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Growth arrest-specific protein 8 homolog (Protein PF2)

 GAS8_CHLRE              Reviewed;         471 AA.
Q7XJ96;
02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
18-JAN-2017, entry version 38.
RecName: Full=Growth arrest-specific protein 8 homolog;
AltName: Full=Protein PF2;
Name=GAS8; Synonyms=PF2;
Chlamydomonas reinhardtii (Chlamydomonas smithii).
Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae;
Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
NCBI_TaxID=3055;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, SUBCELLULAR
LOCATION, AND DISRUPTION PHENOTYPE.
PubMed=12847082; DOI=10.1083/jcb.200303019;
Rupp G., Porter M.E.;
"A subunit of the dynein regulatory complex in Chlamydomonas is a
homologue of a growth arrest-specific gene product.";
J. Cell Biol. 162:47-57(2003).
-!- FUNCTION: Regulates dynein and functions in flagellar motility.
{ECO:0000269|PubMed:12847082}.
-!- SUBUNIT: Component of the dynein regulatory complex (DRC).
{ECO:0000269|PubMed:12847082}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Cytoplasm, cytoskeleton, flagellum axoneme
{ECO:0000269|PubMed:12847082}. Cytoplasm, cytoskeleton, flagellum
basal body {ECO:0000269|PubMed:12847082}.
-!- DISRUPTION PHENOTYPE: Mutants fail to assemble 5 of the 7 DRC-
associated subunits and display both reduced swimming velocities
and aberrant waveforms with reduced shear amplitudes.
{ECO:0000269|PubMed:12847082}.
-!- SIMILARITY: Belongs to the GAS8 family. {ECO:0000305}.
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EMBL; AY309088; AAP57169.1; -; Genomic_DNA.
EMBL; AY309087; AAP57169.1; JOINED; Genomic_DNA.
ProteinModelPortal; Q7XJ96; -.
SMR; Q7XJ96; -.
OMA; EHRTQEG; -.
GO; GO:0097729; C:9+2 motile cilium; IMP:GO_Central.
GO; GO:0005930; C:axoneme; IMP:GO_Central.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0060294; P:cilium movement involved in cell motility; IMP:GO_Central.
InterPro; IPR025593; GAS8.
Pfam; PF13851; GAS; 1.
1: Evidence at protein level;
Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
Flagellum; Microtubule.
CHAIN 1 471 Growth arrest-specific protein 8 homolog.
/FTId=PRO_0000306333.
COILED 23 239 {ECO:0000255}.
COILED 282 425 {ECO:0000255}.
SEQUENCE 471 AA; 55108 MW; 6B974D05A69936C5 CRC64;
MAPKKKGTKK ESKKDAVATG DIEGASVEEL NQKIGTLEKE KNKEEEYRNY MQLERDKINA
FWEITKKDLE DRRAELRNKD REMEEMEERH QVEIKVYKQK VKHLLYEHQN NITTLKSDGE
LALKLQQDEY RKREGDLGKD KRNLKLELKE QELAHQDIIR QLKLEHAKEI TKLRQEFEQQ
AKDLQSKYEK KMKMLRDDME LRRKQEIHEI EERKNTHINE LMKKHERAFA EIKNYYNDIT
HNNLDLIKTL KEDVAEMKRR EAANEKLMYE IAQDNKKLSE PLSRALKEVE LLRQQLANYD
KDKLSLAQTK ARLLNAERQI KNLEWENEVL SQRFSKVQTE RDELYGKFEA SIYDVQQKTG
LKSALLEKKV EALGEALEMK EAQLAEVLTA ANLDPGTLAA INQRLEEVLD NKNQIIKALQ
YDVAKVSKAH NDLIRVYEAK LTEFGIPVDE LGFRPLVTNT STGPAGLVVG A


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