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Gustatory receptor 5a for trehalose (Trehalose receptor)

 GR05A_DROME             Reviewed;         444 AA.
Q9W497; Q68B17; Q68B25; Q68B58; Q68B67; Q68B82; Q68B87; Q68B91;
Q68BB7; Q68BC2; Q68BC4; Q68BC6; Q68BD1; Q68BD4; Q68BE7; Q68BE8;
Q68BF3; Q95NT7; Q95NX8; Q95NY8; Q95NZ9; Q95P00; Q95YH9; Q95YI0;
Q95YI1; Q95YN5; Q95YN6; Q95YN7;
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
07-DEC-2004, sequence version 2.
28-FEB-2018, entry version 122.
RecName: Full=Gustatory receptor 5a for trehalose;
AltName: Full=Trehalose receptor;
Name=Gr5a; Synonyms=GRLU.7, Tre; ORFNames=CG15779;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, VARIANTS, AND
DISRUPTION PHENOTYPE.
STRAIN=AK07, AK10, AK13, AK17, AK19, AK41, Canton-S, EP(X)496, HG84,
Oregon-R, Shanghai, Singapore, Tananarive, w cv, and w cx;
PubMed=11566105; DOI=10.1016/S0960-9822(01)00450-X;
Ueno K., Ohta M., Morita H., Mikuni Y., Nakajima S., Yamamoto K.,
Isono K.;
"Trehalose sensitivity in Drosophila correlates with mutations in and
expression of the gustatory receptor gene Gr5a.";
Curr. Biol. 11:1451-1455(2001).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND VARIANT THR-218.
STRAIN=KY02-C301, KY02-C302, KY02-C303, KY02-C304, KY02-C305,
KY02-C307, KY02-C308, KY02-C309, KY02-C310, KY02-C311, KY02-C312,
KY02-C314, KY02-C315, KY02-C316, KY02-C319, KY02-C320, KY02-C323,
KY02-C325, KY02-C326, KY02-C327, KY02-C330, KY02-C331, KY02-C332,
KY02-C333, KY02-C335, KY02-C336, KY02-C337, KY02-C338, KY02-C341,
KY02-C342, KY02-C343, KY02-C344, KY02-C345, KY02-C346, KY02-C347,
KY02-C348, KY02-C349, KY02-C350, KY02-C351, KY02-C352, KY02-C353,
KY02-C355, KY02-C356, KY02-C358, KY02-C359, KY02-C361, KY02-C362,
KY02-C365, KY02-C366, KY02-C367, KY02-C368, KY02-C370, KY02-C372,
KY02-C373, KY02-C374, KY02-C376, KY02-C377, KY02-C378, KY02-C379,
KY02-C380, KY02-C381, KY02-C382, KY02-C383, KY02-C384, KY02-C387,
KY02-C388, KY02-C389, KY02-C390, KY02-C392, KY02-C393, KY02-C394,
KY02-C395, KY02-C396, KY02-C397, KY02-C400, KY02-C402, KY02-C404,
KY02-C407, KY02-C411, KY02-C412, KY02-C413, KY02-C414, KY02-C417,
KY02-C419, KY02-C420, KY02-C421, KY02-C425, KY02-C426, KY02-C428,
KY02-C429, KY02-C432, KY02-C433, KY02-C434, KY02-C435, KY02-C436,
KY02-C439, KY02-C441, KY02-C443, KY02-C445, KY02-C446, KY02-C447,
KY02-C448, KY02-C449, KY02-C451, KY02-C452, KY02-C453, KY02-C454,
KY02-C455, KY02-C456, KY02-C457, KY02-C460, KY02-C462, KY02-C463,
KY02-C464, KY02-C465, KY02-C467, KY02-C469, KY02-C470, KY02-C476,
KY02-C477, KY02-C478, KY02-C479, KY02-C480, KY02-C481, KY02-C483,
KY02-C484, KY02-C485, KY02-C486, KY02-C487, KY02-C488, KY02-C489,
KY02-C490, KY02-C491, KY02-C492, KY02-C493, KY02-C494, KY02-C496,
KY02-C497, KY02-C500, KY02-C504, KY02-C508, KY02-C510, KY02-C511,
KY02-C512, KY02-C513, KY02-C514, KY02-C515, KY02-C516, KY02-C517,
KY02-C518, KY02-C519, and KY02-C520;
PubMed=15342513; DOI=10.1534/genetics.104.027045;
Inomata N., Goto H., Itoh M., Isono K.;
"A single-amino-acid change of the gustatory receptor gene, Gr5a, has
a major effect on trehalose sensitivity in a natural population of
Drosophila melanogaster.";
Genetics 167:1749-1758(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
IDENTIFICATION.
PubMed=10710312; DOI=10.1126/science.287.5459.1830;
Clyne P.J., Warr C.G., Carlson J.R.;
"Candidate taste receptors in Drosophila.";
Science 287:1830-1834(2000).
[6]
IDENTIFICATION.
PubMed=11516643; DOI=10.1016/S0960-9822(01)00258-5;
Dunipace L., Meister S., McNealy C., Amrein H.;
"Spatially restricted expression of candidate taste receptors in the
Drosophila gustatory system.";
Curr. Biol. 11:822-835(2001).
[7]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=11704765; DOI=10.1038/nn765;
Dahanukar A., Foster K., van der Goes van Naters W.M., Carlson J.R.;
"A Gr receptor is required for response to the sugar trehalose in
taste neurons of Drosophila.";
Nat. Neurosci. 4:1182-1186(2001).
[8]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=14523229; DOI=10.1073/pnas.2135339100;
Chyb S., Dahanukar A., Wickens A., Carlson J.R.;
"Drosophila Gr5a encodes a taste receptor tuned to trehalose.";
Proc. Natl. Acad. Sci. U.S.A. 100:14526-14530(2003).
[9]
IDENTIFICATION IN THE GUSTATORY RECEPTOR SUBFAMILY.
PubMed=14608037; DOI=10.1073/pnas.2335847100;
Robertson H.M., Warr C.G., Carlson J.R.;
"Molecular evolution of the insect chemoreceptor gene superfamily in
Drosophila melanogaster.";
Proc. Natl. Acad. Sci. U.S.A. 100:14537-14542(2003).
[10]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=15202999; DOI=10.1016/j.cub.2004.05.019;
Thorne N., Chromey C., Bray S., Amrein H.;
"Taste perception and coding in Drosophila.";
Curr. Biol. 14:1065-1079(2004).
[11]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=15738154; DOI=10.1093/chemse/bjh221;
Isono K., Morita H., Kohatsu S., Ueno K., Matsubayashi H.,
Yamamoto M.T.;
"Trehalose sensitivity of the gustatory receptor neurons expressing
wild-type, mutant and ectopic Gr5a in Drosophila.";
Chem. Senses 30:I275-I276(2005).
[12]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=16763022; DOI=10.1523/JNEUROSCI.0857-06.2006;
Ueno K., Kohatsu S., Clay C., Forte M., Isono K., Kidokoro Y.;
"Gsalpha is involved in sugar perception in Drosophila melanogaster.";
J. Neurosci. 26:6143-6152(2006).
[13]
FUNCTION IN ACCEPTANCE BEHAVIOR.
PubMed=16423701; DOI=10.1016/j.neuron.2005.11.037;
Marella S., Fischler W., Kong P., Asgarian S., Rueckert E., Scott K.;
"Imaging taste responses in the fly brain reveals a functional map of
taste category and behavior.";
Neuron 49:285-295(2006).
[14]
FUNCTION.
PubMed=17988633; DOI=10.1016/j.neuron.2007.10.024;
Dahanukar A., Lei Y.T., Kwon J.Y., Carlson J.R.;
"Two Gr genes underlie sugar reception in Drosophila.";
Neuron 56:503-516(2007).
[15]
FUNCTION.
PubMed=20543015; DOI=10.1093/chemse/bjq055;
Kain P., Badsha F., Hussain S.M., Nair A., Hasan G., Rodrigues V.;
"Mutants in phospholipid signaling attenuate the behavioral response
of adult Drosophila to trehalose.";
Chem. Senses 35:663-673(2010).
-!- FUNCTION: Gustatory receptor required for response to the sugar
trehalose in taste neurons. Gr5a neurons selectively respond to
sugars, in contrast to Gr66a cells which respond to bitter
compounds. Flies are attracted to sugars and avoid bitter
substances, suggesting that Gr5a neuron activity is sufficient to
mediate acceptance behavior. Sugar signal transduction occurs
through coupling with G-proteins such as Galpha49B and G-
salpha60A. {ECO:0000269|PubMed:11566105,
ECO:0000269|PubMed:11704765, ECO:0000269|PubMed:14523229,
ECO:0000269|PubMed:15202999, ECO:0000269|PubMed:15342513,
ECO:0000269|PubMed:15738154, ECO:0000269|PubMed:16423701,
ECO:0000269|PubMed:16763022, ECO:0000269|PubMed:17988633,
ECO:0000269|PubMed:20543015}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in labellar chemosensory neurons.
{ECO:0000269|PubMed:11704765, ECO:0000269|PubMed:14523229,
ECO:0000269|PubMed:15202999}.
-!- DISRUPTION PHENOTYPE: Flies exhibit trehalose-specific
physiological and behavioral defects (reduced response by
chemosensory neurons of the labellar taste hairs).
{ECO:0000269|PubMed:11566105, ECO:0000269|PubMed:15738154,
ECO:0000269|PubMed:16763022}.
-!- MISCELLANEOUS: Variant Thr-218 was found to be the ancestral form
in D.melanogaster, suggesting that low trehalose sensitivity was
an ancestral form with respect to the receptor function.
-!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
Gustatory receptor (GR) family. Gr5a subfamily. {ECO:0000305}.
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EMBL; AB066619; BAB68243.1; -; Genomic_DNA.
EMBL; AB066620; BAB68244.1; -; Genomic_DNA.
EMBL; AB066621; BAB68245.1; -; Genomic_DNA.
EMBL; AB066622; BAB68246.1; -; Genomic_DNA.
EMBL; AB066623; BAB68247.1; -; Genomic_DNA.
EMBL; AB066624; BAB68248.1; -; Genomic_DNA.
EMBL; AB066625; BAB68249.1; -; Genomic_DNA.
EMBL; AB066626; BAB68250.1; -; Genomic_DNA.
EMBL; AB066627; BAB68251.1; -; Genomic_DNA.
EMBL; AB066628; BAB68252.1; -; Genomic_DNA.
EMBL; AB066629; BAB68253.1; -; Genomic_DNA.
EMBL; AB066630; BAB68254.1; -; Genomic_DNA.
EMBL; AB066631; BAB68255.1; -; Genomic_DNA.
EMBL; AB066632; BAB68256.1; -; Genomic_DNA.
EMBL; AB066633; BAB68257.1; -; Genomic_DNA.
EMBL; AB066634; BAB68258.1; -; Genomic_DNA.
EMBL; AB066635; BAB68259.1; -; Genomic_DNA.
EMBL; AB066636; BAB68260.1; -; Genomic_DNA.
EMBL; AB066637; BAB68261.1; -; Genomic_DNA.
EMBL; AB066638; BAB68262.1; -; Genomic_DNA.
EMBL; AB066639; BAB68263.1; -; Genomic_DNA.
EMBL; AB066640; BAB68264.1; -; Genomic_DNA.
EMBL; AB066641; BAB68265.1; -; mRNA.
EMBL; AB066642; BAB68266.1; -; mRNA.
EMBL; AB066643; BAB68267.1; -; mRNA.
EMBL; AB162449; BAD42667.1; -; Genomic_DNA.
EMBL; AB162450; BAD42668.1; -; Genomic_DNA.
EMBL; AB162451; BAD42669.1; -; Genomic_DNA.
EMBL; AB162452; BAD42670.1; -; Genomic_DNA.
EMBL; AB162453; BAD42671.1; -; Genomic_DNA.
EMBL; AB162454; BAD42672.1; -; Genomic_DNA.
EMBL; AB162455; BAD42673.1; -; Genomic_DNA.
EMBL; AB162456; BAD42674.1; -; Genomic_DNA.
EMBL; AB162457; BAD42675.1; -; Genomic_DNA.
EMBL; AB162458; BAD42676.1; -; Genomic_DNA.
EMBL; AB162459; BAD42677.1; -; Genomic_DNA.
EMBL; AB162460; BAD42678.1; -; Genomic_DNA.
EMBL; AB162461; BAD42679.1; -; Genomic_DNA.
EMBL; AB162462; BAD42680.1; -; Genomic_DNA.
EMBL; AB162463; BAD42681.1; -; Genomic_DNA.
EMBL; AB162464; BAD42682.1; -; Genomic_DNA.
EMBL; AB162465; BAD42683.1; -; Genomic_DNA.
EMBL; AB162466; BAD42684.1; -; Genomic_DNA.
EMBL; AB162467; BAD42685.1; -; Genomic_DNA.
EMBL; AB162468; BAD42686.1; -; Genomic_DNA.
EMBL; AB162469; BAD42687.1; -; Genomic_DNA.
EMBL; AB162470; BAD42688.1; -; Genomic_DNA.
EMBL; AB162471; BAD42689.1; -; Genomic_DNA.
EMBL; AB162472; BAD42690.1; -; Genomic_DNA.
EMBL; AB162473; BAD42691.1; -; Genomic_DNA.
EMBL; AB162474; BAD42692.1; -; Genomic_DNA.
EMBL; AB162475; BAD42693.1; -; Genomic_DNA.
EMBL; AB162476; BAD42694.1; -; Genomic_DNA.
EMBL; AB162477; BAD42695.1; -; Genomic_DNA.
EMBL; AB162478; BAD42696.1; -; Genomic_DNA.
EMBL; AB162479; BAD42697.1; -; Genomic_DNA.
EMBL; AB162480; BAD42698.1; -; Genomic_DNA.
EMBL; AB162481; BAD42699.1; -; Genomic_DNA.
EMBL; AB162482; BAD42700.1; -; Genomic_DNA.
EMBL; AB162483; BAD42701.1; -; Genomic_DNA.
EMBL; AB162484; BAD42702.1; -; Genomic_DNA.
EMBL; AB162485; BAD42703.1; -; Genomic_DNA.
EMBL; AB162486; BAD42704.1; -; Genomic_DNA.
EMBL; AB162487; BAD42705.1; -; Genomic_DNA.
EMBL; AB162488; BAD42706.1; -; Genomic_DNA.
EMBL; AB162489; BAD42707.1; -; Genomic_DNA.
EMBL; AB162490; BAD42708.1; -; Genomic_DNA.
EMBL; AB162491; BAD42709.1; -; Genomic_DNA.
EMBL; AB162492; BAD42710.1; -; Genomic_DNA.
EMBL; AB162493; BAD42711.1; -; Genomic_DNA.
EMBL; AB162494; BAD42712.1; -; Genomic_DNA.
EMBL; AB162495; BAD42713.1; -; Genomic_DNA.
EMBL; AB162496; BAD42714.1; -; Genomic_DNA.
EMBL; AB162497; BAD42715.1; -; Genomic_DNA.
EMBL; AB162498; BAD42716.1; -; Genomic_DNA.
EMBL; AB162499; BAD42717.1; -; Genomic_DNA.
EMBL; AB162500; BAD42718.1; -; Genomic_DNA.
EMBL; AB162501; BAD42719.1; -; Genomic_DNA.
EMBL; AB162502; BAD42720.1; -; Genomic_DNA.
EMBL; AB162503; BAD42721.1; -; Genomic_DNA.
EMBL; AB162504; BAD42722.1; -; Genomic_DNA.
EMBL; AB162505; BAD42723.1; -; Genomic_DNA.
EMBL; AB162506; BAD42724.1; -; Genomic_DNA.
EMBL; AB162507; BAD42725.1; -; Genomic_DNA.
EMBL; AB162508; BAD42726.1; -; Genomic_DNA.
EMBL; AB162509; BAD42727.1; -; Genomic_DNA.
EMBL; AB162510; BAD42728.1; -; Genomic_DNA.
EMBL; AB162511; BAD42729.1; -; Genomic_DNA.
EMBL; AB162512; BAD42730.1; -; Genomic_DNA.
EMBL; AB162513; BAD42731.1; -; Genomic_DNA.
EMBL; AB162514; BAD42732.1; -; Genomic_DNA.
EMBL; AB162515; BAD42733.1; -; Genomic_DNA.
EMBL; AB162516; BAD42734.1; -; Genomic_DNA.
EMBL; AB162517; BAD42735.1; -; Genomic_DNA.
EMBL; AB162518; BAD42736.1; -; Genomic_DNA.
EMBL; AB162519; BAD42737.1; -; Genomic_DNA.
EMBL; AB162520; BAD42738.1; -; Genomic_DNA.
EMBL; AB162521; BAD42739.1; -; Genomic_DNA.
EMBL; AB162522; BAD42740.1; -; Genomic_DNA.
EMBL; AB162523; BAD42741.1; -; Genomic_DNA.
EMBL; AB162524; BAD42742.1; -; Genomic_DNA.
EMBL; AB162525; BAD42743.1; -; Genomic_DNA.
EMBL; AB162526; BAD42744.1; -; Genomic_DNA.
EMBL; AB162527; BAD42745.1; -; Genomic_DNA.
EMBL; AB162528; BAD42746.1; -; Genomic_DNA.
EMBL; AB162529; BAD42747.1; -; Genomic_DNA.
EMBL; AB162530; BAD42748.1; -; Genomic_DNA.
EMBL; AB162531; BAD42749.1; -; Genomic_DNA.
EMBL; AB162532; BAD42750.1; -; Genomic_DNA.
EMBL; AB162533; BAD42751.1; -; Genomic_DNA.
EMBL; AB162534; BAD42752.1; -; Genomic_DNA.
EMBL; AB162535; BAD42753.1; -; Genomic_DNA.
EMBL; AB162536; BAD42754.1; -; Genomic_DNA.
EMBL; AB162537; BAD42755.1; -; Genomic_DNA.
EMBL; AB162538; BAD42756.1; -; Genomic_DNA.
EMBL; AB162539; BAD42757.1; -; Genomic_DNA.
EMBL; AB162540; BAD42758.1; -; Genomic_DNA.
EMBL; AB162541; BAD42759.1; -; Genomic_DNA.
EMBL; AB162542; BAD42760.1; -; Genomic_DNA.
EMBL; AB162543; BAD42761.1; -; Genomic_DNA.
EMBL; AB162544; BAD42762.1; -; Genomic_DNA.
EMBL; AB162545; BAD42763.1; -; Genomic_DNA.
EMBL; AB162546; BAD42764.1; -; Genomic_DNA.
EMBL; AB162547; BAD42765.1; -; Genomic_DNA.
EMBL; AB162548; BAD42766.1; -; Genomic_DNA.
EMBL; AB162549; BAD42767.1; -; Genomic_DNA.
EMBL; AB162550; BAD42768.1; -; Genomic_DNA.
EMBL; AB162551; BAD42769.1; -; Genomic_DNA.
EMBL; AB162552; BAD42770.1; -; Genomic_DNA.
EMBL; AB162553; BAD42771.1; -; Genomic_DNA.
EMBL; AB162555; BAD42773.1; -; Genomic_DNA.
EMBL; AB162554; BAD42772.1; -; Genomic_DNA.
EMBL; AB162556; BAD42774.1; -; Genomic_DNA.
EMBL; AB162557; BAD42775.1; -; Genomic_DNA.
EMBL; AB162558; BAD42776.1; -; Genomic_DNA.
EMBL; AB162559; BAD42777.1; -; Genomic_DNA.
EMBL; AB162560; BAD42778.1; -; Genomic_DNA.
EMBL; AB162561; BAD42779.1; -; Genomic_DNA.
EMBL; AB162562; BAD42780.1; -; Genomic_DNA.
EMBL; AB162563; BAD42781.1; -; Genomic_DNA.
EMBL; AB162564; BAD42782.1; -; Genomic_DNA.
EMBL; AB162565; BAD42783.1; -; Genomic_DNA.
EMBL; AB162566; BAD42784.1; -; Genomic_DNA.
EMBL; AB162567; BAD42785.1; -; Genomic_DNA.
EMBL; AB162568; BAD42786.1; -; Genomic_DNA.
EMBL; AB162569; BAD42787.1; -; Genomic_DNA.
EMBL; AB162570; BAD42788.1; -; Genomic_DNA.
EMBL; AB162571; BAD42789.1; -; Genomic_DNA.
EMBL; AB162572; BAD42790.1; -; Genomic_DNA.
EMBL; AB162573; BAD42791.1; -; Genomic_DNA.
EMBL; AB162574; BAD42792.1; -; Genomic_DNA.
EMBL; AB162575; BAD42793.1; -; Genomic_DNA.
EMBL; AB162576; BAD42794.1; -; Genomic_DNA.
EMBL; AB162577; BAD42795.1; -; Genomic_DNA.
EMBL; AB162578; BAD42796.1; -; Genomic_DNA.
EMBL; AB162579; BAD42797.1; -; Genomic_DNA.
EMBL; AB162580; BAD42798.1; -; Genomic_DNA.
EMBL; AB162581; BAD42799.1; -; Genomic_DNA.
EMBL; AB162582; BAD42800.1; -; Genomic_DNA.
EMBL; AB162583; BAD42801.1; -; Genomic_DNA.
EMBL; AB162584; BAD42802.1; -; Genomic_DNA.
EMBL; AB162585; BAD42803.1; -; Genomic_DNA.
EMBL; AB162586; BAD42804.1; -; Genomic_DNA.
EMBL; AB162587; BAD42805.1; -; Genomic_DNA.
EMBL; AB162588; BAD42806.1; -; Genomic_DNA.
EMBL; AB162589; BAD42807.1; -; Genomic_DNA.
EMBL; AB162590; BAD42808.1; -; Genomic_DNA.
EMBL; AB162591; BAD42809.1; -; Genomic_DNA.
EMBL; AB162592; BAD42810.1; -; Genomic_DNA.
EMBL; AB162593; BAD42811.1; -; Genomic_DNA.
EMBL; AB162594; BAD42812.1; -; Genomic_DNA.
EMBL; AB162595; BAD42813.1; -; Genomic_DNA.
EMBL; AB162596; BAD42814.1; -; Genomic_DNA.
EMBL; AB162597; BAD42815.1; -; Genomic_DNA.
EMBL; AB162598; BAD42816.1; -; Genomic_DNA.
EMBL; AB162599; BAD42817.1; -; Genomic_DNA.
EMBL; AB162600; BAD42818.1; -; Genomic_DNA.
EMBL; AE014298; AAF46060.1; -; Genomic_DNA.
RefSeq; NP_511050.1; NM_078495.3.
UniGene; Dm.19453; -.
SMR; Q9W497; -.
BioGrid; 69345; 2.
DIP; DIP-22363N; -.
IntAct; Q9W497; 1.
STRING; 7227.FBpp0070768; -.
PaxDb; Q9W497; -.
PRIDE; Q9W497; -.
GeneID; 44873; -.
KEGG; dme:Dmel_CG15779; -.
CTD; 44873; -.
FlyBase; FBgn0003747; Gr5a.
eggNOG; ENOG410IWIQ; Eukaryota.
eggNOG; ENOG4111FN9; LUCA.
InParanoid; Q9W497; -.
KO; K08471; -.
OrthoDB; EOG091G0FRV; -.
PhylomeDB; Q9W497; -.
GenomeRNAi; 44873; -.
PRO; PR:Q9W497; -.
Proteomes; UP000000803; Chromosome X.
Bgee; FBgn0003747; -.
ExpressionAtlas; Q9W497; differential.
Genevisible; Q9W497; DM.
GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0033041; F:sweet taste receptor activity; IMP:FlyBase.
GO; GO:0008527; F:taste receptor activity; IMP:UniProtKB.
GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; IMP:UniProtKB.
GO; GO:0050912; P:detection of chemical stimulus involved in sensory perception of taste; IDA:FlyBase.
GO; GO:0007637; P:proboscis extension reflex; IMP:FlyBase.
GO; GO:0010353; P:response to trehalose; IMP:FlyBase.
GO; GO:0050916; P:sensory perception of sweet taste; IMP:FlyBase.
GO; GO:0050909; P:sensory perception of taste; IDA:FlyBase.
InterPro; IPR009318; Gustatory_rcpt.
PANTHER; PTHR21421; PTHR21421; 1.
Pfam; PF06151; Trehalose_recp; 1.
PIRSF; PIRSF038981; GRP; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Membrane; Polymorphism; Receptor;
Reference proteome; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 444 Gustatory receptor 5a for trehalose.
/FTId=PRO_0000216486.
TOPO_DOM 1 56 Cytoplasmic. {ECO:0000250}.
TRANSMEM 57 77 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 78 178 Extracellular. {ECO:0000250}.
TRANSMEM 179 199 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 200 214 Cytoplasmic. {ECO:0000250}.
TRANSMEM 215 235 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 236 240 Extracellular. {ECO:0000250}.
TRANSMEM 241 261 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 262 305 Cytoplasmic. {ECO:0000250}.
TRANSMEM 306 326 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 327 338 Extracellular. {ECO:0000250}.
TRANSMEM 339 359 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 360 410 Cytoplasmic. {ECO:0000250}.
TRANSMEM 411 431 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 432 444 Extracellular. {ECO:0000250}.
VARIANT 5 5 K -> N (in strain: KY02-C351 and KY02-
C372).
VARIANT 19 19 I -> V (in strain: AK17, Berkeley,
Canton-S, EP(X)496, KY02-C304, KY02-C305,
KY02-C312, KY02-C341, KY02-C419, KY02-
C470 and w cx).
VARIANT 23 23 M -> I (in strain: KY02-C331, KY02-C392
and Oregon-R).
VARIANT 59 59 P -> S (in strain: KY02-C493).
VARIANT 73 73 C -> S (in strain: KY02-C301, KY02-C302,
KY02-C308, KY02-C309, KY02-C310, KY02-
C311, KY02-C314, KY02-C315, KY02-C319,
KY02-C320, KY02-C325, KY02-C327, KY02-
C330, KY02-C332, KY02-C335, KY02-C337,
KY02-C342, KY02-C343, KY02-C344, KY02-
C346, KY02-C347, KY02-C349, KY02-C351,
KY02-C352, KY02-C353, KY02-C355, KY02-
C358, KY02-C361, KY02-C367, KY02-C368,
KY02-C372, KY02-C374, KY02-C376, KY02-
C377, KY02-C378, KY02-C379, KY02-C380,
KY02-C381, KY02-C382, KY02-C383, KY02-
C384, KY02-C388, KY02-C389, KY02-C390,
KY02-C393, KY02-C396, KY02-C400, KY02-
C402, KY02-C404, KY02-C411, KY02-C412,
KY02-C413, KY02-C414, KY02-C420, KY02-
C425, KY02-C426, KY02-C429, KY02-C432,
KY02-C433, KY02-C434, KY02-C435, KY02-
C436, KY02-C439, KY02-C441, KY02-C446,
KY02-C447, KY02-C449, KY02-C451, KY02-
C453, KY02-C457, KY02-C460, KY02-C462,
KY02-C463, KY02-C467, KY02-C469, KY02-
C476, KY02-C477, KY02-C480, KY02-C483,
KY02-C484, KY02-C485, KY02-C486, KY02-
C488, KY02-C490, KY02-C491, KY02-C492,
KY02-C493, KY02-C494, KY02-C496, KY02-
C497, KY02-C500, KY02-C504, KY02-C508,
KY02-C510, KY02-C511, KY02-C514, KY02-
C515, KY02-C516, KY02-C517, KY02-C519,
KY02-C520 and Singapore).
VARIANT 164 164 T -> A (in strain: KY02-C302, KY02-C316,
KY02-C346, KY02-C350, KY02-C351, KY02-
C374, KY02-C379, KY02-C380, KY02-C384,
KY02-C390, KY02-C396, KY02-C407, KY02-
C425, KY02-C428, KY02-C439, KY02-C443,
KY02-C456, KY02-C463, KY02-C478, KY02-
C493, KY02-C497, KY02-C500, KY02-C504,
KY02-C517 and Singapore).
VARIANT 185 185 V -> I (in strain: KY02-C336).
VARIANT 216 216 L -> H (in strain: AK10, KY02-C315, KY02-
C335, KY02-C402, KY02-C469, KY02-C516,
KY02-C310, KY02-C319, KY02-C320, KY02-
C330, KY02-C336, KY02-C342, KY02-C347,
KY02-C355, KY02-C358, KY02-C382, KY02-
C393, KY02-C404, KY02-C411, KY02-C432,
KY02-C435, KY02-C449, KY02-C467, KY02-
C483, KY02-C486, KY02-C488, KY02-C492,
KY02-C496, KY02-C514, KY02-C519,
Tananarive and w cv).
VARIANT 218 218 A -> T (in strain: AK07, AK10, AK13,
KY02-C351, KY02-C439, KY02-C510, KY02-
C301, KY02-C302, KY02-C303, KY02-C304,
KY02-C308, KY02-C310, KY02-C311, KY02-
C315, KY02-C316, KY02-C319, KY02-C320,
KY02-C325, KY02-C326, KY02-C330, KY02-
C331, KY02-C332, KY02-C335, KY02-C336,
KY02-C341, KY02-C342, KY02-C346, KY02-
C347, KY02-C348, KY02-C349, KY02-C350,
KY02-C352, KY02-C355, KY02-C356, KY02-
C358, KY02-C359, KY02-C361, KY02-C362,
KY02-C367, KY02-C372, KY02-C373, KY02-
C374, KY02-C376, KY02-C378, KY02-C380,
KY02-C382, KY02-C383, KY02-C384, KY02-
C387, KY02-C388, KY02-C390, KY02-C392,
KY02-C393, KY02-C394, KY02-C400, KY02-
C402, KY02-C404, KY02-C407, KY02-C411,
KY02-C412, KY02-C413, KY02-C417, KY02-
C419, KY02-C421, KY02-C426, KY02-C428,
KY02-C432, KY02-C433, KY02-C434, KY02-
C435, KY02-C441, KY02-C443, KY02-C446,
KY02-C449, KY02-C451, KY02-C453, KY02-
C454, KY02-C456, KY02-C457, KY02-C460,
KY02-C462, KY02-C463, KY02-C467, KY02-
C469, KY02-C470, KY02-C477, KY02-C478,
KY02-C480, KY02-C483, KY02-C484, KY02-
C485, KY02-C486, KY02-C488, KY02-C489,
KY02-C490, KY02-C492, KY02-C493, KY02-
C494, KY02-C496, KY02-C497, KY02-C500,
KY02-C504, KY02-C511, KY02-C513, KY02-
C514, KY02-C515, KY02-C516, KY02-C517,
KY02-C519, KY02-C520, Oregon-R,
Singapore, Tananarive and w cv; decreased
sensitivity to trehalose).
{ECO:0000269|PubMed:15342513}.
VARIANT 248 248 S -> N (in strain: KY02-C316, KY02-C350,
KY02-C428, KY02-C443, KY02-C456 and KY02-
C478).
VARIANT 277 277 R -> L (in strain: KY02-C304, KY02-C341,
KY02-C419 and KY02-C470).
VARIANT 333 333 P -> S (in strain: KY02-C326, KY02-C348,
KY02-C359, KY02-C362, KY02-C373, KY02-
C394, KY02-C417, KY02-C434, KY02-C448,
KY02-C451, KY02-C477 and KY02-C513).
CONFLICT 25 36 LKNLKSGLEQIR -> MSTFILITFYNP (in Ref. 2).
{ECO:0000305}.
SEQUENCE 444 AA; 51169 MW; 1CFD82924C0FF97F CRC64;
MRQLKGRNRC NRAVRHLKIQ GKMWLKNLKS GLEQIRESQV RGTRKNFLHD GSFHEAVAPV
LAVAQCFCLM PVCGISAPTY RGLSFNRRSW RFWYSSLYLC STSVDLAFSI RRVAHSVLDV
RSVEPIVFHV SILIASWQFL NLAQLWPGLM RHWAAVERRL PGYTCCLQRA RPARRLKLVA
FVLLVVSLME HLLSIISVVY YDFCPRRSDP VESYLLGASA QLFEVFPYSN WLAWLGKIQN
VLLTFGWSYM DIFLMMLGMG LSEMLARLNR SLEQQVRQPM PEAYWTWSRT LYRSIVELIR
EVDDAVSGIM LISFGSNLYF ICLQLLKSIN TMPSSAHAVY FYFSLLFLLS RSTAVLLFVS
AINDQAREPL RLLRLVPLKG YHPEVFRFAA ELASDQVALT GLKFFNVTRK LFLAMAGTVA
TYELVLIQFH EDKKTWDCSP FNLD


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