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Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF)

 CSF2_BOVIN              Reviewed;         143 AA.
P11052;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
28-MAR-2018, entry version 114.
RecName: Full=Granulocyte-macrophage colony-stimulating factor;
Short=GM-CSF;
AltName: Full=Colony-stimulating factor;
Short=CSF;
Flags: Precursor;
Name=CSF2;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3062386; DOI=10.1016/0161-5890(88)90120-4;
Maliszewski C.R., Schoenborn M.A., Cerretti D.P., Wignall J.M.,
Picha K.S., Cosman D., Tushinski R.J., Gillis S., Baker P.E.;
"Bovine GM-CSF: molecular cloning and biological activity of the
recombinant protein.";
Mol. Immunol. 25:843-850(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2678728; DOI=10.1016/0165-2427(89)90036-6;
Leong S.R., Flaggs G.M., Lawman M.J.P., Gray P.W.;
"Cloning and expression of the cDNA for bovine granulocyte-macrophage
colony-stimulating factor.";
Vet. Immunol. Immunopathol. 21:261-278(1989).
-!- FUNCTION: Cytokine that stimulates the growth and differentiation
of hematopoietic precursor cells from various lineages, including
granulocytes, macrophages, eosinophils and erythrocytes.
{ECO:0000250}.
-!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a
dodecamer of two head-to-head hexamers of two alpha, two beta, and
two ligand subunits (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
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EMBL; U22385; AAA66075.1; -; mRNA.
PIR; JL0037; FQBOGM.
RefSeq; NP_776452.1; NM_174027.2.
UniGene; Bt.509; -.
ProteinModelPortal; P11052; -.
SMR; P11052; -.
STRING; 9913.ENSBTAP00000002054; -.
PaxDb; P11052; -.
PRIDE; P11052; -.
Ensembl; ENSBTAT00000002054; ENSBTAP00000002054; ENSBTAG00000001570.
GeneID; 281095; -.
KEGG; bta:281095; -.
CTD; 1437; -.
VGNC; VGNC:27755; CSF2.
eggNOG; ENOG410JBQ7; Eukaryota.
eggNOG; ENOG411164J; LUCA.
GeneTree; ENSGT00390000013425; -.
HOGENOM; HOG000037940; -.
HOVERGEN; HBG000532; -.
InParanoid; P11052; -.
KO; K05427; -.
OMA; MWLQNLL; -.
OrthoDB; EOG091G0XFL; -.
TreeFam; TF338611; -.
Reactome; R-BTA-114604; GPVI-mediated activation cascade.
Reactome; R-BTA-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-BTA-512988; Interleukin-3, 5 and GM-CSF signaling.
Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
Reactome; R-BTA-912526; Interleukin receptor SHC signaling.
Proteomes; UP000009136; Chromosome 7.
Bgee; ENSBTAG00000001570; -.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0072651; P:interferon-tau production; ISS:AgBase.
GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0045918; P:negative regulation of cytolysis; IEA:Ensembl.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
GO; GO:1904075; P:positive regulation of trophectodermal cell proliferation; ISS:AgBase.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
CDD; cd00040; CSF2; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000773; GM_colony-stim-fac.
PANTHER; PTHR10059; PTHR10059; 1.
Pfam; PF01109; GM_CSF; 1.
PRINTS; PR00693; GMCSFACTOR.
ProDom; PD007349; GM_colony-stim-fac; 1.
SMART; SM00040; CSF2; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00702; GM_CSF; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 17
CHAIN 18 143 Granulocyte-macrophage colony-stimulating
factor.
/FTId=PRO_0000005860.
CARBOHYD 27 27 O-linked (GalNAc...) threonine.
{ECO:0000250}.
CARBOHYD 44 44 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 54 54 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 70 112 {ECO:0000250}.
DISULFID 104 137 {ECO:0000250}.
SEQUENCE 143 AA; 16157 MW; 4A24E26A870A51EC CRC64;
MWLQNLLLLG TVVCSFSAPT RPPNTATRPW QHVDAIKEAL SLLNHSSDTD AVMNDTEVVS
EKFDSQEPTC LQTRLKLYKN GLQGSLTSLM GSLTMMATHY EKHCPPTPET SCGTQFISFK
NFKEDLKEFL FIIPFDCWEP AQK


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