Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

HERV-H_2q24.3 provirus ancestral Env polyprotein (Env protein HERV-H/p62) (Env protein HERV-H19) (Env protein HERV-Hcl.3) (Envelope polyprotein) (HERV-H/env62) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]

 ENH1_HUMAN              Reviewed;         584 AA.
Q9N2K0; O00354; Q96L63; Q9UNM3;
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
20-JUN-2018, entry version 86.
RecName: Full=HERV-H_2q24.3 provirus ancestral Env polyprotein;
AltName: Full=Env protein HERV-H/p62;
AltName: Full=Env protein HERV-H19;
AltName: Full=Env protein HERV-Hcl.3;
AltName: Full=Envelope polyprotein;
AltName: Full=HERV-H/env62;
Contains:
RecName: Full=Surface protein;
Short=SU;
Contains:
RecName: Full=Transmembrane protein;
Short=TM;
Flags: Precursor;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-81 AND LEU-150.
PubMed=10366582; DOI=10.1006/viro.1999.9750;
Lindeskog M., Mager D.L., Blomberg J.;
"Isolation of a human endogenous retroviral HERV-H element with an
open env reading frame.";
Virology 258:441-450(1999).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-81 AND LEU-150.
PubMed=11162811; DOI=10.1006/viro.2000.0737;
de Parseval N., Casella J.-F., Gressin L., Heidmann T.;
"Characterization of the three HERV-H proviruses with an open envelope
reading frame encompassing the immunosuppressive domain and
evolutionary history in primates.";
Virology 279:558-569(2001).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-402, AND VARIANT LEU-81.
PubMed=12079564; DOI=10.1089/088922202760019383;
Jern P., Lindeskog M., Karlsson D., Blomberg J.;
"Full-length HERV-H elements with env SU open reading frames in the
human genome.";
AIDS Res. Hum. Retroviruses 18:671-676(2002).
[4]
FUNCTION.
PubMed=11562544;
Mangeney M., de Parseval N., Thomas G., Heidmann T.;
"The full-length envelope of an HERV-H human endogenous retrovirus has
immunosuppressive properties.";
J. Gen. Virol. 82:2515-2518(2001).
[5]
FUNCTION.
PubMed=14557543; DOI=10.1073/pnas.2132646100;
Blaise S., de Parseval N., Benit L., Heidmann T.;
"Genomewide screening for fusogenic human endogenous retrovirus
envelopes identifies syncytin 2, a gene conserved on primate
evolution.";
Proc. Natl. Acad. Sci. U.S.A. 100:13013-13018(2003).
[6]
TISSUE SPECIFICITY.
PubMed=12970426; DOI=10.1128/JVI.77.19.10414-10422.2003;
de Parseval N., Lazar V., Casella J.-F., Benit L., Heidmann T.;
"Survey of human genes of retroviral origin: identification and
transcriptome of the genes with coding capacity for complete envelope
proteins.";
J. Virol. 77:10414-10422(2003).
-!- FUNCTION: Retroviral envelope proteins mediate receptor
recognition and membrane fusion during early infection. Endogenous
envelope proteins may have kept, lost or modified their original
function during evolution. This endogenous envelope protein has
lost its original fusogenic properties but has immunosuppressive
properties in vivo. {ECO:0000269|PubMed:11562544,
ECO:0000269|PubMed:14557543}.
-!- FUNCTION: SU mediates receptor recognition. {ECO:0000250}.
-!- FUNCTION: TM anchors the envelope heterodimer to the viral
membrane through one transmembrane domain. The other hydrophobic
domain, called fusion peptide, mediates fusion of the viral
membrane with the target cell membrane (By similarity).
{ECO:0000250}.
-!- SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a
heterodimer. SU and TM are attached by noncovalent interactions or
by a labile interchain disulfide bond (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Virion.
-!- SUBCELLULAR LOCATION: Transmembrane protein: Cell membrane
{ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: Low expression in skin and testis. No
expression in several cell lines. {ECO:0000269|PubMed:12970426}.
-!- DOMAIN: Contains the CKS-17 immunosuppressive domain present in
many retroviral envelope proteins. As a synthetic peptide, it
inhibits immune function in vitro and in vivo (By similarity).
{ECO:0000250}.
-!- PTM: Specific enzymatic cleavages in vivo yield the mature SU and
TM proteins. {ECO:0000250}.
-!- PTM: The CXXC motif is highly conserved across a broad range of
retroviral envelope proteins. It is thought to participate in the
formation of a labile disulfide bond possibly with the CX6CC motif
present in the transmembrane protein. Isomerization of the
intersubunit disulfide bond to an SU intrachain disulfide bond is
thought to occur upon receptor recognition in order to allow
membrane fusion (By similarity). {ECO:0000250}.
-!- POLYMORPHISM: Envelope protein HERV-H19 and HERV-H/p62 are allelic
variants of the same provirus.
-!- MISCELLANEOUS: Ortholog in Pan troglodytes.
-!- MISCELLANEOUS: HERV-H family subgenomic RNAs have been observed.
-!- MISCELLANEOUS: This provirus is intergenic, the closest flanking
genes being TAIP2 and GALNT3.
-!- SIMILARITY: Belongs to the gamma type-C retroviral envelope
protein family. HERV class-I H env subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF108843; AAD34324.1; -; Genomic_DNA.
EMBL; U88902; AAC79121.1; -; Genomic_DNA.
EMBL; AJ289709; CAB94192.1; -; Genomic_DNA.
EMBL; AY050297; AAL11491.1; -; Genomic_DNA.
PIR; B44282; B44282.
ProteinModelPortal; Q9N2K0; -.
SMR; Q9N2K0; -.
PeptideAtlas; Q9N2K0; -.
PRIDE; Q9N2K0; -.
ProteomicsDB; 81855; -.
neXtProt; NX_Q9N2K0; -.
HOVERGEN; HBG017290; -.
PhylomeDB; Q9N2K0; -.
Proteomes; UP000005640; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
InterPro; IPR018154; TLV/ENV_coat_polyprotein.
PANTHER; PTHR10424; PTHR10424; 1.
Pfam; PF00429; TLV_coat; 2.
2: Evidence at transcript level;
Cell membrane; Cleavage on pair of basic residues; Complete proteome;
Disulfide bond; ERV; Glycoprotein; Membrane; Polymorphism;
Reference proteome; Signal; Transmembrane; Transmembrane helix;
Transposable element; Viral envelope protein; Virion.
SIGNAL 1 35 {ECO:0000255}.
CHAIN 36 584 HERV-H_2q24.3 provirus ancestral Env
polyprotein.
/FTId=PRO_0000008460.
CHAIN 36 387 Surface protein. {ECO:0000250}.
/FTId=PRO_0000008461.
CHAIN 388 584 Transmembrane protein. {ECO:0000250}.
/FTId=PRO_0000008462.
TOPO_DOM 36 523 Extracellular. {ECO:0000255}.
TRANSMEM 524 544 Helical. {ECO:0000255}.
TOPO_DOM 545 584 Cytoplasmic. {ECO:0000255}.
REGION 388 408 Fusion peptide. {ECO:0000250}.
MOTIF 64 67 CXXC. {ECO:0000250}.
MOTIF 454 470 CKS-17. {ECO:0000250}.
MOTIF 471 479 CX6CC. {ECO:0000250}.
SITE 387 388 Cleavage. {ECO:0000250}.
CARBOHYD 47 47 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 199 199 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 222 222 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 265 265 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 283 283 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 352 352 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 370 370 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 483 483 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 471 478 {ECO:0000250}.
VARIANT 81 81 V -> L (in allele HERV-H19).
{ECO:0000269|PubMed:10366582,
ECO:0000269|PubMed:11162811,
ECO:0000269|PubMed:12079564}.
/FTId=VAR_017799.
VARIANT 150 150 F -> L (in allele HERV-H19).
{ECO:0000269|PubMed:10366582,
ECO:0000269|PubMed:11162811}.
/FTId=VAR_017800.
CONFLICT 80 80 A -> T (in Ref. 3; AAL11491).
{ECO:0000305}.
CONFLICT 98 98 F -> C (in Ref. 3; AAL11491).
{ECO:0000305}.
CONFLICT 316 316 T -> A (in Ref. 3; AAL11491).
{ECO:0000305}.
CONFLICT 319 319 S -> G (in Ref. 1; AAC79121).
{ECO:0000305}.
SEQUENCE 584 AA; 64318 MW; C03D260B5A60BDAB CRC64;
MIFAGKAPSN TSTLMKFYSL LLYSLLFSFP FLCHPLPLPS YLHHTINLTH SLLAASNPSL
VNNCWLCISL SSSAYTAVPA VQTDWATSPI SLHLRTSFNS PHLYPPEELI YFLDRSSKTS
PDISHQQAAA LLRTYLKNLS PYINSTPPIF GPLTTQTTIP VAAPLCISWQ RPTGIPLGNL
SPSRCSFTLH LRSPTTNINE TIGAFQLHIT DKPSINTDKL KNISSNYCLG RHLPCISLHP
WLSSPCSSDS PPRPSSCLLI PSPENNSERL LVDTRRFLIH HENRTFPSTQ LPHQSPLQPL
TAAALAGSLG VWVQDTPFST PSHLFTLHLQ FCLAQGLFFL CGSSTYMCLP ANWTGTCTLV
FLTPKIQFAN GTEELPVPLM TPTQQKRVIP LIPLMVGLGL SASTVALGTG IAGISTSVMT
FRSLSNDFSA SITDISQTLS VLQAQVDSLA AVVLQNRRGL DLLTAEKGGL CIFLNEECCF
YLNQSGLVYD NIKKLKDRAQ KLANQASNYA EPPWALSNWM SWVLPIVSPL IPIFLLLLFG
PCIFRLVSQF IQNRIQAITN HSIRQMFLLT SPQYHPLPQD LPSA


Related products :

Catalog number Product name Quantity
EIAAB12958 Envelope polyprotein,EnvK2 protein,ERVK6,HERV-K(C7) envelope protein,HERV-K(HML-2.HOM) envelope protein,HERV-K_7p22.1 provirus ancestral Env polyprotein,HERV-K108 envelope protein,Homo sapiens,Human
EIAAB13041 Endogenous retrovirus group W member 1,Envelope polyprotein gPr73,Enverin,Env-W,ERVW-1,ERVWE1,HERV-7q Envelope protein,HERV-W envelope protein,HERV-W_7q21.2 provirus ancestral Env polyprotein,Homo sap
EIAAB45903 ERVK6,HERV-K(C7) Pro protein,HERV-K(HML-2.HOM) Pro protein,HERV-K_7p22.1 provirus ancestral Pro protein,HERV-K108 Pro protein,Homo sapiens,Human,PR,Protease,Proteinase
EIAAB31775 ERVK6,HERV-K(C7) Pol protein,HERV-K(HML-2.HOM) Pol protein,HERV-K_7p22.1 provirus ancestral Pol protein,HERV-K108 Pol protein,Homo sapiens,Human
EIAAB12959 Envelope polyprotein,ERVK5,HERV-K(II) envelope protein,HERV-K_3q12.3 provirus ancestral Env polyprotein,Homo sapiens,Human
EIAAB34176 Central open reading frame,cORF,c-orf,Endogenous retrovirus K protein 6,ERVK6,ERVK-6,HERV-K(C7) Rec protein,HERV-K(HML-2.HOM) Rec protein,HERV-K_7q22.1 provirus Rec protein,HERV-K108 Rec protein,Homo
EIAAB12585 Endogenous retrovirus group FRD member 1,Envelope polyprotein,ERVFRD-1,ERVFRDE1,HERV-FRD,HERV-FRD_6p24.1 provirus ancestral Env polyprotein,Homo sapiens,Human,Syncytin-2,UNQ6191_PRO20218
EIAAB31776 ERVK6,HERV-K(C19) Pol protein,HERV-K_19q12 provirus ancestral Pol protein,Homo sapiens,Human
EIAAB13002 Envelope polyprotein,ERV3,ERV3 envelope protein,ERV-3 envelope protein,ERV3-1,ERV3-1 envelope protein,ERV-R envelope protein,HERV-R envelope protein,HERV-R_7q21.2 provirus ancestral Env polyprotein,Ho
EIAAB27605 Endogenous retrovirus K protein 5,ERVK5,ERVK-5,HERV-K(II) Np9 protein,HERV-K_3q12.3 provirus Np9 protein,Homo sapiens,Human
E15032r Human ELISA Kit FOR HERV-MER_4q12 provirus ancestral Env polyprotein 96T
CSB-EL007811HU Human HERV-K_3q12.3 provirus ancestral Gag polyprotein(ERVK5) ELISA kit 96T
CSB-EL007812HU Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK6) ELISA kit 96T
CSB-EL007815HU Human HERV-W_7q21.2 provirus ancestral Env polyprotein(ERVWE1) ELISA kit 96T
CSB-EL007806HU Human HERV-R_7q21.2 provirus ancestral Env polyprotein(ERV3) ELISA kit 96T
CSB-EL007811HU Human HERV-K_3q12.3 provirus ancestral Gag polyprotein(ERVK5) ELISA kit SpeciesHuman 96T
CSB-EL007806HU Human HERV-R_7q21.2 provirus ancestral Env polyprotein(ERV3) ELISA kit SpeciesHuman 96T
CSB-EL007815HU Human HERV-W_7q21.2 provirus ancestral Env polyprotein(ERVWE1) ELISA kit SpeciesHuman 96T
CSB-EL007812HU Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK6) ELISA kit SpeciesHuman 96T
POK3_HUMAN Human ELISA Kit FOR HERV-K_19q12 provirus ancestral Pol protein 96T
EIAAB13293 Endogenous retrovirus group V, member 1,ENVV1,ERVV-1,HERV-V_19q13.41 provirus ancestral Env polyprotein 1,Homo sapiens,Human
EIAAB13294 Endogenous retrovirus group V, member 2,ENVV2,ERVV-2,HERV-V_19q13.41 provirus ancestral Env polyprotein 2,Homo sapiens,Human
HERM-1811-5 Anti_human Endogenous Retrovirus type K (HERV K) envelope protein. IgG fraction (monoclonal) 100µg
HERM-1821-5 Anti_human Endogenous Retrovirus type K (HERV K) envelope protein. IgG fraction (monoclonal) 100µg
HERM-1821-5 Anti-human Endogenous Retrovirus type K (HERV K) envelope protein. IgG fraction (monoclonal) 100


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur