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Granulocyte colony-stimulating factor

 Q9GJU0_FELCA            Unreviewed;       195 AA.
Q9GJU0;
01-MAR-2001, integrated into UniProtKB/TrEMBL.
01-MAR-2001, sequence version 1.
05-DEC-2018, entry version 107.
SubName: Full=Granulocyte colony-stimulating factor {ECO:0000313|EMBL:BAB17789.1};
Name=G-CSF {ECO:0000313|EMBL:BAB17789.1};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|EMBL:BAB17789.1};
[1] {ECO:0000313|EMBL:BAB17789.1}
NUCLEOTIDE SEQUENCE.
PubMed=11675019; DOI=10.1016/S0378-1119(01)00575-3;
Yamamoto A., Iwata A., Tuchiya K., Katsumata A., Oishi K., Saito T.,
Tsujimoto H., Hasegawa A., Ueda S.;
"Molecular cloning and expression of the cDNA encoding feline
granulocyte colony-stimulating factor.";
Gene 274:263-269(2001).
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EMBL; AB042553; BAB17757.1; -; Genomic_DNA.
EMBL; AB042552; BAB17789.1; -; mRNA.
RefSeq; NP_001009227.1; NM_001009227.1.
RefSeq; XP_006940309.1; XM_006940247.2.
RefSeq; XP_019672441.1; XM_019816882.1.
RefSeq; XP_019672442.1; XM_019816883.1.
RefSeq; XP_019672443.1; XM_019816884.1.
GeneID; 493700; -.
KEGG; fca:493700; -.
CTD; 1440; -.
eggNOG; ENOG410IIM2; Eukaryota.
eggNOG; ENOG4111DA4; LUCA.
HOGENOM; HOG000015371; -.
HOVERGEN; HBG005411; -.
KO; K05423; -.
OMA; HKLCHPE; -.
OrthoDB; EOG091G0NDU; -.
Bgee; ENSFCAG00000014992; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IBA:GO_Central.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IBA:GO_Central.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR040117; GCSF/MGF.
InterPro; IPR030474; IL-6/GCSF/MGF.
InterPro; IPR030473; IL6/GCSF/MGF_CS.
PANTHER; PTHR10511; PTHR10511; 1.
Pfam; PF16647; GCSF; 1.
PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
PRINTS; PR00433; IL6GCSFMGF.
SMART; SM00126; IL6; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00254; INTERLEUKIN_6; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|PIRSR:PIRSR001935-1};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 21 {ECO:0000256|SAM:SignalP}.
CHAIN 22 195 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014108095.
DISULFID 57 63 {ECO:0000256|PIRSR:PIRSR001935-1}.
DISULFID 85 95 {ECO:0000256|PIRSR:PIRSR001935-1}.
SEQUENCE 195 AA; 21255 MW; 544C682909412FCF CRC64;
MKLTALQLLL WHSALWMVQE ATPLGPTSSL PQSFLLKCLE QVRKVQADGT ALQERLCAAH
KLCHPEELVL LGHALGIPQA PLSSCSSQAL QLTGCLRQLH SGLFLYQGLL QALAGISPEL
APTLDMLQLD ITDFAINIWQ QMEDVGMAPA VPPTQGTMPT FTSAFQRRAG GTLVASNLQS
FLEVAYRALR HFTKP


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