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Granzyme D (EC 3.4.21.-)

 GRAD_MOUSE              Reviewed;         252 AA.
P11033; P97387; Q3V2P1;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 4.
05-JUL-2017, entry version 139.
RecName: Full=Granzyme D;
EC=3.4.21.-;
Flags: Precursor;
Name=Gzmd;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3260382; DOI=10.1073/pnas.85.13.4814;
Jenne D.E., Rey C., Haefliger J.-A., Qiao B.-Y., Groscurth P.,
Tschopp J.;
"Identification and sequencing of cDNA clones encoding the granule-
associated serine proteases granzymes D, E, and F of cytolytic T
lymphocytes.";
Proc. Natl. Acad. Sci. U.S.A. 85:4814-4818(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=8917549; DOI=10.1073/pnas.93.23.13090;
Pham C.T.N., MacIvor D.M., Hug B.A., Heusel J.W., Ley T.J.;
"Long-range disruption of gene expression by a selectable marker
cassette.";
Proc. Natl. Acad. Sci. U.S.A. 93:13090-13095(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Placenta;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 21-40.
PubMed=3555842; DOI=10.1016/0092-8674(87)90544-7;
Masson D., Tschopp J.;
"A family of serine esterases in lytic granules of cytolytic T
lymphocytes.";
Cell 49:679-685(1987).
-!- FUNCTION: This enzyme is probably necessary for target cell lysis
in cell-mediated immune responses.
-!- SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic
granules of cytolytic T-lymphocytes.
-!- SIMILARITY: Belongs to the peptidase S1 family. Granzyme
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
-!- SEQUENCE CAUTION:
Sequence=AAB19190.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; J03255; AAA37736.1; -; mRNA.
EMBL; U66472; AAB19190.1; ALT_SEQ; Genomic_DNA.
EMBL; AK131671; BAE20756.1; -; mRNA.
EMBL; AC091783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC141122; AAI41123.1; -; mRNA.
CCDS; CCDS49502.1; -.
PIR; A36172; A36172.
RefSeq; NP_034502.2; NM_010372.2.
UniGene; Mm.482071; -.
ProteinModelPortal; P11033; -.
SMR; P11033; -.
IntAct; P11033; 1.
MINT; MINT-4096686; -.
STRING; 10090.ENSMUSP00000080742; -.
MEROPS; S01.398; -.
EPD; P11033; -.
PaxDb; P11033; -.
PeptideAtlas; P11033; -.
PRIDE; P11033; -.
Ensembl; ENSMUST00000082093; ENSMUSP00000080742; ENSMUSG00000059256.
GeneID; 14941; -.
KEGG; mmu:14941; -.
UCSC; uc007ubp.1; mouse.
CTD; 14941; -.
MGI; MGI:109255; Gzmd.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00760000118895; -.
HOGENOM; HOG000251820; -.
HOVERGEN; HBG013304; -.
InParanoid; P11033; -.
OMA; NEMNICA; -.
OrthoDB; EOG091G0G5F; -.
PhylomeDB; P11033; -.
TreeFam; TF333630; -.
Reactome; R-MMU-75108; Activation, myristolyation of BID and translocation to mitochondria.
PRO; PR:P11033; -.
Proteomes; UP000000589; Chromosome 14.
Bgee; ENSMUSG00000059256; -.
CleanEx; MM_GZMD; -.
Genevisible; P11033; MM.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0030141; C:secretory granule; IBA:GO_Central.
GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
GO; GO:0006508; P:proteolysis; IBA:GO_Central.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Complete proteome; Cytolysis; Direct protein sequencing;
Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome;
Serine protease; Signal; Zymogen.
SIGNAL 1 18
PROPEP 19 20 {ECO:0000269|PubMed:3555842}.
/FTId=PRO_0000027405.
CHAIN 21 252 Granzyme D.
/FTId=PRO_0000027406.
DOMAIN 21 250 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 65 65 Charge relay system. {ECO:0000250}.
ACT_SITE 113 113 Charge relay system. {ECO:0000250}.
ACT_SITE 208 208 Charge relay system. {ECO:0000250}.
CARBOHYD 68 68 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 83 83 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 106 106 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 158 158 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 227 227 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 50 66 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 147 214 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 179 193 {ECO:0000255|PROSITE-ProRule:PRU00274}.
CONFLICT 215 215 D -> H (in Ref. 1; AAA37736 and 2;
AAB19190). {ECO:0000305}.
SEQUENCE 252 AA; 27955 MW; 0A6DDF6459410142 CRC64;
MPPILILLTL LLPLRAGAEE IIGGHVVKPH SRPYMAFVMS VDIKGNRIYC GGFLIQDDFV
LTAAHCKNSS VQSSMTVTLG AHNITAKEET QQIIPVAKDI PHPDYNATIF YSDIMLLKLE
SKAKRTKAVR PLKLPRSNAR VKPGDVCSVA GWGSRSINDT KASARLREVQ LVIQEDEECK
KRFRYYTETT EICAGDLKKI KTPFKGDSGG PLVCDNQAYG LFAYAKNGTI SSGIFTKVVH
FLPWISWNMK LL


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