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Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF)

 CSF2_MOUSE              Reviewed;         141 AA.
P01587;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-APR-1988, sequence version 1.
23-MAY-2018, entry version 146.
RecName: Full=Granulocyte-macrophage colony-stimulating factor;
Short=GM-CSF;
AltName: Full=Colony-stimulating factor;
Short=CSF;
Flags: Precursor;
Name=Csf2; Synonyms=Csfgm;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3876930;
Miyatake S., Otsuka T., Yokota T., Lee F., Arai K.;
"Structure of the chromosomal gene for granulocyte-macrophage colony
stimulating factor: comparison of the mouse and human genes.";
EMBO J. 4:2561-2568(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3876931;
Stanley E.R., Metcalf D., Sobieszczuk P., Gough N.M., Dunn A.R.;
"The structure and expression of the murine gene encoding granulocyte-
macrophage colony stimulating factor: evidence for utilisation of
alternative promoters.";
EMBO J. 4:2569-2573(1985).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3902470;
Delamarter J.F., Mermod J.-J., Liang C.M., Eliason J.F.,
Thatcher D.R.;
"Recombinant murine GM-CSF from E. coli has biological activity and is
neutralized by a specific antiserum.";
EMBO J. 4:2575-2581(1985).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ;
PubMed=3874057;
Gough N.M., Metcalf D., Gough J., Grail D., Dunn A.R.;
"Structure and expression of the mRNA for murine granulocyte-
macrophage colony stimulating factor.";
EMBO J. 4:645-653(1985).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 24-141.
TISSUE=Lung;
PubMed=6610831; DOI=10.1038/309763a0;
Gough N.M., Gough J., Metcalf D., Kelso A., Grail D., Nicola N.A.,
Burgess A.W., Dunn A.R.;
"Molecular cloning of cDNA encoding a murine haematopoietic growth
regulator, granulocyte-macrophage colony stimulating factor.";
Nature 309:763-767(1984).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 18-141.
PubMed=3898082; DOI=10.1073/pnas.82.18.6250;
Cantrell M.A., Anderson D., Cerretti D.P., Price V., McKereghan K.,
Tushinski R.J., Mochizuki D.Y., Larsen A., Grabstein S., Gillis S.,
Cosman D.;
"Cloning, sequence, and expression of a human granulocyte/macrophage
colony-stimulating factor.";
Proc. Natl. Acad. Sci. U.S.A. 82:6250-6254(1985).
[7]
PROTEIN SEQUENCE OF 24-57.
PubMed=3871523; DOI=10.1073/pnas.82.2.292;
Sparrow L.G., Metcalf D., Hunkapiller M.W., Hood L.E., Burgess A.W.;
"Purification and partial amino acid sequence of asialo murine
granulocyte-macrophage colony stimulating factor.";
Proc. Natl. Acad. Sci. U.S.A. 82:292-296(1985).
[8]
DISULFIDE BONDS.
PubMed=3318813; DOI=10.1042/bj2470195;
Schrimser J.L., Rose K., Simona M.G., Wingfield P.;
"Characterization of human and mouse granulocyte-macrophage-colony-
stimulating factors derived from Escherichia coli.";
Biochem. J. 247:195-199(1987).
[9]
MUTAGENESIS.
PubMed=2002066;
Altmann S.W., Johnson G.D., Prystowsky M.B.;
"Single proline substitutions in predicted alpha-helices of murine
granulocyte-macrophage colony-stimulating factor result in a loss in
bioactivity and altered glycosylation.";
J. Biol. Chem. 266:5333-5341(1991).
-!- FUNCTION: Cytokine that stimulates the growth and differentiation
of hematopoietic precursor cells from various lineages, including
granulocytes, macrophages, eosinophils and erythrocytes.
-!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a
dodecamer of two head-to-head hexamers of two alpha, two beta, and
two ligand subunits (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA26192.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X03020; CAA26821.1; -; Genomic_DNA.
EMBL; X03019; CAA26820.1; -; mRNA.
EMBL; X02333; CAA26193.1; -; mRNA.
EMBL; X02333; CAA26192.1; ALT_INIT; mRNA.
EMBL; X05906; CAA29336.1; -; mRNA.
EMBL; M11848; AAA37483.1; -; mRNA.
CCDS; CCDS24692.1; -.
PIR; I48368; FQMSGM.
RefSeq; NP_034099.2; NM_009969.4.
UniGene; Mm.4922; -.
ProteinModelPortal; P01587; -.
SMR; P01587; -.
STRING; 10090.ENSMUSP00000019060; -.
PhosphoSitePlus; P01587; -.
PaxDb; P01587; -.
PRIDE; P01587; -.
Ensembl; ENSMUST00000019060; ENSMUSP00000019060; ENSMUSG00000018916.
GeneID; 12981; -.
KEGG; mmu:12981; -.
UCSC; uc007ixm.1; mouse.
CTD; 1437; -.
MGI; MGI:1339752; Csf2.
eggNOG; ENOG410JBQ7; Eukaryota.
eggNOG; ENOG411164J; LUCA.
GeneTree; ENSGT00390000013425; -.
HOGENOM; HOG000037940; -.
HOVERGEN; HBG000532; -.
InParanoid; P01587; -.
KO; K05427; -.
OMA; MWLQNLL; -.
OrthoDB; EOG091G0XFL; -.
PhylomeDB; P01587; -.
TreeFam; TF338611; -.
Reactome; R-MMU-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-MMU-512988; Interleukin-3, 5 and GM-CSF signaling.
Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
Reactome; R-MMU-912526; Interleukin receptor SHC signaling.
ChiTaRS; Csf2; mouse.
PRO; PR:P01587; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000018916; -.
ExpressionAtlas; P01587; baseline and differential.
Genevisible; P01587; MM.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
GO; GO:0005125; F:cytokine activity; IDA:MGI.
GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISO:MGI.
GO; GO:0097028; P:dendritic cell differentiation; ISO:MGI.
GO; GO:0001892; P:embryonic placenta development; IMP:MGI.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0030224; P:monocyte differentiation; IDA:MGI.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IDA:MGI.
GO; GO:0045918; P:negative regulation of cytolysis; ISO:MGI.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISO:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0030223; P:neutrophil differentiation; IDA:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
GO; GO:0045740; P:positive regulation of DNA replication; ISO:MGI.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0032747; P:positive regulation of interleukin-23 production; ISO:MGI.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; ISO:MGI.
GO; GO:0071803; P:positive regulation of podosome assembly; ISO:MGI.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:MGI.
GO; GO:0042127; P:regulation of cell proliferation; IGI:MGI.
GO; GO:0010468; P:regulation of gene expression; IDA:MGI.
CDD; cd00040; CSF2; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000773; GM_colony-stim-fac.
PANTHER; PTHR10059; PTHR10059; 1.
Pfam; PF01109; GM_CSF; 1.
PRINTS; PR00693; GMCSFACTOR.
ProDom; PD007349; GM_colony-stim-fac; 1.
SMART; SM00040; CSF2; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00702; GM_CSF; 1.
1: Evidence at protein level;
Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
Secreted; Signal.
SIGNAL 1 17
CHAIN 18 141 Granulocyte-macrophage colony-stimulating
factor.
/FTId=PRO_0000005866.
CARBOHYD 22 22 O-linked (GalNAc...) serine.
{ECO:0000250}.
CARBOHYD 27 27 O-linked (GalNAc...) threonine.
{ECO:0000250}.
CARBOHYD 83 83 N-linked (GlcNAc...) asparagine.
CARBOHYD 92 92 N-linked (GlcNAc...) asparagine.
DISULFID 68 110 {ECO:0000269|PubMed:3318813}.
DISULFID 102 135 {ECO:0000269|PubMed:3318813}.
MUTAGEN 38 38 E->P: Reduction in bioactivity.
{ECO:0000269|PubMed:2002066}.
MUTAGEN 73 73 L->P: 25-fold reduction in bioactivity.
{ECO:0000269|PubMed:2002066}.
MUTAGEN 77 77 E->P: 50-fold reduction in bioactivity.
{ECO:0000269|PubMed:2002066}.
MUTAGEN 80 80 L->P: 450-fold reduction in bioactivity.
{ECO:0000269|PubMed:2002066}.
MUTAGEN 124 124 L->P: 5500-fold reduction in bioactivity.
{ECO:0000269|PubMed:2002066}.
CONFLICT 25 25 T -> I (in Ref. 5; CAA29336 and 7; AA
sequence). {ECO:0000305}.
CONFLICT 114 114 V -> A (in Ref. 6; AAA37483).
{ECO:0000305}.
CONFLICT 139 139 G -> S (in Ref. 5; CAA29336).
{ECO:0000305}.
CONFLICT 139 139 G -> V (in Ref. 2; CAA26820, 3; no
nucleotide entry, 4; CAA26192/CAA26193
and 6; AAA37483). {ECO:0000305}.
SEQUENCE 141 AA; 16091 MW; 209C7CBB4FF77349 CRC64;
MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL NEEVEVVSNE
FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT YCPPTPETDC ETQVTTYADF
IDSLKTFLTD IPFECKKPGQ K


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