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Glycine betaine/proline betaine transport system ATP-binding protein ProV

 PROV_ECOLI              Reviewed;         400 AA.
P14175;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
28-MAR-2018, entry version 166.
RecName: Full=Glycine betaine/proline betaine transport system ATP-binding protein ProV {ECO:0000305};
Name=proV {ECO:0000303|PubMed:2649479};
OrderedLocusNames=b2677, JW2652;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2649479; DOI=10.1128/jb.171.4.1923-1931.1989;
Gowrishankar J.;
"Nucleotide sequence of the osmoregulatory proU operon of Escherichia
coli.";
J. Bacteriol. 171:1923-1931(1989).
[2]
ERRATUM.
Gowrishankar J.;
J. Bacteriol. 172:1165-1165(1990).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=9205837; DOI=10.1093/dnares/4.2.91;
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K.,
Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N.,
Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H.,
Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S.,
Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C.,
Yamagata S., Horiuchi T.;
"Construction of a contiguous 874-kb sequence of the Escherichia coli-
K12 genome corresponding to 50.0-68.8 min on the linkage map and
analysis of its sequence features.";
DNA Res. 4:91-113(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-224.
STRAIN=K12;
PubMed=2691838; DOI=10.1111/j.1365-2958.1989.tb00253.x;
Stirling D.A., Hulton C.S.J., Waddell L., Park S.F., Stewart G.S.A.B.,
Booth I.R., Higgins C.F.;
"Molecular characterization of the proU loci of Salmonella typhimurium
and Escherichia coli encoding osmoregulated glycine betaine transport
systems.";
Mol. Microbiol. 3:1025-1038(1989).
[7]
FUNCTION IN GLYCINE BETAINE TRANSPORT.
PubMed=3305496;
Barron A., Jung J.U., Villarejo W.;
"Purification and characterization of a glycine betaine binding
protein from Escherichia coli.";
J. Biol. Chem. 262:11841-11846(1987).
[8]
FUNCTION IN PROLINE BETAINE TRANSPORT.
PubMed=7898450; DOI=10.1007/BF00290728;
Haardt M., Kempf B., Faatz E., Bremer E.;
"The osmoprotectant proline betaine is a major substrate for the
binding-protein-dependent transport system ProU of Escherichia coli K-
12.";
Mol. Gen. Genet. 246:783-786(1995).
[9]
IDENTIFICATION BY 2D-GEL.
PubMed=9298644; DOI=10.1002/elps.1150180805;
VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R.,
Neidhardt F.C.;
"Escherichia coli proteome analysis using the gene-protein database.";
Electrophoresis 18:1243-1251(1997).
[10]
SUBCELLULAR LOCATION.
STRAIN=BL21-DE3;
PubMed=16079137; DOI=10.1074/jbc.M506479200;
Stenberg F., Chovanec P., Maslen S.L., Robinson C.V., Ilag L.,
von Heijne G., Daley D.O.;
"Protein complexes of the Escherichia coli cell envelope.";
J. Biol. Chem. 280:34409-34419(2005).
[11]
FUNCTION IN GLYCINE BETAINE TRANSPORT, AND SUBUNIT.
STRAIN=K12;
PubMed=23249124; DOI=10.3109/09687688.2012.754060;
Gul N., Poolman B.;
"Functional reconstitution and osmoregulatory properties of the ProU
ABC transporter from Escherichia coli.";
Mol. Membr. Biol. 30:138-148(2013).
-!- FUNCTION: Part of the ProU ABC transporter complex involved in
glycine betaine and proline betaine uptake (PubMed:3305496,
PubMed:7898450, PubMed:23249124). Probably responsible for energy
coupling to the transport system (Probable).
{ECO:0000269|PubMed:23249124, ECO:0000269|PubMed:3305496,
ECO:0000269|PubMed:7898450, ECO:0000305}.
-!- SUBUNIT: The complex is composed of two ATP-binding proteins
(ProV), two transmembrane proteins (ProW) and a solute-binding
protein (ProX). {ECO:0000269|PubMed:23249124}.
-!- INTERACTION:
P14176:proW; NbExp=2; IntAct=EBI-546797, EBI-8794761;
-!- SUBCELLULAR LOCATION: Cell inner membrane
{ECO:0000269|PubMed:16079137}; Peripheral membrane protein
{ECO:0000269|PubMed:16079137}.
-!- SIMILARITY: Belongs to the ABC transporter superfamily.
{ECO:0000305}.
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EMBL; M24856; AAA24427.1; -; Genomic_DNA.
EMBL; U00096; AAC75724.1; -; Genomic_DNA.
EMBL; AP009048; BAA16542.1; -; Genomic_DNA.
EMBL; X52694; CAA36923.1; -; Genomic_DNA.
PIR; JS0128; BVECPV.
RefSeq; NP_417163.1; NC_000913.3.
RefSeq; WP_000985494.1; NZ_LN832404.1.
ProteinModelPortal; P14175; -.
SMR; P14175; -.
BioGrid; 4262264; 24.
DIP; DIP-10574N; -.
IntAct; P14175; 6.
STRING; 316407.1800065; -.
TCDB; 3.A.1.12.1; the atp-binding cassette (abc) superfamily.
PaxDb; P14175; -.
PRIDE; P14175; -.
EnsemblBacteria; AAC75724; AAC75724; b2677.
EnsemblBacteria; BAA16542; BAA16542; BAA16542.
GeneID; 947148; -.
KEGG; ecj:JW2652; -.
KEGG; eco:b2677; -.
PATRIC; fig|1411691.4.peg.4064; -.
EchoBASE; EB0764; -.
EcoGene; EG10771; proV.
eggNOG; ENOG4108IJ7; Bacteria.
eggNOG; COG4175; LUCA.
InParanoid; P14175; -.
KO; K02000; -.
OMA; YKVFGRR; -.
PhylomeDB; P14175; -.
BioCyc; EcoCyc:PROV-MONOMER; -.
BioCyc; MetaCyc:PROV-MONOMER; -.
PRO; PR:P14175; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; ISM:EcoCyc.
GO; GO:0005275; F:amine transmembrane transporter activity; IDA:EcoCyc.
GO; GO:0005524; F:ATP binding; ISM:EcoCyc.
GO; GO:0016887; F:ATPase activity; IEA:InterPro.
GO; GO:0005034; F:osmosensor activity; ISM:EcoCyc.
GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
GO; GO:0031460; P:glycine betaine transport; IDA:EcoCyc.
GO; GO:0006972; P:hyperosmotic response; IDA:EcoCyc.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR003439; ABC_transporter-like.
InterPro; IPR017871; ABC_transporter_CS.
InterPro; IPR000644; CBS_dom.
InterPro; IPR005892; Gly-betaine_transp_ATP-bd.
InterPro; IPR027417; P-loop_NTPase.
Pfam; PF00005; ABC_tran; 1.
Pfam; PF00571; CBS; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR01186; proV; 1.
PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PROSITE; PS51371; CBS; 2.
1: Evidence at protein level;
Amino-acid transport; ATP-binding; CBS domain; Cell inner membrane;
Cell membrane; Complete proteome; Membrane; Nucleotide-binding;
Reference proteome; Repeat; Transport.
CHAIN 1 400 Glycine betaine/proline betaine transport
system ATP-binding protein ProV.
/FTId=PRO_0000092761.
DOMAIN 29 265 ABC transporter. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
DOMAIN 282 341 CBS 1. {ECO:0000255|PROSITE-
ProRule:PRU00703}.
DOMAIN 343 400 CBS 2. {ECO:0000255|PROSITE-
ProRule:PRU00703}.
NP_BIND 61 68 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
SEQUENCE 400 AA; 44163 MW; 45A98D45F028B1B9 CRC64;
MAIKLEIKNL YKIFGEHPQR AFKYIEQGLS KEQILEKTGL SLGVKDASLA IEEGEIFVIM
GLSGSGKSTM VRLLNRLIEP TRGQVLIDGV DIAKISDAEL REVRRKKIAM VFQSFALMPH
MTVLDNTAFG MELAGINAEE RREKALDALR QVGLENYAHS YPDELSGGMR QRVGLARALA
INPDILLMDE AFSALDPLIR TEMQDELVKL QAKHQRTIVF ISHDLDEAMR IGDRIAIMQN
GEVVQVGTPD EILNNPANDY VRTFFRGVDI SQVFSAKDIA RRTPNGLIRK TPGFGPRSAL
KLLQDEDREY GYVIERGNKF VGAVSIDSLK TALTQQQGLD AALIDAPLAV DAQTPLSELL
SHVGQAPCAV PVVDEDQQYV GIISKGMLLR ALDREGVNNG


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