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Guanylate cyclase activator 2B [Cleaved into: Uroguanylin (UGN)]

 GUC2B_DIDVI             Reviewed;         109 AA.
Q28358;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 64.
RecName: Full=Guanylate cyclase activator 2B;
Contains:
RecName: Full=Uroguanylin;
Short=UGN;
Flags: Precursor;
Name=GUCA2B;
Didelphis virginiana (North American opossum) (Didelphis marsupialis
virginiana).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Metatheria; Didelphimorphia; Didelphidae; Didelphis.
NCBI_TaxID=9267;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Colon;
PubMed=8605009; DOI=10.1006/bbrc.1996.0255;
Fan X., Hamra F.K., Freeman R.H., Eber S.L., Krause W.J., Lim R.W.,
Pace V.M., Currie M.G., Forte L.R.;
"Uroguanylin: cloning of preprouroguanylin cDNA, mRNA expression in
the intestine and heart and isolation of uroguanylin and
prouroguanylin from plasma.";
Biochem. Biophys. Res. Commun. 219:457-462(1996).
[2]
PROTEIN SEQUENCE OF 95-109.
TISSUE=Urine;
PubMed=7902563; DOI=10.1073/pnas.90.22.10464;
Hamra F.K., Forte L.R., Eber S.L., Pidhorodeckyj N.V., Krause W.J.,
Freeman R.H., Chin D.T., Tompkins J.A., Fok K.F., Smith C.E.,
Duffin K.L., Siegel N.R., Currie M.G.;
"Uroguanylin: structure and activity of a second endogenous peptide
that stimulates intestinal guanylate cyclase.";
Proc. Natl. Acad. Sci. U.S.A. 90:10464-10468(1993).
-!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
stimulates this enzyme through the same receptor binding region as
the heat-stable enterotoxins. May be a potent physiological
regulator of intestinal fluid and electrolyte transport. May be an
autocrine/paracrine regulator of intestinal salt and water
transport.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Small and large intestine and atria and
ventricles of heart. Both uroguanylin and prouroguanylin are found
in plasma.
-!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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EMBL; U49353; AAB00553.1; -; mRNA.
ProteinModelPortal; Q28358; -.
SMR; Q28358; -.
HOVERGEN; HBG051861; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0030250; F:guanylate cyclase activator activity; IEA:InterPro.
Gene3D; 3.90.1450.10; -; 1.
InterPro; IPR000879; Guanylin.
InterPro; IPR036382; Guanylin_sf.
PANTHER; PTHR11318; PTHR11318; 1.
Pfam; PF02058; Guanylin; 1.
PIRSF; PIRSF001849; Guanylin; 1.
PRINTS; PR00774; GUANYLIN.
ProDom; PD005588; Guanylin; 1.
SUPFAM; SSF89890; SSF89890; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Secreted; Signal.
SIGNAL 1 23 {ECO:0000255}.
PROPEP 24 94 {ECO:0000269|PubMed:7902563}.
/FTId=PRO_0000013145.
PEPTIDE 95 109 Uroguanylin.
/FTId=PRO_0000013146.
DISULFID 65 78 {ECO:0000250}.
DISULFID 98 106 {ECO:0000250}.
DISULFID 101 109 {ECO:0000250}.
SEQUENCE 109 AA; 12040 MW; AE948E210CA3AE7A CRC64;
MKVLALPVAV AAMLLVLAQN TQSVYIQYEG FQVKLDSVKK LDELLEQPRS FRHRMGTQRD
PSVLCSDPAL PSDLQPVCEN SQAANIFRAL RSISQEDCEL CINVACTGC


Related products :

Catalog number Product name Quantity
AE1018AG.1 Uroguanylin Guanylate Cyclase Activator 2B antigen: human Uroguanylin, circulating form (aa 1-24) 10
AE1018AG.2 Uroguanylin Guanylate Cyclase Activator 2B antigen: human Uroguanylin, circulating form (aa 1-24) 100
CSB-EL010048RA Rat guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit 96T
GUCY1A3 GUCA2B Gene guanylate cyclase activator 2B (uroguanylin)
A 9851.1 Uroguanylin Guanylate Cyclase Activator 2B host: Rabbit; Serum 20
A 9851.2 Uroguanylin Guanylate Cyclase Activator 2B host: Rabbit; Serum 100
A 7611.1 Uroguanylin Guanylate Cyclase Activator 2B host: Rabbit; Serum 20
CSB-EL010048GU Guinea pig guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit 96T
AE1066.2 Uroguanylin Guanylate Cyclase Activator 2B host: Rabbit; Serum 100
CSB-EL010048MO Mouse guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit 96T
CSB-EL010048HU Human guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit 96T
AE1066.2 Uroguanylin per Guanylate Cyclase Activator 2B Antibody host: Rabbit form: Serum 100
AE1066.1 Uroguanylin per Guanylate Cyclase Activator 2B Antibody host: Rabbit form: Serum 20
A 9851.1 Uroguanylin per Guanylate Cyclase Activator 2B Antibody host: Rabbit form: Serum 20
A 9851.2 Uroguanylin per Guanylate Cyclase Activator 2B Antibody host: Rabbit form: Serum 100
CSB-EL010048PI Pig guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit, Species Pig, Sample Type serum, plasma 96T
CSB-EL010048RA Rat guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL010048MO Mouse guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL010048GU Guinea pig guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit, Species Guinea pig, Sample Type serum, plasma 96T
CSB-EL010048HU Human guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit, Species Human, Sample Type serum, plasma 96T
10-663-45479 Proguanylin Human - Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Gap-I N_A 1 mg
10-663-45479 Proguanylin Human - Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Gap-I N_A 0.002 mg
10-663-45479 Proguanylin Human - Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Gap-I N_A 0.01 mg
06-271-83262 Guanylin Human - Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Gap-I 1 mg
06-271-83262 Guanylin Human - Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Gap-I 0.5 mg


 

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