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H2-K region expressed gene 4, rat orthologue (RCG60794, isoform CRA_a) (Solute carrier family 39 (Zinc transporter), member 7) (Solute carrier family 39 member 7)

 Q6MGB4_RAT              Unreviewed;       468 AA.
Q6MGB4;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
18-JUL-2018, entry version 113.
SubName: Full=H2-K region expressed gene 4, rat orthologue {ECO:0000313|EMBL:CAE83932.1};
SubName: Full=RCG60794, isoform CRA_a {ECO:0000313|EMBL:EDL96824.1};
SubName: Full=Solute carrier family 39 (Zinc transporter), member 7 {ECO:0000313|EMBL:AAH79141.1};
SubName: Full=Solute carrier family 39 member 7 {ECO:0000313|Ensembl:ENSRNOP00000000541};
Name=Slc39a7 {ECO:0000313|EMBL:AAH79141.1,
ECO:0000313|Ensembl:ENSRNOP00000000541, ECO:0000313|RGD:1593280};
Synonyms=AA926063 {ECO:0000313|RGD:1593280},
B3galt4 {ECO:0000313|RGD:1593280},
Cdk2ap1-ps1 {ECO:0000313|RGD:1593280},
Col11a2 {ECO:0000313|RGD:1593280}, Daxx {ECO:0000313|RGD:1593280},
Hsd17b8 {ECO:0000313|RGD:1593280}, Ke4 {ECO:0000313|EMBL:CAE83932.1},
Kifc1 {ECO:0000313|RGD:1593280},
LOC224733l-1 {ECO:0000313|RGD:1593280},
LOC224733l-2 {ECO:0000313|RGD:1593280},
Phf1 {ECO:0000313|RGD:1593280}, Rps25-ps1 {ECO:0000313|RGD:1593280},
RT1-A1 {ECO:0000313|RGD:1593280}, RT1-A2 {ECO:0000313|RGD:1593280},
RT1-A3 {ECO:0000313|RGD:1593280}, RT1-DOa {ECO:0000313|RGD:1593280},
RT1-Hb {ECO:0000313|RGD:1593280}, RT1-Ke4 {ECO:0000313|RGD:1593280},
Rxrb {ECO:0000313|RGD:1593280}, Sacm2l-ps1 {ECO:0000313|RGD:1593280},
Sacm2l-ps2 {ECO:0000313|RGD:1593280},
Sec61-ps {ECO:0000313|RGD:1593280}, Syngap1 {ECO:0000313|RGD:1593280};
ORFNames=rCG_60794 {ECO:0000313|EMBL:EDL96824.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE83932.1};
[1] {ECO:0000313|EMBL:CAE83932.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83932.1};
Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A.,
Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H.,
Sudbrak R., Reinhardt R.;
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:CAE83932.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83932.1};
PubMed=15060004; DOI=10.1101/gr.1987704;
Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T.,
Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
"The genomic sequence and comparative analysis of the rat major
histocompatibility complex.";
Genome Res. 14:631-639(2004).
[3] {ECO:0000313|EMBL:AAH79141.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney {ECO:0000313|EMBL:AAH79141.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4] {ECO:0000313|Ensembl:ENSRNOP00000000541, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000000541,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[5] {ECO:0000313|EMBL:EDL96824.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL96824.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[6] {ECO:0000313|EMBL:EDL96824.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL96824.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|Ensembl:ENSRNOP00000000541}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000000541};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[8] {ECO:0000313|Ensembl:ENSRNOP00000071707}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071707};
Ensembl;
Submitted (JUN-2015) to UniProtKB.
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EMBL; AC098547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC079141; AAH79141.1; -; mRNA.
EMBL; BX883042; CAE83932.1; -; Genomic_DNA.
EMBL; CH473988; EDL96824.1; -; Genomic_DNA.
RefSeq; NP_001008885.1; NM_001008885.2.
RefSeq; NP_001158216.1; NM_001164744.1.
UniGene; Rn.103977; -.
STRING; 10116.ENSRNOP00000000541; -.
Ensembl; ENSRNOT00000000541; ENSRNOP00000000541; ENSRNOG00000000465.
Ensembl; ENSRNOT00000077357; ENSRNOP00000071707; ENSRNOG00000000465.
GeneID; 294281; -.
KEGG; rno:294281; -.
UCSC; RGD:1593280; rat.
CTD; 7922; -.
RGD; 1593280; Slc39a7.
eggNOG; KOG2693; Eukaryota.
eggNOG; COG0428; LUCA.
GeneTree; ENSGT00760000119115; -.
HOGENOM; HOG000185308; -.
HOVERGEN; HBG001037; -.
KO; K14713; -.
OMA; PWVLPFT; -.
OrthoDB; EOG091G0GD1; -.
TreeFam; TF318470; -.
Reactome; R-RNO-442380; Zinc influx into cells by the SLC39 gene family.
Proteomes; UP000002494; Chromosome 20.
Bgee; ENSRNOG00000000465; -.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
InterPro; IPR003689; ZIP.
Pfam; PF02535; Zip; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Membrane {ECO:0000256|SAM:Phobius};
Proteomics identification {ECO:0000213|PeptideAtlas:Q6MGB4};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 27 {ECO:0000256|SAM:SignalP}.
CHAIN 28 468 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015298584.
TRANSMEM 128 150 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 162 187 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 207 227 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 384 405 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 417 435 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 447 467 Helical. {ECO:0000256|SAM:Phobius}.
SEQUENCE 468 AA; 49499 MW; D8306CB026A079DB CRC64;
MARVLRDPHW VAVGLLTWAA LGLLVAGHEG HGDLHRDVEE DFHGHSHGHS HEDFHHGHSH
GHGHTHESIW HGHAHSHDHG HSREDVHHGH SHGHSHDSLH HRGHGHSHGA SREAGAPGIK
HHLDTVTLWA YALGATVLIS AAPFFVLFLI PVESNSPRHR SLLQILLSFA SGGLLGDAFL
HLIPHALEPH SHDTPAQPGH GHSHSGQGPI LSVGLWVLSG IVAFLVVEKF VRHVKGGHGH
AHAHGHGHSH GDSHAHGHSH AHGDRHECPS KGKPSSEDEK EAGGLRKRRG GDTGPRDGPL
KPQNPEEEKT GSDLRVSGYL NLAADLAHNF TDGLAIGASF RGGRGLGILT TMTVLLHEVP
HEVGDFAILV QSGCSKKQAM RLQLLTAIGA LAGTACALLT EGGAVGSEVA GGAGPGWVLP
FTAGGFIYVA TVSVLPELLR EASPLQSLLE VLGLLGGVAM MVLIAHLE


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