TAIR.
GO; GO:0070455; P:positive regulation of heme biosynthetic process; IMP:TAIR.
GO; GO:0009791; P:post-embryonic development; IMP:TAIR.
GO; GO:0033014; P:tetrapyrrole biosynthetic process; IMP:TAIR.
Gene3D; 2.30.110.10; -; 1.
Gene3D; 3.20.180.10; -; 1.
InterPro; IPR019595; DUF2470.
InterPro; IPR037119; Haem_oxidase_HugZ-like_sf.
InterPro; IPR012349; Split_barrel_FMN-bd.
Pfam; PF10615; DUF2470; 1.
1: Evidence at protein level;
3D-structure; Chlorophyll biosynthesis; Chloroplast;
Complete proteome; Heme biosynthesis; Plastid; Reference proteome;
Transit peptide.
TRANSIT 1 42 Chloroplast. {ECO:0000305}.
CHAIN 43 317 Glutamyl-tRNA reductase-binding protein,
chloroplastic. {ECO:0000255}.
/FTId=PRO_0000430936.
CONFLICT 27 27 F -> L (in Ref. 4; AAM65419).
CONFLICT 102 102 V -> I (in Ref. 4; AAM65419).
CONFLICT 154 154 R -> K (in Ref. 4; AAM65419).
CONFLICT 162 162 K -> E (in Ref. 4; AAM65419).
HELIX 61 71 {ECO:0000244|PDB:4N7R}.
STRAND 74 80 {ECO:0000244|PDB:4N7R}.
STRAND 82 84 {ECO:0000244|PDB:4N7R}.
STRAND 86 95 {ECO:0000244|PDB:4N7R}.
STRAND 101 104 {ECO:0000244|PDB:4N7R}.
STRAND 114 120 {ECO:0000244|PDB:4N7R}.
TURN 124 126 {ECO:0000244|PDB:4N7R}.
STRAND 130 138 {ECO:0000244|PDB:4N7R}.
STRAND 141 143 {ECO:0000244|PDB:4N7R}.
HELIX 144 157 {ECO:0000244|PDB:4N7R}.
HELIX 163 165 {ECO:0000244|PDB:4N7R}.
STRAND 166 179 {ECO:0000244|PDB:4N7R}.
STRAND 185 188 {ECO:0000244|PDB:4N7R}.
HELIX 189 194 {ECO:0000244|PDB:4N7R}.
TURN 199 203 {ECO:0000244|PDB:4N7R}.
HELIX 204 214 {ECO:0000244|PDB:4N7R}.
HELIX 216 225 {ECO:0000244|PDB:4N7R}.
STRAND 235 242 {ECO:0000244|PDB:4N7R}.
STRAND 245 251 {ECO:0000244|PDB:4N7R}.
STRAND 256 262 {ECO:0000244|PDB:4N7R}.
HELIX 270 288 {ECO:0000244|PDB:4N7R}.
STRAND 303 305 {ECO:0000244|PDB:4N7R}.
SEQUENCE 317 AA; 35463 MW; B38BDD80F2632F8A CRC64;
MQLQTQSFAL NLLPSPNFAK PIERREFISL KRDPSRPISL RCSVSTTLDT PATASTHKPF
PAEVSRSIME LSSVGTLSTL THDGWPLGVG VRFAVDKDGT PVLCLNRSVS PDKRSALHVQ
LEQCGLRTPQ CTIQGSIGRP GDDTVLKRLS ATWREKFGEE VKEDSLYVVA VDRVLQMEDF
MEDGIWVASS DYKNASPDPL RDIAEDIVNQ INANNMEDIF RFCNVYVDLD FVVSETKMIW
MDRLGFDLRV WSPRGVYDVR IPFPMEVTDE KGAKSSFNGM SQLAWEVEKS YCPADFNKVK
LLKQVVGSSH SHKGGGQ


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