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Granulocyte colony-stimulating factor (G-CSF) (Fragment)

 CSF3_FELCA              Reviewed;         194 AA.
O02708;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
05-JUL-2017, entry version 94.
RecName: Full=Granulocyte colony-stimulating factor;
Short=G-CSF;
Flags: Precursor; Fragment;
Name=CSF3;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=European shorthair; TISSUE=Lung;
PubMed=11497496; DOI=10.1006/cyto.2001.0910;
Dunham S.P., Onions D.E.;
"Isolation, nucleotide sequence and expression of a cDNA encoding
feline granulocyte colony-stimulating factor.";
Cytokine 14:347-351(2001).
-!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
cytokines that act in hematopoiesis by controlling the production,
differentiation, and function of 2 related white cell populations
of the blood, the granulocytes and the monocytes-macrophages. This
CSF induces granulocytes (By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: O-glycosylated. {ECO:0000250}.
-!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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EMBL; Y08558; CAA69853.1; -; mRNA.
PIR; T09255; T09255.
ProteinModelPortal; O02708; -.
SMR; O02708; -.
STRING; 9685.ENSFCAP00000013908; -.
eggNOG; ENOG410IIM2; Eukaryota.
eggNOG; ENOG4111DA4; LUCA.
HOVERGEN; HBG005411; -.
InParanoid; O02708; -.
TreeFam; TF337698; -.
Proteomes; UP000011712; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0030225; P:macrophage differentiation; IBA:GO_Central.
GO; GO:0061515; P:myeloid cell development; IBA:GO_Central.
GO; GO:0030223; P:neutrophil differentiation; IBA:GO_Central.
GO; GO:0008284; P:positive regulation of cell proliferation; IBA:GO_Central.
GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IBA:GO_Central.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR030474; IL-6/GCSF/MGF.
InterPro; IPR030473; IL6/GCSF/MGF_CS.
Pfam; PF16647; GCSF; 1.
PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
PRINTS; PR00433; IL6GCSFMGF.
SMART; SM00126; IL6; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00254; INTERLEUKIN_6; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Growth factor; Reference proteome; Secreted; Signal.
SIGNAL <1 20 {ECO:0000255}.
CHAIN 21 194 Granulocyte colony-stimulating factor.
/FTId=PRO_0000015569.
CARBOHYD 153 153 O-linked (GalNAc...) threonine.
{ECO:0000250}.
DISULFID 56 62 {ECO:0000250}.
DISULFID 84 94 {ECO:0000250}.
NON_TER 1 1
SEQUENCE 194 AA; 21154 MW; F72B7AB3DAE7385E CRC64;
KLMALQLLLW HSALWMVQEA TPLGPTSSLP QSFLLKCLEQ VRKVQADGTA LQERLCAAHK
LCHPEELVLL GHALGIPQAP LSSCSSQALQ LTGCLRQLHS GLFLYQGLLQ ALAGISPELA
PTLDMLQLDI TDFAINIWQQ MEDVGMAPAV PPTQGTMPTF TSAFQRRAGG TLVASNLQSF
LEVAYRALRH FTKP


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