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Growth factor receptor-bound protein 2

 Q3T0F9_BOVIN            Unreviewed;       217 AA.
Q3T0F9;
11-OCT-2005, integrated into UniProtKB/TrEMBL.
11-OCT-2005, sequence version 1.
22-NOV-2017, entry version 119.
SubName: Full=Growth factor receptor-bound protein 2 {ECO:0000313|EMBL:AAI02412.1, ECO:0000313|Ensembl:ENSBTAP00000006216};
Name=GRB2 {ECO:0000313|EMBL:AAI02412.1,
ECO:0000313|Ensembl:ENSBTAP00000006216};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI02412.1};
[1] {ECO:0000313|EMBL:AAI02412.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI02412.1};
TISSUE=Ileum {ECO:0000313|EMBL:AAI02412.1};
Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D.,
Siddiqui A., Holt R., Jones S.J., Marra M.A.;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSBTAP00000006216, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006216,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[3] {ECO:0000313|Ensembl:ENSBTAP00000006216}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006216};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
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EMBL; DAAA02049523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC102411; AAI02412.1; -; mRNA.
RefSeq; NP_001029802.1; NM_001034630.1.
RefSeq; XP_010814868.1; XM_010816566.1.
UniGene; Bt.8815; -.
SMR; Q3T0F9; -.
STRING; 9913.ENSBTAP00000006216; -.
Ensembl; ENSBTAT00000006216; ENSBTAP00000006216; ENSBTAG00000004736.
GeneID; 535298; -.
KEGG; bta:535298; -.
CTD; 2885; -.
eggNOG; KOG3601; Eukaryota.
eggNOG; ENOG410XR1G; LUCA.
GeneTree; ENSGT00820000126999; -.
HOGENOM; HOG000251625; -.
HOVERGEN; HBG005404; -.
KO; K04364; -.
OMA; HWWHGEI; -.
OrthoDB; EOG091G0HWS; -.
TreeFam; TF354288; -.
Reactome; R-BTA-109704; PI3K Cascade.
Reactome; R-BTA-112412; SOS-mediated signalling.
Reactome; R-BTA-114604; GPVI-mediated activation cascade.
Reactome; R-BTA-1250347; SHC1 events in ERBB4 signaling.
Reactome; R-BTA-1257604; PIP3 activates AKT signaling.
Reactome; R-BTA-1295596; Spry regulation of FGF signaling.
Reactome; R-BTA-1433557; Signaling by SCF-KIT.
Reactome; R-BTA-1433559; Regulation of KIT signaling.
Reactome; R-BTA-167044; Signalling to RAS.
Reactome; R-BTA-179812; GRB2 events in EGFR signaling.
Reactome; R-BTA-180292; GAB1 signalosome.
Reactome; R-BTA-180336; SHC1 events in EGFR signaling.
Reactome; R-BTA-182971; EGFR downregulation.
Reactome; R-BTA-186763; Downstream signal transduction.
Reactome; R-BTA-1963640; GRB2 events in ERBB2 signaling.
Reactome; R-BTA-1963642; PI3K events in ERBB2 signaling.
Reactome; R-BTA-2029482; Regulation of actin dynamics for phagocytic cup formation.
Reactome; R-BTA-210993; Tie2 Signaling.
Reactome; R-BTA-2179392; EGFR Transactivation by Gastrin.
Reactome; R-BTA-2424491; DAP12 signaling.
Reactome; R-BTA-2428933; SHC-related events triggered by IGF1R.
Reactome; R-BTA-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
Reactome; R-BTA-2871796; FCERI mediated MAPK activation.
Reactome; R-BTA-2871809; FCERI mediated Ca+2 mobilization.
Reactome; R-BTA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins.
Reactome; R-BTA-375165; NCAM signaling for neurite out-growth.
Reactome; R-BTA-389359; CD28 dependent Vav1 pathway.
Reactome; R-BTA-391160; Signal regulatory protein family interactions.
Reactome; R-BTA-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-BTA-5654688; SHC-mediated cascade:FGFR1.
Reactome; R-BTA-5654689; PI-3K cascade:FGFR1.
Reactome; R-BTA-5654693; FRS-mediated FGFR1 signaling.
Reactome; R-BTA-5654695; PI-3K cascade:FGFR2.
Reactome; R-BTA-5654699; SHC-mediated cascade:FGFR2.
Reactome; R-BTA-5654700; FRS-mediated FGFR2 signaling.
Reactome; R-BTA-5654704; SHC-mediated cascade:FGFR3.
Reactome; R-BTA-5654706; FRS-mediated FGFR3 signaling.
Reactome; R-BTA-5654710; PI-3K cascade:FGFR3.
Reactome; R-BTA-5654712; FRS-mediated FGFR4 signaling.
Reactome; R-BTA-5654719; SHC-mediated cascade:FGFR4.
Reactome; R-BTA-5654720; PI-3K cascade:FGFR4.
Reactome; R-BTA-5654726; Negative regulation of FGFR1 signaling.
Reactome; R-BTA-5654727; Negative regulation of FGFR2 signaling.
Reactome; R-BTA-5654732; Negative regulation of FGFR3 signaling.
Reactome; R-BTA-5654733; Negative regulation of FGFR4 signaling.
Reactome; R-BTA-5663213; RHO GTPases Activate WASPs and WAVEs.
Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
Reactome; R-BTA-6807004; Negative regulation of MET activity.
Reactome; R-BTA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-BTA-74749; Signal attenuation.
Reactome; R-BTA-74751; Insulin receptor signalling cascade.
Reactome; R-BTA-8851805; MET activates RAS signaling.
Reactome; R-BTA-8851907; MET activates PI3K/AKT signaling.
Reactome; R-BTA-8853659; RET signaling.
Reactome; R-BTA-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-BTA-8856828; Clathrin-mediated endocytosis.
Reactome; R-BTA-8865999; MET activates PTPN11.
Reactome; R-BTA-8875555; MET activates RAP1 and RAC1.
Reactome; R-BTA-8875656; MET receptor recycling.
Reactome; R-BTA-8983432; Interleukin-15 signaling.
Reactome; R-BTA-912526; Interleukin receptor SHC signaling.
Reactome; R-BTA-912631; Regulation of signaling by CBL.
Reactome; R-BTA-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
Proteomes; UP000009136; Chromosome 19.
Bgee; ENSBTAG00000004736; -.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
GO; GO:0005768; C:endosome; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
GO; GO:0070436; C:Grb2-EGFR complex; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IEA:Ensembl.
GO; GO:0005168; F:neurotrophin TRKA receptor binding; IEA:Ensembl.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0005102; F:receptor binding; IBA:GO_Central.
GO; GO:0003723; F:RNA binding; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Ensembl.
GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0016477; P:cell migration; IBA:GO_Central.
GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0007265; P:Ras protein signal transduction; IEA:InterPro.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR24418:SF290; PTHR24418:SF290; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 2.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000009136};
Receptor {ECO:0000313|EMBL:AAI02412.1};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS00128814}.
DOMAIN 1 58 SH3. {ECO:0000259|PROSITE:PS50002}.
DOMAIN 60 152 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 156 215 SH3. {ECO:0000259|PROSITE:PS50002}.
SEQUENCE 217 AA; 25206 MW; 83A4B0BA1B248DC4 CRC64;
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV


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