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Granulocyte colony-stimulating factor (G-CSF)

 CSF3_MOUSE              Reviewed;         208 AA.
P09920;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
20-JUN-2018, entry version 140.
RecName: Full=Granulocyte colony-stimulating factor;
Short=G-CSF;
Flags: Precursor;
Name=Csf3; Synonyms=Csfg;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3489940; DOI=10.1073/pnas.83.20.7633;
Tsuchiya M., Asano S., Kaziro Y., Nagata S.;
"Isolation and characterization of the cDNA for murine granulocyte
colony-stimulating factor.";
Proc. Natl. Acad. Sci. U.S.A. 83:7633-7637(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3494605; DOI=10.1111/j.1432-1033.1987.tb11187.x;
Tsuchiya M., Kaziro Y., Nagata S.;
"The chromosomal gene structure for murine granulocyte colony-
stimulating factor.";
Eur. J. Biochem. 165:7-12(1987).
[3]
PARTIAL PROTEIN SEQUENCE.
PubMed=3501294;
Simpson R.J., Nice E.C., Nicola N.A.;
"Structural studies on the murine granulocyte colony-stimulating
factor.";
Biol. Chem. Hoppe-Seyler 368:1327-1331(1987).
-!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
cytokines that act in hematopoiesis by controlling the production,
differentiation, and function of 2 related white cell populations
of the blood, the granulocytes and the monocytes-macrophages. This
CSF induces granulocytes.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: O-glycosylated. {ECO:0000250}.
-!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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EMBL; M13926; AAA37672.1; -; mRNA.
EMBL; X05402; CAA28986.1; -; Genomic_DNA.
CCDS; CCDS25360.1; -.
PIR; A29536; A26496.
RefSeq; NP_034101.1; NM_009971.1.
UniGene; Mm.1238; -.
ProteinModelPortal; P09920; -.
SMR; P09920; -.
DIP; DIP-6118N; -.
STRING; 10090.ENSMUSP00000037762; -.
PhosphoSitePlus; P09920; -.
PaxDb; P09920; -.
PRIDE; P09920; -.
Ensembl; ENSMUST00000038886; ENSMUSP00000037762; ENSMUSG00000038067.
GeneID; 12985; -.
KEGG; mmu:12985; -.
UCSC; uc007lgy.1; mouse.
CTD; 1440; -.
MGI; MGI:1339751; Csf3.
eggNOG; ENOG410IIM2; Eukaryota.
eggNOG; ENOG4111DA4; LUCA.
GeneTree; ENSGT00390000017328; -.
HOGENOM; HOG000015371; -.
HOVERGEN; HBG005411; -.
InParanoid; P09920; -.
KO; K05423; -.
OMA; KLCHPEE; -.
OrthoDB; EOG091G0NDU; -.
PhylomeDB; P09920; -.
TreeFam; TF337698; -.
Reactome; R-MMU-449836; Other interleukin signaling.
PRO; PR:P09920; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000038067; -.
CleanEx; MM_CSF3; -.
ExpressionAtlas; P09920; baseline and differential.
Genevisible; P09920; MM.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0005125; F:cytokine activity; ISO:MGI.
GO; GO:0019899; F:enzyme binding; ISO:MGI.
GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IPI:MGI.
GO; GO:0008083; F:growth factor activity; ISO:MGI.
GO; GO:0071345; P:cellular response to cytokine stimulus; ISO:MGI.
GO; GO:0030851; P:granulocyte differentiation; NAS:UniProtKB.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0030225; P:macrophage differentiation; IBA:GO_Central.
GO; GO:0061515; P:myeloid cell development; IBA:GO_Central.
GO; GO:1901215; P:negative regulation of neuron death; ISO:MGI.
GO; GO:0030223; P:neutrophil differentiation; IBA:GO_Central.
GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISO:MGI.
GO; GO:0030838; P:positive regulation of actin filament polymerization; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI.
GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; ISO:MGI.
GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IGI:MGI.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISO:MGI.
GO; GO:0032092; P:positive regulation of protein binding; ISO:MGI.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR030474; IL-6/GCSF/MGF.
InterPro; IPR030473; IL6/GCSF/MGF_CS.
Pfam; PF16647; GCSF; 1.
PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
PRINTS; PR00433; IL6GCSFMGF.
SMART; SM00126; IL6; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00254; INTERLEUKIN_6; 1.
1: Evidence at protein level;
Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
Secreted; Signal.
SIGNAL 1 30
CHAIN 31 208 Granulocyte colony-stimulating factor.
/FTId=PRO_0000015571.
CARBOHYD 169 169 O-linked (GalNAc...) threonine.
{ECO:0000250}.
DISULFID 72 78 {ECO:0000250}.
DISULFID 100 110 {ECO:0000250}.
SEQUENCE 208 AA; 22421 MW; 0BF3622135C906DB CRC64;
MAQLSAQRRM KLMALQLLLW QSALWSGREA VPLVTVSALP PSLPLPRSFL LKSLEQVRKI
QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC SSQALQQTQC LSQLHSGLCL
YQGLLQALSG ISPALAPTLD LLQLDVANFA TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF
QRRAGGVLAI SYLQGFLETA RLALHHLA


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