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HCLS1 isoform 1 (Hematopoietic cell-specific Lyn substrate 1)

 H2QN71_PANTR            Unreviewed;       484 AA.
H2QN71; A0A2J8M3N3;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
23-MAY-2018, entry version 39.
SubName: Full=HCLS1 isoform 1 {ECO:0000313|EMBL:PNI54127.1};
SubName: Full=Hematopoietic cell-specific Lyn substrate 1 {ECO:0000313|EMBL:JAA37087.1, ECO:0000313|Ensembl:ENSPTRP00000026335};
Name=HCLS1 {ECO:0000313|EMBL:JAA37087.1,
ECO:0000313|Ensembl:ENSPTRP00000026335};
ORFNames=CK820_G0023923 {ECO:0000313|EMBL:PNI54127.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000026335, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000026335, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000026335}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:JAA37087.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA37087.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:PNI54127.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI54127.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI54127.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; AACZ04048108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GABE01007652; JAA37087.1; -; mRNA.
EMBL; NBAG03000270; PNI54127.1; -; Genomic_DNA.
RefSeq; XP_009444536.1; XM_009446261.2.
STRING; 9598.ENSPTRP00000026335; -.
Ensembl; ENSPTRT00000028535; ENSPTRP00000026335; ENSPTRG00000015279.
GeneID; 460623; -.
KEGG; ptr:460623; -.
CTD; 3059; -.
eggNOG; ENOG410IFV2; Eukaryota.
eggNOG; ENOG410XTAK; LUCA.
GeneTree; ENSGT00530000062953; -.
KO; K06106; -.
OMA; YEDVEEM; -.
OrthoDB; EOG091G0CPX; -.
TreeFam; TF318935; -.
Proteomes; UP000002277; Chromosome 3.
Bgee; ENSPTRG00000015279; -.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0003779; F:actin binding; IEA:InterPro.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:2000107; P:negative regulation of leukocyte apoptotic process; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0030854; P:positive regulation of granulocyte differentiation; IEA:Ensembl.
GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:0009725; P:response to hormone; IEA:Ensembl.
InterPro; IPR028534; HS1.
InterPro; IPR003134; Hs1_Cortactin.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR10829:SF5; PTHR10829:SF5; 2.
Pfam; PF02218; HS1_rep; 4.
Pfam; PF00018; SH3_1; 1.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00326; SH3; 1.
SUPFAM; SSF50044; SSF50044; 1.
PROSITE; PS51090; CORTACTIN; 4.
PROSITE; PS50002; SH3; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192}.
DOMAIN 426 484 SH3. {ECO:0000259|PROSITE:PS50002}.
COILED 54 74 {ECO:0000256|SAM:Coils}.
COILED 235 270 {ECO:0000256|SAM:Coils}.
SEQUENCE 484 AA; 53775 MW; EFBCC9FDF331620E CRC64;
MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK
VSEEHDVLKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF
GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKWDK AALGYDYKGE
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGARGLKA
KFESMAEEKR KREEEEKAQQ VARRQQERKA VTKMSPEAPQ PVIAMEEPAV PAPLPKKISS
EAWPPVGTPP SSESEPVRTS REHPVPLLPI RQTLPEDNEE PPALPPRTLE GLQVEEEPVY
EAEPEPEPEP EPEPENDYED VEEMDRHEQE DEPEGDYEEV LEPEDSSFSS ALAGSSGCPA
GAGAGALGIS AVALYDYQGE GSDELSFDPD DVITDIEMVD EGWWRGRCHG HFGLFPANYV
KLLE


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