Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Glycerol-3-phosphate acyltransferase (Acyl-PO4 G3P acyltransferase) (Acyl-phosphate--glycerol-3-phosphate acyltransferase) (G3P acyltransferase) (GPAT) (EC 2.3.1.n3) (Lysophosphatidic acid synthase) (LPA synthase)

 PLSY_STRR6              Reviewed;         213 AA.
P0A4Q0; Q54916;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
05-DEC-2018, entry version 83.
RecName: Full=Glycerol-3-phosphate acyltransferase;
AltName: Full=Acyl-PO4 G3P acyltransferase;
AltName: Full=Acyl-phosphate--glycerol-3-phosphate acyltransferase;
AltName: Full=G3P acyltransferase;
Short=GPAT;
EC=2.3.1.n3;
AltName: Full=Lysophosphatidic acid synthase;
Short=LPA synthase;
Name=plsY; OrderedLocusNames=spr0755;
Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
Streptococcus.
NCBI_TaxID=171101;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-255 / R6;
PubMed=11544234; DOI=10.1128/JB.183.19.5709-5717.2001;
Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E.,
LeBlanc D.J., Lee L.N., Lefkowitz E.J., Lu J., Matsushima P.,
McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I.,
Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P.,
Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G.,
Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L.,
Glass J.I.;
"Genome of the bacterium Streptococcus pneumoniae strain R6.";
J. Bacteriol. 183:5709-5717(2001).
[2]
FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, AND NOMENCLATURE.
PubMed=16949372; DOI=10.1016/j.molcel.2006.06.030;
Lu Y.-J., Zhang Y.-M., Grimes K.D., Qi J., Lee R.E., Rock C.O.;
"Acyl-phosphates initiate membrane phospholipid synthesis in Gram-
positive pathogens.";
Mol. Cell 23:765-772(2006).
[3]
TOPOLOGY, MUTAGENESIS OF SER-36; ASN-43; ARG-46; GLY-102; GLY-103;
LYS-104; HIS-185 AND ASN-188, ACTIVITY REGULATION, AND
BIOPHYSICOCHEMICAL PROPERTIES.
PubMed=17308305; DOI=10.1074/jbc.M700374200;
Lu Y.-J., Zhang F., Grimes K.D., Lee R.E., Rock C.O.;
"Topology and active site of PlsY: the bacterial
acylphosphate:glycerol-3-phosphate acyltransferase.";
J. Biol. Chem. 282:11339-11346(2007).
-!- FUNCTION: Catalyzes the transfer of an acyl group from acyl-
phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form
lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate
as fatty acyl donor, but not acyl-CoA or acyl-ACP.
{ECO:0000269|PubMed:16949372}.
-!- CATALYTIC ACTIVITY:
Reaction=an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-
sn-glycero-3-phosphate + phosphate; Xref=Rhea:RHEA:34075,
ChEBI:CHEBI:43474, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970,
ChEBI:CHEBI:59918; EC=2.3.1.n3;
Evidence={ECO:0000269|PubMed:16949372};
-!- ACTIVITY REGULATION: Inhibited by acyl-CoA and 1-acylglycerol-3-
phosphate. {ECO:0000269|PubMed:16949372,
ECO:0000269|PubMed:17308305}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=100 uM for glycerol-3-phosphate (at 37 degrees Celsius and at
pH 7.4) {ECO:0000269|PubMed:17308305};
KM=30 uM for acyl-phosphate (at 37 degrees Celsius and at pH
7.4) {ECO:0000269|PubMed:17308305};
pH dependence:
Optimum pH is 7.4. {ECO:0000269|PubMed:17308305};
-!- PATHWAY: Lipid metabolism; phospholipid metabolism.
-!- SUBUNIT: Probably interacts with PlsX. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the PlsY family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AE007317; AAK99559.1; -; Genomic_DNA.
PIR; C97966; C97966.
RefSeq; NP_358349.1; NC_003098.1.
RefSeq; WP_000628789.1; NC_003098.1.
STRING; 171101.spr0755; -.
SwissLipids; SLP:000001798; -.
EnsemblBacteria; AAK99559; AAK99559; spr0755.
GeneID; 934290; -.
KEGG; spr:spr0755; -.
PATRIC; fig|171101.6.peg.835; -.
eggNOG; ENOG4105K7Z; Bacteria.
eggNOG; COG0344; LUCA.
HOGENOM; HOG000283807; -.
KO; K08591; -.
OMA; HSQYPKI; -.
BioCyc; MetaCyc:MONOMER-14087; -.
BioCyc; SPNE171101:SPR0755-MONOMER; -.
SABIO-RK; P0A4Q0; -.
UniPathway; UPA00085; -.
Proteomes; UP000000586; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0043772; F:acyl-phosphate glycerol-3-phosphate acyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
HAMAP; MF_01043; PlsY; 1.
InterPro; IPR003811; G3P_acylTferase_PlsY.
PANTHER; PTHR30309; PTHR30309; 1.
Pfam; PF02660; G3P_acyltransf; 1.
SMART; SM01207; G3P_acyltransf; 1.
TIGRFAMs; TIGR00023; TIGR00023; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Lipid biosynthesis;
Lipid metabolism; Membrane; Phospholipid biosynthesis;
Phospholipid metabolism; Reference proteome; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 213 Glycerol-3-phosphate acyltransferase.
/FTId=PRO_0000188465.
TOPO_DOM 1 3 Extracellular. {ECO:0000255}.
TRANSMEM 4 22 Helical. {ECO:0000255}.
TOPO_DOM 23 51 Cytoplasmic. {ECO:0000255}.
TRANSMEM 52 74 Helical. {ECO:0000255}.
TOPO_DOM 75 80 Extracellular. {ECO:0000255}.
TRANSMEM 81 100 Helical. {ECO:0000255}.
TOPO_DOM 101 142 Cytoplasmic. {ECO:0000255}.
TRANSMEM 143 161 Helical. {ECO:0000255}.
TOPO_DOM 162 162 Extracellular. {ECO:0000255}.
TRANSMEM 163 184 Helical. {ECO:0000255}.
TOPO_DOM 185 213 Cytoplasmic. {ECO:0000255}.
MUTAGEN 36 36 S->A: Loss of acyltransferase activity.
{ECO:0000269|PubMed:17308305}.
MUTAGEN 43 43 N->A: 5% of wild-type activity.
{ECO:0000269|PubMed:17308305}.
MUTAGEN 46 46 R->A: Loss of acyltransferase activity.
{ECO:0000269|PubMed:17308305}.
MUTAGEN 102 102 G->A: Defect in substrate binding.
{ECO:0000269|PubMed:17308305}.
MUTAGEN 103 103 G->A: Defect in substrate binding.
{ECO:0000269|PubMed:17308305}.
MUTAGEN 104 104 K->A: Loss of acyltransferase activity.
{ECO:0000269|PubMed:17308305}.
MUTAGEN 185 185 H->A: 0.6% of wild-type activity.
{ECO:0000269|PubMed:17308305}.
MUTAGEN 188 188 N->A: Loss of acyltransferase activity.
{ECO:0000269|PubMed:17308305}.
SEQUENCE 213 AA; 22929 MW; 22CB089C17750818 CRC64;
MITIVLLILA YLLGSIPSGL WIGQVFFQIN LREHGSGNTG TTNTFRILGK KAGMATFVID
FFKGTLATLL PIIFHLQGVS PLIFGLLAVI GHTFPIFAGF KGGKAVATSA GVIFGFAPIF
CLYLAIIFFG ALYLGSMISL SSVTASIAAV IGVLLFPLFG FILSNYDSLF IAIILALASL
IIIRHKDNIA RIKNKTENLV PWGLNLTHQD PKK


Related products :

Catalog number Product name Quantity
EIAAB31420 1-acylglycerol-3-phosphate O-acyltransferase 2,1-acyl-sn-glycerol-3-phosphate acyltransferase beta,1-AGP acyltransferase 2,1-AGPAT 2,Agpat2,LPAAT-beta,Lysophosphatidic acid acyltransferase beta,Mouse,
EIAAB31416 1-acylglycerol-3-phosphate O-acyltransferase 1,1-acyl-sn-glycerol-3-phosphate acyltransferase alpha,1-AGP acyltransferase 1,1-AGPAT 1,Agpat1,LPAAT-alpha,Lysophosphatidic acid acyltransferase alpha,Mou
EIAAB31435 1-acylglycerol-3-phosphate O-acyltransferase 3,1-acyl-sn-glycerol-3-phosphate acyltransferase gamma,1-AGP acyltransferase 3,1-AGPAT 3,Agpat3,LPAAT-gamma,Lysophosphatidic acid acyltransferase gamma,Mou
EIAAB31439 1-acylglycerol-3-phosphate O-acyltransferase 4,1-acyl-sn-glycerol-3-phosphate acyltransferase delta,1-AGP acyltransferase 4,1-AGPAT 4,Agpat4,LPAAT-delta,Lysophosphatidic acid acyltransferase delta,Rat
EIAAB31437 1-acylglycerol-3-phosphate O-acyltransferase 4,1-acyl-sn-glycerol-3-phosphate acyltransferase delta,1-AGP acyltransferase 4,1-AGPAT 4,Agpat4,LPAAT-delta,Lysophosphatidic acid acyltransferase delta,Mou
EIAAB31452 1-acylglycerol-3-phosphate O-acyltransferase 5,1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon,1-AGP acyltransferase 5,1-AGPAT 5,AGPAT5,Homo sapiens,Human,LPAAT-epsilon,Lysophosphatidic acid ac
EIAAB31417 1-acylglycerol-3-phosphate O-acyltransferase 1,1-acyl-sn-glycerol-3-phosphate acyltransferase alpha,1-AGP acyltransferase 1,1-AGPAT 1,AGPAT1,Bos taurus,Bovine,LPAAT-alpha,Lysophosphatidic acid acyltra
EIAAB31438 1-acylglycerol-3-phosphate O-acyltransferase 4,1-acyl-sn-glycerol-3-phosphate acyltransferase delta,1-AGP acyltransferase 4,1-AGPAT 4,AGPAT4,Bos taurus,Bovine,LPAAT-delta,Lysophosphatidic acid acyltra
EIAAB31418 1-acylglycerol-3-phosphate O-acyltransferase 1,1-acyl-sn-glycerol-3-phosphate acyltransferase alpha,1-AGP acyltransferase 1,1-AGPAT 1,AGPAT1,G15,Homo sapiens,Human,LPAAT-alpha,Lysophosphatidic acid ac
EIAAB31451 1-acylglycerol-3-phosphate O-acyltransferase 5,1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon,1-AGP acyltransferase 5,1-AGPAT 5,Agpat5,D8Ertd319e,LPAAT-epsilon,Lysophosphatidic acid acyltransf
EIAAB31436 1-acylglycerol-3-phosphate O-acyltransferase 4,1-acyl-sn-glycerol-3-phosphate acyltransferase delta,1-AGP acyltransferase 4,1-AGPAT 4,AGPAT4,Homo sapiens,Human,LPAAT-delta,Lysophosphatidic acid acyltr
EIAAB31419 1-acylglycerol-3-phosphate O-acyltransferase 2,1-acyl-sn-glycerol-3-phosphate acyltransferase beta,1-AGP acyltransferase 2,1-AGPAT 2,AGPAT2,Homo sapiens,Human,LPAAT-beta,Lysophosphatidic acid acyltran
EIAAB31434 1-acylglycerol-3-phosphate O-acyltransferase 3,1-acyl-sn-glycerol-3-phosphate acyltransferase gamma,1-AGP acyltransferase 3,1-AGPAT 3,AGPAT3,Homo sapiens,Human,LPAAT-gamma,Lysophosphatidic acid acyltr
CSB-EL001452RA Rat 1-acyl-sn-glycerol-3-phosphate acyltransferase delta(AGPAT4) ELISA kit 96T
E1550c Human ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase delta 96T
E11254m Mouse ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma 96T
E0505m Human ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha 96T
PLCA_BOVIN Bovine ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha 96T
E1672r Bovine ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase delta 96T
PLCE_MOUSE Mouse ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 96T
ZN238_BOVIN Mouse ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 96T
FUT9_MOUSE Mouse ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 96T
PLCA_MOUSE Mouse ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha 96T
PARF_BOVIN Human ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha 96T
E0172h Mouse ELISA Kit FOR 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur