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H2-K region expressed gene 2, rat orthologue (MHC class II region expressed gene KE2, isoform CRA_a) (Prefoldin subunit 6)

 Q6MGC4_RAT              Unreviewed;       127 AA.
Q6MGC4;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
18-JUL-2018, entry version 112.
SubName: Full=H2-K region expressed gene 2, rat orthologue {ECO:0000313|EMBL:CAE83922.1};
SubName: Full=MHC class II region expressed gene KE2, isoform CRA_a {ECO:0000313|EMBL:EDL96846.1};
SubName: Full=Prefoldin subunit 6 {ECO:0000313|Ensembl:ENSRNOP00000000553};
Name=Pfdn6 {ECO:0000313|Ensembl:ENSRNOP00000000553,
ECO:0000313|RGD:1303006};
Synonyms=AA926063 {ECO:0000313|RGD:1303006},
B3galt4 {ECO:0000313|RGD:1303006},
Cdk2ap1-ps1 {ECO:0000313|RGD:1303006},
Col11a2 {ECO:0000313|RGD:1303006}, Daxx {ECO:0000313|RGD:1303006},
Hsd17b8 {ECO:0000313|RGD:1303006}, Ke2 {ECO:0000313|EMBL:CAE83922.1},
Kifc1 {ECO:0000313|RGD:1303006},
LOC224733l-1 {ECO:0000313|RGD:1303006},
LOC224733l-2 {ECO:0000313|RGD:1303006},
Phf1 {ECO:0000313|RGD:1303006}, Rps25-ps1 {ECO:0000313|RGD:1303006},
RT1-A1 {ECO:0000313|RGD:1303006}, RT1-A2 {ECO:0000313|RGD:1303006},
RT1-A3 {ECO:0000313|RGD:1303006}, RT1-DOa {ECO:0000313|RGD:1303006},
RT1-Hb {ECO:0000313|RGD:1303006}, RT1-Ke4 {ECO:0000313|RGD:1303006},
Rxrb {ECO:0000313|RGD:1303006}, Sacm2l-ps1 {ECO:0000313|RGD:1303006},
Sacm2l-ps2 {ECO:0000313|RGD:1303006},
Sec61-ps {ECO:0000313|RGD:1303006}, Syngap1 {ECO:0000313|RGD:1303006};
ORFNames=rCG_61038 {ECO:0000313|EMBL:EDL96846.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE83922.1};
[1] {ECO:0000313|EMBL:CAE83922.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83922.1};
Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A.,
Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H.,
Sudbrak R., Reinhardt R.;
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:CAE83922.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83922.1};
PubMed=15060004; DOI=10.1101/gr.1987704;
Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T.,
Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
"The genomic sequence and comparative analysis of the rat major
histocompatibility complex.";
Genome Res. 14:631-639(2004).
[3] {ECO:0000313|Ensembl:ENSRNOP00000000553, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000000553,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[4] {ECO:0000313|EMBL:EDL96846.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL96846.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[5] {ECO:0000313|EMBL:EDL96846.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL96846.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|Ensembl:ENSRNOP00000000553}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000000553};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[7] {ECO:0000313|Ensembl:ENSRNOP00000075862}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075862};
Ensembl;
Submitted (DEC-2015) to UniProtKB.
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EMBL; AC128962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BX883042; CAE83922.1; -; Genomic_DNA.
EMBL; CH473988; EDL96846.1; -; Genomic_DNA.
EMBL; CH473988; EDL96847.1; -; Genomic_DNA.
RefSeq; NP_001158190.1; NM_001164718.1.
RefSeq; NP_997671.1; NM_212506.2.
UniGene; Rn.109; -.
STRING; 10116.ENSRNOP00000000553; -.
ChEMBL; CHEMBL2096; -.
Ensembl; ENSRNOT00000000553; ENSRNOP00000000553; ENSRNOG00000000473.
Ensembl; ENSRNOT00000092676; ENSRNOP00000075862; ENSRNOG00000000473.
GeneID; 309629; -.
KEGG; rno:309629; -.
UCSC; RGD:1303006; rat.
CTD; 10471; -.
RGD; 1303006; Pfdn6.
eggNOG; KOG3478; Eukaryota.
eggNOG; COG1382; LUCA.
GeneTree; ENSGT00390000010512; -.
HOGENOM; HOG000196242; -.
HOVERGEN; HBG000199; -.
KO; K04798; -.
OMA; IYKLTGP; -.
OrthoDB; EOG091G105E; -.
TreeFam; TF315166; -.
Proteomes; UP000002494; Chromosome 20.
Bgee; ENSRNOG00000000473; -.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
GO; GO:0051131; P:chaperone-mediated protein complex assembly; IBA:GO_Central.
GO; GO:0006457; P:protein folding; IBA:GO_Central.
Gene3D; 1.10.287.370; -; 1.
InterPro; IPR002777; PFD_beta-like.
InterPro; IPR009053; Prefoldin.
Pfam; PF01920; Prefoldin_2; 1.
1: Evidence at protein level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Proteomics identification {ECO:0000213|PeptideAtlas:Q6MGC4};
Reference proteome {ECO:0000313|Proteomes:UP000002494}.
COILED 2 36 {ECO:0000256|SAM:Coils}.
COILED 80 121 {ECO:0000256|SAM:Coils}.
SEQUENCE 127 AA; 14498 MW; B81EB0ADB312A9BF CRC64;
MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL DGSNVVFKLL
GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ SEQQRETLAQ LQQEFQRAQN
AKAPGKA


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