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Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CD antigen CD116)

 CSF2R_MOUSE             Reviewed;         388 AA.
Q00941; E9QJX0;
24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
31-JAN-2018, entry version 147.
RecName: Full=Granulocyte-macrophage colony-stimulating factor receptor subunit alpha;
Short=GM-CSF-R-alpha;
Short=GMCSFR-alpha;
Short=GMR-alpha;
AltName: CD_antigen=CD116;
Flags: Precursor;
Name=Csf2ra; Synonyms=Csfgmra;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Neonatal spleen;
PubMed=1533931; DOI=10.1073/pnas.89.10.4295;
Park L.S., Martin U., Sorensen R., Luhr S., Morrissey P.J., Cosman D.,
Larsen A.;
"Cloning of the low-affinity murine granulocyte-macrophage colony-
stimulating factor receptor and reconstitution of a high-affinity
receptor complex.";
Proc. Natl. Acad. Sci. U.S.A. 89:4295-4299(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
-!- FUNCTION: Low affinity receptor for granulocyte-macrophage colony-
stimulating factor. Transduces a signal that results in the
proliferation, differentiation, and functional activation of
hematopoietic cells.
-!- SUBUNIT: Heterodimer of an alpha and a beta subunit. The beta
subunit is common to the IL3, IL5 and GM-CSF receptors. The
signaling GM-CSF receptor complex is a dodecamer of two head-to-
head hexamers of two alpha, two beta, and two ligand subunits (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
membrane protein {ECO:0000305}.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M85078; AAA37421.1; -; mRNA.
EMBL; AC165327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS29946.1; -.
PIR; A45304; A45304.
RefSeq; NP_034100.2; NM_009970.2.
UniGene; Mm.287228; -.
ProteinModelPortal; Q00941; -.
STRING; 10090.ENSMUSP00000075423; -.
PhosphoSitePlus; Q00941; -.
PaxDb; Q00941; -.
PRIDE; Q00941; -.
Ensembl; ENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326.
GeneID; 12982; -.
KEGG; mmu:12982; -.
UCSC; uc008icj.2; mouse.
CTD; 1438; -.
MGI; MGI:1339754; Csf2ra.
eggNOG; ENOG410IKK3; Eukaryota.
eggNOG; ENOG411157B; LUCA.
GeneTree; ENSGT00520000055993; -.
HOVERGEN; HBG051129; -.
InParanoid; Q00941; -.
KO; K05066; -.
OMA; YLDFQYQ; -.
OrthoDB; EOG091G0935; -.
TreeFam; TF331549; -.
Reactome; R-MMU-114604; GPVI-mediated activation cascade.
Reactome; R-MMU-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-MMU-512988; Interleukin-3, 5 and GM-CSF signaling.
Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
Reactome; R-MMU-5683826; Surfactant metabolism.
Reactome; R-MMU-912526; Interleukin receptor SHC signaling.
PRO; PR:Q00941; -.
Proteomes; UP000000589; Chromosome 19.
Bgee; ENSMUSG00000059326; -.
Genevisible; Q00941; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0051916; F:granulocyte colony-stimulating factor binding; IDA:MGI.
GO; GO:0004902; F:granulocyte colony-stimulating factor receptor activity; IDA:MGI.
GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IDA:MGI.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
InterPro; IPR015321; TypeI_recpt_CBD.
Pfam; PF09240; IL6Ra-bind; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
2: Evidence at transcript level;
Complete proteome; Glycoprotein; Membrane; Receptor;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 29 {ECO:0000255}.
CHAIN 30 388 Granulocyte-macrophage colony-stimulating
factor receptor subunit alpha.
/FTId=PRO_0000010873.
TOPO_DOM 30 327 Extracellular. {ECO:0000255}.
TRANSMEM 328 348 Helical. {ECO:0000255}.
TOPO_DOM 349 388 Cytoplasmic. {ECO:0000255}.
DOMAIN 228 324 Fibronectin type-III.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOTIF 310 314 WSXWS motif.
MOTIF 359 367 Box 1 motif.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 63 63 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 106 106 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 132 132 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 165 165 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 237 237 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 124 124 G -> S (in Ref. 1; AAA37421).
{ECO:0000305}.
SEQUENCE 388 AA; 41769 MW; 8877B0743D99B0FE CRC64;
MTSSHAMNIT PLAQLALLFS TLLLPGTQAL LAPTTPDAGS ALNLTFDPWT RTLTWACDTA
AGNVTVTSCT VTSREAGIHR RVSPFGCRCW FRRMMALHHG VTLDVNGTVG GAAAHWRLSF
VNEGAAGSGA ENLTCEIRAA RFLSCAWREG PAAPADVRYS LRVLNSTGHD VARCMADPGD
DVITQCIAND LSLLGSEAYL VVTGRSGAGP VRFLDDVVAT KALERLGPPR DVTASCNSSH
CTVSWAPPST WASLTARDFQ FEVQWQSAEP GSTPRKVLVV EETRLAFPSP APHGGHKVKV
RAGDTRMKHW GEWSPAHPLE AEDTRVPGAL LYAVTACAVL LCALALGVTC RRFEVTRRLF
PPIPGIRDKV SDDVRVNPET LRKDLLQP


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