Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Granzyme C (EC 3.4.21.-) (B10) (Cytotoxic cell protease 2) (CCP2)

 GRAC_MOUSE              Reviewed;         248 AA.
P08882; Q61389;
01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
01-NOV-1988, sequence version 1.
25-OCT-2017, entry version 139.
RecName: Full=Granzyme C;
EC=3.4.21.-;
AltName: Full=B10;
AltName: Full=Cytotoxic cell protease 2;
Short=CCP2;
Flags: Precursor;
Name=Gzmc; Synonyms=Ctla-5, Ctla5;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3292281; DOI=10.1016/0014-5793(88)81323-1;
Bleackley R.C., Duggan B., Ehrman N., Lobe C.G.;
"Isolation of two cDNA sequences which encode cytotoxic cell
proteases.";
FEBS Lett. 234:153-159(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3264185; DOI=10.1021/bi00418a040;
Lobe C.G., Upton C., Duggan B., Ehrman N., Letellier M., Bell J.,
McFadden G., Bleackley R.C.;
"Organization of two genes encoding cytotoxic T lymphocyte-specific
serine proteases CCPI and CCPII.";
Biochemistry 27:6941-6946(1988).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3257230;
Jenne D.E., Rey C., Masson D., Stanley K.K., Herz J., Plaetinck G.,
Tschopp J.;
"cDNA cloning of granzyme C, a granule-associated serine protease of
cytolytic T lymphocytes.";
J. Immunol. 140:318-323(1988).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 159-248.
PubMed=3518058; DOI=10.1126/science.3518058;
Lobe C.G., Finlay B.B., Paranchych W., Paetkau V.H., Bleackley R.C.;
"Novel serine proteases encoded by two cytotoxic T lymphocyte-specific
genes.";
Science 232:858-861(1986).
[5]
PROTEIN SEQUENCE OF 21-40.
PubMed=3555842; DOI=10.1016/0092-8674(87)90544-7;
Masson D., Tschopp J.;
"A family of serine esterases in lytic granules of cytolytic T
lymphocytes.";
Cell 49:679-685(1987).
-!- FUNCTION: This enzyme is probably necessary for target cell lysis
in cell-mediated immune responses.
-!- SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic
granules of cytolytic T-lymphocytes.
-!- SIMILARITY: Belongs to the peptidase S1 family. Granzyme
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M22527; AAA85454.1; -; Genomic_DNA.
EMBL; X12822; CAA31309.1; -; mRNA.
EMBL; M18459; AAA37734.1; -; mRNA.
EMBL; M12301; AAA37384.1; -; mRNA.
CCDS; CCDS27146.1; -.
PIR; B28952; PRMSC2.
RefSeq; NP_034501.2; NM_010371.3.
RefSeq; XP_011243265.1; XM_011244963.2.
UniGene; Mm.14465; -.
PDB; 3FZZ; X-ray; 2.50 A; A/B=21-247.
PDB; 3G01; X-ray; 2.50 A; A/B=21-247.
PDBsum; 3FZZ; -.
PDBsum; 3G01; -.
ProteinModelPortal; P08882; -.
SMR; P08882; -.
IntAct; P08882; 1.
MINT; MINT-4096670; -.
STRING; 10090.ENSMUSP00000015585; -.
MEROPS; S01.137; -.
iPTMnet; P08882; -.
PhosphoSitePlus; P08882; -.
EPD; P08882; -.
PaxDb; P08882; -.
PeptideAtlas; P08882; -.
PRIDE; P08882; -.
Ensembl; ENSMUST00000015585; ENSMUSP00000015585; ENSMUSG00000079186.
GeneID; 14940; -.
KEGG; mmu:14940; -.
UCSC; uc007ubu.2; mouse.
CTD; 14940; -.
MGI; MGI:109256; Gzmc.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00760000118895; -.
HOGENOM; HOG000251820; -.
HOVERGEN; HBG013304; -.
InParanoid; P08882; -.
OMA; RNAHVKP; -.
OrthoDB; EOG091G0G5F; -.
PhylomeDB; P08882; -.
TreeFam; TF333630; -.
Reactome; R-MMU-75108; Activation, myristolyation of BID and translocation to mitochondria.
EvolutionaryTrace; P08882; -.
PRO; PR:P08882; -.
Proteomes; UP000000589; Chromosome 14.
Bgee; ENSMUSG00000079186; -.
CleanEx; MM_GZMC; -.
ExpressionAtlas; P08882; baseline and differential.
Genevisible; P08882; MM.
GO; GO:0030141; C:secretory granule; IBA:GO_Central.
GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
GO; GO:0008626; P:granzyme-mediated apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0006508; P:proteolysis; IBA:GO_Central.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytolysis; Direct protein sequencing;
Disulfide bond; Hydrolase; Protease; Reference proteome;
Serine protease; Signal; Zymogen.
SIGNAL 1 18
PROPEP 19 20 {ECO:0000269|PubMed:3555842}.
/FTId=PRO_0000027403.
CHAIN 21 248 Granzyme C.
/FTId=PRO_0000027404.
DOMAIN 21 246 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 65 65 Charge relay system. {ECO:0000250}.
ACT_SITE 109 109 Charge relay system. {ECO:0000250}.
ACT_SITE 204 204 Charge relay system. {ECO:0000250}.
DISULFID 50 66 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 143 210 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 174 189 {ECO:0000255|PROSITE-ProRule:PRU00274}.
CONFLICT 69 69 S -> R (in Ref. 3; AAA37734).
{ECO:0000305}.
CONFLICT 181 181 S -> F (in Ref. 4; AAA37384).
{ECO:0000305}.
STRAND 35 41 {ECO:0000244|PDB:3FZZ}.
STRAND 43 45 {ECO:0000244|PDB:3FZZ}.
STRAND 47 56 {ECO:0000244|PDB:3FZZ}.
STRAND 59 62 {ECO:0000244|PDB:3FZZ}.
STRAND 69 76 {ECO:0000244|PDB:3FZZ}.
STRAND 88 97 {ECO:0000244|PDB:3FZZ}.
TURN 103 106 {ECO:0000244|PDB:3FZZ}.
STRAND 111 117 {ECO:0000244|PDB:3FZZ}.
STRAND 142 149 {ECO:0000244|PDB:3FZZ}.
STRAND 162 168 {ECO:0000244|PDB:3FZZ}.
HELIX 171 178 {ECO:0000244|PDB:3FZZ}.
TURN 179 181 {ECO:0000244|PDB:3FZZ}.
TURN 184 186 {ECO:0000244|PDB:3FZZ}.
STRAND 187 190 {ECO:0000244|PDB:3FZZ}.
TURN 200 205 {ECO:0000244|PDB:3FZZ}.
STRAND 207 210 {ECO:0000244|PDB:3FZZ}.
STRAND 213 220 {ECO:0000244|PDB:3FZZ}.
STRAND 223 225 {ECO:0000244|PDB:3G01}.
STRAND 226 233 {ECO:0000244|PDB:3FZZ}.
HELIX 234 236 {ECO:0000244|PDB:3FZZ}.
HELIX 238 245 {ECO:0000244|PDB:3FZZ}.
SEQUENCE 248 AA; 27311 MW; AA6247655EC52289 CRC64;
MPPVLILLTL LLPLRAGAEE IIGGNEISPH SRPYMAYYEF LKVGGKKMFC GGFLVRDKFV
LTAAHCKGSS MTVTLGAHNI KAKEETQQII PVAKAIPHPD YNPDDRSNDI MLLKLVRNAK
RTRAVRPLNL PRRNAHVKPG DECYVAGWGK VTPDGEFPKT LHEVKLTVQK DQVCESQFQS
SYNRANEICV GDSKIKGASF EEDSGGPLVC KRAAAGIVSY GQTDGSAPQV FTRVLSFVSW
IKKTMKHS


Related products :

Catalog number Product name Quantity
20-272-192383 Granzyme B - Mouse monoclonal [O2C5 _ F5] to Granzyme B; EC 3.4.21.79; T-cell serine protease 1-3E; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; SECT; Granzyme-2; Cathepsin G-like 1; CTSG 0.05 mg
20-272-190401 Granzyme B - Mouse monoclonal [GB7] to Granzyme B; EC 3.4.21.79; T-cell serine protease 1-3E; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; SECT; Granzyme-2; Cathepsin G-like 1; CTSGL1; CT 0.05 mg
18-272-196365 Granzyme B prediluted - Rabbit polyclonal to Granzyme B prediluted; EC 3.4.21.79; T-cell serine protease 1-3E; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; SECT; Granzyme-2; Cathepsin G-l 7 ml
20-272-191579 Granzyme B (FITC) - Mouse monoclonal [B18.1.] to Granzyme B (FITC); EC 3.4.21.79; T-cell serine protease 1-3E; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; SECT; Granzyme-2; Cathepsin G-l 50 TESTS
18-003-43748 Granzyme H - EC 3.4.21.-; Cytotoxic T-lymphocyte proteinase; Cathepsin G-like 2; CTSGL2; CCP-X; Cytotoxic serine protease C; CSP-C Polyclonal 0.1 mg Protein A
E0600m ELISA kit CCP1,Ctla1,CTLA-1,Ctla-1,Cytotoxic cell protease 1,Fragmentin-2,Granzyme B(G,H),Gzmb,Mouse,Mus musculus 96T
E0600m ELISA CCP1,Ctla1,CTLA-1,Ctla-1,Cytotoxic cell protease 1,Fragmentin-2,Granzyme B(G,H),Gzmb,Mouse,Mus musculus 96T
U0600m CLIA CCP1,Ctla1,CTLA-1,Ctla-1,Cytotoxic cell protease 1,Fragmentin-2,Granzyme B(G,H),Gzmb,Mouse,Mus musculus 96T
E0599m ELISA Autocrine thymic lymphoma granzyme-like serine protease,Ctla3,CTLA-3,Ctla-3,Fragmentin-1,Granzyme A,Gzma,Mouse,Mtsp-1,Mus musculus,T cell-specific serine protease 1,TSP-1 96T
E0599m ELISA kit Autocrine thymic lymphoma granzyme-like serine protease,Ctla3,CTLA-3,Ctla-3,Fragmentin-1,Granzyme A,Gzma,Mouse,Mtsp-1,Mus musculus,T cell-specific serine protease 1,TSP-1 96T
U0599m CLIA Autocrine thymic lymphoma granzyme-like serine protease,Ctla3,CTLA-3,Ctla-3,Fragmentin-1,Granzyme A,Gzma,Mouse,Mtsp-1,Mus musculus,T cell-specific serine protease 1,TSP-1 96T
201-20-2458 GZMB{granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)}rabbit.pAb 0.2ml
GZMH GZMA Gene granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
201-20-2457 GZMA{granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)}rabbit.pAb 0.2ml
GZMK GZMB Gene granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GS-0936a granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) primary antibody, Host: 200ul
GS-0935a granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) primary antibody, Host: Rabbit 200ul
GWB-16FDCE Granzyme B (granzyme 2 Cytotoxic T-lymphocyte-associated Serine Esterase 1) (GZMB) Rabbit anti-Human Polyclonal (N-Terminus) An
20-272-190303 Granzyme A - Mouse monoclonal [GA6] to Granzyme A; EC 3.4.21.78; Cytotoxic T-lymphocyte proteinase 1; Hanukkah factor; H factor; HF; Granzyme-1; CTL tryptase; Fragmentin-1 Monoclonal 0.05 mg
gen8742 GRAB_MOUSE Cytotoxic cell protease 1 ELISA tesk kit 1
1P-634-T100 Mouse Monoclonal to HIV protease Antigen HIV protease Species Reactivity Negative Species Clone CLB_GB11 Isotype IgG1 Application FC Immunogen Human NK cell line YT_INDY_derived granzyme B 100 tests
11-634-C100 Mouse Monoclonal to HIV protease Antigen HIV protease Species Reactivity Negative Species Clone CLB_GB11 Isotype IgG1 Application FC Immunogen Human NK cell line YT_INDY_derived granzyme B 0.1 mg
18-783-77708 RABBIT ANTI HUMAN GRANZYME A - EC 3.4.21.78; Cytotoxic T-lymphocyte proteinase 1; Hanukkah factor; H factor; HF; Granzyme-1; CTL tryptase; Fragmentin-1 Polyclonal 1 ml
CSB-EL010081BO Bovine granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) (GZMA) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
U0599h CLIA CTL tryptase,CTLA3,Cytotoxic T-lymphocyte proteinase 1,Fragmentin-1,Granzyme A,Granzyme-1,GZMA,H factor,Hanukkah factor,HF,HFSP,Homo sapiens,Human 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur