GENTAUR Molecular Products.

 Q8I0C2_DROME            Unreviewed;       278 AA.
 Q8I0C2;
 01-MAR-2003, integrated into UniProtKB/TrEMBL.
 01-MAR-2003, sequence version 1.
 18-JUL-2018, entry version 129.
 SubName: Full=HIF prolyl hydroxylase, isoform B {ECO:0000313|EMBL:AAN13268.1};
 SubName: Full=RE46204p {ECO:0000313|EMBL:AAN71414.1};
 Name=Hph {ECO:0000313|EMBL:AAN13268.1,
 ECO:0000313|FlyBase:FBgn0264785};
 Synonyms=0303 {ECO:0000313|EMBL:AAN13268.1},
 04 {ECO:0000313|EMBL:AAN13268.1}, 31543 {ECO:0000313|EMBL:AAN13268.1},
 anon-EST:Posey69 {ECO:0000313|EMBL:AAN13268.1},
 CG1114 {ECO:0000313|EMBL:AAN13268.1},
 CG14665 {ECO:0000313|EMBL:AAN13268.1},
 CG2676 {ECO:0000313|EMBL:AAN13268.1},
 CG31543 {ECO:0000313|EMBL:AAN13268.1},
 CR31541 {ECO:0000313|EMBL:AAN13268.1},
 dHPH {ECO:0000313|EMBL:AAN13268.1},
 Dm.egl-9 {ECO:0000313|EMBL:AAN13268.1},
 Dmel\CG44015 {ECO:0000313|EMBL:AAN13268.1},
 dmHPH {ECO:0000313|EMBL:AAN13268.1},
 dPHD {ECO:0000313|EMBL:AAN13268.1},
 dPHD2 {ECO:0000313|EMBL:AAN13268.1},
 fga {ECO:0000313|EMBL:AAN13268.1}, hph {ECO:0000313|EMBL:AAN13268.1},
 l(3)02255 {ECO:0000313|EMBL:AAN13268.1},
 l(3)82Fe {ECO:0000313|EMBL:AAN13268.1},
 l(3)S030304 {ECO:0000313|EMBL:AAN13268.1},
 PHD {ECO:0000313|EMBL:AAN13268.1};
 ORFNames=CG44015 {ECO:0000313|EMBL:AAN13268.1,
 ECO:0000313|FlyBase:FBgn0264785},
 Dmel_CG44015 {ECO:0000313|EMBL:AAN13268.1};
 Drosophila melanogaster (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
 Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
 Ephydroidea; Drosophilidae; Drosophila; Sophophora.
 NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803};
 [1] {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=10731132; DOI=10.1126/science.287.5461.2185;
 Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
 Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
 George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
 Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
 Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
 Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
 Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
 Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
 Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
 Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
 Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
 Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
 de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
 Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
 Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
 Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
 Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
 Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
 Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
 Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
 Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
 Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
 Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
 Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
 Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
 Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
 Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
 Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
 Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
 Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
 Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
 Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
 Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
 Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
 Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
 Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
 "The genome sequence of Drosophila melanogaster.";
 Science 287:2185-2195(2000).
 [2] {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537568;
 Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
 Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
 George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
 Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
 Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
 Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
 "Finishing a whole-genome shotgun: release 3 of the Drosophila
 melanogaster euchromatic genome sequence.";
 Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
 [3] {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803}
 GENOME REANNOTATION.
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
 Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
 Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
 Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
 Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
 Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
 Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
 Lewis S.E.;
 "Annotation of the Drosophila melanogaster euchromatic genome: a
 systematic review.";
 Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
 [4] {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537573;
 Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
 Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
 Ashburner M., Celniker S.E.;
 "The transposable elements of the Drosophila melanogaster euchromatin:
 a genomics perspective.";
 Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
 [5] {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537574;
 Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
 Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
 Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
 Karpen G.H.;
 "Heterochromatic sequences in a Drosophila whole-genome shotgun
 assembly.";
 Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
 [6] {ECO:0000313|EMBL:AAN71414.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=Berkeley {ECO:0000313|EMBL:AAN71414.1};
 Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.,
 Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
 George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G.,
 Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S.,
 Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M.,
 Celniker S.;
 Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
 [7] {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
 Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
 Ashburner M., Anxolabehere D.;
 "Combined evidence annotation of transposable elements in genome
 sequences.";
 PLoS Comput. Biol. 1:166-175(2005).
 [8] {ECO:0000313|EMBL:AAN13268.1}
 NUCLEOTIDE SEQUENCE.
 Berkeley Drosophila Genome Project;
 Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
 Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
 Yu C., Rubin G.;
 "Drosophila melanogaster release 4 sequence.";
 Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
 [9] {ECO:0000313|EMBL:AAN13268.1}
 NUCLEOTIDE SEQUENCE.
 Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
 Svirskas R., Rubin G.;
 Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
 [10] {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=17569856; DOI=10.1126/science.1139815;
 Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
 "The Release 5.1 annotation of Drosophila melanogaster
 heterochromatin.";
 Science 316:1586-1591(2007).
 [11] {ECO:0000313|EMBL:AAN13268.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=17569867; DOI=10.1126/science.1139816;
 Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
 Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
 Dimitri P., Karpen G.H., Celniker S.E.;
 "Sequence finishing and mapping of Drosophila melanogaster
 heterochromatin.";
 Science 316:1625-1628(2007).
 [12] {ECO:0000313|EMBL:AAN13268.1}
 NUCLEOTIDE SEQUENCE.
 FlyBase;
 Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
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 EMBL; AE014297; AAN13268.1; -; Genomic_DNA.
 EMBL; BT001659; AAN71414.1; -; mRNA.
 RefSeq; NP_730908.1; NM_169037.3.
 UniGene; Dm.20436; -.
 SMR; Q8I0C2; -.
 PRIDE; Q8I0C2; -.
 EnsemblMetazoa; FBtr0334274; FBpp0306389; FBgn0264785.
 EnsemblMetazoa; FBtr0334275; FBpp0306390; FBgn0264785.
 GeneID; 40633; -.
 UCSC; CG31543-RB; d. melanogaster.
 CTD; 40633; -.
 FlyBase; FBgn0264785; Hph.
 eggNOG; KOG3710; Eukaryota.
 eggNOG; ENOG410ZHZN; LUCA.
 GeneTree; ENSGT00390000001936; -.
 OrthoDB; EOG091G03SP; -.
 Reactome; R-DME-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
 ChiTaRS; ph-d; fly.
 GenomeRNAi; 40633; -.
 Proteomes; UP000000803; Chromosome 3R.
 Bgee; FBgn0264785; -.
 GO; GO:0005654; C:nucleoplasm; IDA:FlyBase.
 GO; GO:0005506; F:iron ion binding; ISM:FlyBase.
 GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
 GO; GO:0031545; F:peptidyl-proline 4-dioxygenase activity; ISS:FlyBase.
 GO; GO:0031543; F:peptidyl-proline dioxygenase activity; IDA:FlyBase.
 GO; GO:0008270; F:zinc ion binding; ISM:FlyBase.
 GO; GO:0071456; P:cellular response to hypoxia; IMP:FlyBase.
 GO; GO:0019511; P:peptidyl-proline hydroxylation; IDA:FlyBase.
 GO; GO:0018401; P:peptidyl-proline hydroxylation to 4-hydroxy-L-proline; ISS:FlyBase.
 GO; GO:0030307; P:positive regulation of cell growth; IMP:FlyBase.
 GO; GO:0006611; P:protein export from nucleus; IMP:FlyBase.
 GO; GO:0008104; P:protein localization; IMP:FlyBase.
 GO; GO:0001666; P:response to hypoxia; IMP:FlyBase.
 InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
 InterPro; IPR006620; Pro_4_hyd_alph.
 Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
 SMART; SM00702; P4Hc; 1.
 PROSITE; PS51471; FE2OG_OXY; 1.
 2: Evidence at transcript level;
 Complete proteome {ECO:0000313|Proteomes:UP000000803};
 Iron {ECO:0000256|SAAS:SAAS00964055};
 Metal-binding {ECO:0000256|SAAS:SAAS00964050};
 Reference proteome {ECO:0000313|Proteomes:UP000000803}.
 DOMAIN      103    201       Fe2OG dioxygenase.
                              {ECO:0000259|PROSITE:PS51471}.
 SEQUENCE   278 AA;  30593 MW;  A6C224F86342B549 CRC64;
 MNQYGLSVVD DFLGMETGLK ILNEVRSMYN AGAFQDGQVV TNQTPDAPAV RGDKIRGDKI
 KWVGGNEPGC SNVWYLTNQI DSVVYRVNTM KDNGILGNYH IRERTRAMVA CYPGSGTHYV
 MHVDNPQKDG RVITAIYYLN INWDARESGG ILRIRPTPGT TVADIEPKFD RLIFFWSDIR
 NPHEVQPAHR TRYAITVWYF DAKEREEALI RAKLENSKTN NLAAQAQAQQ AEPDSTTTPP
 AAPASSASSL PVSMSTGTGA LNANVSSNSC ATSSEICT

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