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Glycoprotein 55 (gp55)

 ENV_FRSF5               Reviewed;         409 AA.
P03393;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
28-MAR-2018, entry version 105.
RecName: Full=Glycoprotein 55;
Short=gp55;
Flags: Precursor;
Name=env;
Friend spleen focus-forming virus (isolate 502) (FSFFV).
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
Gammaretrovirus; unclassified Gammaretrovirus.
NCBI_TaxID=355329;
NCBI_TaxID=10088; Mus.
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=6576374; DOI=10.1073/pnas.80.16.5037;
Clark S.P., Mak T.W.;
"Complete nucleotide sequence of an infectious clone of Friend spleen
focus-forming provirus: gp55 is an envelope fusion glycoprotein.";
Proc. Natl. Acad. Sci. U.S.A. 80:5037-5041(1983).
[2]
CHARACTERIZATION.
PubMed=2159537;
Watanabe N., Nishi M., Ikawa Y., Amanuma H.;
"A deletion in the Friend spleen focus-forming virus env gene is
necessary for its product (gp55) to be leukemogenic.";
J. Virol. 64:2678-2686(1990).
[3]
ERRATUM.
Watanabe N., Nishi M., Ikawa Y., Amanuma H.;
J. Virol. 64:5694-5694(1990).
[4]
REVIEW.
PubMed=11090047;
Ney P.A., D'Andrea A.D.;
"Friend erythroleukemia revisited.";
Blood 96:3675-3680(2000).
[5]
FUNCTION, AND INTERACTION WITH MOUSE MST1R ISOFORM SF-STK.
PubMed=11483734; DOI=10.1128/JVI.75.17.7893-7903.2001;
Nishigaki K., Thompson D., Hanson C., Yugawa T., Ruscetti S.;
"The envelope glycoprotein of friend spleen focus-forming virus
covalently interacts with and constitutively activates a truncated
form of the receptor tyrosine kinase Stk.";
J. Virol. 75:7893-7903(2001).
[6]
FUNCTION, SUBUNIT, AND INTERACTION WITH MOUSE EPOR.
PubMed=12930840; DOI=10.1074/jbc.M302974200;
Constantinescu S.N., Keren T., Russ W.P., Ubarretxena-Belandia I.,
Malka Y., Kubatzky K.F., Engelman D.M., Lodish H.F., Henis Y.I.;
"The erythropoietin receptor transmembrane domain mediates complex
formation with viral anemic and polycythemic gp55 proteins.";
J. Biol. Chem. 278:43755-43763(2003).
-!- FUNCTION: This envelope-like membrane glycoprotein is responsible
for ligand-independent activation of the erythropoietin receptor
EPOR leading to the abnormally rapid proliferation of erythroid
precursor cells. In the first stage of Friend disease,
constitutive activation of EPOR by gp55 causes uncontrolled,
polyclonal proliferation of infected erythroblasts, leading to
polycythemia (massive increase in the number of mature red cells).
Host susceptibility to SSFV-induced erythroblastosis depends on
the expression of the truncated isoform of MST1R receptor tyrosine
kinase (MST1R isoform sf-Stk). Interaction with SSFV gp 55 results
in constitutive tyrosine phosphorylation and activation of MST1R
isoform sf-Stk. {ECO:0000269|PubMed:11483734,
ECO:0000269|PubMed:12930840}.
-!- SUBUNIT: Homooligomer (Probable). Forms heterooligomers with mouse
EPOR, probably via their respective transmembrane domains. Forms
covalent heterodimers with mouse MST1R isoform sf-Stk, probably
via disulfide bonds. {ECO:0000269|PubMed:12930840, ECO:0000305}.
-!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane; Single-
pass type I membrane protein. Host cell membrane; Single-pass type
I membrane protein. Virion membrane {ECO:0000305}; Single-pass
type I membrane protein {ECO:0000305}. Note=The envelope-like
membrane glycoprotein gp55 is defective in its transport to the
cell surface and remains associated predominantly with the rough
endoplasmic reticulum (RER) membrane. It is almost not
incorporated into virions. Host cell surface expression appears to
be a prerequisite for its leukemogenicity.
-!- MISCELLANEOUS: Compared to other gammaretroviruses which possess 2
envelope proteins (gp70 and p15E), gp55 corresponds to a gp70-p15E
fusion protein with a deletion of a portion of p15E. It is encoded
by the defective env gene of the virus.
-!- MISCELLANEOUS: The Friend murine leukemia virus complex induces a
rapid and fatal erythroleukemia in adult mice. It is the
replication-defective spleen focus-forming virus (SFFV) contained
in this complex that causes foci of proliferating erythroid cells
in spleens of infected mice. The second component is a replication
competent Friend murine leukemia virus (F-MuLV) that serves as a
helper virus for SFFV.
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EMBL; K00021; AAA46487.1; -; Genomic_RNA.
PIR; A03993; VCVW5S.
RefSeq; NP_041218.1; NC_001500.1.
ProteinModelPortal; P03393; -.
SMR; P03393; -.
UniCarbKB; P03393; -.
GeneID; 1491889; -.
KEGG; vg:1491889; -.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
Gene3D; 3.90.310.10; -; 1.
InterPro; IPR008981; FMuLV_rcpt-bd.
InterPro; IPR018154; TLV/ENV_coat_polyprotein.
PANTHER; PTHR10424; PTHR10424; 2.
Pfam; PF00429; TLV_coat; 3.
SUPFAM; SSF49830; SSF49830; 1.
1: Evidence at protein level;
Disulfide bond; Fusion of virus membrane with host cell membrane;
Fusion of virus membrane with host membrane; Glycoprotein;
Host cell membrane; Host endoplasmic reticulum; Host membrane;
Host-virus interaction; Membrane; Oncogene; Signal; Transmembrane;
Transmembrane helix; Viral attachment to host cell;
Viral envelope protein; Viral penetration into host cytoplasm; Virion;
Virus entry into host cell.
SIGNAL 1 32 {ECO:0000255}.
CHAIN 33 409 Glycoprotein 55.
/FTId=PRO_0000040718.
TOPO_DOM 33 384 Virion surface. {ECO:0000255}.
TRANSMEM 385 405 Helical. {ECO:0000255}.
TOPO_DOM 406 409 Intravirion. {ECO:0000255}.
COMPBIAS 229 278 Pro-rich.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 58 58 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 296 296 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 328 328 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 377 377 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
SEQUENCE 409 AA; 44777 MW; 407F56F769863D74 CRC64;
MKGPAFSKPL KDKINPWGPL IVLGILIRAG VSVQHDSPHQ VFNVTWRVTN LMTGQTANAT
SLLGTMTDAF PMLHFDLCDL IGDDWDETGL ECRTPGGRKR ARTFDFYVCP GHTVPTGCGG
PREGYCGKWG CETTGQAYWK PSSSWDLISL KRGNTPKDRG PCYDSSVSSG VQGATPGGRC
NPLVLKFTDA GKKASWDSPK VWGLRLYRPT GIDPVTRFSL TRQVLNIGPR IPIGPNPVII
GQLPPSRPVQ VRLPRPPQPP PTGAASMVPG TAPPSQQPGT GDRLLNLVQG AYQALNLTNP
DKTQECWLCL VSGPPYYEGV AVLGTNSNHT SALKEKCCFY ADHTGLVRDS MAKLRKRLTQ
RQKLFESSQG WFEGSFNRSP WFTTLISTIM GLLIILLLLL ILLLWTLHS


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