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Gustatory receptor for sugar taste 43a

 GR43A_DROME             Reviewed;         427 AA.
Q9V4K2; Q4V4B7;
02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
10-MAY-2004, sequence version 3.
27-SEP-2017, entry version 115.
RecName: Full=Gustatory receptor for sugar taste 43a;
Name=Gr43a; Synonyms=GR43.1; ORFNames=CG1712;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley;
Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A.,
Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
[4]
IDENTIFICATION, AND TISSUE SPECIFICITY.
PubMed=10710312; DOI=10.1126/science.287.5459.1830;
Clyne P.J., Warr C.G., Carlson J.R.;
"Candidate taste receptors in Drosophila.";
Science 287:1830-1834(2000).
[5]
IDENTIFICATION.
PubMed=11516643; DOI=10.1016/S0960-9822(01)00258-5;
Dunipace L., Meister S., McNealy C., Amrein H.;
"Spatially restricted expression of candidate taste receptors in the
Drosophila gustatory system.";
Curr. Biol. 11:822-835(2001).
[6]
TISSUE SPECIFICITY.
PubMed=22031876; DOI=10.1523/JNEUROSCI.3363-11.2011;
Kwon J.Y., Dahanukar A., Weiss L.A., Carlson J.R.;
"Molecular and cellular organization of the taste system in the
Drosophila larva.";
J. Neurosci. 31:15300-15309(2011).
[7]
FUNCTION.
PubMed=21709218; DOI=10.1073/pnas.1019622108;
Sato K., Tanaka K., Touhara K.;
"Sugar-regulated cation channel formed by an insect gustatory
receptor.";
Proc. Natl. Acad. Sci. U.S.A. 108:11680-11685(2011).
[8]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=23178127; DOI=10.1016/j.cell.2012.10.024;
Miyamoto T., Slone J., Song X., Amrein H.;
"A fructose receptor functions as a nutrient sensor in the Drosophila
brain.";
Cell 151:1113-1125(2012).
[9]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=23850280; DOI=10.1016/j.cub.2013.06.028;
Mishra D., Miyamoto T., Rezenom Y.H., Broussard A., Yavuz A.,
Slone J., Russell D.H., Amrein H.;
"The molecular basis of sugar sensing in Drosophila larvae.";
Curr. Biol. 23:1466-1471(2013).
-!- FUNCTION: Gustatory receptor which mediates acceptance or
avoidance behavior, depending on its substrates. Gr43a is the main
sugar receptor in larvae. Functions as a narrowly tuned fructose
receptor in taste neurons but also as a fructose receptor in the
brain. Necessary and sufficient to sense hemolymph fructose and
promote feeding in hungry flies but suppress feeding in satiated
flies. {ECO:0000269|PubMed:21709218, ECO:0000269|PubMed:23178127,
ECO:0000269|PubMed:23850280}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in the adult labellar chemosensory
neurons and in the adult head, abdomen, leg and wing. In larvae,
is expressed in taste organs, as well as the brain and the
gastrointestinal system. {ECO:0000269|PubMed:10710312,
ECO:0000269|PubMed:22031876, ECO:0000269|PubMed:23178127,
ECO:0000269|PubMed:23850280}.
-!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
Gustatory receptor (GR) family. Gr21a subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AE013599; AAF59268.3; -; Genomic_DNA.
EMBL; BT023089; AAY55505.1; -; mRNA.
RefSeq; NP_523650.2; NM_078926.3.
UniGene; Dm.26868; -.
BioGrid; 61536; 1.
DIP; DIP-22568N; -.
IntAct; Q9V4K2; 1.
MINT; MINT-821566; -.
STRING; 7227.FBpp0110117; -.
TCDB; 1.A.69.3.2; the heteromeric odorant receptor channel (horc) family.
PaxDb; Q9V4K2; -.
PRIDE; Q9V4K2; -.
EnsemblMetazoa; FBtr0089014; FBpp0088086; FBgn0041243.
GeneID; 35655; -.
KEGG; dme:Dmel_CG1712; -.
CTD; 35655; -.
FlyBase; FBgn0041243; Gr43a.
eggNOG; ENOG410J1HW; Eukaryota.
eggNOG; ENOG4111ZS8; LUCA.
HOGENOM; HOG000263946; -.
InParanoid; Q9V4K2; -.
KO; K08471; -.
OrthoDB; EOG091G07Z2; -.
PhylomeDB; Q9V4K2; -.
GenomeRNAi; 35655; -.
PRO; PR:Q9V4K2; -.
Proteomes; UP000000803; Chromosome 2R.
Bgee; FBgn0041243; -.
ExpressionAtlas; Q9V4K2; differential.
Genevisible; Q9V4K2; DM.
GO; GO:0030424; C:axon; IBA:GO_Central.
GO; GO:0030425; C:dendrite; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0033041; F:sweet taste receptor activity; IMP:FlyBase.
GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
GO; GO:0008343; P:adult feeding behavior; IMP:FlyBase.
GO; GO:0071332; P:cellular response to fructose stimulus; IMP:FlyBase.
GO; GO:0007635; P:chemosensory behavior; IBA:GO_Central.
GO; GO:0008049; P:male courtship behavior; IBA:GO_Central.
GO; GO:0032098; P:regulation of appetite; IMP:FlyBase.
GO; GO:0060259; P:regulation of feeding behavior; IMP:FlyBase.
GO; GO:0010037; P:response to carbon dioxide; IBA:GO_Central.
GO; GO:0050913; P:sensory perception of bitter taste; IBA:GO_Central.
GO; GO:0050916; P:sensory perception of sweet taste; IMP:FlyBase.
GO; GO:0050909; P:sensory perception of taste; NAS:UniProtKB.
InterPro; IPR013604; 7TM_chemorcpt.
Pfam; PF08395; 7tm_7; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Glycoprotein; Membrane; Receptor;
Reference proteome; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 427 Gustatory receptor for sugar taste 43a.
/FTId=PRO_0000216514.
TOPO_DOM 1 2 Cytoplasmic. {ECO:0000250}.
TRANSMEM 3 23 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 24 33 Extracellular. {ECO:0000250}.
TRANSMEM 34 54 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 55 81 Cytoplasmic. {ECO:0000250}.
TRANSMEM 82 102 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 103 131 Extracellular. {ECO:0000250}.
TRANSMEM 132 152 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 153 171 Cytoplasmic. {ECO:0000250}.
TRANSMEM 172 192 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 193 295 Extracellular. {ECO:0000250}.
TRANSMEM 296 316 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 317 402 Cytoplasmic. {ECO:0000250}.
TRANSMEM 403 423 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 424 427 Extracellular. {ECO:0000250}.
CARBOHYD 103 103 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 219 219 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 234 234 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 427 AA; 47573 MW; 19928FBA374AABAB CRC64;
MEISQPSIGI FYISKVLALA PYATVRNSKG RVEIGRSWLF TVYSATLTVV MVFLTYRGLL
FDANSEIPVR MKSATSKVVT ALDVSVVVMA IVSGVYCGLF SLNDTLELND RLNKIDNTLN
AYNNFRRDRW RALGMAAVSL LAISILVGLD VGTWMRIAQD MNIAQSDTEL NVHWYIPFYS
LYFILTGLQV NIANTAYGLG RRFGRLNRML SSSFLAENNA TSAIKPQKVS TVKNVSVNRP
AMPSALHASL TKLNGETLPS EAAAKNKGLL LKSLADSHES LGKCVHLLSN SFGIAVLFIL
VSCLLHLVAT AYFLFLELLS KRDNGYLWVQ MLWICFHFLR LLMVVEPCHL AARESRKTIQ
IVCEIERKVH EPILAEAVKK FWQQLLVVDA DFSACGLCRV NRTILTSFAS AIATYLVILI
QFQRTNG


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