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Granulocyte-macrophage colony-stimulating factor

 I3L8Q3_PIG              Unreviewed;       144 AA.
I3L8Q3;
11-JUL-2012, integrated into UniProtKB/TrEMBL.
11-JUL-2012, sequence version 1.
23-MAY-2018, entry version 34.
SubName: Full=Granulocyte-macrophage colony-stimulating factor {ECO:0000313|Ensembl:ENSSSCP00000020413};
Name=CSF2 {ECO:0000313|Ensembl:ENSSSCP00000020413};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020413, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000020413, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020413};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000020413}
IDENTIFICATION.
Ensembl;
Submitted (MAY-2012) to UniProtKB.
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EMBL; AEMK02000012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
PRIDE; I3L8Q3; -.
Ensembl; ENSSSCT00000027098; ENSSSCP00000020413; ENSSSCG00000023737.
eggNOG; ENOG410JBQ7; Eukaryota.
eggNOG; ENOG411164J; LUCA.
GeneTree; ENSGT00390000013425; -.
OMA; MWLQNLL; -.
OrthoDB; EOG091G0XFL; -.
TreeFam; TF338611; -.
Reactome; R-SSC-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-SSC-512988; Interleukin-3, 5 and GM-CSF signaling.
Reactome; R-SSC-5673001; RAF/MAP kinase cascade.
Reactome; R-SSC-912526; Interleukin receptor SHC signaling.
Proteomes; UP000008227; Chromosome 2.
Bgee; ENSSSCG00000023737; -.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:InterPro.
GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IMP:AgBase.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0072651; P:interferon-tau production; IMP:AgBase.
GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0045918; P:negative regulation of cytolysis; IEA:Ensembl.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IMP:AgBase.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
GO; GO:1904075; P:positive regulation of trophectodermal cell proliferation; IMP:AgBase.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IMP:AgBase.
GO; GO:0031929; P:TOR signaling; IMP:AgBase.
CDD; cd00040; CSF2; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000773; GM_colony-stim-fac.
PANTHER; PTHR10059; PTHR10059; 1.
Pfam; PF01109; GM_CSF; 1.
PRINTS; PR00693; GMCSFACTOR.
ProDom; PD007349; GM_colony-stim-fac; 1.
SMART; SM00040; CSF2; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00702; GM_CSF; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000008227};
Reference proteome {ECO:0000313|Proteomes:UP000008227};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 17 {ECO:0000256|SAM:SignalP}.
CHAIN 18 144 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003675385.
SEQUENCE 144 AA; 16268 MW; C8D2B2592CE14C6C CRC64;
MWLQNLLLLG TVVCSISAPT RPPSPVTRPW QHVDAIKEAL SLLNNSNDTA AVMNETVDIV
CEMFDPQEPT CVQTRLNLYK QGLRGSLTRL KSPLTLLAKH YEQHCPLTEE TSCETQSITF
KSFKDSLNKF LFTIPFDCWG PVKK


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