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Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)

 GRB2_XENTR              Reviewed;         229 AA.
Q66II3;
24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
25-OCT-2017, entry version 89.
RecName: Full=Growth factor receptor-bound protein 2;
AltName: Full=Adapter protein GRB2;
AltName: Full=SH2/SH3 adapter GRB2;
Name=grb2 {ECO:0000312|EMBL:AAH81338.1};
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Silurana.
NCBI_TaxID=8364;
[1] {ECO:0000312|EMBL:AAH81338.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo {ECO:0000312|EMBL:AAH81338.1};
NIH - Xenopus Gene Collection (XGC) project;
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Adapter protein that provides a critical link between
cell surface growth factor receptors and the Ras signaling
pathway. Promotes meiotic reinitiation during oocyte maturation.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
{ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus
{ECO:0000250}.
-!- DOMAIN: The two SH3 domains and the SH2 domain are necessary for
the reinitiation of oocyte meiosis.
{ECO:0000250|UniProtKB:P87379}.
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EMBL; BC081338; AAH81338.1; -; mRNA.
RefSeq; NP_001008130.1; NM_001008129.1.
RefSeq; XP_012827139.1; XM_012971685.2.
RefSeq; XP_012827140.1; XM_012971686.2.
RefSeq; XP_012827141.1; XM_012971687.2.
RefSeq; XP_012827142.1; XM_012971688.2.
UniGene; Str.3248; -.
ProteinModelPortal; Q66II3; -.
SMR; Q66II3; -.
STRING; 8364.ENSXETP00000027387; -.
PaxDb; Q66II3; -.
PRIDE; Q66II3; -.
Ensembl; ENSXETT00000027387; ENSXETP00000027387; ENSXETG00000012520.
GeneID; 493492; -.
KEGG; xtr:493492; -.
CTD; 2885; -.
Xenbase; XB-GENE-6070000; grb2.
eggNOG; KOG3601; Eukaryota.
eggNOG; ENOG410XR1G; LUCA.
GeneTree; ENSGT00820000126999; -.
HOGENOM; HOG000251625; -.
HOVERGEN; HBG005404; -.
InParanoid; Q66II3; -.
KO; K04364; -.
OMA; FIRMREC; -.
OrthoDB; EOG091G0HWS; -.
TreeFam; TF354288; -.
Reactome; R-XTR-109704; PI3K Cascade.
Reactome; R-XTR-112412; SOS-mediated signalling.
Reactome; R-XTR-114604; GPVI-mediated activation cascade.
Reactome; R-XTR-1250347; SHC1 events in ERBB4 signaling.
Reactome; R-XTR-1257604; PIP3 activates AKT signaling.
Reactome; R-XTR-1295596; Spry regulation of FGF signaling.
Reactome; R-XTR-1433557; Signaling by SCF-KIT.
Reactome; R-XTR-1433559; Regulation of KIT signaling.
Reactome; R-XTR-167044; Signalling to RAS.
Reactome; R-XTR-179812; GRB2 events in EGFR signaling.
Reactome; R-XTR-180292; GAB1 signalosome.
Reactome; R-XTR-180336; SHC1 events in EGFR signaling.
Reactome; R-XTR-182971; EGFR downregulation.
Reactome; R-XTR-186763; Downstream signal transduction.
Reactome; R-XTR-1963640; GRB2 events in ERBB2 signaling.
Reactome; R-XTR-1963642; PI3K events in ERBB2 signaling.
Reactome; R-XTR-2029482; Regulation of actin dynamics for phagocytic cup formation.
Reactome; R-XTR-210993; Tie2 Signaling.
Reactome; R-XTR-2179392; EGFR Transactivation by Gastrin.
Reactome; R-XTR-2424491; DAP12 signaling.
Reactome; R-XTR-2428933; SHC-related events triggered by IGF1R.
Reactome; R-XTR-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
Reactome; R-XTR-2871796; FCERI mediated MAPK activation.
Reactome; R-XTR-2871809; FCERI mediated Ca+2 mobilization.
Reactome; R-XTR-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins.
Reactome; R-XTR-375165; NCAM signaling for neurite out-growth.
Reactome; R-XTR-389359; CD28 dependent Vav1 pathway.
Reactome; R-XTR-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-XTR-5654688; SHC-mediated cascade:FGFR1.
Reactome; R-XTR-5654689; PI-3K cascade:FGFR1.
Reactome; R-XTR-5654693; FRS-mediated FGFR1 signaling.
Reactome; R-XTR-5654695; PI-3K cascade:FGFR2.
Reactome; R-XTR-5654699; SHC-mediated cascade:FGFR2.
Reactome; R-XTR-5654700; FRS-mediated FGFR2 signaling.
Reactome; R-XTR-5654704; SHC-mediated cascade:FGFR3.
Reactome; R-XTR-5654706; FRS-mediated FGFR3 signaling.
Reactome; R-XTR-5654710; PI-3K cascade:FGFR3.
Reactome; R-XTR-5654712; FRS-mediated FGFR4 signaling.
Reactome; R-XTR-5654719; SHC-mediated cascade:FGFR4.
Reactome; R-XTR-5654720; PI-3K cascade:FGFR4.
Reactome; R-XTR-5654726; Negative regulation of FGFR1 signaling.
Reactome; R-XTR-5654727; Negative regulation of FGFR2 signaling.
Reactome; R-XTR-5654732; Negative regulation of FGFR3 signaling.
Reactome; R-XTR-5654733; Negative regulation of FGFR4 signaling.
Reactome; R-XTR-5663213; RHO GTPases Activate WASPs and WAVEs.
Reactome; R-XTR-5673001; RAF/MAP kinase cascade.
Reactome; R-XTR-6807004; Negative regulation of MET activity.
Reactome; R-XTR-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-XTR-74749; Signal attenuation.
Reactome; R-XTR-74751; Insulin receptor signalling cascade.
Reactome; R-XTR-8851805; MET activates RAS signaling.
Reactome; R-XTR-8851907; MET activates PI3K/AKT signaling.
Reactome; R-XTR-8853659; RET signaling.
Reactome; R-XTR-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-XTR-8856828; Clathrin-mediated endocytosis.
Reactome; R-XTR-8865999; MET activates PTPN11.
Reactome; R-XTR-8875555; MET activates RAP1 and RAC1.
Reactome; R-XTR-8875656; MET receptor recycling.
Reactome; R-XTR-912526; Interleukin receptor SHC signaling.
Reactome; R-XTR-912631; Regulation of signaling by CBL.
Reactome; R-XTR-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
Proteomes; UP000008143; Unassembled WGS sequence.
Bgee; ENSXETG00000012520; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.
GO; GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0005102; F:receptor binding; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0016477; P:cell migration; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central.
GO; GO:0007265; P:Ras protein signal transduction; IEA:InterPro.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR24418:SF290; PTHR24418:SF290; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Developmental protein; Endosome;
Golgi apparatus; Meiosis; Nucleus; Reference proteome; Repeat;
SH2 domain; SH3 domain.
CHAIN 1 229 Growth factor receptor-bound protein 2.
/FTId=PRO_0000088205.
DOMAIN 1 58 SH3 1. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
DOMAIN 60 171 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 168 227 SH3 2. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
SEQUENCE 229 AA; 26422 MW; ACC0DCFC344F154B CRC64;
MEAVAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQVHGG DRATNLLQQP TYVQALFDFD
PQEDGELGFR RGDFIQVVDN SDPNWWKGTC LGQTGMFPRN YVTPVNRNM


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