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Glycoprotein 42 (gp42)

 ENV_FRSFB               Reviewed;         356 AA.
P31793;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
25-OCT-2017, entry version 92.
RecName: Full=Glycoprotein 42;
Short=gp42;
Flags: Precursor;
Name=env;
Friend spleen focus-forming virus (strain BB6) (FSFFV).
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
Gammaretrovirus; unclassified Gammaretrovirus.
NCBI_TaxID=31692;
NCBI_TaxID=10090; Mus musculus (Mouse).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1583724;
Majumdar M.K., Cho C.L., Fox M.T., Eckner K.L., Kozak S., Kabat D.,
Geib R.W.;
"Mutations in the env gene of friend spleen focus-forming virus
overcome Fv-2r-mediated resistance to Friend virus-induced
erythroleukemia.";
J. Virol. 66:3652-3660(1992).
-!- FUNCTION: This envelope-like membrane glycoprotein is responsible
for ligand-independent activation of the erythropoietin receptor
EPOR leading to the abnormally rapid proliferation of erythroid
precursor cells. In the first stage of Friend disease,
constitutive activation of the EPOR by gp42 causes uncontrolled,
polyclonal proliferation of infected erythroblasts, leading to
polycythemia (massive increase in the number of mature red cells).
Host susceptibility to SSFV-induced erythroblastosis usually
depends on the expression of the truncated isoform of MST1R
receptor tyrosine kinase (MST1R isoform sf-Stk), but the deletion
mutant BB6 apparently can overcome its absence.
-!- SUBUNIT: Homooligomer. Forms heterooligomers with mouse EPOR,
probably via their respective transmembrane domains. BB6 deletion
mutant does not interact with mouse MST1R isoform sf-Stk.
-!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane; Single-
pass type I membrane protein. Host cell membrane; Single-pass type
I membrane protein. Virion membrane; Single-pass type I membrane
protein. Note=The envelope-like membrane glycoprotein gp55 is
defective in its transport to the cell surface and remains
associated predominantly with the rough endoplasmic reticulum
(RER) membrane. It is almost not incorporated into virions. Host
cell surface expression appears to be a prerequisite for its
leukemogenicity (By similarity). {ECO:0000250}.
-!- MISCELLANEOUS: Compared to other gammaretroviruses which possess 2
envelope proteins (gp70 and p15E), FSFFV gp55 corresponds to a
gp70-p15E fusion protein with a deletion of a portion of p15E. It
is encoded by the defective env gene of the virus. Strain BB6 gp42
is a truncated form of gp55.
-!- MISCELLANEOUS: The Friend murine leukemia virus complex induces a
rapid and fatal erythroleukemia in adult mice. It is the
replication-defective spleen focus-forming virus (SFFV) contained
in this complex that causes foci of proliferating erythroid cells
in spleens of infected mice. The second component is a replication
competent Friend murine leukemia virus (F-MuLV) that serves as a
helper virus for SFFV.
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EMBL; M90673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
PIR; A41995; VCVWB6.
ProteinModelPortal; P31793; -.
SMR; P31793; -.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019028; C:viral capsid; IEA:InterPro.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
Gene3D; 3.90.310.10; -; 2.
InterPro; IPR008981; FMuLV_rcpt-bd.
InterPro; IPR018154; TLV/ENV_coat_polyprotein.
PANTHER; PTHR10424; PTHR10424; 2.
Pfam; PF00429; TLV_coat; 2.
SUPFAM; SSF49830; SSF49830; 1.
3: Inferred from homology;
Fusion of virus membrane with host cell membrane;
Fusion of virus membrane with host membrane; Glycoprotein;
Host cell membrane; Host endoplasmic reticulum; Host membrane;
Host-virus interaction; Membrane; Oncogene; Signal; Transmembrane;
Transmembrane helix; Viral attachment to host cell;
Viral envelope protein; Viral penetration into host cytoplasm; Virion;
Virus entry into host cell.
SIGNAL 1 32 {ECO:0000255}.
CHAIN 33 356 Glycoprotein 42.
/FTId=PRO_0000040722.
TOPO_DOM 33 331 Virion surface. {ECO:0000255}.
TRANSMEM 332 352 Helical. {ECO:0000255}.
TOPO_DOM 353 356 Intravirion. {ECO:0000255}.
MOTIF 306 309 CXXC.
COMPBIAS 229 278 Pro-rich.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 58 58 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 296 296 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 328 328 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
SEQUENCE 356 AA; 38778 MW; 0C7893BE2794F980 CRC64;
MEGPAFSKPL KDKINPWGPL IVLGILIRAG VSVQRDSPHQ VFNVTWRVTN LMTGQTANAT
SLLGTMTDAF PKLYFDLCDL IGNDWDETRL GCRTPGEGKR ARTFDLYVCP GHTVPTGCGG
PREGYCGKWG CETTGQAYWK PSSSWDLISL KRGNTPKDRG PCYDSSVSSG VQGATPGGRC
NPLVLKFTDA GKKASWDAPK VWGLRLYRST GTDPVTRFSL TRQVLNIGPR VPIGPNPVIS
DQLPPSRPAQ IMLPRPPQPP PPGTASIVPE TAPPSQQPGT RDRLLNLVNK AYQALNLTSP
DKTQECWLCL VSRPPYYEGV AVLGTNSNHT TLISTIMGLL IILLLLLILL LWTLHS


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