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Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)

 GOGA2_HUMAN             Reviewed;        1002 AA.
Q08379; A0A0C4DGS5; Q6GRM9; Q9BRB0; Q9NYF9;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
20-APR-2010, sequence version 3.
25-OCT-2017, entry version 166.
RecName: Full=Golgin subfamily A member 2;
AltName: Full=130 kDa cis-Golgi matrix protein {ECO:0000303|PubMed:8315394};
Short=GM130 {ECO:0000303|PubMed:8315394};
AltName: Full=GM130 autoantigen {ECO:0000303|PubMed:8315394};
AltName: Full=Golgin-95 {ECO:0000303|PubMed:8315394};
Name=GOLGA2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Liver;
PubMed=8315394; DOI=10.1084/jem.178.1.49;
Fritzler M.J., Hamel J.C., Ochs R.L., Chan E.K.L.;
"Molecular characterization of two human autoantigens: unique cDNAs
encoding 95- and 160-kD proteins of a putative family in the Golgi
complex.";
J. Exp. Med. 178:49-62(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164053; DOI=10.1038/nature02465;
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Colon adenocarcinoma;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 13-1002 (ISOFORM 1), AND INTERACTION
WITH RAB1B.
TISSUE=Placenta;
PubMed=11306556; DOI=10.1093/embo-reports/kve065;
Weide T., Bayer M., Koester M., Siebrasse J.-P., Peters R.,
Barnekow A.;
"The Golgi matrix protein GM130: a specific interacting partner of the
small GTPase rab1b.";
EMBO Rep. 2:336-341(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-1002 (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[7]
SUBCELLULAR LOCATION.
PubMed=11781572; DOI=10.1038/ncb1201-1101;
Marra P., Maffucci T., Daniele T., Tullio G.D., Ikehara Y., Chan E.K.,
Luini A., Beznoussenko G., Mironov A., De Matteis M.A.;
"The GM130 and GRASP65 Golgi proteins cycle through and define a
subdomain of the intermediate compartment.";
Nat. Cell Biol. 3:1101-1113(2001).
[8]
CLEAVAGE BY CASPASE.
PubMed=15003503; DOI=10.1016/j.bbrc.2004.02.015;
Walker A., Ward C., Sheldrake T.A., Dransfield I., Rossi A.G.,
Pryde J.G., Haslett C.;
"Golgi fragmentation during Fas-mediated apoptosis is associated with
the rapid loss of GM130.";
Biochem. Biophys. Res. Commun. 316:6-11(2004).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=16964243; DOI=10.1038/nbt1240;
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein
phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[10]
FUNCTION, AND INTERACTION WITH GORASP1.
PubMed=16489344; DOI=10.1038/ncb1366;
Puthenveedu M.A., Bachert C., Puri S., Lanni F., Linstedt A.D.;
"GM130 and GRASP65-dependent lateral cisternal fusion allows uniform
Golgi-enzyme distribution.";
Nat. Cell Biol. 8:238-248(2006).
[11]
FUNCTION.
PubMed=17314401; DOI=10.1091/mbc.E06-10-0886;
Marra P., Salvatore L., Mironov A. Jr., Di Campli A., Di Tullio G.,
Trucco A., Beznoussenko G., Mironov A., De Matteis M.A.;
"The biogenesis of the Golgi ribbon: the roles of membrane input from
the ER and of GM130.";
Mol. Biol. Cell 18:1595-1608(2007).
[12]
INTERACTION WITH ZFPL1.
PubMed=18323775; DOI=10.1038/emboj.2008.40;
Chiu C.-F., Ghanekar Y., Frost L., Diao A., Morrison D., McKenzie E.,
Lowe M.;
"ZFPL1, a novel ring finger protein required for cis-Golgi integrity
and efficient ER-to-Golgi transport.";
EMBO J. 27:934-947(2008).
[13]
FUNCTION, AND INTERACTION WITH GORASP1.
PubMed=18045989; DOI=10.1091/mbc.E07-08-0847;
Kodani A., Sutterlin C.;
"The Golgi protein GM130 regulates centrosome morphology and
function.";
Mol. Biol. Cell 19:745-753(2008).
[14]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of
the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-438, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[16]
FUNCTION, AND INTERACTION WITH AKAP9.
PubMed=19242490; DOI=10.1038/emboj.2009.47;
Rivero S., Cardenas J., Bornens M., Rios R.M.;
"Microtubule nucleation at the cis-side of the Golgi apparatus
requires AKAP450 and GM130.";
EMBO J. 28:1016-1028(2009).
[17]
FUNCTION.
PubMed=19109421; DOI=10.1091/mbc.E08-08-0834;
Kodani A., Kristensen I., Huang L., Sutterlin C.;
"GM130-dependent control of Cdc42 activity at the Golgi regulates
centrosome organization.";
Mol. Biol. Cell 20:1192-1200(2009).
[18]
FUNCTION, PHOSPHORYLATION AT SER-37, METHYLATION AT ARG-18; ARG-30 AND
ARG-35, AND MUTAGENESIS OF ARG-18; ARG-30 AND ARG-35.
PubMed=20421892; DOI=10.1038/cr.2010.56;
Zhou Z., Sun X., Zou Z., Sun L., Zhang T., Guo S., Wen Y., Liu L.,
Wang Y., Qin J., Li L., Gong W., Bao S.;
"PRMT5 regulates Golgi apparatus structure through methylation of the
golgin GM130.";
Cell Res. 20:1023-1033(2010).
[19]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[20]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[21]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-438; SER-953 AND
SER-981, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[22]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-690 AND
SER-937, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[23]
FUNCTION, SUBCELLULAR LOCATION, DOMAIN, PHOSPHORYLATION, AND
MUTAGENESIS OF 26-LYS--LYS-49 AND SER-37.
PubMed=26165940; DOI=10.1016/j.cell.2015.06.014;
Wei J.H., Zhang Z.C., Wynn R.M., Seemann J.;
"GM130 regulates Golgi-derived spindle assembly by activating TPX2 and
capturing microtubules.";
Cell 162:287-299(2015).
[24]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
-!- FUNCTION: Peripheral membrane component of the cis-Golgi stack
that acts as a membrane skeleton that maintains the structure of
the Golgi apparatus, and as a vesicle thether that facilitates
vesicle fusion to the Golgi membrane. Together with p115/USO1 and
STX5, involved in vesicle tethering and fusion at the cis-Golgi
membrane to maintain the stacked and inter-connected structure of
the Golgi apparatus. Plays a central role in mitotic Golgi
disassembly: phosphorylation at Ser-37 by CDK1 at the onset of
mitosis inhibits the interaction with p115/USO1, preventing
tethering of COPI vesicles and thereby inhibiting transport
through the Golgi apparatus during mitosis (By similarity). Also
plays a key role in spindle pole assembly and centrosome
organization (PubMed:26165940). Promotes the mitotic spindle pole
assembly by activating the spindle assembly factor TPX2 to
nucleate microtubules around the Golgi and capture them to couple
mitotic membranes to the spindle: upon phosphorylation at the
onset of mitosis, GOLGA2 interacts with importin-alpha via the
nuclear localization signal region, leading to recruit importin-
alpha to the Golgi membranes and liberate the spindle assembly
factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase
and stimulates local microtubule nucleation. Upon filament
assembly, nascent microtubules are further captured by GOLGA2,
thus linking Golgi membranes to the spindle (PubMed:19242490,
PubMed:26165940). Regulates the meiotic spindle pole assembly,
probably via the same mechanism (By similarity). Also regulates
the centrosome organization (PubMed:18045989, PubMed:19109421).
Also required for the Golgi ribbon formation and glycosylation of
membrane and secretory proteins (PubMed:16489344,
PubMed:17314401). {ECO:0000250|UniProtKB:Q62839,
ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344,
ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989,
ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490,
ECO:0000269|PubMed:26165940}.
-!- SUBUNIT: Part of a larger oligomeric complex (By similarity).
Interacts with p115/USO1 (By similarity). Interacts with RAB1B
that has been activated by GTP-binding (PubMed:11306556).
Interacts with GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989).
Interacts with ZFPL1 (PubMed:18323775). Interacts with
AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi
(PubMed:19242490). {ECO:0000250|UniProtKB:Q62839,
ECO:0000269|PubMed:11306556, ECO:0000269|PubMed:16489344,
ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:18323775,
ECO:0000269|PubMed:19242490}.
-!- INTERACTION:
A8K2R3:-; NbExp=3; IntAct=EBI-618309, EBI-9977437;
P29991:- (xeno); NbExp=3; IntAct=EBI-618309, EBI-8826488;
Q9WMX2:- (xeno); NbExp=2; IntAct=EBI-618309, EBI-6863748;
O75689:ADAP1; NbExp=3; IntAct=EBI-618309, EBI-714732;
Q08117:AES; NbExp=3; IntAct=EBI-618309, EBI-717810;
Q08117-2:AES; NbExp=5; IntAct=EBI-618309, EBI-11741437;
Q9UHB7:AFF4; NbExp=3; IntAct=EBI-618309, EBI-395282;
Q9UHB7-2:AFF4; NbExp=3; IntAct=EBI-618309, EBI-10261324;
Q99996:AKAP9; NbExp=3; IntAct=EBI-618309, EBI-1048311;
Q96Q83:ALKBH3; NbExp=3; IntAct=EBI-618309, EBI-6658697;
Q9Y2J4-4:AMOTL2; NbExp=3; IntAct=EBI-618309, EBI-10187270;
Q96IX9:ANKRD36BP1; NbExp=5; IntAct=EBI-618309, EBI-744859;
Q0P5N6:ARL16; NbExp=5; IntAct=EBI-618309, EBI-10186132;
P40617:ARL4A; NbExp=5; IntAct=EBI-618309, EBI-2875746;
O15145:ARPC3; NbExp=5; IntAct=EBI-618309, EBI-351829;
Q8NEY4-2:ATP6V1C2; NbExp=5; IntAct=EBI-618309, EBI-10270867;
Q6PJ05:ATP6V1D; NbExp=3; IntAct=EBI-618309, EBI-10253919;
Q8N5Z9:ATP6V1D; NbExp=3; IntAct=EBI-618309, EBI-10266952;
O75348:ATP6V1G1; NbExp=3; IntAct=EBI-618309, EBI-711802;
Q8TBE0:BAHD1; NbExp=3; IntAct=EBI-618309, EBI-742750;
A0AVN2:BARD1; NbExp=3; IntAct=EBI-618309, EBI-9977322;
Q99728:BARD1; NbExp=5; IntAct=EBI-618309, EBI-473181;
A0A0A0MR97:BAZ2B; NbExp=4; IntAct=EBI-618309, EBI-11985607;
O75934:BCAS2; NbExp=7; IntAct=EBI-618309, EBI-1050106;
P41182:BCL6; NbExp=4; IntAct=EBI-618309, EBI-765407;
A8KA13:BCL6B; NbExp=3; IntAct=EBI-618309, EBI-10174813;
Q13895:BYSL; NbExp=7; IntAct=EBI-618309, EBI-358049;
Q8NA57:C12orf50; NbExp=5; IntAct=EBI-618309, EBI-10268935;
Q9NVL8:C14orf105; NbExp=5; IntAct=EBI-618309, EBI-10238351;
Q9NX04:C1orf109; NbExp=3; IntAct=EBI-618309, EBI-8643161;
Q53TS8:C2CD6; NbExp=5; IntAct=EBI-618309, EBI-739879;
Q9HC52:CBX8; NbExp=5; IntAct=EBI-618309, EBI-712912;
Q8IX12:CCAR1; NbExp=5; IntAct=EBI-618309, EBI-356265;
Q8IYE0-2:CCDC146; NbExp=3; IntAct=EBI-618309, EBI-10247802;
Q8NCX0:CCDC150; NbExp=3; IntAct=EBI-618309, EBI-10269342;
Q96LX7:CCDC17; NbExp=3; IntAct=EBI-618309, EBI-719840;
Q6NSX1:CCDC70; NbExp=3; IntAct=EBI-618309, EBI-6873045;
Q9NVE4:CCDC87; NbExp=5; IntAct=EBI-618309, EBI-749261;
Q9BW85:CCDC94; NbExp=7; IntAct=EBI-618309, EBI-10300345;
Q8TD31-3:CCHCR1; NbExp=7; IntAct=EBI-618309, EBI-10175300;
P24863:CCNC; NbExp=3; IntAct=EBI-618309, EBI-395261;
P51946:CCNH; NbExp=5; IntAct=EBI-618309, EBI-741406;
Q86Y33:CDC20B; NbExp=3; IntAct=EBI-618309, EBI-10260504;
Q99459:CDC5L; NbExp=5; IntAct=EBI-618309, EBI-374880;
Q6P1J9:CDC73; NbExp=10; IntAct=EBI-618309, EBI-930143;
Q07002:CDK18; NbExp=3; IntAct=EBI-618309, EBI-746238;
Q8IVW4:CDKL3; NbExp=3; IntAct=EBI-618309, EBI-3919850;
Q6IPU0:CENPP; NbExp=3; IntAct=EBI-618309, EBI-10250303;
Q8IYX8:CEP57L1; NbExp=7; IntAct=EBI-618309, EBI-1104570;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-618309, EBI-10181988;
Q9Y6H1:CHCHD2; NbExp=5; IntAct=EBI-618309, EBI-2321769;
Q9NX63:CHCHD3; NbExp=3; IntAct=EBI-618309, EBI-743375;
Q9BW66:CINP; NbExp=7; IntAct=EBI-618309, EBI-739784;
P31146:CORO1A; NbExp=3; IntAct=EBI-618309, EBI-1046676;
Q1MSJ5-1:CSPP1; NbExp=3; IntAct=EBI-618309, EBI-10239122;
Q93034:CUL5; NbExp=3; IntAct=EBI-618309, EBI-1057139;
Q6BCY4:CYB5R2; NbExp=3; IntAct=EBI-618309, EBI-744761;
Q9UER7:DAXX; NbExp=7; IntAct=EBI-618309, EBI-77321;
Q9UJW0:DCTN4; NbExp=4; IntAct=EBI-618309, EBI-2134033;
O43602:DCX; NbExp=4; IntAct=EBI-618309, EBI-8646694;
P26196:DDX6; NbExp=5; IntAct=EBI-618309, EBI-351257;
Q05D60:DEUP1; NbExp=6; IntAct=EBI-618309, EBI-748597;
Q15398:DLGAP5; NbExp=3; IntAct=EBI-618309, EBI-748280;
Q08495:DMTN; NbExp=3; IntAct=EBI-618309, EBI-715275;
Q86UW9:DTX2; NbExp=3; IntAct=EBI-618309, EBI-740376;
Q5JVL4:EFHC1; NbExp=3; IntAct=EBI-618309, EBI-743105;
O75821:EIF3G; NbExp=3; IntAct=EBI-618309, EBI-366632;
Q6UWV6:ENPP7; NbExp=4; IntAct=EBI-618309, EBI-12047821;
Q9NQT4:EXOSC5; NbExp=3; IntAct=EBI-618309, EBI-371876;
Q9BQ89:FAM110A; NbExp=5; IntAct=EBI-618309, EBI-1752811;
Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-618309, EBI-741626;
Q8IXS8:FAM126B; NbExp=3; IntAct=EBI-618309, EBI-8787606;
Q3B820:FAM161A; NbExp=4; IntAct=EBI-618309, EBI-719941;
Q96MY7:FAM161B; NbExp=4; IntAct=EBI-618309, EBI-7225287;
Q6P9G8:FAM184A; NbExp=3; IntAct=EBI-618309, EBI-10253239;
Q96PV7-2:FAM193B; NbExp=3; IntAct=EBI-618309, EBI-10292648;
Q9NSI2:FAM207A; NbExp=3; IntAct=EBI-618309, EBI-5457304;
Q32MH5:FAM214A; NbExp=3; IntAct=EBI-618309, EBI-2866142;
Q9Y247:FAM50B; NbExp=3; IntAct=EBI-618309, EBI-742802;
Q86YD7:FAM90A1; NbExp=7; IntAct=EBI-618309, EBI-6658203;
Q8TES7-6:FBF1; NbExp=3; IntAct=EBI-618309, EBI-10244131;
Q96D16:FBXL18; NbExp=3; IntAct=EBI-618309, EBI-744419;
Q9NVF7:FBXO28; NbExp=8; IntAct=EBI-618309, EBI-740282;
Q6UN15:FIP1L1; NbExp=3; IntAct=EBI-618309, EBI-1021914;
A4D1I3:FLJ34048; NbExp=3; IntAct=EBI-618309, EBI-10173415;
Q9BVV2:FNDC11; NbExp=3; IntAct=EBI-618309, EBI-744935;
P23769:GATA2; NbExp=3; IntAct=EBI-618309, EBI-2806671;
Q8WXI9:GATAD2B; NbExp=3; IntAct=EBI-618309, EBI-923440;
Q96CN9:GCC1; NbExp=5; IntAct=EBI-618309, EBI-746252;
P55040:GEM; NbExp=5; IntAct=EBI-618309, EBI-744104;
P14136:GFAP; NbExp=8; IntAct=EBI-618309, EBI-744302;
Q86UU5:GGN; NbExp=4; IntAct=EBI-618309, EBI-10259069;
Q8IVS8:GLYCTK; NbExp=5; IntAct=EBI-618309, EBI-748515;
P63218:GNG5; NbExp=3; IntAct=EBI-618309, EBI-10220734;
Q9H8Y8:GORASP2; NbExp=4; IntAct=EBI-618309, EBI-739467;
O95872:GPANK1; NbExp=3; IntAct=EBI-618309, EBI-751540;
Q92917:GPKOW; NbExp=5; IntAct=EBI-618309, EBI-746309;
Q14687:GSE1; NbExp=5; IntAct=EBI-618309, EBI-372619;
A4D1E9:GTPBP10; NbExp=3; IntAct=EBI-618309, EBI-5453796;
Q96CS2:HAUS1; NbExp=3; IntAct=EBI-618309, EBI-2514791;
Q643R0:HCTP4; NbExp=3; IntAct=EBI-618309, EBI-10248808;
P56524:HDAC4; NbExp=3; IntAct=EBI-618309, EBI-308629;
P17482:HOXB9; NbExp=3; IntAct=EBI-618309, EBI-745290;
Q96KN8-3:HRASLS5; NbExp=5; IntAct=EBI-618309, EBI-10290304;
Q96M11:HYLS1; NbExp=3; IntAct=EBI-618309, EBI-720016;
Q8IY31:IFT20; NbExp=3; IntAct=EBI-618309, EBI-744203;
Q9BW83:IFT27; NbExp=3; IntAct=EBI-618309, EBI-747093;
Q15735:INPP5J; NbExp=7; IntAct=EBI-618309, EBI-10236940;
Q9H1K1:ISCU; NbExp=3; IntAct=EBI-618309, EBI-1047335;
P27987:ITPKB; NbExp=4; IntAct=EBI-618309, EBI-751388;
Q63ZY3:KANK2; NbExp=6; IntAct=EBI-618309, EBI-2556193;
Q7Z3B3:KANSL1; NbExp=4; IntAct=EBI-618309, EBI-740244;
Q92993:KAT5; NbExp=3; IntAct=EBI-618309, EBI-399080;
Q5T5P2-6:KIAA1217; NbExp=5; IntAct=EBI-618309, EBI-10188326;
Q9BVG8:KIFC3; NbExp=3; IntAct=EBI-618309, EBI-2125614;
P04264:KRT1; NbExp=5; IntAct=EBI-618309, EBI-298429;
P05783:KRT18; NbExp=6; IntAct=EBI-618309, EBI-297888;
P02538:KRT6A; NbExp=6; IntAct=EBI-618309, EBI-702198;
P04259:KRT6B; NbExp=3; IntAct=EBI-618309, EBI-740907;
P48668:KRT6C; NbExp=3; IntAct=EBI-618309, EBI-2564105;
Q14847:LASP1; NbExp=3; IntAct=EBI-618309, EBI-742828;
Q6PJG3:LATS1; NbExp=3; IntAct=EBI-618309, EBI-10253976;
Q96JN0:LCOR; NbExp=3; IntAct=EBI-618309, EBI-746045;
Q13094:LCP2; NbExp=5; IntAct=EBI-618309, EBI-346946;
Q96BZ8:LENG1; NbExp=7; IntAct=EBI-618309, EBI-726510;
P17931:LGALS3; NbExp=3; IntAct=EBI-618309, EBI-1170392;
Q6NVH9:LGALS3; NbExp=3; IntAct=EBI-618309, EBI-10187804;
Q7Z4I7-5:LIMS2; NbExp=3; IntAct=EBI-618309, EBI-10257651;
O14910:LIN7A; NbExp=3; IntAct=EBI-618309, EBI-2513988;
Q96FE5:LINGO1; NbExp=3; IntAct=EBI-618309, EBI-719955;
P25800:LMO1; NbExp=5; IntAct=EBI-618309, EBI-8639312;
P25791:LMO2; NbExp=3; IntAct=EBI-618309, EBI-739696;
Q8TAP4-4:LMO3; NbExp=4; IntAct=EBI-618309, EBI-11742507;
P61968:LMO4; NbExp=5; IntAct=EBI-618309, EBI-2798728;
Q6IAQ1:LYPLA1; NbExp=3; IntAct=EBI-618309, EBI-10249913;
Q96S90:LYSMD1; NbExp=3; IntAct=EBI-618309, EBI-10293291;
Q9Y586:MAB21L2; NbExp=3; IntAct=EBI-618309, EBI-6659161;
P61326:MAGOH; NbExp=5; IntAct=EBI-618309, EBI-299134;
Q96A72:MAGOHB; NbExp=7; IntAct=EBI-618309, EBI-746778;
O95983:MBD3; NbExp=3; IntAct=EBI-618309, EBI-1783068;
Q7L590-2:MCM10; NbExp=3; IntAct=EBI-618309, EBI-10233517;
P33993:MCM7; NbExp=3; IntAct=EBI-618309, EBI-355924;
P55081:MFAP1; NbExp=5; IntAct=EBI-618309, EBI-1048159;
Q9UJV3-2:MID2; NbExp=3; IntAct=EBI-618309, EBI-10172526;
Q9BU76:MMTAG2; NbExp=4; IntAct=EBI-618309, EBI-742459;
Q9UBU8:MORF4L1; NbExp=3; IntAct=EBI-618309, EBI-399246;
Q15014:MORF4L2; NbExp=3; IntAct=EBI-618309, EBI-399257;
Q6PF18:MORN3; NbExp=5; IntAct=EBI-618309, EBI-9675802;
P00540:MOS; NbExp=5; IntAct=EBI-618309, EBI-1757866;
Q8IXL7:MSRB3; NbExp=3; IntAct=EBI-618309, EBI-8634060;
Q499L9:MST4; NbExp=3; IntAct=EBI-618309, EBI-6137569;
Q6P444:MTFR2; NbExp=3; IntAct=EBI-618309, EBI-10252703;
Q9P2K5-2:MYEF2; NbExp=5; IntAct=EBI-618309, EBI-10318831;
P19878:NCF2; NbExp=6; IntAct=EBI-618309, EBI-489611;
Q9GZM8:NDEL1; NbExp=3; IntAct=EBI-618309, EBI-928842;
O76041:NEBL; NbExp=3; IntAct=EBI-618309, EBI-2880203;
Q9Y5B8:NME7; NbExp=5; IntAct=EBI-618309, EBI-744782;
P29474:NOS3; NbExp=5; IntAct=EBI-618309, EBI-1391623;
O43809:NUDT21; NbExp=7; IntAct=EBI-618309, EBI-355720;
Q9NPJ8:NXT2; NbExp=3; IntAct=EBI-618309, EBI-752122;
Q96F82:ORC1L; NbExp=3; IntAct=EBI-618309, EBI-10285558;
Q9BYG5:PARD6B; NbExp=3; IntAct=EBI-618309, EBI-295391;
Q86TB9:PATL1; NbExp=5; IntAct=EBI-618309, EBI-2562092;
O75928:PIAS2; NbExp=3; IntAct=EBI-618309, EBI-348555;
Q7Z2X4:PID1; NbExp=3; IntAct=EBI-618309, EBI-10256685;
O00459:PIK3R2; NbExp=3; IntAct=EBI-618309, EBI-346930;
Q13526:PIN1; NbExp=7; IntAct=EBI-618309, EBI-714158;
P78337:PITX1; NbExp=3; IntAct=EBI-618309, EBI-748265;
Q16512:PKN1; NbExp=5; IntAct=EBI-618309, EBI-602382;
Q99569:PKP4; NbExp=3; IntAct=EBI-618309, EBI-726447;
Q8WUT1:POLDIP3; NbExp=3; IntAct=EBI-618309, EBI-10276663;
Q15319:POU4F3; NbExp=4; IntAct=EBI-618309, EBI-12033574;
Q96T49:PPP1R16B; NbExp=5; IntAct=EBI-618309, EBI-10293968;
Q6NYC8:PPP1R18; NbExp=5; IntAct=EBI-618309, EBI-2557469;
Q7Z5V6-2:PPP1R32; NbExp=4; IntAct=EBI-618309, EBI-12000762;
O60828:PQBP1; NbExp=3; IntAct=EBI-618309, EBI-713867;
Q13131:PRKAA1; NbExp=3; IntAct=EBI-618309, EBI-1181405;
O43741:PRKAB2; NbExp=7; IntAct=EBI-618309, EBI-1053424;
Q8WWY3:PRPF31; NbExp=10; IntAct=EBI-618309, EBI-1567797;
P25786:PSMA1; NbExp=5; IntAct=EBI-618309, EBI-359352;
P25789:PSMA4; NbExp=3; IntAct=EBI-618309, EBI-359310;
P61019:RAB2A; NbExp=6; IntAct=EBI-618309, EBI-752037;
Q8WUD1:RAB2B; NbExp=5; IntAct=EBI-618309, EBI-5542466;
Q14964:RAB39A; NbExp=5; IntAct=EBI-618309, EBI-3048577;
Q96DA2:RAB39B; NbExp=3; IntAct=EBI-618309, EBI-9089467;
Q96I25:RBM17; NbExp=6; IntAct=EBI-618309, EBI-740272;
Q14498-3:RBM39; NbExp=3; IntAct=EBI-618309, EBI-6654703;
Q96IZ5:RBM41; NbExp=5; IntAct=EBI-618309, EBI-740773;
Q9P2K3:RCOR3; NbExp=3; IntAct=EBI-618309, EBI-743428;
P57771:RGS8; NbExp=3; IntAct=EBI-618309, EBI-10216117;
Q9BSD3:RHNO1; NbExp=3; IntAct=EBI-618309, EBI-9658624;
Q8N443:RIBC1; NbExp=3; IntAct=EBI-618309, EBI-10265323;
Q96K30:RITA1; NbExp=4; IntAct=EBI-618309, EBI-2836148;
Q8IUD6:RNF135; NbExp=5; IntAct=EBI-618309, EBI-9916363;
Q63HN8-6:RNF213; NbExp=3; IntAct=EBI-618309, EBI-10248548;
Q9UHP6:RSPH14; NbExp=5; IntAct=EBI-618309, EBI-748350;
Q7L4I2-2:RSRC2; NbExp=3; IntAct=EBI-618309, EBI-10256202;
Q14D33:RTP5; NbExp=3; IntAct=EBI-618309, EBI-10217913;
Q9UPU9:SAMD4A; NbExp=3; IntAct=EBI-618309, EBI-1047497;
Q9UHR5:SAP30BP; NbExp=3; IntAct=EBI-618309, EBI-751683;
Q9UPN6:SCAF8; NbExp=3; IntAct=EBI-618309, EBI-7954236;
O95171:SCEL; NbExp=4; IntAct=EBI-618309, EBI-7543896;
Q9BWG6:SCNM1; NbExp=5; IntAct=EBI-618309, EBI-748391;
Q96T21:SECISBP2; NbExp=3; IntAct=EBI-618309, EBI-954116;
P59797:SELENOV; NbExp=3; IntAct=EBI-618309, EBI-10216195;
Q6NXQ0:SFRS2; NbExp=7; IntAct=EBI-618309, EBI-10251550;
Q9H788:SH2D4A; NbExp=5; IntAct=EBI-618309, EBI-747035;
Q9H788-2:SH2D4A; NbExp=3; IntAct=EBI-618309, EBI-10308083;
Q08AM8:SH3RF2; NbExp=3; IntAct=EBI-618309, EBI-10225873;
Q92529:SHC3; NbExp=3; IntAct=EBI-618309, EBI-79084;
O95391:SLU7; NbExp=5; IntAct=EBI-618309, EBI-750559;
Q969G3:SMARCE1; NbExp=5; IntAct=EBI-618309, EBI-455078;
P49901:SMCP; NbExp=3; IntAct=EBI-618309, EBI-750494;
Q5SQN1:SNAP47; NbExp=3; IntAct=EBI-618309, EBI-10244848;
Q96H20:SNF8; NbExp=3; IntAct=EBI-618309, EBI-747719;
P14678-2:SNRPB; NbExp=3; IntAct=EBI-618309, EBI-372475;
P08579:SNRPB2; NbExp=3; IntAct=EBI-618309, EBI-1053651;
Q5TAL4:SNRPC; NbExp=3; IntAct=EBI-618309, EBI-10246938;
Q13573:SNW1; NbExp=5; IntAct=EBI-618309, EBI-632715;
Q9UM82:SPATA2; NbExp=3; IntAct=EBI-618309, EBI-744066;
Q8NHS9:SPATA22; NbExp=3; IntAct=EBI-618309, EBI-7067260;
Q9NZD8:SPG21; NbExp=4; IntAct=EBI-618309, EBI-742688;
Q96FJ0:STAMBPL1; NbExp=3; IntAct=EBI-618309, EBI-745021;
O00506:STK25; NbExp=10; IntAct=EBI-618309, EBI-618295;
Q9P289:STK26; NbExp=4; IntAct=EBI-618309, EBI-618239;
Q5T7P8-2:SYT6; NbExp=5; IntAct=EBI-618309, EBI-10246152;
Q9NU19:TBC1D22B; NbExp=4; IntAct=EBI-618309, EBI-8787464;
Q32MN6:TBP; NbExp=5; IntAct=EBI-618309, EBI-10239991;
Q15560:TCEA2; NbExp=5; IntAct=EBI-618309, EBI-710310;
Q8N8B7:TCEANC; NbExp=3; IntAct=EBI-618309, EBI-954696;
D2IYK5:TCF19; NbExp=3; IntAct=EBI-618309, EBI-10176552;
Q9Y242:TCF19; NbExp=3; IntAct=EBI-618309, EBI-7413767;
P56279:TCL1A; NbExp=7; IntAct=EBI-618309, EBI-749995;
D3DUQ6:TEAD4; NbExp=3; IntAct=EBI-618309, EBI-10176734;
Q01664:TFAP4; NbExp=5; IntAct=EBI-618309, EBI-2514218;
Q9BT49:THAP7; NbExp=3; IntAct=EBI-618309, EBI-741350;
P09493:TPM1; NbExp=3; IntAct=EBI-618309, EBI-351158;
P09493-10:TPM1; NbExp=3; IntAct=EBI-618309, EBI-12123928;
P09493-5:TPM1; NbExp=3; IntAct=EBI-618309, EBI-10196387;
Q9BUZ4:TRAF4; NbExp=4; IntAct=EBI-618309, EBI-3650647;
Q14134:TRIM29; NbExp=5; IntAct=EBI-618309, EBI-702370;
Q8IWZ5:TRIM42; NbExp=3; IntAct=EBI-618309, EBI-5235829;
Q8IV54:TSC22D4; NbExp=3; IntAct=EBI-618309, EBI-10261521;
Q9Y5U2:TSSC4; NbExp=3; IntAct=EBI-618309, EBI-717229;
Q96PN8:TSSK3; NbExp=5; IntAct=EBI-618309, EBI-3918381;
Q5W5X9:TTC23; NbExp=3; IntAct=EBI-618309, EBI-6447954;
Q96NG3:TTC25; NbExp=3; IntAct=EBI-618309, EBI-1046387;
Q8N5M4:TTC9C; NbExp=3; IntAct=EBI-618309, EBI-2851213;
P40222:TXLNA; NbExp=3; IntAct=EBI-618309, EBI-359793;
P63279:UBE2I; NbExp=3; IntAct=EBI-618309, EBI-80168;
Q5VVX9:UBE2U; NbExp=4; IntAct=EBI-618309, EBI-2130181;
Q15386:UBE3C; NbExp=3; IntAct=EBI-618309, EBI-1058871;
O75604:USP2; NbExp=5; IntAct=EBI-618309, EBI-743272;
Q08E77:UTP14C; NbExp=3; IntAct=EBI-618309, EBI-10225961;
Q5TAP6:UTP14C; NbExp=4; IntAct=EBI-618309, EBI-11737646;
Q548N1:VPS28; NbExp=3; IntAct=EBI-618309, EBI-10243107;
A5D8V6:VPS37C; NbExp=3; IntAct=EBI-618309, EBI-2559305;
Q9Y3C0:WASHC3; NbExp=5; IntAct=EBI-618309, EBI-712969;
Q96HA8:WDYHV1; NbExp=7; IntAct=EBI-618309, EBI-741158;
Q05516:ZBTB16; NbExp=7; IntAct=EBI-618309, EBI-711925;
B2RXF5:ZBTB42; NbExp=4; IntAct=EBI-618309, EBI-12287587;
Q8IUH5:ZDHHC17; NbExp=3; IntAct=EBI-618309, EBI-524753;
G3V1X1:ZFC3H1; NbExp=3; IntAct=EBI-618309, EBI-6448783;
Q6ZN57:ZFP2; NbExp=3; IntAct=EBI-618309, EBI-7236323;
Q68DK2-5:ZFYVE26; NbExp=3; IntAct=EBI-618309, EBI-8656416;
Q8N5A5:ZGPAT; NbExp=3; IntAct=EBI-618309, EBI-3439227;
Q8N5A5-2:ZGPAT; NbExp=5; IntAct=EBI-618309, EBI-10183064;
Q96NC0:ZMAT2; NbExp=5; IntAct=EBI-618309, EBI-2682299;
Q15973:ZNF124; NbExp=3; IntAct=EBI-618309, EBI-2555767;
P15622-3:ZNF250; NbExp=7; IntAct=EBI-618309, EBI-10177272;
Q86VK4:ZNF410; NbExp=3; IntAct=EBI-618309, EBI-720304;
Q96IQ9:ZNF414; NbExp=5; IntAct=EBI-618309, EBI-744257;
Q8TAU3:ZNF417; NbExp=3; IntAct=EBI-618309, EBI-740727;
Q96MN9:ZNF488; NbExp=3; IntAct=EBI-618309, EBI-948288;
Q7Z3I7:ZNF572; NbExp=6; IntAct=EBI-618309, EBI-10172590;
Q9P0T4:ZNF581; NbExp=3; IntAct=EBI-618309, EBI-745520;
Q96SQ5:ZNF587; NbExp=3; IntAct=EBI-618309, EBI-6427977;
Q6NX45:ZNF774; NbExp=5; IntAct=EBI-618309, EBI-10251462;
-!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
{ECO:0000269|PubMed:11781572}; Peripheral membrane protein
{ECO:0000250|UniProtKB:Q62839}. Cytoplasm, cytoskeleton, spindle
pole {ECO:0000269|PubMed:26165940}. Note=Peripheral membrane
protein associated with cis-Golgi stacks (By similarity).
Associates with the mitotic spindle during mitosis
(PubMed:26165940). {ECO:0000250|UniProtKB:Q62839,
ECO:0000269|PubMed:26165940}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q08379-1; Sequence=Displayed;
Name=2;
IsoId=Q08379-2; Sequence=VSP_007727;
-!- DOMAIN: The nuclear localization signal (cNLS) mediates
interaction with importin-alpha, recruiting importin-alpha to the
Golgi membrane and liberating TPX2. {ECO:0000269|PubMed:26165940}.
-!- PTM: Cleaved by caspases at the onset of apoptosis.
{ECO:0000269|PubMed:15003503}.
-!- PTM: Methylation by PRMT5 is required for Golgi ribbon formation.
While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it
is unclear whether Arg-18 is methylated in vivo.
{ECO:0000269|PubMed:20421892}.
-!- PTM: Phosphorylated at Ser-37 by CDK1 at the onset of mitosis,
inhibiting the interaction with p115/USO1 and triggering Golgi
disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at
Ser-37 in prophase as the Golgi complex starts to break down, and
remains phosphorylated during further breakdown and partitioning
of the Golgi fragments in metaphase and anaphase. In telophase,
GM130 is dephosphorylated by PP2A as the Golgi fragments start to
reassemble (By similarity). {ECO:0000250|UniProtKB:Q62839,
ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:26165940}.
-!- SIMILARITY: Belongs to the GOLGA2 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH69268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAP35912.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown after position 826 due to an internal deletion.; Evidence={ECO:0000305};
Sequence=EAW87762.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; L06147; AAA35920.1; -; mRNA.
EMBL; AL590708; CAI13841.2; -; Genomic_DNA.
EMBL; CH471090; EAW87762.1; ALT_SEQ; Genomic_DNA.
EMBL; BC014188; AAH14188.2; -; mRNA.
EMBL; BC069268; AAH69268.1; ALT_INIT; mRNA.
EMBL; AF248953; AAF65550.1; -; mRNA.
EMBL; BT007248; AAP35912.1; ALT_SEQ; mRNA.
CCDS; CCDS6896.2; -. [Q08379-1]
PIR; JH0821; JH0821.
RefSeq; NP_004477.3; NM_004486.4. [Q08379-1]
UniGene; Hs.155827; -.
PDB; 4REY; X-ray; 1.96 A; B=980-1002.
PDBsum; 4REY; -.
ProteinModelPortal; Q08379; -.
SMR; Q08379; -.
BioGrid; 109063; 332.
CORUM; Q08379; -.
DIP; DIP-34271N; -.
IntAct; Q08379; 466.
MINT; MINT-1343711; -.
STRING; 9606.ENSP00000416097; -.
iPTMnet; Q08379; -.
PhosphoSitePlus; Q08379; -.
BioMuta; GOLGA2; -.
DMDM; 294862511; -.
EPD; Q08379; -.
MaxQB; Q08379; -.
PaxDb; Q08379; -.
PeptideAtlas; Q08379; -.
PRIDE; Q08379; -.
DNASU; 2801; -.
Ensembl; ENST00000421699; ENSP00000416097; ENSG00000167110. [Q08379-1]
Ensembl; ENST00000611957; ENSP00000478799; ENSG00000167110. [Q08379-1]
GeneID; 2801; -.
KEGG; hsa:2801; -.
UCSC; uc011maw.2; human. [Q08379-1]
CTD; 2801; -.
DisGeNET; 2801; -.
EuPathDB; HostDB:ENSG00000167110.16; -.
GeneCards; GOLGA2; -.
H-InvDB; HIX0010915; -.
H-InvDB; HIX0017404; -.
H-InvDB; HIX0177625; -.
H-InvDB; HIX0177626; -.
HGNC; HGNC:4425; GOLGA2.
HPA; CAB015421; -.
HPA; HPA021178; -.
HPA; HPA021230; -.
HPA; HPA021799; -.
MIM; 602580; gene.
neXtProt; NX_Q08379; -.
OpenTargets; ENSG00000167110; -.
PharmGKB; PA28805; -.
eggNOG; ENOG410INYK; Eukaryota.
eggNOG; ENOG4111MFD; LUCA.
GeneTree; ENSGT00530000062932; -.
HOGENOM; HOG000218631; -.
HOVERGEN; HBG051752; -.
InParanoid; Q08379; -.
KO; K20358; -.
OMA; RRMLKQR; -.
OrthoDB; EOG091G0DDT; -.
PhylomeDB; Q08379; -.
TreeFam; TF316990; -.
Reactome; R-HSA-162658; Golgi Cisternae Pericentriolar Stack Reorganization.
Reactome; R-HSA-204005; COPII (Coat Protein 2) Mediated Vesicle Transport.
Reactome; R-HSA-6807878; COPI-mediated anterograde transport.
Reactome; R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.
SIGNOR; Q08379; -.
ChiTaRS; GOLGA2; human.
GeneWiki; GOLGA2; -.
GenomeRNAi; 2801; -.
PRO; PR:Q08379; -.
Proteomes; UP000005640; Chromosome 9.
Bgee; ENSG00000167110; -.
CleanEx; HS_GOLGA2; -.
ExpressionAtlas; Q08379; baseline and differential.
Genevisible; Q08379; HS.
GO; GO:0005801; C:cis-Golgi network; IDA:UniProtKB.
GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IMP:UniProtKB.
GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO; GO:0000137; C:Golgi cis cisterna; IDA:CACAO.
GO; GO:0032580; C:Golgi cisterna membrane; ISS:UniProtKB.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
GO; GO:0045296; F:cadherin binding; IDA:BHF-UCL.
GO; GO:0061676; F:importin-alpha family protein binding; ISS:UniProtKB.
GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO; GO:0019905; F:syntaxin binding; IPI:UniProtKB.
GO; GO:0008356; P:asymmetric cell division; ISS:UniProtKB.
GO; GO:0007098; P:centrosome cycle; IDA:UniProtKB.
GO; GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO; GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
GO; GO:0090166; P:Golgi disassembly; ISS:UniProtKB.
GO; GO:0090161; P:Golgi ribbon formation; IMP:UniProtKB.
GO; GO:0007020; P:microtubule nucleation; IDA:UniProtKB.
GO; GO:0090307; P:mitotic spindle assembly; IDA:UniProtKB.
GO; GO:0010507; P:negative regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO; GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO; GO:0060050; P:positive regulation of protein glycosylation; IMP:ParkinsonsUK-UCL.
GO; GO:1904668; P:positive regulation of ubiquitin protein ligase activity; TAS:Reactome.
GO; GO:0006486; P:protein glycosylation; IMP:UniProtKB.
GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
GO; GO:0051225; P:spindle assembly; IMP:UniProtKB.
GO; GO:0090306; P:spindle assembly involved in meiosis; ISS:UniProtKB.
InterPro; IPR024858; Golgin_A.
Pfam; PF15070; GOLGA2L5; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell cycle; Cell division;
Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton;
Golgi apparatus; Membrane; Methylation; Microtubule; Mitosis;
Phosphoprotein; Polymorphism; Reference proteome.
CHAIN 1 1002 Golgin subfamily A member 2.
/FTId=PRO_0000190054.
REGION 1 84 Interaction with p115/USO1.
{ECO:0000250|UniProtKB:Q62839}.
REGION 992 1002 Interaction with GORASP1/GRASP65.
{ECO:0000250|UniProtKB:Q62839}.
COILED 16 892 {ECO:0000255}.
MOTIF 26 49 Nuclear localization signal.
{ECO:0000269|PubMed:26165940}.
COMPBIAS 46 51 Poly-Lys.
COMPBIAS 449 455 Poly-Pro.
COMPBIAS 704 715 Poly-Glu.
MOD_RES 18 18 Omega-N-methylated arginine.
{ECO:0000305|PubMed:20421892}.
MOD_RES 30 30 Dimethylated arginine.
{ECO:0000269|PubMed:20421892}.
MOD_RES 35 35 Dimethylated arginine.
{ECO:0000269|PubMed:20421892}.
MOD_RES 37 37 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:18691976,
ECO:0000269|PubMed:20421892}.
MOD_RES 66 66 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 273 273 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 438 438 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 690 690 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 937 937 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 953 953 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 981 981 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
VAR_SEQ 1 382 Missing (in isoform 2).
{ECO:0000303|PubMed:8315394}.
/FTId=VSP_007727.
VARIANT 902 902 R -> G (in dbSNP:rs2240961).
/FTId=VAR_033974.
MUTAGEN 18 18 R->K: Impaired methylation; when
associated with R-30 and R-35.
{ECO:0000269|PubMed:20421892}.
MUTAGEN 26 49 KKKLREYQQRNSPGVPTGAKKKKK->AAALAEYQQANSPGV
PTGAAAAAA: Abolishes interaction with
importin-alpha.
{ECO:0000269|PubMed:26165940}.
MUTAGEN 30 30 R->K: Impaired methylation; when
associated with R-18 and R-35.
{ECO:0000269|PubMed:20421892}.
MUTAGEN 35 35 R->K: Impaired methylation; when
associated with R-18 and R-35.
{ECO:0000269|PubMed:20421892}.
MUTAGEN 37 37 S->D: Phosphomimetic mutant. Does not
affect interaction with importin-alpha.
{ECO:0000269|PubMed:26165940}.
CONFLICT 709 709 Missing (in Ref. 6; AAP35912).
{ECO:0000305}.
CONFLICT 762 762 R -> S (in Ref. 6; AAP35912).
{ECO:0000305}.
SEQUENCE 1002 AA; 113086 MW; BD067145C5092237 CRC64;
MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI KNGSNPETTT
SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM AASQNHDADN VPNLMDETKT
FSSTESLRQL SQQLNGLVCE SATCVNGEGP ASSANLKDLE SRYQQLAVAL DSSYVTNKQL
NITIEKLKQQ NQEITDQLEE EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT
QHAARQKEGE SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ QFSSRCEAPD
ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL KGESAMWRQR MQQMSEQVHT
LREEKECSMS RVQELETSLA ELRNQMAEPP PPEPPAGPSE VEQQLQAEAE HLRKELEGLA
GQLQAQVQDN EGLSRLNREQ EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS
QNRELKEQLA ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL QQQEAQGKAV
AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG LDREEEEDEE EEEEEAVAVP
QPMPSIPEDL ESREAMVAFF NSAVASAEEE QARLRGQLKE QRVRCRRLAH LLASAQKEPE
AAAPAPGTGG DSVCGETHRA LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET
DTIGEYIALY QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR EGSPRDNPTA
QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT VI


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