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Guanylin (Guanylate cyclase activator 2A)

 GUC2A_RAT               Reviewed;         115 AA.
P28902;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
01-DEC-1992, sequence version 1.
12-SEP-2018, entry version 113.
RecName: Full=Guanylin;
AltName: Full=Guanylate cyclase activator 2A;
Flags: Precursor;
Name=Guca2a; Synonyms=Guca2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Intestine;
PubMed=1379587;
Schulz S., Chrisman T.D., Garbers D.L.;
"Cloning and expression of guanylin. Its existence in various
mammalian tissues.";
J. Biol. Chem. 267:16019-16021(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1378267; DOI=10.1016/0006-291X(92)91699-Q;
Wiegand R.C., Kato J., Currie M.G.;
"Rat guanylin cDNA: characterization of the precursor of an endogenous
activator of intestinal guanylate cyclase.";
Biochem. Biophys. Res. Commun. 185:812-817(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 101-115.
STRAIN=Lewis; TISSUE=Duodenum;
Maegert H.J., Khun M., Kruhoffer M., Forssmann W.-G.;
Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
[4]
PROTEIN SEQUENCE OF 101-115.
TISSUE=Jejunum;
PubMed=1346555; DOI=10.1073/pnas.89.3.947;
Currie M.G., Fok K.F., Kato J., Moore R.J., Hamra F.K., Duffin K.L.,
Smith C.E.;
"Guanylin: an endogenous activator of intestinal guanylate cyclase.";
Proc. Natl. Acad. Sci. U.S.A. 89:947-951(1992).
-!- FUNCTION: Endogenous activator of intestinal guanylate cyclase. It
stimulates this enzyme through the same receptor binding region as
the heat-stable enterotoxins.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Intestine and in low abundance in adrenal
gland, kidney, and uterus/oviduct.
-!- SIMILARITY: Belongs to the guanylin family. {ECO:0000305}.
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EMBL; M95493; AAA41302.1; -; mRNA.
EMBL; M93005; AAA41300.1; -; mRNA.
EMBL; X67669; CAA47901.1; -; mRNA.
PIR; JN0318; JN0318.
RefSeq; NP_037250.1; NM_013118.1.
UniGene; Rn.11388; -.
ProteinModelPortal; P28902; -.
SMR; P28902; -.
STRING; 10116.ENSRNOP00000011867; -.
PaxDb; P28902; -.
PRIDE; P28902; -.
Ensembl; ENSRNOT00000011867; ENSRNOP00000011867; ENSRNOG00000008849.
GeneID; 25656; -.
KEGG; rno:25656; -.
CTD; 2980; -.
RGD; 2766; Guca2a.
eggNOG; ENOG410J44S; Eukaryota.
eggNOG; ENOG410Z6NA; LUCA.
GeneTree; ENSGT00730000111358; -.
HOGENOM; HOG000231183; -.
HOVERGEN; HBG051861; -.
InParanoid; P28902; -.
OMA; SCEICAF; -.
OrthoDB; EOG091G0WKF; -.
PhylomeDB; P28902; -.
TreeFam; TF330731; -.
Reactome; R-RNO-8935690; Digestion.
PRO; PR:P28902; -.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000008849; Expressed in 9 organ(s), highest expression level in colon.
Genevisible; P28902; RN.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0030250; F:guanylate cyclase activator activity; IDA:RGD.
GO; GO:0030249; F:guanylate cyclase regulator activity; NAS:RGD.
Gene3D; 3.90.1450.10; -; 1.
InterPro; IPR000879; Guanylin.
InterPro; IPR036382; Guanylin_sf.
PANTHER; PTHR11318; PTHR11318; 1.
Pfam; PF02058; Guanylin; 1.
PIRSF; PIRSF001849; Guanylin; 1.
PRINTS; PR00774; GUANYLIN.
ProDom; PD005588; Guanylin; 1.
SUPFAM; SSF89890; SSF89890; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Reference proteome; Secreted; Signal.
SIGNAL 1 23 {ECO:0000255}.
PROPEP 24 100 {ECO:0000269|PubMed:1346555}.
/FTId=PRO_0000013141.
PEPTIDE 101 115 Guanylin.
/FTId=PRO_0000013142.
DISULFID 69 82 {ECO:0000250}.
DISULFID 104 112 {ECO:0000250}.
DISULFID 107 115 {ECO:0000250}.
SEQUENCE 115 AA; 12574 MW; 35AC63C7AC130EE5 CRC64;
MNAWLLSVLC LLGALAVLVE GVTVQDGDLS FPLESVKQLK HLREVQEPTL MSHKKFALRL
PKPVAPELCS QSAFPEALRP LCEKPNAEEI LQRLEAIAQD PNTCEICAYA ACTGC


Related products :

Catalog number Product name Quantity
06-271-83262 Guanylin Human - Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Gap-I 1 mg
06-271-83262 Guanylin Human - Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Gap-I 0.5 mg
AE1019AG.1 Guanylin Guanylate Cyclase Activator 2A antigen: rat Guanylin (aa 78-92) (active peptide) 100
AE1019AG.2 Guanylin Guanylate Cyclase Activator 2A antigen: rat Guanylin (aa 78-92) (active peptide) 1 mg
AE1113AG.2 Guanylin Guanylate Cyclase Activator 2A antigen: human pro-Guanylin (aa 4-16) 1 mg
AE1114AG.1 Guanylin Guanylate Cyclase Activator 2A antigen: human pro-Guanylin (aa 13-25) 100
AE1009AG.1 Guanylin Guanylate Cyclase Activator 2A antigen: human pro-Guanylin (aa 78-94) 100
AE1114AG.2 Guanylin Guanylate Cyclase Activator 2A antigen: human pro-Guanylin (aa 13-25) 1 mg
AE1009AG.2 Guanylin Guanylate Cyclase Activator 2A antigen: human pro-Guanylin (aa 78-94) 1 mg
AE1113AG.1 Guanylin Guanylate Cyclase Activator 2A antigen: human pro-Guanylin (aa 4-16) 100
AE1017AG.2 Guanylin Guanylate Cyclase Activator 2A antigen: human Guanylin (aa 80-94) (active peptide) 1 mg
AE1017AG.1 Guanylin Guanylate Cyclase Activator 2A antigen: human Guanylin (aa 80-94) (active peptide) 100
06-271-83263 Guanylin Rat Mouse - Guanylate cyclase activator 2A 0.5 mg
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GUCY1A2 GUCA2A Gene guanylate cyclase activator 2A (guanylin)
AE1009.1 Guanylin Guanylate Cyclase Activator 2A host: Rabbit; Serum 10
AE1113.2 Guanylin Guanylate Cyclase Activator 2A host: Rabbit; Serum 100
AE1114.2 Guanylin Guanylate Cyclase Activator 2A host: Rabbit; Serum 100
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AE1114.1 Guanylin Guanylate Cyclase Activator 2A host: Rabbit; Serum 20
AE1017.1 Guanylin Guanylate Cyclase Activator 2A host: Mouse Balb c; mAb 20
A 1019.1 Guanylin Guanylate Cyclase Activator 2A host: Rabbit; Serum 20
AE1019.1 Guanylin Guanylate Cyclase Activator 2A host: Rabbit; Serum 20
AE1019.2 Guanylin Guanylate Cyclase Activator 2A host: Rabbit; Serum 100
AE1017.2 Guanylin Guanylate Cyclase Activator 2A host: Rabbit; Serum 100


 

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