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Growth hormone 1 (Growth hormone I) (somatotropin precursor)

 Q5SDS1_SALSA            Unreviewed;       210 AA.
Q5SDS1;
10-MAY-2005, integrated into UniProtKB/TrEMBL.
10-MAY-2005, sequence version 1.
25-OCT-2017, entry version 73.
SubName: Full=Growth hormone 1 {ECO:0000313|EMBL:ACD37713.1};
SubName: Full=Growth hormone I {ECO:0000313|EMBL:AAU11454.1};
SubName: Full=somatotropin precursor {ECO:0000313|RefSeq:NP_001117148.1};
Name=LOC100136588 {ECO:0000313|RefSeq:NP_001117148.1};
Synonyms=gh {ECO:0000313|RefSeq:NP_001117148.1};
Salmo salar (Atlantic salmon).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Salmoninae; Salmo.
NCBI_TaxID=8030 {ECO:0000313|EMBL:AAU11454.1};
[1] {ECO:0000313|RefSeq:NP_001117148.1}
NUCLEOTIDE SEQUENCE.
PubMed=2753360; DOI=10.1016/0378-1119(89)90079-6;
Johansen B., Johnsen O.C., Valla S.;
"The complete nucleotide sequence of the growth-hormone gene from
Atlantic salmon (Salmo salar).";
Gene 77:317-324(1989).
[2] {ECO:0000313|RefSeq:NP_001117148.1}
NUCLEOTIDE SEQUENCE.
PubMed=2704622; DOI=10.1093/nar/17.6.2352;
Lorens J., Nerland A.H., Male R., Lossius I., Telle W., Totland G.;
"The nucleotide sequence of Atlantic salmon growth hormone cDNA.";
Nucleic Acids Res. 17:2352-2353(1989).
[3] {ECO:0000313|RefSeq:NP_001117148.1}
NUCLEOTIDE SEQUENCE.
PubMed=1562611; DOI=10.1016/0167-4781(92)90452-6;
Male R., Nerland A.H., Lorens J.B., Telle W., Lossius I.,
Totland G.K.;
"The complete nucleotide sequence of the Atlantic salmon growth
hormone I gene.";
Biochim. Biophys. Acta 1130:345-348(1992).
[4] {ECO:0000313|EMBL:AAU11454.1, ECO:0000313|RefSeq:NP_001117148.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Ss10_GH1 {ECO:0000313|EMBL:AAU11460.1},
Ss11_GH1 {ECO:0000313|EMBL:AAU11461.1},
Ss2_GH1 {ECO:0000313|EMBL:AAU11453.1},
Ss3_GH1 {ECO:0000313|EMBL:AAU11454.1},
Ss5_GH1 {ECO:0000313|EMBL:AAU11455.1},
Ss6_GH1 {ECO:0000313|EMBL:AAU11456.1},
Ss7_GH1 {ECO:0000313|EMBL:AAU11457.1},
Ss8_GH1 {ECO:0000313|EMBL:AAU11458.1}, and
Ss9_GH1 {ECO:0000313|EMBL:AAU11459.1};
PubMed=15548297; DOI=10.1111/j.1365-294X.2004.02370.x;
Ryynanen H.J., Primmer C.R.;
"Distribution of genetic variation in the growth hormone 1 gene in
Atlantic salmon (Salmo salar) populations from Europe and North
America.";
Mol. Ecol. 13:3857-3869(2004).
[5] {ECO:0000313|EMBL:AAU11454.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Ss2_GH1 {ECO:0000313|EMBL:AAU11453.1},
Ss3_GH1 {ECO:0000313|EMBL:AAU11454.1},
Ss5_GH1 {ECO:0000313|EMBL:AAU11455.1},
Ss6_GH1 {ECO:0000313|EMBL:AAU11456.1},
Ss7_GH1 {ECO:0000313|EMBL:AAU11457.1},
Ss8_GH1 {ECO:0000313|EMBL:AAU11458.1}, and
Ss9_GH1 {ECO:0000313|EMBL:AAU11459.1};
Ryynanen H.J., Primmer C.R.;
"Primers for sequence characterization and polymorphism detection in
the Atlantic salmon (Salmo salar) growth hormone 1 (GH1) gene.";
Mol. Ecol. Notes 4:664-667(2004).
[6] {ECO:0000313|EMBL:ACD37713.1, ECO:0000313|RefSeq:NP_001117148.1}
NUCLEOTIDE SEQUENCE.
PubMed=18980692; DOI=10.1186/1471-2164-9-522;
von Schalburg K.R., Yazawa R., de Boer J., Lubieniecki K.P., Goh B.,
Straub C.A., Beetz-Sargent M.R., Robb A., Davidson W.S., Devlin R.H.,
Koop B.F.;
"Isolation, characterization and comparison of Atlantic and Chinook
salmon growth hormone 1 and 2.";
BMC Genomics 9:522-522(2008).
[7] {ECO:0000313|RefSeq:NP_001117148.1}
IDENTIFICATION.
RefSeq;
Submitted (FEB-2017) to UniProtKB.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU003618,
ECO:0000256|SAAS:SAAS00687159}.
-!- SIMILARITY: Belongs to the somatotropin/prolactin family.
{ECO:0000256|RuleBase:RU003618, ECO:0000256|SAAS:SAAS00680088}.
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EMBL; AY614002; AAU11453.1; -; Genomic_DNA.
EMBL; AY614003; AAU11454.1; -; Genomic_DNA.
EMBL; AY614004; AAU11455.1; -; Genomic_DNA.
EMBL; AY614005; AAU11456.1; -; Genomic_DNA.
EMBL; AY614006; AAU11457.1; -; Genomic_DNA.
EMBL; AY614007; AAU11458.1; -; Genomic_DNA.
EMBL; AY614008; AAU11459.1; -; Genomic_DNA.
EMBL; AY614009; AAU11460.1; -; Genomic_DNA.
EMBL; AY614010; AAU11461.1; -; Genomic_DNA.
EMBL; EU621898; ACD37713.1; -; Genomic_DNA.
RefSeq; NP_001117148.1; NM_001123676.1.
UniGene; Ssa.902; -.
GeneID; 100136588; -.
KEGG; sasa:100136588; -.
HOVERGEN; HBG011318; -.
KO; K05438; -.
Proteomes; UP000087266; Genome assembly.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0005131; F:growth hormone receptor binding; IPI:AgBase.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0055074; P:calcium ion homeostasis; ISS:AgBase.
GO; GO:0042538; P:hyperosmotic salinity response; ISS:AgBase.
GO; GO:0042539; P:hypotonic salinity response; IDA:AgBase.
GO; GO:0010960; P:magnesium ion homeostasis; ISS:AgBase.
GO; GO:0009648; P:photoperiodism; IDA:AgBase.
GO; GO:0045919; P:positive regulation of cytolysis; ISS:AgBase.
GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
GO; GO:0051023; P:regulation of immunoglobulin secretion; ISS:AgBase.
GO; GO:0032355; P:response to estradiol; IDA:AgBase.
GO; GO:0032094; P:response to food; IDA:AgBase.
GO; GO:0009416; P:response to light stimulus; IDA:AgBase.
GO; GO:0014070; P:response to organic cyclic compound; IDA:AgBase.
GO; GO:0042594; P:response to starvation; IDA:AgBase.
GO; GO:0055078; P:sodium ion homeostasis; ISS:AgBase.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR034975; Somatotropin.
InterPro; IPR001400; Somatotropin/Prolactin.
InterPro; IPR018116; Somatotropin_CS.
PANTHER; PTHR11417; PTHR11417; 1.
PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
Pfam; PF00103; Hormone_1; 1.
PRINTS; PR00836; SOMATOTROPIN.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00266; SOMATOTROPIN_1; 1.
PROSITE; PS00338; SOMATOTROPIN_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000087266};
Disulfide bond {ECO:0000256|SAAS:SAAS00887446};
Hormone {ECO:0000256|RuleBase:RU003618,
ECO:0000256|SAAS:SAAS00887457};
Reference proteome {ECO:0000313|Proteomes:UP000087266};
Secreted {ECO:0000256|SAAS:SAAS00119356};
Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001117148.1}.
SIGNAL 1 22 {ECO:0000256|SAM:SignalP}.
CHAIN 23 210 {ECO:0000256|SAM:SignalP,
ECO:0000313|RefSeq:NP_001117148.1}.
/FTId=PRO_5009732063.
CHAIN 23 210 somatotropin.
{ECO:0000313|RefSeq:NP_001117148.1}.
/FTId=PRO_5009732062.
SEQUENCE 210 AA; 23894 MW; 20A6BA82A69A6368 CRC64;
MGQVFLLMPV LLVSCFLSQG AAMENQRLFN IAVNRVQHLH LMAQKMFNDF EGTLLPDERR
QLNKIFLLDF CNSDSIVSPI DKLETQKSSV LKLLHISFRL IESWEYPSQT LTISNSLMVR
NSNQISEKLS DLKVGINLLI KGSQDGVLSL DDNDSQQLPP YGNYYQNLGG DGNVRRNYEL
LACFKKDMHK VETYLTVAKC RKSLEANCTL


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