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Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)

 GLRX5_DANRE             Reviewed;         155 AA.
Q6PBM1;
23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
25-OCT-2017, entry version 95.
RecName: Full=Glutaredoxin-related protein 5, mitochondrial;
AltName: Full=Monothiol glutaredoxin-5;
Flags: Precursor;
Name=glrx5; Synonyms=grx5, shiraz; ORFNames=si:ch211-121d13.1;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
DISRUPTION PHENOTYPE.
PubMed=16110529; DOI=10.1038/nature03887;
The Tuebingen 2000 screen consortium;
Wingert R.A., Galloway J.L., Barut B., Foott H., Fraenkel P.,
Axe J.L., Weber G.J., Dooley K., Davidson A.J., Schmid B., Paw B.H.,
Shaw G.C., Kingsley P., Palis J., Schubert H., Chen O., Kaplan J.,
Zon L.I.;
"Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for
vertebrate haem synthesis.";
Nature 436:1035-1039(2005).
[2]
ERRATUM.
The Tuebingen 2000 screen consortium;
Wingert R.A., Galloway J.L., Barut B., Foott H., Fraenkel P.,
Axe J.L., Weber G.J., Dooley K., Davidson A.J., Schmid B., Paw B.H.,
Shaw G.C., Kingsley P., Palis J., Schubert H., Chen O., Kaplan J.;
Nature 437:920-920(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Monothiol glutaredoxin involved in iron-sulfur
biogenesis. Required for normal iron homeostasis. Required for
normal hemoglobin biosynthesis. {ECO:0000269|PubMed:16110529}.
-!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16110529}.
-!- DEVELOPMENTAL STAGE: Detected in embryonic intermediate cell mass
(site of hematopoiesis), liver and heart.
-!- DISRUPTION PHENOTYPE: Lethal between 7 and 10 dpf. Embryos show
hypochromia, and circulating blood cells are pale due to a defect
in hemoglobin biosynthesis. {ECO:0000269|PubMed:16110529}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; DQ083329; AAZ30729.1; -; mRNA.
EMBL; AL845550; CAI11571.1; -; Genomic_DNA.
EMBL; BC059659; AAH59659.1; -; mRNA.
RefSeq; NP_998186.1; NM_213021.1.
UniGene; Dr.75137; -.
ProteinModelPortal; Q6PBM1; -.
SMR; Q6PBM1; -.
STRING; 7955.ENSDARP00000064111; -.
PaxDb; Q6PBM1; -.
PRIDE; Q6PBM1; -.
Ensembl; ENSDART00000064112; ENSDARP00000064111; ENSDARG00000043665.
GeneID; 406294; -.
KEGG; dre:406294; -.
CTD; 51218; -.
ZFIN; ZDB-GENE-040426-1957; glrx5.
eggNOG; KOG0911; Eukaryota.
eggNOG; COG0278; LUCA.
GeneTree; ENSGT00550000075082; -.
HOGENOM; HOG000095211; -.
HOVERGEN; HBG105368; -.
InParanoid; Q6PBM1; -.
KO; K07390; -.
OMA; KGTKLMP; -.
OrthoDB; EOG091G0YN0; -.
PhylomeDB; Q6PBM1; -.
TreeFam; TF318988; -.
Reactome; R-DRE-1362409; Mitochondrial iron-sulfur cluster biogenesis.
PRO; PR:Q6PBM1; -.
Proteomes; UP000000437; Chromosome 20.
Bgee; ENSDARG00000043665; -.
GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
GO; GO:0005739; C:mitochondrion; IDA:ZFIN.
GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
GO; GO:0030097; P:hemopoiesis; IMP:ZFIN.
GO; GO:0016226; P:iron-sulfur cluster assembly; IMP:ZFIN.
CDD; cd03028; GRX_PICOT_like; 1.
InterPro; IPR002109; Glutaredoxin.
InterPro; IPR033658; GRX_PICOT-like.
InterPro; IPR014434; Monothiol_GRX.
InterPro; IPR004480; Monothiol_GRX-rel.
InterPro; IPR036249; Thioredoxin-like_sf.
PANTHER; PTHR10293; PTHR10293; 1.
Pfam; PF00462; Glutaredoxin; 1.
PIRSF; PIRSF005894; Monothiol_GRX; 1.
SUPFAM; SSF52833; SSF52833; 1.
TIGRFAMs; TIGR00365; TIGR00365; 1.
PROSITE; PS51354; GLUTAREDOXIN_2; 1.
2: Evidence at transcript level;
2Fe-2S; Complete proteome; Iron; Iron-sulfur; Metal-binding;
Mitochondrion; Redox-active center; Reference proteome;
Transit peptide.
TRANSIT 1 14 Mitochondrion. {ECO:0000255}.
CHAIN 15 155 Glutaredoxin-related protein 5,
mitochondrial.
/FTId=PRO_0000392601.
DOMAIN 42 145 Glutaredoxin. {ECO:0000255|PROSITE-
ProRule:PRU00686}.
REGION 97 101 Glutathione binding. {ECO:0000250}.
REGION 122 123 Glutathione binding. {ECO:0000250}.
METAL 67 67 Iron-sulfur (2Fe-2S); shared with dimeric
partner. {ECO:0000250}.
BINDING 59 59 Glutathione. {ECO:0000250}.
BINDING 109 109 Glutathione; via amide nitrogen and
carbonyl oxygen. {ECO:0000250}.
SEQUENCE 155 AA; 17377 MW; F0B356FA69AAEA27 CRC64;
MNSVFRSTAR CLRSATWQYK TAHKNGELSV GRARLMCSSA GQKNLEEMVK KDKVVVFMKG
TPAQPMCGFS NAVVQILRMH GVDNYASYNV LDDQDVRQGI KTFSNWPTIP QVFFNGEFVG
GCDILLQMHQ SGDLVEELQK LGIRSALLDQ EKESK


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