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Growth factor receptor-bound protein 2-A (Adapter protein GRB2-A) (SH2/SH3 adapter GRB2-A)

 GRB2A_XENLA             Reviewed;         229 AA.
P87379; Q6GME6; Q9PU11;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
24-JAN-2006, sequence version 2.
28-FEB-2018, entry version 98.
RecName: Full=Growth factor receptor-bound protein 2-A;
AltName: Full=Adapter protein GRB2-A;
AltName: Full=SH2/SH3 adapter GRB2-A;
Name=grb2-a;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Lu W., Mayer B.J.;
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Embryo;
Goisset C., Shi D.L., Boucaut J.-C.;
"Selective inhibition of neural induction but not mesoderm induction
by interfering mutants of Sem-5/Grb2.";
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Kidney;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
FUNCTION, DOMAIN, AND MUTAGENESIS OF PRO-49 AND GLY-215.
PubMed=11257447; DOI=10.1016/S0898-6568(00)00138-8;
Cailliau K., Browaeys-Poly E., Broutin-L'Hermite I., Nioche P.,
Garbay C., Ducruix A., Vilain J.P.;
"Grb2 promotes reinitiation of meiosis in Xenopus oocytes.";
Cell. Signal. 13:51-55(2001).
-!- FUNCTION: Adapter protein that provides a critical link between
cell surface growth factor receptors and the Ras signaling pathway
(By similarity). Promotes meiotic reinitiation during oocyte
maturation. {ECO:0000250, ECO:0000269|PubMed:11257447}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
{ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus
{ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P87379-1; Sequence=Displayed;
Note=May be due to partial intron retention. No experimental
confirmation available.;
Name=2;
IsoId=P87379-2; Sequence=VSP_017084;
-!- DOMAIN: The two SH3 domains and the SH2 domain are necessary for
the reinitiation of oocyte meiosis. {ECO:0000269|PubMed:11257447}.
-!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
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EMBL; U89775; AAB49699.1; -; mRNA.
EMBL; AJ223061; CAB59279.1; -; mRNA.
EMBL; BC074118; AAH74118.1; -; mRNA.
RefSeq; NP_001084357.1; NM_001090888.1.
RefSeq; XP_018089703.1; XM_018234214.1. [P87379-1]
RefSeq; XP_018089704.1; XM_018234215.1. [P87379-1]
UniGene; Xl.7698; -.
ProteinModelPortal; P87379; -.
SMR; P87379; -.
IntAct; P87379; 2.
MINT; P87379; -.
PRIDE; P87379; -.
GeneID; 399458; -.
KEGG; xla:399458; -.
CTD; 399458; -.
Xenbase; XB-GENE-6253891; grb2.
HOVERGEN; HBG005404; -.
KO; K04364; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.
GO; GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO; GO:0007143; P:female meiotic nuclear division; IDA:UniProtKB.
GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0007265; P:Ras protein signal transduction; IEA:InterPro.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR24418:SF290; PTHR24418:SF290; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
1: Evidence at protein level;
Alternative splicing; Cytoplasm; Developmental protein; Endosome;
Golgi apparatus; Meiosis; Nucleus; Repeat; SH2 domain; SH3 domain.
CHAIN 1 229 Growth factor receptor-bound protein 2-A.
/FTId=PRO_0000088203.
DOMAIN 1 58 SH3 1. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
DOMAIN 60 152 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 168 227 SH3 2. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
VAR_SEQ 155 166 Missing (in isoform 2).
{ECO:0000303|Ref.1, ECO:0000303|Ref.2}.
/FTId=VSP_017084.
MUTAGEN 49 49 P->L: Unable to reinitiate oocyte
meiosis. {ECO:0000269|PubMed:11257447}.
MUTAGEN 215 215 G->R: Unable to reinitiate oocyte
meiosis. {ECO:0000269|PubMed:11257447}.
CONFLICT 27 27 V -> A (in Ref. 2; CAB59279).
{ECO:0000305}.
CONFLICT 112 112 R -> P (in Ref. 1; AAB49699).
{ECO:0000305}.
SEQUENCE 229 AA; 26383 MW; 7B278E2DC6B33133 CRC64;
MEAIAKYDFK ATADDELSFK RGDVLKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKAHPW
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQVHGG DRATSLPQQP TYVQALFDFD
PQEDGELGFR RGDFIQVVDN SDPNWWKGTC LSQTGMFPRN YVTPVNRNM


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