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Guanine nucleotide-binding protein alpha-2 subunit (GP2-alpha)

 GPA2_KLULA              Reviewed;         554 AA.
P54111; Q6CR89;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
27-SEP-2004, sequence version 2.
10-OCT-2018, entry version 113.
RecName: Full=Guanine nucleotide-binding protein alpha-2 subunit;
AltName: Full=GP2-alpha;
Name=GPA2; OrderedLocusNames=KLLA0D10956g;
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
NCBI_TaxID=284590;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=15229592; DOI=10.1038/nature02579;
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-554.
STRAIN=CBS 2359 / IFO 1267 / NRRL Y-1140 / WM37;
PubMed=8896279;
DOI=10.1002/(SICI)1097-0061(19960915)12:11<1125::AID-YEA7>3.0.CO;2-2;
Savinon-Tejeda A., Ongay-Larios L., Ramirez J., Coria R.;
"Isolation of a gene encoding a G protein alpha subunit involved in
the regulation of cAMP levels in the yeast Kluyveromyces lactis.";
Yeast 12:1125-1133(1996).
-!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
involved as modulators or transducers in various transmembrane
signaling systems. This protein may be involved in the
determination of the cAMP level according to nutritional
conditions, most probably as a regulator of adenylyl cyclase.
-!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
gamma. The alpha chain contains the guanine nucleotide binding
site.
-!- SIMILARITY: Belongs to the G-alpha family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA75112.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; CR382124; CAH00646.1; -; Genomic_DNA.
EMBL; L47105; AAA75112.1; ALT_INIT; Genomic_DNA.
PIR; S72195; S72195.
RefSeq; XP_453550.1; XM_453550.1.
ProteinModelPortal; P54111; -.
SMR; P54111; -.
STRING; 284590.XP_453550.1; -.
EnsemblFungi; CAH00646; CAH00646; KLLA0_D10956g.
GeneID; 2893290; -.
KEGG; kla:KLLA0_D10956g; -.
eggNOG; KOG0082; Eukaryota.
eggNOG; ENOG410XNVQ; LUCA.
HOGENOM; HOG000038730; -.
InParanoid; P54111; -.
KO; K04630; -.
OrthoDB; EOG092C25Q3; -.
Proteomes; UP000000598; Chromosome D.
GO; GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
GO; GO:0001664; F:G-protein coupled receptor binding; IEA:InterPro.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:EnsemblFungi.
GO; GO:0030437; P:ascospore formation; IEA:EnsemblFungi.
GO; GO:0010255; P:glucose mediated signaling pathway; IEA:EnsemblFungi.
GO; GO:0001403; P:invasive growth in response to glucose limitation; IEA:EnsemblFungi.
GO; GO:0007124; P:pseudohyphal growth; IEA:EnsemblFungi.
GO; GO:0001302; P:replicative cell aging; IEA:EnsemblFungi.
CDD; cd00066; G-alpha; 1.
Gene3D; 1.10.400.10; -; 1.
InterPro; IPR002975; Fungi_Gprotein_alpha.
InterPro; IPR001019; Gprotein_alpha_su.
InterPro; IPR011025; GproteinA_insert.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR10218; PTHR10218; 1.
Pfam; PF00503; G-alpha; 1.
PRINTS; PR00318; GPROTEINA.
PRINTS; PR01241; GPROTEINAFNG.
SMART; SM00275; G_alpha; 1.
SUPFAM; SSF47895; SSF47895; 1.
SUPFAM; SSF52540; SSF52540; 2.
3: Inferred from homology;
Complete proteome; GTP-binding; Lipoprotein; Magnesium; Metal-binding;
Myristate; Nucleotide-binding; Palmitate; Reference proteome;
Transducer.
INIT_MET 1 1 Removed. {ECO:0000255}.
CHAIN 2 554 Guanine nucleotide-binding protein alpha-
2 subunit.
/FTId=PRO_0000203603.
NP_BIND 236 243 GTP. {ECO:0000250}.
NP_BIND 376 382 GTP. {ECO:0000250}.
NP_BIND 402 406 GTP. {ECO:0000250}.
NP_BIND 471 474 GTP. {ECO:0000250}.
COMPBIAS 82 177 Asn-rich.
METAL 243 243 Magnesium. {ECO:0000250}.
METAL 382 382 Magnesium. {ECO:0000250}.
BINDING 526 526 GTP; via amide nitrogen. {ECO:0000250}.
LIPID 2 2 N-myristoyl glycine. {ECO:0000255}.
LIPID 4 4 S-palmitoyl cysteine. {ECO:0000255}.
SEQUENCE 554 AA; 61459 MW; 5F7064B798B36084 CRC64;
MGLCASKDSR ESTHDGGPRV NRPGANDANR RNDVRKGAGD KKQDKKNKKA KGSIVNAASN
INNSSSGKTK ISTVSEDGTV SNGVGNTAEY DNANNKNNGN NNNSNNNDNN NNNNNNIGNN
INGNNNNDSE NIHDSNNSNI ENKRYFNNIN TGVLNGVNGN STNSDKALSN QFDQSNNSET
HSGTMTGISQ ALALNDSGVN GFDTDLAKRN GTVNASGGQS PGGSETVNAL KVLLLGSGES
GKSTVLQQLK ILHQNGFSRE ELLEYKPFIF DNIIETGKDL AKARRTFNVQ LEEDAEISES
DLDELLSQQY QPTKLPCLPA DLAKTLKILW NLQSTQDLLV SEHRSSFYLM DSASYFYENL
DRISEPKYIP TITDVIRTRK KTSGIFDTMI DLDKNLKLHF FDVGGQRSER KKWIHCFDNV
TLIIFCVSLS EYDQTLLEDN SQNRLEESLI LFDSVVNSRW FARSSVVLFL NKIDIFAEKL
RHVPLEKYFP DYTGGKDINK AAKYILWRFV QLNRANLNIY PHVTQATDTS NIKLVFAAIK
ETILENSLKD SGVL


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