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Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)

 GOGA2_HUMAN             Reviewed;        1002 AA.
Q08379; A0A0C4DGS5; Q6GRM9; Q9BRB0; Q9NYF9;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
20-APR-2010, sequence version 3.
10-OCT-2018, entry version 175.
RecName: Full=Golgin subfamily A member 2;
AltName: Full=130 kDa cis-Golgi matrix protein {ECO:0000303|PubMed:8315394};
Short=GM130 {ECO:0000303|PubMed:26363069, ECO:0000303|PubMed:8315394};
AltName: Full=GM130 autoantigen {ECO:0000303|PubMed:8315394};
AltName: Full=Golgin-95 {ECO:0000303|PubMed:8315394};
Name=GOLGA2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND SUBCELLULAR LOCATION.
TISSUE=Liver;
PubMed=8315394; DOI=10.1084/jem.178.1.49;
Fritzler M.J., Hamel J.C., Ochs R.L., Chan E.K.L.;
"Molecular characterization of two human autoantigens: unique cDNAs
encoding 95- and 160-kD proteins of a putative family in the Golgi
complex.";
J. Exp. Med. 178:49-62(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164053; DOI=10.1038/nature02465;
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Colon adenocarcinoma;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 13-1002 (ISOFORM 1), AND INTERACTION
WITH RAB1B.
TISSUE=Placenta;
PubMed=11306556; DOI=10.1093/embo-reports/kve065;
Weide T., Bayer M., Koester M., Siebrasse J.-P., Peters R.,
Barnekow A.;
"The Golgi matrix protein GM130: a specific interacting partner of the
small GTPase rab1b.";
EMBO Rep. 2:336-341(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-1002 (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[7]
SUBCELLULAR LOCATION.
PubMed=11781572; DOI=10.1038/ncb1201-1101;
Marra P., Maffucci T., Daniele T., Tullio G.D., Ikehara Y., Chan E.K.,
Luini A., Beznoussenko G., Mironov A., De Matteis M.A.;
"The GM130 and GRASP65 Golgi proteins cycle through and define a
subdomain of the intermediate compartment.";
Nat. Cell Biol. 3:1101-1113(2001).
[8]
CLEAVAGE BY CASPASE.
PubMed=15003503; DOI=10.1016/j.bbrc.2004.02.015;
Walker A., Ward C., Sheldrake T.A., Dransfield I., Rossi A.G.,
Pryde J.G., Haslett C.;
"Golgi fragmentation during Fas-mediated apoptosis is associated with
the rapid loss of GM130.";
Biochem. Biophys. Res. Commun. 316:6-11(2004).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=16964243; DOI=10.1038/nbt1240;
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein
phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[10]
FUNCTION, AND INTERACTION WITH GORASP1.
PubMed=16489344; DOI=10.1038/ncb1366;
Puthenveedu M.A., Bachert C., Puri S., Lanni F., Linstedt A.D.;
"GM130 and GRASP65-dependent lateral cisternal fusion allows uniform
Golgi-enzyme distribution.";
Nat. Cell Biol. 8:238-248(2006).
[11]
FUNCTION.
PubMed=17314401; DOI=10.1091/mbc.E06-10-0886;
Marra P., Salvatore L., Mironov A. Jr., Di Campli A., Di Tullio G.,
Trucco A., Beznoussenko G., Mironov A., De Matteis M.A.;
"The biogenesis of the Golgi ribbon: the roles of membrane input from
the ER and of GM130.";
Mol. Biol. Cell 18:1595-1608(2007).
[12]
INTERACTION WITH ZFPL1.
PubMed=18323775; DOI=10.1038/emboj.2008.40;
Chiu C.-F., Ghanekar Y., Frost L., Diao A., Morrison D., McKenzie E.,
Lowe M.;
"ZFPL1, a novel ring finger protein required for cis-Golgi integrity
and efficient ER-to-Golgi transport.";
EMBO J. 27:934-947(2008).
[13]
FUNCTION, AND INTERACTION WITH GORASP1.
PubMed=18045989; DOI=10.1091/mbc.E07-08-0847;
Kodani A., Sutterlin C.;
"The Golgi protein GM130 regulates centrosome morphology and
function.";
Mol. Biol. Cell 19:745-753(2008).
[14]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of
the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-438, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[16]
FUNCTION, AND INTERACTION WITH AKAP9.
PubMed=19242490; DOI=10.1038/emboj.2009.47;
Rivero S., Cardenas J., Bornens M., Rios R.M.;
"Microtubule nucleation at the cis-side of the Golgi apparatus
requires AKAP450 and GM130.";
EMBO J. 28:1016-1028(2009).
[17]
FUNCTION.
PubMed=19109421; DOI=10.1091/mbc.E08-08-0834;
Kodani A., Kristensen I., Huang L., Sutterlin C.;
"GM130-dependent control of Cdc42 activity at the Golgi regulates
centrosome organization.";
Mol. Biol. Cell 20:1192-1200(2009).
[18]
FUNCTION, PHOSPHORYLATION AT SER-37, METHYLATION AT ARG-18; ARG-30 AND
ARG-35, AND MUTAGENESIS OF ARG-18; ARG-30 AND ARG-35.
PubMed=20421892; DOI=10.1038/cr.2010.56;
Zhou Z., Sun X., Zou Z., Sun L., Zhang T., Guo S., Wen Y., Liu L.,
Wang Y., Qin J., Li L., Gong W., Bao S.;
"PRMT5 regulates Golgi apparatus structure through methylation of the
golgin GM130.";
Cell Res. 20:1023-1033(2010).
[19]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[20]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[21]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-438; SER-953 AND
SER-981, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[22]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-690 AND
SER-937, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[23]
FUNCTION, SUBCELLULAR LOCATION, DOMAIN, PHOSPHORYLATION, AND
MUTAGENESIS OF 26-LYS--LYS-49 AND SER-37.
PubMed=26165940; DOI=10.1016/j.cell.2015.06.014;
Wei J.H., Zhang Z.C., Wynn R.M., Seemann J.;
"GM130 regulates Golgi-derived spindle assembly by activating TPX2 and
capturing microtubules.";
Cell 162:287-299(2015).
[24]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[25] {ECO:0000244|PDB:4REY}
X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 980-1002 IN COMPLEX WITH
GORASP1, INTERACTION WITH GORASP1, FUNCTION, SUBUNIT, AND MUTAGENESIS
OF PHE-987 AND ILE-1002.
PubMed=26363069; DOI=10.1074/jbc.M115.657940;
Hu F., Shi X., Li B., Huang X., Morelli X., Shi N.;
"Structural basis for the interaction between the Golgi reassembly-
stacking protein GRASP65 and the Golgi matrix protein GM130.";
J. Biol. Chem. 290:26373-26382(2015).
-!- FUNCTION: Peripheral membrane component of the cis-Golgi stack
that acts as a membrane skeleton that maintains the structure of
the Golgi apparatus, and as a vesicle thether that facilitates
vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344).
Required for normal protein transport from the endoplasmic
reticulum to the Golgi apparatus and the cell membrane (By
similarity). Together with p115/USO1 and STX5, involved in vesicle
tethering and fusion at the cis-Golgi membrane to maintain the
stacked and inter-connected structure of the Golgi apparatus.
Plays a central role in mitotic Golgi disassembly: phosphorylation
at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction
with p115/USO1, preventing tethering of COPI vesicles and thereby
inhibiting transport through the Golgi apparatus during mitosis
(By similarity). Also plays a key role in spindle pole assembly
and centrosome organization (PubMed:26165940). Promotes the
mitotic spindle pole assembly by activating the spindle assembly
factor TPX2 to nucleate microtubules around the Golgi and capture
them to couple mitotic membranes to the spindle: upon
phosphorylation at the onset of mitosis, GOLGA2 interacts with
importin-alpha via the nuclear localization signal region, leading
to recruit importin-alpha to the Golgi membranes and liberate the
spindle assembly factor TPX2 from importin-alpha. TPX2 then
activates AURKA kinase and stimulates local microtubule
nucleation. Upon filament assembly, nascent microtubules are
further captured by GOLGA2, thus linking Golgi membranes to the
spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic
spindle pole assembly, probably via the same mechanism (By
similarity). Also regulates the centrosome organization
(PubMed:18045989, PubMed:19109421). Also required for the Golgi
ribbon formation and glycosylation of membrane and secretory
proteins (PubMed:16489344, PubMed:17314401).
{ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4,
ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401,
ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421,
ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940,
ECO:0000305|PubMed:26363069}.
-!- SUBUNIT: Homodimer, may assemble into homohexamers
(PubMed:26363069). Homotetramer; forms a parallel homotetramer
with a flexible rod-like structure that can give rise to I- and Y-
shaped conformations (By similarity). Interacts with
GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989,
PubMed:26363069). The homooligomer forms a complex with GORASP1
with a 1:1 stoichiometry (By similarity). Interacts with RAB1B
that has been activated by GTP-binding (PubMed:11306556).
Interacts with p115/USO1; interaction with p115/USO1 inhibits
interaction with STX5 and/or RAB1B. Interacts with STX5 (By
similarity). Interacts with ZFPL1 (PubMed:18323775). Interacts
with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-
Golgi (PubMed:19242490). {ECO:0000250|UniProtKB:Q62839,
ECO:0000269|PubMed:11306556, ECO:0000269|PubMed:16489344,
ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:18323775,
ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26363069}.
-!- INTERACTION:
Self; NbExp=6; IntAct=EBI-618309, EBI-618309;
A8K2R3:-; NbExp=3; IntAct=EBI-618309, EBI-9977437;
P29991:- (xeno); NbExp=3; IntAct=EBI-618309, EBI-8826488;
Q9WMX2:- (xeno); NbExp=2; IntAct=EBI-618309, EBI-6863748;
O75689:ADAP1; NbExp=3; IntAct=EBI-618309, EBI-714732;
Q08117:AES; NbExp=3; IntAct=EBI-618309, EBI-717810;
Q08117-2:AES; NbExp=5; IntAct=EBI-618309, EBI-11741437;
Q9UHB7:AFF4; NbExp=3; IntAct=EBI-618309, EBI-395282;
Q9UHB7-2:AFF4; NbExp=3; IntAct=EBI-618309, EBI-10261324;
Q99996:AKAP9; NbExp=3; IntAct=EBI-618309, EBI-1048311;
Q96Q83:ALKBH3; NbExp=3; IntAct=EBI-618309, EBI-6658697;
Q9Y2J4-4:AMOTL2; NbExp=3; IntAct=EBI-618309, EBI-10187270;
Q96IX9:ANKRD36BP1; NbExp=5; IntAct=EBI-618309, EBI-744859;
Q0P5N6:ARL16; NbExp=5; IntAct=EBI-618309, EBI-10186132;
P40617:ARL4A; NbExp=5; IntAct=EBI-618309, EBI-2875746;
O15145:ARPC3; NbExp=5; IntAct=EBI-618309, EBI-351829;
Q8NEY4-2:ATP6V1C2; NbExp=5; IntAct=EBI-618309, EBI-10270867;
Q6PJ05:ATP6V1D; NbExp=3; IntAct=EBI-618309, EBI-10253919;
Q8N5Z9:ATP6V1D; NbExp=3; IntAct=EBI-618309, EBI-10266952;
O75348:ATP6V1G1; NbExp=3; IntAct=EBI-618309, EBI-711802;
O15169:AXIN1; NbExp=3; IntAct=EBI-618309, EBI-710484;
Q8TBE0:BAHD1; NbExp=3; IntAct=EBI-618309, EBI-742750;
A0AVN2:BARD1; NbExp=3; IntAct=EBI-618309, EBI-9977322;
Q99728:BARD1; NbExp=5; IntAct=EBI-618309, EBI-473181;
O75934:BCAS2; NbExp=7; IntAct=EBI-618309, EBI-1050106;
P41182:BCL6; NbExp=4; IntAct=EBI-618309, EBI-765407;
A8KA13:BCL6B; NbExp=3; IntAct=EBI-618309, EBI-10174813;
Q13895:BYSL; NbExp=7; IntAct=EBI-618309, EBI-358049;
Q8NA57:C12orf50; NbExp=5; IntAct=EBI-618309, EBI-10268935;
Q9NX04:C1orf109; NbExp=3; IntAct=EBI-618309, EBI-8643161;
Q53TS8:C2CD6; NbExp=5; IntAct=EBI-618309, EBI-739879;
Q9HC52:CBX8; NbExp=5; IntAct=EBI-618309, EBI-712912;
Q8IX12:CCAR1; NbExp=5; IntAct=EBI-618309, EBI-356265;
Q8IYE0-2:CCDC146; NbExp=3; IntAct=EBI-618309, EBI-10247802;
Q8NCX0:CCDC150; NbExp=3; IntAct=EBI-618309, EBI-10269342;
Q96LX7:CCDC17; NbExp=3; IntAct=EBI-618309, EBI-719840;
Q9NVL8:CCDC198; NbExp=3; IntAct=EBI-618309, EBI-10238351;
Q6NSX1:CCDC70; NbExp=3; IntAct=EBI-618309, EBI-6873045;
Q9NVE4:CCDC87; NbExp=5; IntAct=EBI-618309, EBI-749261;
Q8TD31-3:CCHCR1; NbExp=7; IntAct=EBI-618309, EBI-10175300;
P24863:CCNC; NbExp=3; IntAct=EBI-618309, EBI-395261;
P51946:CCNH; NbExp=5; IntAct=EBI-618309, EBI-741406;
Q86Y33:CDC20B; NbExp=3; IntAct=EBI-618309, EBI-10260504;
Q99459:CDC5L; NbExp=5; IntAct=EBI-618309, EBI-374880;
Q6P1J9:CDC73; NbExp=10; IntAct=EBI-618309, EBI-930143;
Q07002:CDK18; NbExp=5; IntAct=EBI-618309, EBI-746238;
Q8IVW4:CDKL3; NbExp=3; IntAct=EBI-618309, EBI-3919850;
Q6IPU0:CENPP; NbExp=3; IntAct=EBI-618309, EBI-10250303;
Q8IYX8:CEP57L1; NbExp=5; IntAct=EBI-618309, EBI-1104570;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-618309, EBI-10181988;
Q9Y6H1:CHCHD2; NbExp=5; IntAct=EBI-618309, EBI-2321769;
Q9NX63:CHCHD3; NbExp=3; IntAct=EBI-618309, EBI-743375;
Q96RK0:CIC; NbExp=3; IntAct=EBI-618309, EBI-945857;
Q9BW66:CINP; NbExp=5; IntAct=EBI-618309, EBI-739784;
P31146:CORO1A; NbExp=3; IntAct=EBI-618309, EBI-1046676;
Q1MSJ5-1:CSPP1; NbExp=3; IntAct=EBI-618309, EBI-10239122;
Q93034:CUL5; NbExp=3; IntAct=EBI-618309, EBI-1057139;
Q6BCY4:CYB5R2; NbExp=3; IntAct=EBI-618309, EBI-744761;
Q9UER7:DAXX; NbExp=7; IntAct=EBI-618309, EBI-77321;
Q9UJW0:DCTN4; NbExp=7; IntAct=EBI-618309, EBI-2134033;
O43602:DCX; NbExp=4; IntAct=EBI-618309, EBI-8646694;
P26196:DDX6; NbExp=5; IntAct=EBI-618309, EBI-351257;
Q05D60:DEUP1; NbExp=6; IntAct=EBI-618309, EBI-748597;
Q15398:DLGAP5; NbExp=3; IntAct=EBI-618309, EBI-748280;
Q08495:DMTN; NbExp=3; IntAct=EBI-618309, EBI-715275;
Q86UW9:DTX2; NbExp=3; IntAct=EBI-618309, EBI-740376;
Q5JVL4:EFHC1; NbExp=3; IntAct=EBI-618309, EBI-743105;
A0A0S2Z3U4:EGR2; NbExp=6; IntAct=EBI-618309, EBI-16431598;
O75821:EIF3G; NbExp=3; IntAct=EBI-618309, EBI-366632;
Q9NQT4:EXOSC5; NbExp=3; IntAct=EBI-618309, EBI-371876;
Q9BQ89:FAM110A; NbExp=5; IntAct=EBI-618309, EBI-1752811;
Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-618309, EBI-741626;
Q8IXS8:FAM126B; NbExp=3; IntAct=EBI-618309, EBI-8787606;
Q3B820:FAM161A; NbExp=4; IntAct=EBI-618309, EBI-719941;
Q6P9G8:FAM184A; NbExp=3; IntAct=EBI-618309, EBI-10253239;
Q96PV7-2:FAM193B; NbExp=3; IntAct=EBI-618309, EBI-10292648;
Q9NSI2:FAM207A; NbExp=3; IntAct=EBI-618309, EBI-5457304;
Q32MH5:FAM214A; NbExp=3; IntAct=EBI-618309, EBI-2866142;
Q9Y247:FAM50B; NbExp=3; IntAct=EBI-618309, EBI-742802;
Q86YD7:FAM90A1; NbExp=7; IntAct=EBI-618309, EBI-6658203;
Q8TES7-6:FBF1; NbExp=3; IntAct=EBI-618309, EBI-10244131;
Q96D16:FBXL18; NbExp=3; IntAct=EBI-618309, EBI-744419;
Q9NVF7:FBXO28; NbExp=6; IntAct=EBI-618309, EBI-740282;
Q6UN15:FIP1L1; NbExp=3; IntAct=EBI-618309, EBI-1021914;
A4D1I3:FLJ34048; NbExp=3; IntAct=EBI-618309, EBI-10173415;
Q9BVV2:FNDC11; NbExp=3; IntAct=EBI-618309, EBI-744935;
P23769:GATA2; NbExp=3; IntAct=EBI-618309, EBI-2806671;
Q8WXI9:GATAD2B; NbExp=3; IntAct=EBI-618309, EBI-923440;
Q96CN9:GCC1; NbExp=5; IntAct=EBI-618309, EBI-746252;
P55040:GEM; NbExp=5; IntAct=EBI-618309, EBI-744104;
P14136:GFAP; NbExp=8; IntAct=EBI-618309, EBI-744302;
Q8IVS8:GLYCTK; NbExp=5; IntAct=EBI-618309, EBI-748515;
P63218:GNG5; NbExp=3; IntAct=EBI-618309, EBI-10220734;
Q9H8Y8:GORASP2; NbExp=6; IntAct=EBI-618309, EBI-739467;
O95872:GPANK1; NbExp=3; IntAct=EBI-618309, EBI-751540;
Q92917:GPKOW; NbExp=5; IntAct=EBI-618309, EBI-746309;
Q14687:GSE1; NbExp=6; IntAct=EBI-618309, EBI-372619;
A4D1E9:GTPBP10; NbExp=3; IntAct=EBI-618309, EBI-5453796;
Q96CS2:HAUS1; NbExp=3; IntAct=EBI-618309, EBI-2514791;
Q643R0:HCTP4; NbExp=3; IntAct=EBI-618309, EBI-10248808;
P56524:HDAC4; NbExp=3; IntAct=EBI-618309, EBI-308629;
A0A0S2Z4Q4:HGS; NbExp=3; IntAct=EBI-618309, EBI-16429135;
O14964:HGS; NbExp=3; IntAct=EBI-618309, EBI-740220;
P17482:HOXB9; NbExp=3; IntAct=EBI-618309, EBI-745290;
Q96KN8-3:HRASLS5; NbExp=5; IntAct=EBI-618309, EBI-10290304;
Q96M11:HYLS1; NbExp=3; IntAct=EBI-618309, EBI-720016;
Q8IY31:IFT20; NbExp=3; IntAct=EBI-618309, EBI-744203;
Q9BW83:IFT27; NbExp=3; IntAct=EBI-618309, EBI-747093;
Q15735:INPP5J; NbExp=5; IntAct=EBI-618309, EBI-10236940;
Q9H1K1:ISCU; NbExp=3; IntAct=EBI-618309, EBI-1047335;
P27987:ITPKB; NbExp=4; IntAct=EBI-618309, EBI-751388;
Q63ZY3:KANK2; NbExp=6; IntAct=EBI-618309, EBI-2556193;
Q7Z3B3:KANSL1; NbExp=4; IntAct=EBI-618309, EBI-740244;
Q92993:KAT5; NbExp=3; IntAct=EBI-618309, EBI-399080;
Q5T5P2-6:KIAA1217; NbExp=5; IntAct=EBI-618309, EBI-10188326;
Q9BVG8:KIFC3; NbExp=3; IntAct=EBI-618309, EBI-2125614;
P04264:KRT1; NbExp=5; IntAct=EBI-618309, EBI-298429;
P05783:KRT18; NbExp=6; IntAct=EBI-618309, EBI-297888;
P02538:KRT6A; NbExp=6; IntAct=EBI-618309, EBI-702198;
P04259:KRT6B; NbExp=3; IntAct=EBI-618309, EBI-740907;
P48668:KRT6C; NbExp=3; IntAct=EBI-618309, EBI-2564105;
Q14847:LASP1; NbExp=3; IntAct=EBI-618309, EBI-742828;
Q6PJG3:LATS1; NbExp=3; IntAct=EBI-618309, EBI-10253976;
Q96JN0:LCOR; NbExp=3; IntAct=EBI-618309, EBI-746045;
Q13094:LCP2; NbExp=5; IntAct=EBI-618309, EBI-346946;
Q96BZ8:LENG1; NbExp=7; IntAct=EBI-618309, EBI-726510;
P17931:LGALS3; NbExp=3; IntAct=EBI-618309, EBI-1170392;
Q6NVH9:LGALS3; NbExp=3; IntAct=EBI-618309, EBI-10187804;
A0A0S2Z5S9:LHX4; NbExp=3; IntAct=EBI-618309, EBI-16429099;
Q7Z4I7-5:LIMS2; NbExp=3; IntAct=EBI-618309, EBI-10257651;
O14910:LIN7A; NbExp=3; IntAct=EBI-618309, EBI-2513988;
Q96FE5:LINGO1; NbExp=3; IntAct=EBI-618309, EBI-719955;
P25800:LMO1; NbExp=5; IntAct=EBI-618309, EBI-8639312;
P25791:LMO2; NbExp=3; IntAct=EBI-618309, EBI-739696;
Q8TAP4-4:LMO3; NbExp=4; IntAct=EBI-618309, EBI-11742507;
P61968:LMO4; NbExp=5; IntAct=EBI-618309, EBI-2798728;
Q6IAQ1:LYPLA1; NbExp=3; IntAct=EBI-618309, EBI-10249913;
Q96S90:LYSMD1; NbExp=3; IntAct=EBI-618309, EBI-10293291;
Q9Y586:MAB21L2; NbExp=3; IntAct=EBI-618309, EBI-6659161;
P61326:MAGOH; NbExp=5; IntAct=EBI-618309, EBI-299134;
Q96A72:MAGOHB; NbExp=5; IntAct=EBI-618309, EBI-746778;
O95983:MBD3; NbExp=3; IntAct=EBI-618309, EBI-1783068;
Q7L590-2:MCM10; NbExp=3; IntAct=EBI-618309, EBI-10233517;
P33993:MCM7; NbExp=3; IntAct=EBI-618309, EBI-355924;
P55081:MFAP1; NbExp=5; IntAct=EBI-618309, EBI-1048159;
Q9UJV3-2:MID2; NbExp=3; IntAct=EBI-618309, EBI-10172526;
Q9BU76:MMTAG2; NbExp=4; IntAct=EBI-618309, EBI-742459;
P51948:MNAT1; NbExp=3; IntAct=EBI-618309, EBI-716139;
Q9UBU8:MORF4L1; NbExp=3; IntAct=EBI-618309, EBI-399246;
Q15014:MORF4L2; NbExp=3; IntAct=EBI-618309, EBI-399257;
Q6PF18:MORN3; NbExp=5; IntAct=EBI-618309, EBI-9675802;
P00540:MOS; NbExp=5; IntAct=EBI-618309, EBI-1757866;
Q8IXL7:MSRB3; NbExp=3; IntAct=EBI-618309, EBI-8634060;
Q499L9:MST4; NbExp=3; IntAct=EBI-618309, EBI-6137569;
Q6P444:MTFR2; NbExp=3; IntAct=EBI-618309, EBI-10252703;
Q9P2K5-2:MYEF2; NbExp=5; IntAct=EBI-618309, EBI-10318831;
P19878:NCF2; NbExp=9; IntAct=EBI-618309, EBI-489611;
Q9GZM8:NDEL1; NbExp=3; IntAct=EBI-618309, EBI-928842;
O76041:NEBL; NbExp=3; IntAct=EBI-618309, EBI-2880203;
I6L9F6:NEFL; NbExp=3; IntAct=EBI-618309, EBI-10178578;
P07196:NEFL; NbExp=3; IntAct=EBI-618309, EBI-475646;
Q9Y5B8:NME7; NbExp=5; IntAct=EBI-618309, EBI-744782;
P29474:NOS3; NbExp=5; IntAct=EBI-618309, EBI-1391623;
O43809:NUDT21; NbExp=5; IntAct=EBI-618309, EBI-355720;
Q9NPJ8:NXT2; NbExp=3; IntAct=EBI-618309, EBI-752122;
Q96F82:ORC1L; NbExp=3; IntAct=EBI-618309, EBI-10285558;
Q9BYG5:PARD6B; NbExp=3; IntAct=EBI-618309, EBI-295391;
Q86TB9:PATL1; NbExp=5; IntAct=EBI-618309, EBI-2562092;
O75928:PIAS2; NbExp=3; IntAct=EBI-618309, EBI-348555;
Q7Z2X4:PID1; NbExp=3; IntAct=EBI-618309, EBI-10256685;
O00459:PIK3R2; NbExp=3; IntAct=EBI-618309, EBI-346930;
Q9BSJ6:PIMREG; NbExp=3; IntAct=EBI-618309, EBI-2568609;
Q13526:PIN1; NbExp=5; IntAct=EBI-618309, EBI-714158;
P78337:PITX1; NbExp=3; IntAct=EBI-618309, EBI-748265;
Q16512:PKN1; NbExp=5; IntAct=EBI-618309, EBI-602382;
Q99569:PKP4; NbExp=3; IntAct=EBI-618309, EBI-726447;
Q8WUT1:POLDIP3; NbExp=3; IntAct=EBI-618309, EBI-10276663;
Q96T49:PPP1R16B; NbExp=5; IntAct=EBI-618309, EBI-10293968;
Q6NYC8:PPP1R18; NbExp=5; IntAct=EBI-618309, EBI-2557469;
O60828:PQBP1; NbExp=6; IntAct=EBI-618309, EBI-713867;
Q13131:PRKAA1; NbExp=3; IntAct=EBI-618309, EBI-1181405;
O43741:PRKAB2; NbExp=7; IntAct=EBI-618309, EBI-1053424;
Q8WWY3:PRPF31; NbExp=10; IntAct=EBI-618309, EBI-1567797;
P25786:PSMA1; NbExp=5; IntAct=EBI-618309, EBI-359352;
P25789:PSMA4; NbExp=3; IntAct=EBI-618309, EBI-359310;
P61019:RAB2A; NbExp=6; IntAct=EBI-618309, EBI-752037;
Q8WUD1:RAB2B; NbExp=5; IntAct=EBI-618309, EBI-5542466;
Q14964:RAB39A; NbExp=5; IntAct=EBI-618309, EBI-3048577;
Q96DA2:RAB39B; NbExp=3; IntAct=EBI-618309, EBI-9089467;
Q96I25:RBM17; NbExp=6; IntAct=EBI-618309, EBI-740272;
Q14498-3:RBM39; NbExp=3; IntAct=EBI-618309, EBI-6654703;
Q96IZ5:RBM41; NbExp=5; IntAct=EBI-618309, EBI-740773;
Q9P2K3:RCOR3; NbExp=3; IntAct=EBI-618309, EBI-743428;
P57771:RGS8; NbExp=3; IntAct=EBI-618309, EBI-10216117;
Q9BSD3:RHNO1; NbExp=3; IntAct=EBI-618309, EBI-9658624;
Q8N443:RIBC1; NbExp=3; IntAct=EBI-618309, EBI-10265323;
Q96K30:RITA1; NbExp=4; IntAct=EBI-618309, EBI-2836148;
Q8IUD6:RNF135; NbExp=5; IntAct=EBI-618309, EBI-9916363;
Q63HN8-6:RNF213; NbExp=3; IntAct=EBI-618309, EBI-10248548;
A0A0S2Z4G9:RNF6; NbExp=6; IntAct=EBI-618309, EBI-16428950;
Q9UHP6:RSPH14; NbExp=5; IntAct=EBI-618309, EBI-748350;
Q7L4I2-2:RSRC2; NbExp=3; IntAct=EBI-618309, EBI-10256202;
Q14D33:RTP5; NbExp=3; IntAct=EBI-618309, EBI-10217913;
A0A0S2Z4M5:RXRB; NbExp=3; IntAct=EBI-618309, EBI-16436147;
P28702-3:RXRB; NbExp=6; IntAct=EBI-618309, EBI-16429492;
Q9UPU9:SAMD4A; NbExp=3; IntAct=EBI-618309, EBI-1047497;
Q9UHR5:SAP30BP; NbExp=3; IntAct=EBI-618309, EBI-751683;
Q9UPN6:SCAF8; NbExp=3; IntAct=EBI-618309, EBI-7954236;
O95171:SCEL; NbExp=4; IntAct=EBI-618309, EBI-7543896;
Q9BWG6:SCNM1; NbExp=5; IntAct=EBI-618309, EBI-748391;
Q96T21:SECISBP2; NbExp=3; IntAct=EBI-618309, EBI-954116;
P59797:SELENOV; NbExp=3; IntAct=EBI-618309, EBI-10216195;
Q6NXQ0:SFRS2; NbExp=3; IntAct=EBI-618309, EBI-10251550;
Q9H788:SH2D4A; NbExp=5; IntAct=EBI-618309, EBI-747035;
Q9H788-2:SH2D4A; NbExp=3; IntAct=EBI-618309, EBI-10308083;
Q08AM8:SH3RF2; NbExp=3; IntAct=EBI-618309, EBI-10225873;
Q92529:SHC3; NbExp=3; IntAct=EBI-618309, EBI-79084;
O95391:SLU7; NbExp=5; IntAct=EBI-618309, EBI-750559;
Q969G3:SMARCE1; NbExp=5; IntAct=EBI-618309, EBI-455078;
P49901:SMCP; NbExp=3; IntAct=EBI-618309, EBI-750494;
Q5SQN1:SNAP47; NbExp=3; IntAct=EBI-618309, EBI-10244848;
Q96H20:SNF8; NbExp=3; IntAct=EBI-618309, EBI-747719;
P14678-2:SNRPB; NbExp=3; IntAct=EBI-618309, EBI-372475;
P08579:SNRPB2; NbExp=3; IntAct=EBI-618309, EBI-1053651;
Q5TAL4:SNRPC; NbExp=3; IntAct=EBI-618309, EBI-10246938;
Q13573:SNW1; NbExp=5; IntAct=EBI-618309, EBI-632715;
Q9UM82:SPATA2; NbExp=3; IntAct=EBI-618309, EBI-744066;
Q8NHS9:SPATA22; NbExp=3; IntAct=EBI-618309, EBI-7067260;
Q96FJ0:STAMBPL1; NbExp=3; IntAct=EBI-618309, EBI-745021;
O00506:STK25; NbExp=13; IntAct=EBI-618309, EBI-618295;
Q9P289:STK26; NbExp=4; IntAct=EBI-618309, EBI-618239;
Q5T7P8-2:SYT6; NbExp=5; IntAct=EBI-618309, EBI-10246152;
Q9NU19:TBC1D22B; NbExp=4; IntAct=EBI-618309, EBI-8787464;
Q32MN6:TBP; NbExp=5; IntAct=EBI-618309, EBI-10239991;
Q15560:TCEA2; NbExp=5; IntAct=EBI-618309, EBI-710310;
Q8N8B7:TCEANC; NbExp=3; IntAct=EBI-618309, EBI-954696;
D2IYK5:TCF19; NbExp=3; IntAct=EBI-618309, EBI-10176552;
Q9Y242:TCF19; NbExp=3; IntAct=EBI-618309, EBI-7413767;
P56279:TCL1A; NbExp=7; IntAct=EBI-618309, EBI-749995;
D3DUQ6:TEAD4; NbExp=3; IntAct=EBI-618309, EBI-10176734;
Q15561:TEAD4; NbExp=5; IntAct=EBI-618309, EBI-747736;
A0A0S2Z5Z9:TEX9; NbExp=3; IntAct=EBI-618309, EBI-16431655;
Q8N6V9:TEX9; NbExp=3; IntAct=EBI-618309, EBI-746341;
Q01664:TFAP4; NbExp=5; IntAct=EBI-618309, EBI-2514218;
Q9BT49:THAP7; NbExp=3; IntAct=EBI-618309, EBI-741350;
P09493:TPM1; NbExp=3; IntAct=EBI-618309, EBI-351158;
P09493-10:TPM1; NbExp=3; IntAct=EBI-618309, EBI-12123928;
P09493-5:TPM1; NbExp=3; IntAct=EBI-618309, EBI-10196387;
Q9BUZ4:TRAF4; NbExp=4; IntAct=EBI-618309, EBI-3650647;
Q14134:TRIM29; NbExp=5; IntAct=EBI-618309, EBI-702370;
Q8IWZ5:TRIM42; NbExp=3; IntAct=EBI-618309, EBI-5235829;
Q8IV54:TSC22D4; NbExp=3; IntAct=EBI-618309, EBI-10261521;
Q9Y5U2:TSSC4; NbExp=3; IntAct=EBI-618309, EBI-717229;
Q96PN8:TSSK3; NbExp=5; IntAct=EBI-618309, EBI-3918381;
Q5W5X9:TTC23; NbExp=3; IntAct=EBI-618309, EBI-6447954;
Q96NG3:TTC25; NbExp=3; IntAct=EBI-618309, EBI-1046387;
Q8N5M4:TTC9C; NbExp=3; IntAct=EBI-618309, EBI-2851213;
P40222:TXLNA; NbExp=3; IntAct=EBI-618309, EBI-359793;
P63279:UBE2I; NbExp=4; IntAct=EBI-618309, EBI-80168;
Q5VVX9:UBE2U; NbExp=4; IntAct=EBI-618309, EBI-2130181;
Q15386:UBE3C; NbExp=3; IntAct=EBI-618309, EBI-1058871;
O75604:USP2; NbExp=5; IntAct=EBI-618309, EBI-743272;
Q08E77:UTP14C; NbExp=3; IntAct=EBI-618309, EBI-10225961;
Q5TAP6:UTP14C; NbExp=4; IntAct=EBI-618309, EBI-11737646;
Q548N1:VPS28; NbExp=3; IntAct=EBI-618309, EBI-10243107;
Q9UK41:VPS28; NbExp=6; IntAct=EBI-618309, EBI-727424;
A5D8V6:VPS37C; NbExp=3; IntAct=EBI-618309, EBI-2559305;
Q9Y3C0:WASHC3; NbExp=5; IntAct=EBI-618309, EBI-712969;
Q96HA8:WDYHV1; NbExp=7; IntAct=EBI-618309, EBI-741158;
Q9BW85:YJU2; NbExp=7; IntAct=EBI-618309, EBI-10300345;
Q05516:ZBTB16; NbExp=7; IntAct=EBI-618309, EBI-711925;
Q8IUH5:ZDHHC17; NbExp=3; IntAct=EBI-618309, EBI-524753;
G3V1X1:ZFC3H1; NbExp=3; IntAct=EBI-618309, EBI-6448783;
Q6ZN57:ZFP2; NbExp=3; IntAct=EBI-618309, EBI-7236323;
Q68DK2-5:ZFYVE26; NbExp=3; IntAct=EBI-618309, EBI-8656416;
A0A0S2Z6H0:ZGPAT; NbExp=6; IntAct=EBI-618309, EBI-16428984;
Q8N5A5:ZGPAT; NbExp=3; IntAct=EBI-618309, EBI-3439227;
Q8N5A5-2:ZGPAT; NbExp=11; IntAct=EBI-618309, EBI-10183064;
Q96NC0:ZMAT2; NbExp=5; IntAct=EBI-618309, EBI-2682299;
Q15973:ZNF124; NbExp=3; IntAct=EBI-618309, EBI-2555767;
P15622-3:ZNF250; NbExp=7; IntAct=EBI-618309, EBI-10177272;
Q86VK4:ZNF410; NbExp=3; IntAct=EBI-618309, EBI-720304;
Q96IQ9:ZNF414; NbExp=5; IntAct=EBI-618309, EBI-744257;
Q8TAU3:ZNF417; NbExp=3; IntAct=EBI-618309, EBI-740727;
Q96MN9:ZNF488; NbExp=3; IntAct=EBI-618309, EBI-948288;
Q7Z3I7:ZNF572; NbExp=6; IntAct=EBI-618309, EBI-10172590;
Q9P0T4:ZNF581; NbExp=3; IntAct=EBI-618309, EBI-745520;
Q96SQ5:ZNF587; NbExp=3; IntAct=EBI-618309, EBI-6427977;
A0A0S2Z5X4:ZNF688; NbExp=6; IntAct=EBI-618309, EBI-16429014;
A0A0S2Z6P0:ZNF688; NbExp=3; IntAct=EBI-618309, EBI-16429989;
Q6NX45:ZNF774; NbExp=5; IntAct=EBI-618309, EBI-10251462;
-!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
{ECO:0000269|PubMed:11781572, ECO:0000305|PubMed:8315394};
Peripheral membrane protein {ECO:0000269|PubMed:11781572};
Cytoplasmic side {ECO:0000269|PubMed:11781572}. Endoplasmic
reticulum-Golgi intermediate compartment membrane
{ECO:0000269|PubMed:11781572}; Peripheral membrane protein
{ECO:0000269|PubMed:11781572}; Cytoplasmic side
{ECO:0000269|PubMed:11781572}. Cytoplasm, cytoskeleton, spindle
pole {ECO:0000269|PubMed:26165940}. Note=Associates with the
mitotic spindle during mitosis (PubMed:26165940).
{ECO:0000250|UniProtKB:Q62839, ECO:0000269|PubMed:26165940}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q08379-1; Sequence=Displayed;
Name=2;
IsoId=Q08379-2; Sequence=VSP_007727;
-!- DOMAIN: Extended rod-like protein with long coiled-coil domains.
{ECO:0000250|UniProtKB:Q62839}.
-!- DOMAIN: The nuclear localization signal (cNLS) mediates
interaction with importin-alpha, recruiting importin-alpha to the
Golgi membrane and liberating TPX2. {ECO:0000269|PubMed:26165940}.
-!- PTM: Cleaved by caspases at the onset of apoptosis.
{ECO:0000269|PubMed:15003503}.
-!- PTM: Methylation by PRMT5 is required for Golgi ribbon formation.
While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it
is unclear whether Arg-18 is methylated in vivo.
{ECO:0000269|PubMed:20421892}.
-!- PTM: Phosphorylated at Ser-37 by CDK1 at the onset of mitosis,
inhibiting the interaction with p115/USO1 and triggering Golgi
disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at
Ser-37 in prophase as the Golgi complex starts to break down, and
remains phosphorylated during further breakdown and partitioning
of the Golgi fragments in metaphase and anaphase. In telophase,
GM130 is dephosphorylated by PP2A as the Golgi fragments start to
reassemble (By similarity). {ECO:0000250|UniProtKB:Q62839,
ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:26165940}.
-!- SIMILARITY: Belongs to the GOLGA2 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH69268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAP35912.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown after position 826 due to an internal deletion.; Evidence={ECO:0000305};
Sequence=EAW87762.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; L06147; AAA35920.1; -; mRNA.
EMBL; AL590708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471090; EAW87762.1; ALT_SEQ; Genomic_DNA.
EMBL; BC014188; AAH14188.2; -; mRNA.
EMBL; BC069268; AAH69268.1; ALT_INIT; mRNA.
EMBL; AF248953; AAF65550.1; -; mRNA.
EMBL; BT007248; AAP35912.1; ALT_SEQ; mRNA.
CCDS; CCDS6896.2; -. [Q08379-1]
PIR; JH0821; JH0821.
RefSeq; NP_004477.3; NM_004486.4. [Q08379-1]
UniGene; Hs.155827; -.
PDB; 4REY; X-ray; 1.96 A; B=980-1002.
PDBsum; 4REY; -.
ProteinModelPortal; Q08379; -.
SMR; Q08379; -.
BioGrid; 109063; 373.
CORUM; Q08379; -.
DIP; DIP-34271N; -.
IntAct; Q08379; 561.
MINT; Q08379; -.
STRING; 9606.ENSP00000416097; -.
MoonDB; Q08379; Predicted.
iPTMnet; Q08379; -.
PhosphoSitePlus; Q08379; -.
BioMuta; GOLGA2; -.
DMDM; 294862511; -.
EPD; Q08379; -.
MaxQB; Q08379; -.
PaxDb; Q08379; -.
PeptideAtlas; Q08379; -.
PRIDE; Q08379; -.
ProteomicsDB; 58604; -.
ProteomicsDB; 58605; -. [Q08379-2]
DNASU; 2801; -.
Ensembl; ENST00000421699; ENSP00000416097; ENSG00000167110. [Q08379-1]
Ensembl; ENST00000611957; ENSP00000478799; ENSG00000167110. [Q08379-1]
GeneID; 2801; -.
KEGG; hsa:2801; -.
UCSC; uc011maw.2; human. [Q08379-1]
CTD; 2801; -.
DisGeNET; 2801; -.
EuPathDB; HostDB:ENSG00000167110.16; -.
GeneCards; GOLGA2; -.
H-InvDB; HIX0010915; -.
H-InvDB; HIX0017404; -.
H-InvDB; HIX0177625; -.
H-InvDB; HIX0177626; -.
HGNC; HGNC:4425; GOLGA2.
HPA; CAB015421; -.
HPA; HPA021178; -.
HPA; HPA021230; -.
HPA; HPA021799; -.
MIM; 602580; gene.
neXtProt; NX_Q08379; -.
OpenTargets; ENSG00000167110; -.
PharmGKB; PA28805; -.
eggNOG; ENOG410INYK; Eukaryota.
eggNOG; ENOG4111MFD; LUCA.
GeneTree; ENSGT00530000062932; -.
HOGENOM; HOG000218631; -.
HOVERGEN; HBG051752; -.
InParanoid; Q08379; -.
KO; K20358; -.
OMA; TQRRMLK; -.
OrthoDB; EOG091G0DDT; -.
PhylomeDB; Q08379; -.
TreeFam; TF316990; -.
Reactome; R-HSA-162658; Golgi Cisternae Pericentriolar Stack Reorganization.
Reactome; R-HSA-204005; COPII-mediated vesicle transport.
Reactome; R-HSA-6807878; COPI-mediated anterograde transport.
Reactome; R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.
SIGNOR; Q08379; -.
ChiTaRS; GOLGA2; human.
GeneWiki; GOLGA2; -.
GenomeRNAi; 2801; -.
PRO; PR:Q08379; -.
Proteomes; UP000005640; Chromosome 9.
Bgee; ENSG00000167110; Expressed in 206 organ(s), highest expression level in adenohypophysis.
CleanEx; HS_GOLGA2; -.
ExpressionAtlas; Q08379; baseline and differential.
Genevisible; Q08379; HS.
GO; GO:0005801; C:cis-Golgi network; IDA:UniProtKB.
GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IMP:UniProtKB.
GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO; GO:0000137; C:Golgi cis cisterna; IDA:CACAO.
GO; GO:0032580; C:Golgi cisterna membrane; ISS:UniProtKB.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IDA:UniProtKB.
GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0061676; F:importin-alpha family protein binding; ISS:UniProtKB.
GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO; GO:0019905; F:syntaxin binding; IPI:UniProtKB.
GO; GO:0008356; P:asymmetric cell division; ISS:UniProtKB.
GO; GO:0007098; P:centrosome cycle; IDA:UniProtKB.
GO; GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO; GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
GO; GO:0090166; P:Golgi disassembly; ISS:UniProtKB.
GO; GO:0090161; P:Golgi ribbon formation; IMP:UniProtKB.
GO; GO:0007020; P:microtubule nucleation; IDA:UniProtKB.
GO; GO:0090307; P:mitotic spindle assembly; IDA:UniProtKB.
GO; GO:0010507; P:negative regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO; GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO; GO:0060050; P:positive regulation of protein glycosylation; IMP:ParkinsonsUK-UCL.
GO; GO:1904668; P:positive regulation of ubiquitin protein ligase activity; TAS:Reactome.
GO; GO:0006486; P:protein glycosylation; IMP:UniProtKB.
GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
GO; GO:0051225; P:spindle assembly; IMP:UniProtKB.
GO; GO:0090306; P:spindle assembly involved in meiosis; ISS:UniProtKB.
InterPro; IPR024858; Golgin_A.
PANTHER; PTHR10881; PTHR10881; 1.
Pfam; PF15070; GOLGA2L5; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell cycle; Cell division;
Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton;
Golgi apparatus; Membrane; Methylation; Microtubule; Mitosis;
Phosphoprotein; Polymorphism; Protein transport; Reference proteome;
Transport.
CHAIN 1 1002 Golgin subfamily A member 2.
/FTId=PRO_0000190054.
REGION 1 84 Interaction with p115/USO1.
{ECO:0000250|UniProtKB:Q62839}.
REGION 992 1002 Interaction with GORASP1/GRASP65.
{ECO:0000250|UniProtKB:Q62839}.
COILED 16 892 {ECO:0000255}.
MOTIF 26 49 Nuclear localization signal.
{ECO:0000269|PubMed:26165940}.
COMPBIAS 46 51 Poly-Lys.
COMPBIAS 449 455 Poly-Pro.
COMPBIAS 704 715 Poly-Glu.
MOD_RES 18 18 Omega-N-methylated arginine.
{ECO:0000305|PubMed:20421892}.
MOD_RES 30 30 Dimethylated arginine.
{ECO:0000269|PubMed:20421892}.
MOD_RES 35 35 Dimethylated arginine.
{ECO:0000269|PubMed:20421892}.
MOD_RES 37 37 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:18691976,
ECO:0000269|PubMed:20421892}.
MOD_RES 66 66 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 273 273 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 438 438 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 690 690 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 937 937 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 953 953 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 981 981 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
VAR_SEQ 1 382 Missing (in isoform 2).
{ECO:0000303|PubMed:8315394}.
/FTId=VSP_007727.
VARIANT 902 902 R -> G (in dbSNP:rs2240961).
/FTId=VAR_033974.
MUTAGEN 18 18 R->K: Impaired methylation; when
associated with R-30 and R-35.
{ECO:0000269|PubMed:20421892}.
MUTAGEN 26 49 KKKLREYQQRNSPGVPTGAKKKKK->AAALAEYQQANSPGV
PTGAAAAAA: Abolishes interaction with
importin-alpha.
{ECO:0000269|PubMed:26165940}.
MUTAGEN 30 30 R->K: Impaired methylation; when
associated with R-18 and R-35.
{ECO:0000269|PubMed:20421892}.
MUTAGEN 35 35 R->K: Impaired methylation; when
associated with R-18 and R-35.
{ECO:0000269|PubMed:20421892}.
MUTAGEN 37 37 S->D: Phosphomimetic mutant. Does not
affect interaction with importin-alpha.
{ECO:0000269|PubMed:26165940}.
MUTAGEN 987 987 F->A: Abolishes interaction with GORASP1.
Abolishes membrane clustering.
{ECO:0000269|PubMed:26363069}.
MUTAGEN 1002 1002 I->R: Abolishes interaction with GORASP1.
Abolishes membrane clustering.
{ECO:0000269|PubMed:26363069}.
CONFLICT 709 709 Missing (in Ref. 6; AAP35912).
{ECO:0000305}.
CONFLICT 762 762 R -> S (in Ref. 6; AAP35912).
{ECO:0000305}.
SEQUENCE 1002 AA; 113086 MW; BD067145C5092237 CRC64;
MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI KNGSNPETTT
SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM AASQNHDADN VPNLMDETKT
FSSTESLRQL SQQLNGLVCE SATCVNGEGP ASSANLKDLE SRYQQLAVAL DSSYVTNKQL
NITIEKLKQQ NQEITDQLEE EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT
QHAARQKEGE SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ QFSSRCEAPD
ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL KGESAMWRQR MQQMSEQVHT
LREEKECSMS RVQELETSLA ELRNQMAEPP PPEPPAGPSE VEQQLQAEAE HLRKELEGLA
GQLQAQVQDN EGLSRLNREQ EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS
QNRELKEQLA ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL QQQEAQGKAV
AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG LDREEEEDEE EEEEEAVAVP
QPMPSIPEDL ESREAMVAFF NSAVASAEEE QARLRGQLKE QRVRCRRLAH LLASAQKEPE
AAAPAPGTGG DSVCGETHRA LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET
DTIGEYIALY QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR EGSPRDNPTA
QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT VI


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