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H-2 class I histocompatibility antigen, alpha chain (Clone PAG64) (Fragment)

 HA1Y_MOUSE              Reviewed;         298 AA.
P01895;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
23-MAY-2018, entry version 139.
RecName: Full=H-2 class I histocompatibility antigen, alpha chain;
AltName: Full=Clone PAG64;
Flags: Fragment;
Name=H2-D1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-285 (CLONE PAG64).
PubMed=6318117; DOI=10.1038/306756a0;
Brickell P.M., Latchman D.S., Murphy D., Willison K., Rigby P.W.J.;
"Activation of a Qa/Tla class I major histocompatibility antigen gene
is a general feature of oncogenesis in the mouse.";
Nature 306:756-760(1983).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 90-298 (CLONE PH-2D-1).
PubMed=6895103; DOI=10.1038/292078a0;
Bregegere F., Abastado J.P., Kvist S., Rask L., Lalanne J.-L.,
Garoff H., Cami B., Wiman K.G., Larhammar D., Peterson P.A.,
Gachelin G., Kourilsky P., Dobberstein B.;
"Structure of C-terminal half of two H-2 antigens from cloned mRNA.";
Nature 292:78-81(1981).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-292, VARIANT
[LARGE SCALE ANALYSIS] GLY-285, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[4]
VARIANT [LARGE SCALE ANALYSIS] GLY-285, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Involved in the presentation of foreign antigens to the
immune system.
-!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
microglobulin).
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P01895-1; Sequence=Displayed;
Name=2;
IsoId=P01895-2; Sequence=VSP_003228;
Note=Exon 7 is missing.;
-!- MISCELLANEOUS: The antigen encoded by the PAG64 clone, normally
expressed only on lymphocyte subsets and thymocytes, is found in
increased concentrations in all transformed cells tested, in an
embryonic carcinoma cell line, and in pluripotent embryonic cells.
Activation of the gene appears to be a general feature of
carcinogenesis in the mouse. The PAG64 clone, and related cDNA
clones, have in common a repetitive sequence in their 3'
transcription units that has characteristics of a transposable
element.
-!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
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EMBL; X00246; CAA25061.1; -; mRNA.
PIR; A93322; HLMS1.
UniGene; Mm.439675; -.
ProteinModelPortal; P01895; -.
SMR; P01895; -.
iPTMnet; P01895; -.
MaxQB; P01895; -.
PeptideAtlas; P01895; -.
PRIDE; P01895; -.
MGI; MGI:95896; H2-D1.
HOVERGEN; HBG016709; -.
ChiTaRS; H2-D1; mouse.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_H2-D1; -.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
GO; GO:0070971; C:endoplasmic reticulum exit site; ISO:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
GO; GO:0005797; C:Golgi medial cisterna; ISO:MGI.
GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0042612; C:MHC class I protein complex; ISO:MGI.
GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0030881; F:beta-2-microglobulin binding; ISO:MGI.
GO; GO:0042605; F:peptide antigen binding; ISO:MGI.
GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
GO; GO:0042608; F:T cell receptor binding; ISO:MGI.
GO; GO:0046977; F:TAP binding; ISO:MGI.
GO; GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0010977; P:negative regulation of neuron projection development; IDA:MGI.
GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 3.30.500.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003006; Ig/MHC_CS.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR011161; MHC_I-like_Ag-recog.
InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
InterPro; IPR011162; MHC_I/II-like_Ag-recog.
InterPro; IPR001039; MHC_I_a_a1/a2.
InterPro; IPR010579; MHC_I_a_C.
Pfam; PF07654; C1-set; 1.
Pfam; PF00129; MHC_I; 1.
Pfam; PF06623; MHC_I_C; 1.
PRINTS; PR01638; MHCCLASSI.
SMART; SM00407; IGc1; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF54452; SSF54452; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00290; IG_MHC; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
Immunity; Membrane; MHC I; Phosphoprotein; Reference proteome;
Transmembrane; Transmembrane helix.
CHAIN <1 298 H-2 class I histocompatibility antigen,
alpha chain.
/FTId=PRO_0000080742.
TOPO_DOM <1 244 Extracellular. {ECO:0000255}.
TRANSMEM 245 265 Helical. {ECO:0000255}.
TOPO_DOM 266 298 Cytoplasmic. {ECO:0000255}.
DOMAIN 142 230 Ig-like C1-type.
MOD_RES 289 289 Phosphoserine.
{ECO:0000244|PubMed:19144319}.
MOD_RES 292 292 Phosphoserine.
{ECO:0000244|PubMed:19144319}.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 133 133 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 58 121 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 160 216 {ECO:0000255|PROSITE-ProRule:PRU00114}.
VAR_SEQ 286 298 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_003228.
VARIANT 212 212 Q -> L (in clone PH-2D-1).
VARIANT 223 223 Missing (in clone PH-2D-1).
VARIANT 285 285 V -> G (in clone PH-2D-1).
{ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
NON_TER 1 1
SEQUENCE 298 AA; 33850 MW; 7F9CE29A053B06FB CRC64;
RYEPRARWIE QEGPEYWERE TRRAKGNEQS FRVDLRTALR YYNQSAGGSH TLQWMAGCDV
ESDGRLLRGY WQFAYDGCDY IALNEDLKTW TAADMAAQIT RRKWEQAGAA ERDRAYLEGE
CVEWLRRYLK NGNATLLRTD PPKAHVTHHR RPEGDVTLRC WALGFYPADI TLTWQLNGEE
LTQEMELVET RPAGDGTFQK WASVVVPLGK EQKYTCHVEH EGLPEPLTLR WGKEEPPSST
KTNTVIIAVP VVLGAVVILG AVMAFVMKRR RNTGGKGGDY ALAPVSQSSD MSLPDCKV


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