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Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)

 GRB2_PONAB              Reviewed;         217 AA.
Q5R4J7;
15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
25-OCT-2017, entry version 106.
RecName: Full=Growth factor receptor-bound protein 2;
AltName: Full=Adapter protein GRB2;
AltName: Full=SH2/SH3 adapter GRB2;
Name=GRB2;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Adapter protein that provides a critical link between
cell surface growth factor receptors and the Ras signaling
pathway. {ECO:0000250}.
-!- SUBUNIT: Associates (via SH2 domain) with activated EGF and PDGF
receptors (tyrosine phosphorylated). Interacts with PDGFRA
(tyrosine phosphorylated); the interaction may be indirect.
Interacts with IRS4 (when Tyr-phosphorylated). Also associates to
other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, SHC
and LNK; probably via the concerted action of both its SH2 and SH3
domains. It also seems to interact with RAS in the signaling
pathway leading to DNA synthesis. Interacts with SOS1. Forms a
complex with MUC1 and SOS1, through interaction of the SH3 domains
with SOS1 and the SH2 domain with phosphorylated MUC1. Interacts
with phosphorylated MET. Interacts with phosphorylated TOM1L1.
Interacts with the phosphorylated C-terminus of SH2B2. Interacts
with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR
and/or BCR activation. Interacts with NISCH, PTPNS1 and REPS2.
Interacts with syntrophin SNTA1. Interacts (via SH3 domains) with
REPS1. Interacts (via SH3 domains) with PIK3C2B. Interacts with
CBL and CBLB. Interacts with AJUBA and CLNK. Interacts (via SH2
domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with
SHB, INPP5D/SHIP1, SKAP1 and SKAP2. Interacts with PTPN11.
Interacts with PRNP. Interacts with RALGPS1. Interacts also with
HCST. Interacts with KDR. Interacts with FLT1 (tyrosine-
phosphorylated). Interacts with GAPT and PTPRE. Interacts (via SH2
domain) with KIF26A. Interacts (via SH3 2) with GAB2. Interacts
with ADAM15. Interacts with THEMIS2. Interacts (via SH2 domain)
with AXL (phosphorylated). Interacts (via SH2 domain) with KIT
(phosphorylated). Interacts with PTPRJ and BCR. Interacts with
PTPN23. Interacts with FLT4 (tyrosine phosphorylated). Interacts
with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate
cell migration. Part of a complex including TNK2, GRB2 and one
receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which
GRB2 promotes RTK recruitment by TNK2. Interacts (via SH2 domain)
with CSF1R (tyrosine phosphorylated). Interacts with ERBB4.
Interacts with NTRK1 (phosphorylated upon ligand-binding).
Interacts with PTK2/FAK1 (tyrosine phosphorylated). Interacts with
PTK2B/PYK2 (tyrosine phosphorylated). Interacts with SCIMP.
Interacts (via SH3 domains) with GAREM1 (via proline-rich domain
and tyrosine phosphorylated); the interaction occurs upon EGF
stimulation. Interacts with DAB2. Interacts with TESPA1. Interacts
with THEMIS. Interacts with PLCG1, LAT and THEMIS upon TCR
activation in thymocytes; the association is weaker in the absence
of TESPA1. Interacts with CD28. Interacts with RAB13; may recruit
RAB13 to the leading edge of migrating endothelial cells where it
can activate RHOA. Interacts with ASAP3 (phosphorylated form).
Interacts (via SH2 domain) with PTPRH (phosphorylated form).
Interacts with PTPRO (phosphorylated form). Interacts with PTPRB
(phosphorylated form). Interacts (via SH3 domain 2) with PRR14
(via proline-rich region). Interacts with FCRL6 (tyrosine
phosphorylated form) (By similarity).
{ECO:0000250|UniProtKB:P62993, ECO:0000250|UniProtKB:Q60631}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
{ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus
{ECO:0000250}.
-!- DOMAIN: The SH3 domains mediate interaction with RALGPS1 and SHB.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
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EMBL; CR860761; CAH92874.1; -; mRNA.
EMBL; CR861250; CAH93319.1; -; mRNA.
RefSeq; NP_001126954.1; NM_001133482.1.
RefSeq; XP_009250292.1; XM_009252017.1.
RefSeq; XP_009250293.1; XM_009252018.1.
ProteinModelPortal; Q5R4J7; -.
SMR; Q5R4J7; -.
STRING; 9601.ENSPPYP00000009686; -.
PRIDE; Q5R4J7; -.
Ensembl; ENSPPYT00000010071; ENSPPYP00000009686; ENSPPYG00000008626.
GeneID; 100173972; -.
KEGG; pon:100173972; -.
CTD; 2885; -.
eggNOG; KOG3601; Eukaryota.
eggNOG; ENOG410XR1G; LUCA.
GeneTree; ENSGT00820000126999; -.
HOVERGEN; HBG005404; -.
InParanoid; Q5R4J7; -.
KO; K04364; -.
OMA; HWWHGEI; -.
OrthoDB; EOG091G0HWS; -.
TreeFam; TF354288; -.
Proteomes; UP000001595; Chromosome 17.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0008180; C:COP9 signalosome; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0070436; C:Grb2-EGFR complex; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IEA:Ensembl.
GO; GO:0005168; F:neurotrophin TRKA receptor binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0003723; F:RNA binding; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; ISS:UniProtKB.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Ensembl.
GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0007265; P:Ras protein signal transduction; IEA:InterPro.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR24418:SF290; PTHR24418:SF290; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 2.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
2: Evidence at transcript level;
Acetylation; Complete proteome; Cytoplasm; Endosome; Golgi apparatus;
Nucleus; Phosphoprotein; Reference proteome; Repeat; SH2 domain;
SH3 domain.
CHAIN 1 217 Growth factor receptor-bound protein 2.
/FTId=PRO_0000088200.
DOMAIN 1 58 SH3 1. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
DOMAIN 60 152 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 156 215 SH3 2. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P62993}.
MOD_RES 6 6 N6-acetyllysine.
{ECO:0000250|UniProtKB:P62993}.
MOD_RES 50 50 N6-acetyllysine.
{ECO:0000250|UniProtKB:P62993}.
MOD_RES 109 109 N6-acetyllysine.
{ECO:0000250|UniProtKB:P62993}.
MOD_RES 211 211 Phosphothreonine.
{ECO:0000250|UniProtKB:P62993}.
SEQUENCE 217 AA; 25206 MW; 83A4B0BA1B248DC4 CRC64;
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV


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