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Granulocyte colony-stimulating factor (G-CSF)

 CSF3_BOVIN              Reviewed;         195 AA.
P35833; Q9TV89;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 2.
05-DEC-2018, entry version 115.
RecName: Full=Granulocyte colony-stimulating factor;
Short=G-CSF;
Flags: Precursor;
Name=CSF3; Synonyms=GCSF;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Holstein;
PubMed=10690933; DOI=10.1016/S0165-2427(99)00164-6;
Heidari M., Kehrli M.E. Jr.;
"Cloning, sequencing, and analysis of cDNA encoding bovine
granulocyte-colony stimulating factor.";
Vet. Immunol. Immunopathol. 73:183-191(2000).
[2]
X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
PubMed=7504736; DOI=10.1006/jmbi.1993.1617;
Lovejoy B., Cascio D., Eisenberg D.;
"Crystal structure of canine and bovine granulocyte-colony stimulating
factor (G-CSF).";
J. Mol. Biol. 234:640-653(1993).
-!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
cytokines that act in hematopoiesis by controlling the production,
differentiation, and function of 2 related white cell populations
of the blood, the granulocytes and the monocytes-macrophages. This
CSF induces granulocytes.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: O-glycosylated.
-!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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EMBL; AF092533; AAD16102.1; -; mRNA.
RefSeq; NP_776453.1; NM_174028.1.
UniGene; Bt.4660; -.
PDB; 1BGC; X-ray; 1.70 A; A=22-195.
PDBsum; 1BGC; -.
ProteinModelPortal; P35833; -.
SMR; P35833; -.
STRING; 9913.ENSBTAP00000028610; -.
PaxDb; P35833; -.
Ensembl; ENSBTAT00000028610; ENSBTAP00000028610; ENSBTAG00000021462.
GeneID; 281096; -.
KEGG; bta:281096; -.
CTD; 1440; -.
VGNC; VGNC:27757; CSF3.
eggNOG; ENOG410IIM2; Eukaryota.
eggNOG; ENOG4111DA4; LUCA.
GeneTree; ENSGT00390000017328; -.
HOGENOM; HOG000015371; -.
HOVERGEN; HBG005411; -.
InParanoid; P35833; -.
KO; K05423; -.
OMA; HKLCHPE; -.
OrthoDB; EOG091G0NDU; -.
TreeFam; TF337698; -.
Reactome; R-BTA-449836; Other interleukin signaling.
EvolutionaryTrace; P35833; -.
Proteomes; UP000009136; Chromosome 19.
Bgee; ENSBTAG00000021462; Expressed in 5 organ(s), highest expression level in colon.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IBA:GO_Central.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IBA:GO_Central.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR040117; GCSF/MGF.
InterPro; IPR030474; IL-6/GCSF/MGF.
InterPro; IPR030473; IL6/GCSF/MGF_CS.
PANTHER; PTHR10511; PTHR10511; 1.
Pfam; PF16647; GCSF; 1.
PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
PRINTS; PR00433; IL6GCSFMGF.
SMART; SM00126; IL6; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00254; INTERLEUKIN_6; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytokine; Disulfide bond;
Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 195 Granulocyte colony-stimulating factor.
/FTId=PRO_0000015568.
CARBOHYD 154 154 O-linked (GalNAc...) threonine.
{ECO:0000250}.
DISULFID 57 63
DISULFID 85 95
CONFLICT 93 94 TS -> RG (in Ref. 2). {ECO:0000305}.
HELIX 32 60 {ECO:0000244|PDB:1BGC}.
HELIX 65 69 {ECO:0000244|PDB:1BGC}.
HELIX 72 75 {ECO:0000244|PDB:1BGC}.
HELIX 83 85 {ECO:0000244|PDB:1BGC}.
TURN 87 89 {ECO:0000244|PDB:1BGC}.
HELIX 92 112 {ECO:0000244|PDB:1BGC}.
TURN 113 115 {ECO:0000244|PDB:1BGC}.
TURN 118 120 {ECO:0000244|PDB:1BGC}.
HELIX 121 145 {ECO:0000244|PDB:1BGC}.
HELIX 164 191 {ECO:0000244|PDB:1BGC}.
SEQUENCE 195 AA; 21431 MW; 8C06119E4ADFBA73 CRC64;
MKLMVLQLLL WHSALWTVHE ATPLGPARSL PQSFLLKCLE QVRKIQADGA ELQERLCAAH
KLCHPEELML LRHSLGIPQA PLSSCSSQSL QLTSCLNQLH GGLFLYQGLL QALAGISPEL
APTLDTLQLD VTDFATNIWL QMEDLGAAPA VQPTQGAMPT FTSAFQRRAG GVLVASQLHR
FLELAYRGLR YLAEP


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