Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF)

 CSF2_RAT                Reviewed;         144 AA.
P48750;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 2.
23-MAY-2018, entry version 114.
RecName: Full=Granulocyte-macrophage colony-stimulating factor;
Short=GM-CSF;
AltName: Full=Colony-stimulating factor;
Short=CSF;
Flags: Precursor;
Name=Csf2; Synonyms=Csfgm;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15057822; DOI=10.1038/nature02426;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 18-144.
STRAIN=Lewis; TISSUE=Splenocyte;
PubMed=8225444; DOI=10.1007/BF00171806;
Smith L.R., Lundeen K.A., Diveley J.P., Carlo D.J., Brostoff S.W.;
"Nucleotide sequence of the Lewis rat granulocyte-macrophage colony
stimulating factor.";
Immunogenetics 39:80-80(1994).
-!- FUNCTION: Cytokine that stimulates the growth and differentiation
of hematopoietic precursor cells from various lineages, including
granulocytes, macrophages, eosinophils and erythrocytes.
{ECO:0000250}.
-!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a
dodecamer of two head-to-head hexamers of two alpha, two beta, and
two ligand subunits (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AABR03075230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; U00620; AAA18281.1; -; mRNA.
PIR; I46269; I46269.
RefSeq; NP_446304.1; NM_053852.1.
UniGene; Rn.44285; -.
SMR; P48750; -.
STRING; 10116.ENSRNOP00000034235; -.
PhosphoSitePlus; P48750; -.
PaxDb; P48750; -.
Ensembl; ENSRNOT00000032333; ENSRNOP00000034235; ENSRNOG00000026805.
GeneID; 116630; -.
KEGG; rno:116630; -.
UCSC; RGD:621065; rat.
CTD; 1437; -.
RGD; 621065; Csf2.
eggNOG; ENOG410JBQ7; Eukaryota.
eggNOG; ENOG411164J; LUCA.
GeneTree; ENSGT00390000013425; -.
HOGENOM; HOG000037940; -.
HOVERGEN; HBG000532; -.
InParanoid; P48750; -.
KO; K05427; -.
OMA; MWLQNLL; -.
OrthoDB; EOG091G0XFL; -.
PhylomeDB; P48750; -.
TreeFam; TF338611; -.
Reactome; R-RNO-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-RNO-512988; Interleukin-3, 5 and GM-CSF signaling.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
Reactome; R-RNO-912526; Interleukin receptor SHC signaling.
PRO; PR:P48750; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000026805; -.
Genevisible; P48750; RN.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IDA:RGD.
GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
GO; GO:0097028; P:dendritic cell differentiation; IDA:RGD.
GO; GO:0050673; P:epithelial cell proliferation; TAS:RGD.
GO; GO:0042045; P:epithelial fluid transport; IDA:RGD.
GO; GO:0001821; P:histamine secretion; IDA:RGD.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0042116; P:macrophage activation; IMP:RGD.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0045918; P:negative regulation of cytolysis; IEA:Ensembl.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0045651; P:positive regulation of macrophage differentiation; TAS:RGD.
GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IMP:RGD.
GO; GO:0034405; P:response to fluid shear stress; IEP:RGD.
GO; GO:0034021; P:response to silicon dioxide; IEP:RGD.
CDD; cd00040; CSF2; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000773; GM_colony-stim-fac.
PANTHER; PTHR10059; PTHR10059; 1.
Pfam; PF01109; GM_CSF; 1.
PRINTS; PR00693; GMCSFACTOR.
ProDom; PD007349; GM_colony-stim-fac; 1.
SMART; SM00040; CSF2; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00702; GM_CSF; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 17 {ECO:0000250}.
CHAIN 18 144 Granulocyte-macrophage colony-stimulating
factor.
/FTId=PRO_0000144833.
CARBOHYD 22 22 O-linked (GalNAc...) serine.
{ECO:0000250}.
CARBOHYD 27 27 O-linked (GalNAc...) threonine.
{ECO:0000250}.
CARBOHYD 86 86 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 71 113 {ECO:0000250}.
DISULFID 105 138 {ECO:0000250}.
SEQUENCE 144 AA; 16562 MW; 7385E93CC40836B1 CRC64;
MWLQNLLFLG IVVYSFSAPT RSPNPVTRPW KHVDAIKEAL SLLNDMRALE NEKNEDVDII
SNEFSIQRPT CVQTRLKLYK QGLRGNLTKL NGALTMIASH YQTNCPPTPE TDCEIEVTTF
EDFIKNLKGF LFDIPFDCWK PVQK


Related products :

Catalog number Product name Quantity
20-663-48028 Granulocyte Macrophage Colony Stimulating Factor (mAHuGM-CSF) - Mouse Anti-Human Granulocyte Macrophage Colony Stimulating Factor (mAHuGM-CSF); GM-CSF; Colony-stimulating factor; CSF; Sargramostim; Mo 1 mg
20-663-48028 Granulocyte Macrophage Colony Stimulating Factor (mAHuGM-CSF) - Mouse Anti-Human Granulocyte Macrophage Colony Stimulating Factor (mAHuGM-CSF); GM-CSF; Colony-stimulating factor; CSF; Sargramostim; Mo 0.5 mg
RF0036- Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim, rHuman GM-CSF (Granulocyte-macrophage colony-stimulating factor ) 20ug
RF0036- Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim, rHuman GM-CSF (Granulocyte-macrophage colony-stimulating factor ) 50ug
RF0036- Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim, rHuman GM-CSF (Granulocyte-macrophage colony-stimulating factor ) 10ug
RF0036- Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim, rHuman GM-CSF (Granulocyte-macrophage colony-stimulating factor ) 100ug
RF0036-10 rHuman GM-CSF (Granulocyte-macrophage colony-stimulating factor ); Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim 10ug
RF0036-20 rHuman GM-CSF (Granulocyte-macrophage colony-stimulating factor ); Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim 20ug
RF0036-100 rHuman GM-CSF (Granulocyte-macrophage colony-stimulating factor ); Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim 100ug
RF0036-50 rHuman GM-CSF (Granulocyte-macrophage colony-stimulating factor ); Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim 50ug
20-321-175014 GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF) - MONOCLONAL ANTIBODY TO MOUSE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF); GM-CSF; Colony-stimulating factor; CSF Monoclonal 0.1 mg
20-321-175015 GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF) - MONOCLONAL ANTIBODY TO MOUSE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF); GM-CSF; Colony-stimulating factor; CSF Monoclonal 0.5 mg
20-321-175012 GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF) - MONOCLONAL ANTIBODY TO MOUSE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF); GM-CSF; Colony-stimulating factor; CSF Monoclonal 0.1 mg
PNb-034 GM-CSF Human Host: Nicotiana benthamiana CSF2; GMCSF Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim 50
PNb-033 GM-CSF Human Host: Nicotiana benthamiana CSF2; GMCSF Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim 20
PNb-032 GM-CSF Human Host: Nicotiana benthamiana CSF2; GMCSF Granulocyte-macrophage colony-stimulating factor (GM-CSF), Colony-stimulating factor (CSF), Molgramostin, Sargramostim 10
U0045h CLIA Colony-stimulating factor,CSF,CSF2,GMCSF,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Homo sapiens,Human,Molgramostin,Sargramostim 96T
E0045h ELISA kit Colony-stimulating factor,CSF,CSF2,GMCSF,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Homo sapiens,Human,Molgramostin,Sargramostim 96T
E0045h ELISA Colony-stimulating factor,CSF,CSF2,GMCSF,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Homo sapiens,Human,Molgramostin,Sargramostim 96T
U0045r CLIA Colony-stimulating factor,CSF,Csf2,Csfgm,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Rat,Rattus norvegicus 96T
E0045r ELISA kit Colony-stimulating factor,CSF,Csf2,Csfgm,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Rat,Rattus norvegicus 96T
E0045m ELISA Colony-stimulating factor,CSF,Csf2,Csfgm,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Mouse,Mus musculus 96T
E0045m ELISA kit Colony-stimulating factor,CSF,Csf2,Csfgm,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Mouse,Mus musculus 96T
E0045r ELISA Colony-stimulating factor,CSF,Csf2,Csfgm,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Rat,Rattus norvegicus 96T
U0045m CLIA Colony-stimulating factor,CSF,Csf2,Csfgm,GM-CSF,Granulocyte-macrophage colony-stimulating factor,Mouse,Mus musculus 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur