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Guanine nucleotide-binding protein alpha-1 subunit (GP1-alpha)

 GPA1_KLULA              Reviewed;         447 AA.
Q9Y7B7; Q6CIK5;
11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 4.
10-OCT-2018, entry version 132.
RecName: Full=Guanine nucleotide-binding protein alpha-1 subunit;
AltName: Full=GP1-alpha;
Name=GPA1; OrderedLocusNames=KLLA0F25916g;
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
NCBI_TaxID=284590;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=11114921; DOI=10.1128/JB.183.1.229-234.2001;
Savinon-Tejeda A.L., Ongay-Larios L., Valdes-Rodriguez J., Coria R.;
"The KlGpa1 gene encodes a G-protein alpha subunit that is a positive
control element in the mating pathway of the budding yeast
Kluyveromyces lactis.";
J. Bacteriol. 183:229-234(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=15229592; DOI=10.1038/nature02579;
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
-!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
involved as modulators or transducers in various transmembrane
signaling systems. This protein is involved in the mating response
pathway.
-!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
gamma. The alpha chain contains the guanine nucleotide binding
site.
-!- SIMILARITY: Belongs to the G-alpha family. {ECO:0000305}.
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EMBL; AF135552; AAD33674.1; -; Genomic_DNA.
EMBL; CR382126; CAG98942.1; -; Genomic_DNA.
RefSeq; XP_456234.1; XM_456234.1.
ProteinModelPortal; Q9Y7B7; -.
STRING; 284590.XP_456234.1; -.
EnsemblFungi; CAG98942; CAG98942; KLLA0_F25916g.
GeneID; 2894996; -.
KEGG; kla:KLLA0_F25916g; -.
eggNOG; KOG0082; Eukaryota.
eggNOG; ENOG410XNVQ; LUCA.
HOGENOM; HOG000038730; -.
InParanoid; Q9Y7B7; -.
KO; K19860; -.
OMA; VARMEDT; -.
OrthoDB; EOG092C25Q3; -.
Proteomes; UP000000598; Chromosome F.
GO; GO:0005768; C:endosome; IEA:EnsemblFungi.
GO; GO:0005834; C:heterotrimeric G-protein complex; IEA:EnsemblFungi.
GO; GO:0031681; F:G-protein beta-subunit binding; IEA:EnsemblFungi.
GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
GO; GO:0001664; F:G-protein coupled receptor binding; IEA:InterPro.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; IEA:EnsemblFungi.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro.
GO; GO:0048017; P:inositol lipid-mediated signaling; IEA:EnsemblFungi.
GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IEA:EnsemblFungi.
GO; GO:0000743; P:nuclear migration involved in conjugation with cellular fusion; IEA:EnsemblFungi.
GO; GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IEA:EnsemblFungi.
GO; GO:0071701; P:regulation of MAPK export from nucleus; IEA:EnsemblFungi.
CDD; cd00066; G-alpha; 1.
Gene3D; 1.10.400.10; -; 2.
InterPro; IPR002975; Fungi_Gprotein_alpha.
InterPro; IPR001019; Gprotein_alpha_su.
InterPro; IPR011025; GproteinA_insert.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR10218; PTHR10218; 1.
Pfam; PF00503; G-alpha; 1.
PRINTS; PR00318; GPROTEINA.
PRINTS; PR01241; GPROTEINAFNG.
SMART; SM00275; G_alpha; 1.
SUPFAM; SSF47895; SSF47895; 2.
SUPFAM; SSF52540; SSF52540; 2.
3: Inferred from homology;
Complete proteome; GTP-binding; Lipoprotein; Magnesium; Metal-binding;
Myristate; Nucleotide-binding; Palmitate; Pheromone response;
Reference proteome; Transducer.
INIT_MET 1 1 Removed. {ECO:0000250}.
CHAIN 2 447 Guanine nucleotide-binding protein alpha-
1 subunit.
/FTId=PRO_0000203602.
NP_BIND 48 55 GTP. {ECO:0000250}.
NP_BIND 269 275 GTP. {ECO:0000250}.
NP_BIND 294 298 GTP. {ECO:0000250}.
NP_BIND 363 366 GTP. {ECO:0000250}.
METAL 55 55 Magnesium. {ECO:0000250}.
METAL 275 275 Magnesium. {ECO:0000250}.
BINDING 419 419 GTP; via amide nitrogen. {ECO:0000250}.
LIPID 2 2 N-myristoyl glycine. {ECO:0000250}.
LIPID 3 3 S-palmitoyl cysteine. {ECO:0000250}.
CONFLICT 271 271 G -> V (in Ref. 1; AAD33674).
{ECO:0000305}.
SEQUENCE 447 AA; 50938 MW; 29BADC2166158F98 CRC64;
MGCVASTGNY ENEDDPFIQN KRANDLIEQN LQQERNKNKN EVKLLLLGAG ESGKSTVLKQ
MKLLHQGGFT HRERMQYGQV IWADAIESMR TLILQAGKLG IELDSDLKNA HSGQLVNTEL
HQCKEKIFRA NTLDQIDARM AGGSEFLNEY VLKYNGIGSK KKRQTTLGFK ESNGADPEEE
DETDAFLSEK LAGTSYTGSS ETSELKRIDQ STNEEIAYAI KKLWTQDKGI RQCFNRSSEF
QLEGSASYYF DNIEKFARVD YVCDDMDILK GRIKTTGITE NSFKIGPSTF KVYDAGGQRS
ERRKWIHCFE GITAVVFVIA ISEYDQMLFE DERVNRMHES IVLLDTLLNS RWFANTPFIL
FLNKVDIFQE KVKRSPIRTW FPNYPGKLGD SETGLKYFES LFLSLNRSNK PIYVHRTCAT
DTQSMRFVLG AVTDLVIQQN LKKSGIL


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