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Granzyme M (Granzyme M (Lymphocyte met-ase 1)) (Granzyme M (Lymphocyte met-ase 1), isoform CRA_b) (Granzyme M (lymphocyte met-ase 1)) (Granzyme Met-ase-1 precurser)

 O08643_MOUSE            Unreviewed;       264 AA.
O08643;
01-JUL-1997, integrated into UniProtKB/TrEMBL.
01-JUL-1997, sequence version 1.
22-NOV-2017, entry version 143.
SubName: Full=Granzyme M {ECO:0000313|EMBL:BAA78336.1};
SubName: Full=Granzyme M (Lymphocyte Met-ase 1) {ECO:0000313|EMBL:AAI39218.1, ECO:0000313|Ensembl:ENSMUSP00000020549};
SubName: Full=Granzyme M (Lymphocyte met-ase 1), isoform CRA_b {ECO:0000313|EMBL:EDL31677.1};
SubName: Full=Granzyme Met-ase-1 precurser {ECO:0000313|EMBL:AAB51606.1};
Name=Gzmm {ECO:0000313|EMBL:AAI39218.1,
ECO:0000313|Ensembl:ENSMUSP00000020549, ECO:0000313|MGI:MGI:99549};
Synonyms=LMet-1 {ECO:0000313|EMBL:AAB51606.1},
MMET-1 {ECO:0000313|EMBL:BAA78336.1};
ORFNames=mCG_13391 {ECO:0000313|EMBL:EDL31677.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:AAB51606.1};
[1] {ECO:0000313|EMBL:AAB51606.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BALB/c {ECO:0000313|EMBL:AAB51606.1};
TISSUE=Spleen {ECO:0000313|EMBL:AAB51606.1};
PubMed=8781119; DOI=10.1007/s002510050135;
Kelly J.M., O'Connor M.D., Hulett M.D., Thia K.Y.T., Smyth M.J.;
"Cloning and expression of the recombinant mouse natural killer cell
granzyme Met-ase-1.";
Immunogenetics 44:340-350(1996).
[2] {ECO:0000313|EMBL:BAA78336.1}
NUCLEOTIDE SEQUENCE.
PubMed=10498337; DOI=10.1016/S0168-0102(99)00036-X;
Taniguchi M., Tani N., Suemoto T., Ishimoto I., Shiosaka S.,
Yoshida S.;
"High expression of alternative transcript of granzyme M in the mouse
retina.";
Neurosci. Res. 34:115-123(1999).
[3] {ECO:0000313|EMBL:EDL31677.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL31677.1};
PubMed=12040188; DOI=10.1126/science.1069193;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
"A comparison of whole-genome shotgun-derived mouse chromosome 16 and
the human genome.";
Science 296:1661-1671(2002).
[4] {ECO:0000313|EMBL:AAI39218.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain {ECO:0000313|EMBL:AAI39218.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5] {ECO:0000313|EMBL:EDL31677.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL31677.1};
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|Ensembl:ENSMUSP00000020549, ECO:0000313|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000020549,
ECO:0000313|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[7] {ECO:0000313|Ensembl:ENSMUSP00000020549}
IDENTIFICATION.
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000020549};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- SIMILARITY: Belongs to the peptidase S1 family.
{ECO:0000256|SAAS:SAAS00559343}.
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EMBL; AC151828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; L76741; AAB51606.1; -; mRNA.
EMBL; BC139217; AAI39218.1; -; mRNA.
EMBL; BC139218; AAI39219.1; -; mRNA.
EMBL; AB015728; BAA78336.1; -; mRNA.
EMBL; CH466553; EDL31677.1; -; Genomic_DNA.
RefSeq; NP_032530.1; NM_008504.3.
UniGene; Mm.378960; -.
STRING; 10090.ENSMUSP00000020549; -.
MEROPS; S01.139; -.
Ensembl; ENSMUST00000020549; ENSMUSP00000020549; ENSMUSG00000054206.
GeneID; 16904; -.
UCSC; uc007fzj.2; mouse.
CTD; 3004; -.
MGI; MGI:99549; Gzmm.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00760000118895; -.
HOGENOM; HOG000251820; -.
HOVERGEN; HBG013304; -.
OMA; CNNSRFW; -.
OrthoDB; EOG091G0HUQ; -.
TreeFam; TF335738; -.
BRENDA; 3.4.21.B2; 3474.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000054206; -.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0004175; F:endopeptidase activity; IDA:MGI.
GO; GO:0004252; F:serine-type endopeptidase activity; ISO:MGI.
GO; GO:0008219; P:cell death; ISO:MGI.
GO; GO:0019835; P:cytolysis; IDA:MGI.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR033040; GZMM.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
PANTHER; PTHR43890:SF18; PTHR43890:SF18; 1.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000589};
Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
Hydrolase {ECO:0000256|RuleBase:RU363034};
Protease {ECO:0000256|RuleBase:RU363034};
Reference proteome {ECO:0000313|Proteomes:UP000000589};
Serine protease {ECO:0000256|RuleBase:RU363034};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 18 {ECO:0000256|SAM:SignalP}.
CHAIN 19 264 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5011208624.
DOMAIN 27 256 Peptidase S1.
{ECO:0000259|PROSITE:PS50240}.
SEQUENCE 264 AA; 29122 MW; 496E644D2630CD14 CRC64;
MEVCWSLLLL LALKTLWAAG NRFETQIIGG REAVPHSRPY MASLQKAKSH VCGGVLVHRK
WVLTAAHCLS EPLQNLKLVL GLHNLHDLQD PGLTFYIREA IKHPGYNHKY ENDLALLKLD
RRVQPSKNVK PLALPRKPRS KPAEGTWCST AGWGMTHQGG PRARALQELD LRVLDTQMCN
NSRFWNGVLI DSMLCLKAGS KSQAPCKGDS GGPLVCGKGQ VDGILSFSSK TCTDIFKPPV
ATAVAPYSSW IRKVIGRWSP QSLV


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