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Granulocyte colony-stimulating factor (G-CSF)

 CSF3_CANLF              Reviewed;         175 AA.
P35834;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
05-JUL-2017, entry version 99.
RecName: Full=Granulocyte colony-stimulating factor;
Short=G-CSF;
Name=CSF3;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
PubMed=7504736; DOI=10.1006/jmbi.1993.1617;
Lovejoy B., Cascio D., Eisenberg D.;
"Crystal structure of canine and bovine granulocyte-colony stimulating
factor (G-CSF).";
J. Mol. Biol. 234:640-653(1993).
-!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
cytokines that act in hematopoiesis by controlling the production,
differentiation, and function of 2 related white cell populations
of the blood, the granulocytes and the monocytes-macrophages. This
CSF induces granulocytes.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: O-glycosylated.
-!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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PDB; 1BGD; X-ray; 2.30 A; A=1-175.
PDB; 1BGE; X-ray; 2.20 A; A/B=1-175.
PDBsum; 1BGD; -.
PDBsum; 1BGE; -.
ProteinModelPortal; P35834; -.
SMR; P35834; -.
STRING; 9615.ENSCAFP00000023945; -.
PaxDb; P35834; -.
eggNOG; ENOG410IIM2; Eukaryota.
eggNOG; ENOG4111DA4; LUCA.
HOGENOM; HOG000015371; -.
HOVERGEN; HBG005411; -.
InParanoid; P35834; -.
EvolutionaryTrace; P35834; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0030225; P:macrophage differentiation; IBA:GO_Central.
GO; GO:0061515; P:myeloid cell development; IBA:GO_Central.
GO; GO:0030223; P:neutrophil differentiation; IBA:GO_Central.
GO; GO:0008284; P:positive regulation of cell proliferation; IBA:GO_Central.
GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IBA:GO_Central.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR030474; IL-6/GCSF/MGF.
InterPro; IPR030473; IL6/GCSF/MGF_CS.
Pfam; PF16647; GCSF; 1.
PRINTS; PR00433; IL6GCSFMGF.
SMART; SM00126; IL6; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00254; INTERLEUKIN_6; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytokine; Disulfide bond;
Glycoprotein; Growth factor; Reference proteome; Secreted.
CHAIN 1 175 Granulocyte colony-stimulating factor.
/FTId=PRO_0000058759.
CARBOHYD 134 134 O-linked (GalNAc...) threonine.
{ECO:0000250}.
DISULFID 37 43
DISULFID 65 75
HELIX 12 39 {ECO:0000244|PDB:1BGE}.
HELIX 45 55 {ECO:0000244|PDB:1BGE}.
HELIX 63 65 {ECO:0000244|PDB:1BGE}.
TURN 67 69 {ECO:0000244|PDB:1BGE}.
HELIX 72 92 {ECO:0000244|PDB:1BGE}.
TURN 93 95 {ECO:0000244|PDB:1BGE}.
TURN 98 100 {ECO:0000244|PDB:1BGE}.
HELIX 101 125 {ECO:0000244|PDB:1BGE}.
HELIX 144 171 {ECO:0000244|PDB:1BGE}.
SEQUENCE 175 AA; 18858 MW; 28C26B24990C6DB3 CRC64;
MAPLGPTGPL PQSFLLKCLE QMRKVQADGT ALQETLCATH QLCHPEELVL LGHALGIPQP
PLSSCSSQAL QLMGCLRQLH SGLFLYQGLL QALAGISPEL APTLDTLQLD TTDFAINIWQ
QMEDLGMAPA VPPTQGTMPA FTSAFQRRAG GVLVASNLQS FLELAYRALR HFAKP


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