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Growth arrest-specific protein 1 (GAS-1)

 GAS1_MOUSE              Reviewed;         343 AA.
Q01721;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
16-MAY-2003, sequence version 2.
27-SEP-2017, entry version 126.
RecName: Full=Growth arrest-specific protein 1;
Short=GAS-1;
Flags: Precursor;
Name=Gas1; Synonyms=Gas-1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=1505026; DOI=10.1016/0092-8674(92)90429-G;
del Sal G., Ruaro M.E., Philipson L., Schneider C.;
"The growth arrest-specific gene, gas1, is involved in growth
suppression.";
Cell 70:595-607(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Specific growth arrest protein involved in growth
suppression. Blocks entry to S phase. Prevents cycling of normal
and transformed cells. {ECO:0000269|PubMed:1505026}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor,
GPI-anchor {ECO:0000250}.
-!- SEQUENCE CAUTION:
Sequence=CAA46256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; X65128; CAA46256.1; ALT_INIT; mRNA.
EMBL; BC058628; AAH58628.1; -; mRNA.
PIR; S25771; S25771.
RefSeq; NP_032112.1; NM_008086.2.
UniGene; Mm.22701; -.
ProteinModelPortal; Q01721; -.
SMR; Q01721; -.
BioGrid; 199832; 1.
DIP; DIP-59801N; -.
STRING; 10090.ENSMUSP00000064555; -.
iPTMnet; Q01721; -.
PhosphoSitePlus; Q01721; -.
MaxQB; Q01721; -.
PaxDb; Q01721; -.
PeptideAtlas; Q01721; -.
PRIDE; Q01721; -.
GeneID; 14451; -.
KEGG; mmu:14451; -.
UCSC; uc007qvi.2; mouse.
CTD; 2619; -.
MGI; MGI:95655; Gas1.
eggNOG; ENOG410IW52; Eukaryota.
eggNOG; ENOG4111JS0; LUCA.
HOGENOM; HOG000233688; -.
HOVERGEN; HBG005804; -.
InParanoid; Q01721; -.
KO; K06232; -.
PhylomeDB; Q01721; -.
TreeFam; TF329660; -.
PRO; PR:Q01721; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_GAS1; -.
GO; GO:0046658; C:anchored component of plasma membrane; IDA:UniProtKB.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0007411; P:axon guidance; IMP:MGI.
GO; GO:0043010; P:camera-type eye development; IMP:MGI.
GO; GO:0007050; P:cell cycle arrest; TAS:MGI.
GO; GO:0045165; P:cell fate commitment; IMP:MGI.
GO; GO:0021587; P:cerebellum morphogenesis; IMP:MGI.
GO; GO:0048589; P:developmental growth; IMP:MGI.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IMP:MGI.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.
GO; GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
GO; GO:0048598; P:embryonic morphogenesis; IMP:MGI.
GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
GO; GO:0048592; P:eye morphogenesis; IMP:MGI.
GO; GO:0042474; P:middle ear morphogenesis; IMP:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO; GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0010955; P:negative regulation of protein processing; ISS:UniProtKB.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IDA:MGI.
GO; GO:0042476; P:odontogenesis; IMP:UniProtKB.
GO; GO:0042473; P:outer ear morphogenesis; IMP:MGI.
GO; GO:0060021; P:palate development; IMP:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:MGI.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.
GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IDA:MGI.
GO; GO:0012501; P:programmed cell death; IDA:MGI.
GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
GO; GO:0008589; P:regulation of smoothened signaling pathway; IMP:UniProtKB.
InterPro; IPR016017; GDNF/GAS1.
Pfam; PF02351; GDNF; 1.
SMART; SM00907; GDNF; 2.
2: Evidence at transcript level;
Cell cycle; Cell membrane; Complete proteome; Glycoprotein;
GPI-anchor; Growth arrest; Lipoprotein; Membrane; Reference proteome;
Signal.
SIGNAL 1 38 {ECO:0000255}.
CHAIN 39 315 Growth arrest-specific protein 1.
/FTId=PRO_0000021320.
PROPEP 316 343 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000021321.
COMPBIAS 281 284 Poly-Asp.
COMPBIAS 293 296 Poly-Ala.
COMPBIAS 310 315 Poly-Ser.
COMPBIAS 331 339 Poly-Leu.
LIPID 315 315 GPI-anchor amidated serine.
{ECO:0000255}.
CARBOHYD 114 114 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 321 321 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 343 AA; 35694 MW; F85D393F248B8895 CRC64;
MLAALLGGAG ARTGTLPGAL LCLMALLQLL CSAPRGSGLA HGRRLICWQA LLQCQGEPDC
SYAYSQYAEA CAPVLAQRGG ADAPGPAGAF PASAASSPRW RCPSHCISAL IQLNHTRRGP
ALEDCDCAQD EHCRSTKRAI EPCLPRTSSV GPGAGAGSVM GCTEARRRCD RDSRCNLALS
RYLAYCGKLF NGLRCTDECR AVIEDMLAVP KAALLNDCVC DGLERPICES VKENMARLCF
GPDASNGPGS SGSDGGLDDY YDEEYDDEQR AGAAGGEQPL DDDDGLARPG GGAAAAGGRG
DLPHGPGRRS SSSGSGGHWA NRSAWTPFAC LLLLLLLLLG SHL


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