Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)

 GRB2_CHICK              Reviewed;         217 AA.
Q07883;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
25-OCT-2017, entry version 101.
RecName: Full=Growth factor receptor-bound protein 2;
AltName: Full=Adapter protein GRB2;
AltName: Full=SH2/SH3 adapter GRB2;
Name=GRB2;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=8262390; DOI=10.1016/0378-1119(93)90111-F;
Wasenius V.-M., Merilainen J., Lehto V.-P.;
"Sequence of a chicken cDNA encoding a GRB2 protein.";
Gene 134:299-300(1993).
[2]
INTERACTION WITH LAT2.
PubMed=15539154; DOI=10.1016/j.immuni.2004.09.007;
Stork B., Engelke M., Frey J., Horejsi V., Hamm-Baarke A.,
Schraven B., Kurosaki T., Wienands J.;
"Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-
regulating signal circuit in B lymphocytes.";
Immunity 21:681-691(2004).
-!- FUNCTION: Adapter protein that provides a critical link between
cell surface growth factor receptors and the Ras signaling
pathway. {ECO:0000250}.
-!- SUBUNIT: Associates with activated Tyr-phosphorylated EGF
receptors and PDGF receptors via its SH2 domain. Also associates
to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1,
SHC and LNK; probably via the concerted action of both its SH2 and
SH3 domains. It also seems to interact with RAS in the signaling
pathway leading to DNA synthesis. Binds to and translocates the
guanine nucleotide exchange factors SOS (By similarity). Interacts
with phosphorylated LAT2. {ECO:0000250,
ECO:0000269|PubMed:15539154}.
-!- INTERACTION:
Q7L591:DOK3 (xeno); NbExp=3; IntAct=EBI-7061573, EBI-2834978;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
{ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus
{ECO:0000250}.
-!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; L19258; AAA16318.1; -; mRNA.
PIR; JT0664; JT0664.
RefSeq; NP_989742.1; NM_204411.1.
UniGene; Gga.2170; -.
UniGene; Gga.41897; -.
ProteinModelPortal; Q07883; -.
SMR; Q07883; -.
IntAct; Q07883; 2.
MINT; MINT-4329661; -.
STRING; 9031.ENSGALP00000012993; -.
PaxDb; Q07883; -.
PRIDE; Q07883; -.
GeneID; 386572; -.
KEGG; gga:386572; -.
CTD; 2885; -.
eggNOG; KOG3601; Eukaryota.
eggNOG; ENOG410XR1G; LUCA.
HOGENOM; HOG000251625; -.
HOVERGEN; HBG005404; -.
InParanoid; Q07883; -.
KO; K04364; -.
PhylomeDB; Q07883; -.
PRO; PR:Q07883; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0005102; F:receptor binding; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0016477; P:cell migration; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central.
GO; GO:0007265; P:Ras protein signal transduction; IEA:InterPro.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR24418:SF290; PTHR24418:SF290; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 2.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Endosome; Golgi apparatus; Nucleus;
Reference proteome; Repeat; SH2 domain; SH3 domain.
CHAIN 1 217 Growth factor receptor-bound protein 2.
/FTId=PRO_0000088202.
DOMAIN 1 58 SH3 1. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
DOMAIN 60 152 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 156 215 SH3 2. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
SEQUENCE 217 AA; 25076 MW; DDC9A84ECDC52859 CRC64;
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKGGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQQFKV LRDGAGKYLL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EEGELGFRRG
DFIQVLDNSD PNWWKGACHG QTGMFPRNYV TPVNRNI


Related products :

Catalog number Product name Quantity
15-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Polyclonal 0.05 mg
15-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Polyclonal 0.1 mg
10-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash 0.05 mg
10-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash 0.1 mg
18-783-78613 GOAT ANTI HUMAN Grb2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Polyclonal 0.1 mg
20-272-192014 GRB2 - Mouse monoclonal [R13] to GRB2; Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Monoclonal 1 ml
20-272-192013 GRB2 - Mouse monoclonal [R11] to GRB2; Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Monoclonal 1 ml
DL-Grb2-Hu Human Growth Factor Receptor Bound Protein 2 (Grb2) ELISA Kit 96T
CE35 Growth Factor Receptor-Bound Protein 2 GRB2 500
CE35 Growth Factor Receptor-Bound Protein 2 GRB2 lmg
GRD1 GRB2 Gene growth factor receptor-bound protein 2
C048 Human Growth Factor Receptor-Bound Protein 2 GRB2 50
E-EL-R0467 Rat GRB2 (Growth Factor Receptor Bound Protein 2) ELISA Kit 96T
CSB-EL009889RA Rat Growth factor receptor-bound protein 2(GRB2) ELISA kit 96T
E92514Hu ELISA Kit for Growth Factor Receptor Bound Protein 2 (Grb2) 96T/Kit
pro-678 Recombinant Human Growth Factor Receptor-Bound Protein 2 GRB2 1mg
GRB2 GRB10 Gene growth factor receptor-bound protein 10
E02G0247 Rat Growth Factor Receptor Bound Protein 2 ELISA , Grb2
CD19 Human Growth Factor Receptor-Bound Protein 2 GRB2 l0
pro-678 Recombinant Human Growth Factor Receptor-Bound Protein 2 GRB2 5
201-20-2382 GRB2{growth factor receptor-bound protein 2}rabbit.pAb 0.2ml
E02G0247 Rat Growth Factor Receptor Bound Protein 2 Elisa Kit (Grb2) 96 Tests/kit
pro-678 Recombinant Human Growth Factor Receptor-Bound Protein 2 GRB2 25
E02G0247 Rat Growth Factor Receptor Bound Protein 2 ELISA , Grb2 96 Tests/kit
FP-0032 Growth factor receptor-bound protein 2 (ASH protein).; SH2-Domain: GRB2 10ug


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur