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HEX (Hematopoietically expressed homeobox) (Hematopoietically expressed homeobox, isoform CRA_a)

 Q9WV22_RAT              Unreviewed;       271 AA.
Q9WV22;
01-NOV-1999, integrated into UniProtKB/TrEMBL.
01-NOV-1999, sequence version 1.
23-MAY-2018, entry version 138.
SubName: Full=HEX {ECO:0000313|EMBL:BAA78692.1};
SubName: Full=Hematopoietically expressed homeobox {ECO:0000313|EMBL:AAH88135.1};
SubName: Full=Hematopoietically expressed homeobox, isoform CRA_a {ECO:0000313|EMBL:EDM13199.1};
Name=Hhex {ECO:0000313|EMBL:AAH88135.1, ECO:0000313|RGD:619932};
Synonyms=Hex {ECO:0000313|EMBL:BAA78692.1};
ORFNames=rCG_48013 {ECO:0000313|EMBL:EDM13199.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:BAA78692.1};
[1] {ECO:0000313|EMBL:BAA78692.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Sprague-Dawley {ECO:0000313|EMBL:BAA78692.1};
TISSUE=Liver {ECO:0000313|EMBL:BAA78692.1};
PubMed=10085234; DOI=10.1042/0264-6021:3390111;
Tanaka T., Inazu T., Yamada K., Myint Z., Keng V.W., Inoue Y.,
Taniguchi N., Noguchi T.;
"cDNA cloning and expression of rat homeobox gene, Hex, and functional
characterization of the protein.";
Biochem. J. 339:111-117(1999).
[2] {ECO:0000313|EMBL:AAH88135.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Spleen {ECO:0000313|EMBL:AAH88135.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3] {ECO:0000313|EMBL:EDM13199.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDM13199.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[4] {ECO:0000313|EMBL:EDM13199.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDM13199.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
ProRule:PRU00108, ECO:0000256|RuleBase:RU000682,
ECO:0000256|SAAS:SAAS00860360}.
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EMBL; BC088135; AAH88135.1; -; mRNA.
EMBL; D86383; BAA78692.1; -; mRNA.
EMBL; CH473953; EDM13199.1; -; Genomic_DNA.
RefSeq; NP_077361.1; NM_024385.1.
UniGene; Rn.12188; -.
SMR; Q9WV22; -.
GeneID; 79237; -.
KEGG; rno:79237; -.
UCSC; RGD:619932; rat.
CTD; 3087; -.
RGD; 619932; Hhex.
eggNOG; KOG0483; Eukaryota.
eggNOG; ENOG410Z2UE; LUCA.
HOGENOM; HOG000049110; -.
HOVERGEN; HBG055460; -.
KO; K08024; -.
OrthoDB; EOG091G0RNV; -.
TreeFam; TF325047; -.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
GO; GO:0030154; P:cell differentiation; IDA:RGD.
GO; GO:0030097; P:hemopoiesis; TAS:RGD.
GO; GO:0016525; P:negative regulation of angiogenesis; IDA:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:RGD.
GO; GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; IDA:BHF-UCL.
GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
GO; GO:0009611; P:response to wounding; IEP:RGD.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00860283,
ECO:0000313|EMBL:AAH88135.1};
Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00860291,
ECO:0000313|EMBL:AAH88135.1};
Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00860284}.
DOMAIN 136 196 Homeobox. {ECO:0000259|PROSITE:PS50071}.
DNA_BIND 138 197 Homeobox. {ECO:0000256|PROSITE-
ProRule:PRU00108}.
SEQUENCE 271 AA; 29955 MW; FDB973B6A5027DF2 CRC64;
MQFPHPGPAA APAVGVPLYA PTPLLQPAHP TPFYIDDILG RGPAAPTPTP TLPSPNSSFT
SLVSSYRTPV YEPTPVHPAF SHHPAAALAA AYGPGGFGGP LYPFPRTVND YTHALLRHDP
LGKPLLWNPF LQRPLHKRKG GQVRFSNDQT IELEKKFETQ KYLSPPERKR LAKMLQLSER
QVKTWFQNRR AKWRRLKQEN PQSNKKDELD SLDTSCDQGQ DLPSEQNKGA SLDSSQCSPS
PASPEDPESE ISEDSDQEVD IEGDKGYFNA G


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