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Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF)

 CSF2_SHEEP              Reviewed;         144 AA.
P28773;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
01-DEC-1992, sequence version 1.
23-MAY-2018, entry version 85.
RecName: Full=Granulocyte-macrophage colony-stimulating factor;
Short=GM-CSF;
AltName: Full=Colony-stimulating factor;
Short=CSF;
Flags: Precursor;
Name=CSF2;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1937025; DOI=10.1016/0378-1119(91)90163-6;
McInnes C.J., Haig M.C.K.;
"Cloning and expression of a cDNA encoding ovine granulocyte-
macrophage colony-stimulating factor.";
Gene 105:275-279(1991).
-!- FUNCTION: Cytokine that stimulates the growth and differentiation
of hematopoietic precursor cells from various lineages, including
granulocytes, macrophages, eosinophils and erythrocytes.
{ECO:0000250}.
-!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a
dodecamer of two head-to-head hexamers of two alpha, two beta, and
two ligand subunits (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
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EMBL; X53561; CAA37632.1; -; mRNA.
PIR; JH0469; JH0469.
RefSeq; NP_001009805.1; NM_001009805.1.
UniGene; Oar.458; -.
PDB; 5D22; X-ray; 1.99 A; A/B=18-144.
PDB; 5D28; X-ray; 2.85 A; B/C=18-144.
PDBsum; 5D22; -.
PDBsum; 5D28; -.
ProteinModelPortal; P28773; -.
SMR; P28773; -.
Ensembl; ENSOART00000016787; ENSOARP00000016551; ENSOARG00000015430.
GeneID; 443400; -.
KEGG; oas:443400; -.
CTD; 1437; -.
GeneTree; ENSGT00390000013425; -.
HOVERGEN; HBG000532; -.
KO; K05427; -.
OMA; MWLQNLL; -.
OrthoDB; EOG091G0XFL; -.
Proteomes; UP000002356; Chromosome 5.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0045918; P:negative regulation of cytolysis; IEA:Ensembl.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
CDD; cd00040; CSF2; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000773; GM_colony-stim-fac.
PANTHER; PTHR10059; PTHR10059; 1.
Pfam; PF01109; GM_CSF; 1.
PRINTS; PR00693; GMCSFACTOR.
ProDom; PD007349; GM_colony-stim-fac; 1.
SMART; SM00040; CSF2; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00702; GM_CSF; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytokine; Disulfide bond;
Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 17 {ECO:0000250}.
CHAIN 18 144 Granulocyte-macrophage colony-stimulating
factor.
/FTId=PRO_0000005868.
CARBOHYD 24 24 O-linked (GalNAc...) serine.
{ECO:0000250}.
CARBOHYD 27 27 O-linked (GalNAc...) threonine.
{ECO:0000250}.
CARBOHYD 44 44 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 71 113 {ECO:0000250}.
DISULFID 105 138 {ECO:0000250}.
HELIX 31 44 {ECO:0000244|PDB:5D22}.
HELIX 50 53 {ECO:0000244|PDB:5D22}.
STRAND 56 60 {ECO:0000244|PDB:5D22}.
STRAND 66 68 {ECO:0000244|PDB:5D22}.
HELIX 72 82 {ECO:0000244|PDB:5D22}.
HELIX 85 90 {ECO:0000244|PDB:5D22}.
HELIX 91 104 {ECO:0000244|PDB:5D22}.
STRAND 115 119 {ECO:0000244|PDB:5D22}.
HELIX 120 133 {ECO:0000244|PDB:5D22}.
SEQUENCE 144 AA; 16318 MW; ABAAC8733B580008 CRC64;
MWLQNLLLLG TVVCSFSAPT RQPSPVTRPW QHVDAIKEAL SLLNDSTDTA AVMDETVEVV
SEMFDSQEPT CLQTRLELYK QGLRGSLTSL TGSLTMMASH YKKHCPPTQE TSCETQIITF
KSFKENLKDF LFIIPFDCWE PVQK


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