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Growth arrest-specific protein 8 (GAS-8) (Growth arrest-specific protein 11) (GAS-11)

 GAS8_MOUSE              Reviewed;         478 AA.
Q60779; Q99L71;
19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
19-JUL-2003, sequence version 2.
07-JUN-2017, entry version 120.
RecName: Full=Growth arrest-specific protein 8;
Short=GAS-8;
AltName: Full=Growth arrest-specific protein 11;
Short=GAS-11;
Name=Gas8; Synonyms=Gas11;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=11751847; DOI=10.1074/jbc.M106941200;
Yeh S.-D., Chen Y.-J., Chang A.C.Y., Ray R., She B.-R., Lee W.-S.,
Chiang H.-S., Cohen S.N., Lin-Chao S.;
"Isolation and properties of Gas8, a growth arrest-specific gene
regulated during male gametogenesis to produce a protein associated
with the sperm motility apparatus.";
J. Biol. Chem. 277:6311-6317(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
SUBCELLULAR LOCATION.
PubMed=16643277; DOI=10.1111/j.1600-0854.2006.00411.x;
Colantonio J.R., Bekker J.M., Kim S.J., Morrissey K.M., Crosbie R.H.,
Hill K.L.;
"Expanding the role of the dynein regulatory complex to non-axonemal
functions: association of GAS11 with the Golgi apparatus.";
Traffic 7:538-548(2006).
[4]
FUNCTION, INTERACTION WITH MICROTUBULES, AND SUBCELLULAR LOCATION.
PubMed=17366626; DOI=10.1002/cm.20196;
Bekker J.M., Colantonio J.R., Stephens A.D., Clarke W.T., King S.J.,
Hill K.L., Crosbie R.H.;
"Direct interaction of Gas11 with microtubules: implications for the
dynein regulatory complex.";
Cell Motil. Cytoskeleton 64:461-473(2007).
[5]
SUBCELLULAR LOCATION.
PubMed=26387594; DOI=10.1016/j.ajhg.2015.08.012;
Olbrich H., Cremers C., Loges N.T., Werner C., Nielsen K.G.,
Marthin J.K., Philipsen M., Wallmeier J., Pennekamp P., Menchen T.,
Edelbusch C., Dougherty G.W., Schwartz O., Thiele H., Altmueller J.,
Rommelmann F., Omran H.;
"Loss-of-function GAS8 mutations cause primary ciliary dyskinesia and
disrupt the nexin-dynein regulatory complex.";
Am. J. Hum. Genet. 97:546-554(2015).
-!- FUNCTION: Cytoskeletal linker which binds microtubules and
probably functions in axonemal and non-axonemal dynein regulation
(PubMed:17366626). May play a role in the spermatozoa motility
(PubMed:11751847). May play a role in cilia motility (By
similarity). {ECO:0000250|UniProtKB:O95995,
ECO:0000269|PubMed:11751847, ECO:0000269|PubMed:17366626}.
-!- SUBUNIT: Interacts with microtubules.
{ECO:0000269|PubMed:17366626}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11751847}.
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17366626}. Cell
projection, cilium, flagellum {ECO:0000269|PubMed:11751847}.
Cytoplasm, cytoskeleton, cilium axoneme
{ECO:0000269|PubMed:11751847, ECO:0000269|PubMed:26387594}.
Cytoplasm, cytoskeleton, cilium basal body
{ECO:0000269|PubMed:16643277}. Golgi apparatus
{ECO:0000250|UniProtKB:O95995}. Note=Associates with microtubules
(PubMed:17366626). Localized to the cytoplasm of round spermatids,
the tails of elongating spermatids, and mature spermatid tail
bundles protruding into the lumen, and in the flagellum of
epididymal spermatozoa (PubMed:11751847).
{ECO:0000269|PubMed:11751847, ECO:0000269|PubMed:17366626}.
-!- TISSUE SPECIFICITY: Highly expressed in adult testes. Weakly or
not expressed in other tested tissues.
{ECO:0000269|PubMed:11751847}.
-!- DEVELOPMENTAL STAGE: Weakly or not expressed in neonates and young
adolescents. Then, it is strongly expressed postmeiotically.
Accumulates in gametocytes as they approach the lumen of
seminiferous tubules and thereafter.
{ECO:0000269|PubMed:11751847}.
-!- INDUCTION: Expressed during serum starvation or contact inhibition
of cells grown in murine fibroblasts.
-!- SIMILARITY: Belongs to the GAS8 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA85258.1; Type=Frameshift; Positions=3, 471; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; U19859; AAA85258.1; ALT_FRAME; mRNA.
EMBL; BC003779; AAH03779.2; -; mRNA.
CCDS; CCDS40512.1; -.
RefSeq; NP_061343.2; NM_018855.2.
UniGene; Mm.117265; -.
ProteinModelPortal; Q60779; -.
SMR; Q60779; -.
STRING; 10090.ENSMUSP00000090730; -.
iPTMnet; Q60779; -.
PhosphoSitePlus; Q60779; -.
MaxQB; Q60779; -.
PaxDb; Q60779; -.
PRIDE; Q60779; -.
Ensembl; ENSMUST00000093043; ENSMUSP00000090730; ENSMUSG00000040220.
GeneID; 104346; -.
KEGG; mmu:104346; -.
UCSC; uc009nwk.1; mouse.
CTD; 2622; -.
MGI; MGI:1202386; Gas8.
eggNOG; ENOG410IE2T; Eukaryota.
eggNOG; ENOG410XPBD; LUCA.
GeneTree; ENSGT00390000009477; -.
HOGENOM; HOG000038763; -.
HOVERGEN; HBG039458; -.
InParanoid; Q60779; -.
KO; K19942; -.
OMA; EHRTQEG; -.
OrthoDB; EOG091G0851; -.
PhylomeDB; Q60779; -.
TreeFam; TF323819; -.
Reactome; R-MMU-5635838; Activation of SMO.
PRO; PR:Q60779; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000040220; -.
CleanEx; MM_GAS8; -.
ExpressionAtlas; Q60779; baseline and differential.
Genevisible; Q60779; MM.
GO; GO:0097729; C:9+2 motile cilium; IDA:MGI.
GO; GO:0005930; C:axoneme; ISS:UniProtKB.
GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
GO; GO:0005929; C:cilium; ISO:MGI.
GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
GO; GO:0005874; C:microtubule; ISO:MGI.
GO; GO:0015630; C:microtubule cytoskeleton; IDA:UniProtKB.
GO; GO:0031514; C:motile cilium; IDA:MGI.
GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO; GO:0017137; F:Rab GTPase binding; IDA:MGI.
GO; GO:0035082; P:axoneme assembly; IMP:MGI.
GO; GO:0007420; P:brain development; IMP:MGI.
GO; GO:0034613; P:cellular protein localization; IDA:MGI.
GO; GO:0060294; P:cilium movement involved in cell motility; ISO:MGI.
GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
GO; GO:0003351; P:epithelial cilium movement; IMP:MGI.
GO; GO:0030317; P:flagellated sperm motility; IEP:UniProtKB.
GO; GO:1904526; P:regulation of microtubule binding; IDA:UniProtKB.
InterPro; IPR025593; GAS8.
Pfam; PF13851; GAS; 1.
1: Evidence at protein level;
Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm;
Cytoskeleton; Flagellum; Golgi apparatus; Microtubule;
Reference proteome.
CHAIN 1 478 Growth arrest-specific protein 8.
/FTId=PRO_0000220378.
REGION 1 114 Regulates microtubule-binding.
{ECO:0000269|PubMed:17366626}.
REGION 115 258 Microtubule-binding.
{ECO:0000269|PubMed:17366626}.
COILED 24 207 {ECO:0000255}.
COILED 242 426 {ECO:0000255}.
CONFLICT 283 283 L -> Q (in Ref. 1; AAA85258).
{ECO:0000305}.
CONFLICT 339 339 Q -> L (in Ref. 1; AAA85258).
{ECO:0000305}.
CONFLICT 451 451 N -> D (in Ref. 1; AAA85258).
{ECO:0000305}.
CONFLICT 459 459 T -> I (in Ref. 1; AAA85258).
{ECO:0000305}.
CONFLICT 476 476 A -> S (in Ref. 1; AAA85258).
{ECO:0000305}.
SEQUENCE 478 AA; 56264 MW; A11AD16EFA2DE5E9 CRC64;
MAPKKKGKKG KAKGTAIVDG VAPEDMTKEQ VEEHVARIRE ELDREREERN YFQLERDKIH
TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ KVKHLLYEHQ NNLAEVKAEG
TVVMKLAQKE HRTQEGALRK DMRVLKVELK EQELANEVVI KNLCLKQAEE ITKMRNDFER
QVREIEAKYD KKMKMLRDEL DLRRKTEIHE VEERKNGQIS TLMQRHEEAF TDIKNYYNDI
TLNNLALINS LKEQMEDMRK KEEHMEREMA EVTLQNRRLA DPLQKAKDEM NEMQKRLGNH
ERDKQILVCT KARLKVAERE LKDLKWEHEV LEQRFIKVQQ EREELYRKFA DAIQEVQQKT
GFKNLLLERK LQALNAAVEK REVQFNEVLA ASNLDPTALT LVSRKLEDVL ESKNTTIKDL
QYELARVCKA HNDLLRTYEA KLLAFGIPLD NVGFKPLETA VIGQTLGQGP AGLVGAPT


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