Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Guanine nucleotide-binding protein subunit beta-2-like 1 [Cleaved into: Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed]

 GBLP_MACFA              Reviewed;         317 AA.
Q4R7Y4;
04-APR-2006, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
28-FEB-2018, entry version 80.
RecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1;
Contains:
RecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed;
Name=GNB2L1; ORFNames=QtsA-14081;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
International consortium for macaque cDNA sequencing and analysis;
"DNA sequences of macaque genes expressed in brain or testis and its
evolutionary implications.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in the recruitment, assembly and/or regulation
of a variety of signaling molecules. Interacts with a wide variety
of proteins and plays a role in many cellular processes. Component
of the 40S ribosomal subunit involved in translational repression.
Binds to and stabilizes activated protein kinase C (PKC),
increasing PKC-mediated phosphorylation. May recruit activated PKC
to the ribosome, leading to phosphorylation of EIF6. Inhibits the
activity of SRC kinases including SRC, LCK and YES1. Inhibits cell
growth by prolonging the G0/G1 phase of the cell cycle. Enhances
phosphorylation of BMAL1 by PRKCA and inhibits transcriptional
activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-
independent nuclear translocation of AR following PKC activation,
represses AR transactivation activity and is required for
phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin
signaling and promotes cell spreading and contact with the
extracellular matrix. Involved in PKC-dependent translocation of
ADAM12 to the cell membrane. Promotes the ubiquitination and
proteasome-mediated degradation of proteins such as CLEC1B and
HIF1A. Required for VANGL2 membrane localization, inhibits Wnt
signaling, and regulates cellular polarization and oriented cell
division during gastrulation. Required for PTK2/FAK1
phosphorylation and dephosphorylation. Regulates internalization
of the muscarinic receptor CHRM2. Promotes apoptosis by increasing
oligomerization of BAX and disrupting the interaction of BAX with
the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity.
Regulates cell surface expression of some GPCRs such as TBXA2R.
Plays a role in regulation of FLT1-mediated cell migration (By
similarity). Involved in the transport of ABCB4 from the Golgi to
the apical bile canalicular membrane (By similarity).
{ECO:0000250, ECO:0000250|UniProtKB:P63244}.
-!- SUBUNIT: Interacts with CPNE3 (By similarity). May interact with
ABCB4 (By similarity). Component of the small (40S) ribosomal
subunit. Exists as a monomer and also forms oligomers. Binds
SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts
with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain);
the interaction is enhanced by tyrosine phosphorylation of RACK1.
Recruited in a circadian manner into a nuclear complex which also
includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R
but not with INSR. Interacts with ADAM12. Interacts with CLEC1B
(via N-terminal region) and with HIF1A; the interaction promotes
their degradation. Interacts with RHOA; this enhances RHOA
activation and promotes cell migration. Interacts with CHRM2; the
interaction regulates CHRM2 internalization. Interacts with TRPM6
(via kinase domain). Interacts with PTK2/FAK1; required for
PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with
FLT1. Interacts with HRAS. Interacts with LARP4B. Interacts with
PKD2L1 (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:P63244}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P63244}; Peripheral membrane protein
{ECO:0000250|UniProtKB:P63244}. Cytoplasm
{ECO:0000250|UniProtKB:P63244}. Cytoplasm, perinuclear region
{ECO:0000250|UniProtKB:P63244}. Nucleus
{ECO:0000250|UniProtKB:P63244}. Perikaryon
{ECO:0000250|UniProtKB:P68040}. Cell projection, dendrite
{ECO:0000250|UniProtKB:P68040}. Note=Recruited to the plasma
membrane through interaction with KRT1 which binds to membrane-
bound ITGB1. Also associated with the membrane in oncogene-
transformed cells. PKC activation induces translocation from the
perinuclear region to the cell periphery (By similarity). In the
brain, detected mainly in cell bodies and dendrites with little
expression in axonal fibers or nuclei (By similarity).
{ECO:0000250|UniProtKB:P63244, ECO:0000250|UniProtKB:P68040}.
-!- PTM: Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is
required for binding to SRC (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the WD repeat G protein beta family.
Ribosomal protein RACK1 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB168677; BAE00788.1; -; mRNA.
UniGene; Mfa.342; -.
ProteinModelPortal; Q4R7Y4; -.
SMR; Q4R7Y4; -.
PRIDE; Q4R7Y4; -.
HOVERGEN; HBG000277; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
GO; GO:0030496; C:midbody; ISS:UniProtKB.
GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0001891; C:phagocytic cup; ISS:UniProtKB.
GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
GO; GO:0005080; F:protein kinase C binding; ISS:UniProtKB.
GO; GO:0030292; F:protein tyrosine kinase inhibitor activity; ISS:UniProtKB.
GO; GO:0030971; F:receptor tyrosine kinase binding; ISS:UniProtKB.
GO; GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0071363; P:cellular response to growth factor stimulus; ISS:UniProtKB.
GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO; GO:0050765; P:negative regulation of phagocytosis; ISS:UniProtKB.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
GO; GO:0042998; P:positive regulation of Golgi to plasma membrane protein transport; ISS:UniProtKB.
GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO; GO:0032464; P:positive regulation of protein homooligomerization; ISS:UniProtKB.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
GO; GO:0051302; P:regulation of cell division; ISS:UniProtKB.
GO; GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB.
GO; GO:0032880; P:regulation of protein localization; ISS:UniProtKB.
GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
Pfam; PF00400; WD40; 7.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 7.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 4.
PROSITE; PS50082; WD_REPEATS_2; 6.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
2: Evidence at transcript level;
Acetylation; Apoptosis; Biological rhythms; Cell cycle; Cell membrane;
Cell projection; Cytoplasm; Developmental protein; Gastrulation;
Growth regulation; Membrane; Nucleus; Phosphoprotein; Repeat;
Ribonucleoprotein; Ribosomal protein; Translation regulation;
WD repeat.
CHAIN 1 317 Guanine nucleotide-binding protein
subunit beta-2-like 1.
/FTId=PRO_0000232130.
INIT_MET 1 1 Removed; alternate.
{ECO:0000250|UniProtKB:P63244}.
CHAIN 2 317 Guanine nucleotide-binding protein
subunit beta-2-like 1, N-terminally
processed.
/FTId=PRO_0000424481.
REPEAT 13 44 WD 1.
REPEAT 61 91 WD 2.
REPEAT 103 133 WD 3.
REPEAT 146 178 WD 4.
REPEAT 190 220 WD 5.
REPEAT 231 260 WD 6.
REPEAT 281 311 WD 7.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 2 2 N-acetylthreonine; in Guanine nucleotide-
binding protein subunit beta-2-like 1, N-
terminally processed.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 6 6 Phosphothreonine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 10 10 Phosphothreonine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 52 52 Phosphotyrosine; by ABL1.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 96 96 Phosphothreonine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 130 130 N6-acetyllysine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 183 183 N6-acetyllysine.
{ECO:0000250|UniProtKB:P68040}.
MOD_RES 228 228 Phosphotyrosine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 276 276 Phosphoserine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 277 277 Phosphothreonine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 278 278 Phosphoserine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 279 279 Phosphoserine.
{ECO:0000250|UniProtKB:P63244}.
MOD_RES 316 316 Phosphothreonine.
{ECO:0000250|UniProtKB:P68040}.
SEQUENCE 317 AA; 35077 MW; 257F91E369ED2044 CRC64;
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI
VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA
GYTDNLVRVW QVTIGTR


Related products :

Catalog number Product name Quantity
18-003-44199 Guanine nucleotide-binding protein subunit beta-2-like 1 - Guanine nucleotide-binding protein subunit beta-like protein 12.3; Receptor of activated protein kinase C 1; RACK1; Receptor for activated C 0.05 mg Aff Pur
10-288-21993F Guanine nucleotide-binding protein subunit beta 4 - Transducin beta chain 4 0.1 mg
10-288-21993F Guanine nucleotide-binding protein subunit beta 4 - Transducin beta chain 4 0.05 mg
15-288-21993 Guanine nucleotide-binding protein subunit beta 4 - Transducin beta chain 4 Polyclonal 0.1 mg
15-288-21993 Guanine nucleotide-binding protein subunit beta 4 - Transducin beta chain 4 Polyclonal 0.05 mg
EH1311 Guanine nucleotide-binding protein G(I) per G(S) per G(T) subunit beta-3 Elisa Kit 96T
GBB4_RAT Rat ELISA Kit FOR Guanine nucleotide-binding protein subunit beta-4 96T
E1009r Bovine ELISA Kit FOR Guanine nucleotide-binding protein G(I) per G(S) per G(T) subunit beta-1 96T
CSB-EL009605RA Rat Guanine nucleotide-binding protein subunit beta-2-like 1(GNB2L1) ELISA kit 96T
E10159r Mouse ELISA Kit FOR Guanine nucleotide-binding protein subunit beta-4 96T
GBLP_CHICK Chicken ELISA Kit FOR Guanine nucleotide-binding protein subunit beta-2-like 1 96T
KCNS2_HUMAN Human ELISA Kit FOR Guanine nucleotide-binding protein subunit beta-4 96T
CSB-RP050644h Recombinant human Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 500ug
E13897m Mouse ELISA Kit FOR Guanine nucleotide-binding protein subunit beta-5 96T
CSB-EL009607RA Rat Guanine nucleotide-binding protein subunit beta-4(GNB4) ELISA kit 96T
E0952h Mouse ELISA Kit FOR Guanine nucleotide-binding protein G(I) per G(S) per G(T) subunit beta-2 96T
CYC2_BOVIN Human ELISA Kit FOR Guanine nucleotide-binding protein subunit beta-4 96T
E0213m Human ELISA Kit FOR Guanine nucleotide-binding protein subunit beta-4 96T
CSB-EL009608RA Rat Guanine nucleotide-binding protein subunit beta-5(GNB5) ELISA kit 96T
CSB-EL009605PI Pig Guanine nucleotide-binding protein subunit beta-2-like 1(GNB2L1) ELISA kit SpeciesPig 96T
CSB-EL009605HU Human Guanine nucleotide-binding protein subunit beta-2-like 1(GNB2L1) ELISA kit 96T
CSB-EL009607HU Human Guanine nucleotide-binding protein subunit beta-4(GNB4) ELISA kit 96T
CSB-EL009605CH Chicken Guanine nucleotide-binding protein subunit beta-2-like 1(GNB2L1) ELISA kit 96T
CSB-EL009608HU Human Guanine nucleotide-binding protein subunit beta-5(GNB5) ELISA kit 96T
CSB-EL009608RA Rat Guanine nucleotide-binding protein subunit beta-5(GNB5) ELISA kit SpeciesRat 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur