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HLA class I histocompatibility antigen, B-35 alpha chain (MHC class I antigen B*35)

 1B35_HUMAN              Reviewed;         362 AA.
P30685; O62919; P30468; P30469; P30470; P30471; P30472; P30473;
P30474; Q9GJM7; Q9TPV2; Q9TQH3; Q9TQH9; Q9TQN4; Q9TQN6;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
25-OCT-2017, entry version 163.
RecName: Full=HLA class I histocompatibility antigen, B-35 alpha chain;
AltName: Full=MHC class I antigen B*35;
Flags: Precursor;
Name=HLA-B; Synonyms=HLAB;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*35:01).
PubMed=2788131; DOI=10.1007/BF02421534;
Ooba T., Hayashi H., Karaki S., Tanabe M., Kano K., Takiguchi M.;
"The structure of HLA-B35 suggests that it is derived from HLA-Bw58 by
two genetic mechanisms.";
Immunogenetics 30:76-80(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*35:02).
PubMed=1890016; DOI=10.1016/0198-8859(91)90020-A;
Chertkoff L.P., Herrera M., Fainboim L., Satz M.L.;
"Complete nucleotide sequence of a genomic clone encoding HLA-B35
isolated from a Caucasian individual of Hispanic origin.
Identification of a new variant of HLA-B35.";
Hum. Immunol. 31:153-158(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*35:03).
PubMed=1541831;
Zemmour J., Little A.-M., Schendel D.J., Parham P.;
"The HLA-A,B 'negative' mutant cell line C1R expresses a novel HLA-B35
allele, which also has a point mutation in the translation initiation
codon.";
J. Immunol. 148:1941-1948(1992).
[4]
NUCLEOTIDE SEQUENCE (ALLELE B*35:03).
TISSUE=Blood;
PubMed=7759996; DOI=10.1084/jem.181.6.2037;
Beck Y., Satz L., Takamiya Y., Nakayama S., Ling L., Ishikawa Y.,
Nagao T., Uchida H., Tokunaga K., Mueller C., Juji T., Takiguchi M.;
"Polymorphism of human minor histocompatibility antigens: T cell
recognition of human minor histocompatibility peptides presented by
HLA-B35 subtype molecules.";
J. Exp. Med. 181:2037-2048(1995).
[5]
NUCLEOTIDE SEQUENCE (ALLELES B*35:05 AND B*35:06).
PubMed=1317015; DOI=10.1038/357326a0;
Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J.,
Williams R.C., Luz R., Petzl-Erler M.L., Parham P.;
"Unusual HLA-B alleles in two tribes of Brazilian Indians.";
Nature 357:326-329(1992).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*35:07 AND B*35:08).
PubMed=8316945; DOI=10.1111/j.1399-0039.1993.tb01993.x;
Theiler G., Pando M., Delfino J.M., Takiguchi M., Satz M.L.;
"Isolation and characterization of two new functional subtypes of HLA-
B35.";
Tissue Antigens 41:143-147(1993).
[7]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*35:08).
PubMed=8138421; DOI=10.1016/0198-8859(93)90553-D;
Steinle A., Reinhardt C., Noessner E., Uchanska-Ziegler B.,
Ziegler A., Schendel D.J.;
"Microheterogeneity in HLA-B35 alleles influences peptide-dependent
allorecognition by cytotoxic T cells but not binding of a peptide-
restricted monoclonal antibody.";
Hum. Immunol. 38:261-269(1993).
[8]
NUCLEOTIDE SEQUENCE OF 9-362 (ALLELE B*35:04).
PubMed=1589035; DOI=10.1038/357329a0;
Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L.,
Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H.,
Troup G.M., Hughes A.L., Letvin N.L.;
"New recombinant HLA-B alleles in a tribe of South American
Amerindians indicate rapid evolution of MHC class I loci.";
Nature 357:329-333(1992).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*35:29 AND
B*35:32).
PubMed=10777103; DOI=10.1034/j.1399-0039.2000.550311.x;
Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Greville W.D.,
Kennedy A., Taverniti A., Moses J.H., Clow N., Watson N., Dunckley H.;
"Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides
(PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529,
B*3532, B*4025, B*5304 and B*5508.";
Tissue Antigens 55:266-270(2000).
[10]
NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES B*35:25; B*35:28; B*35:29;
B*35:30 AND B*35:36).
PubMed=11556976; DOI=10.1034/j.1399-0039.2001.057005481.x;
Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G.,
Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D.,
Mitton W., Ng J., Hartzman R.J., Hurley C.K.;
"Twenty-nine new HLA-B alleles associated with antigens in the 5C
CREG.";
Tissue Antigens 57:481-485(2001).
[11]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[12]
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 25-300.
PubMed=8624811; DOI=10.1016/S1074-7613(00)80429-X;
Smith K.J., Reid S.W., Stuart D.I., McMichael A.J., Jones E.Y.,
Bell J.I.;
"An altered position of the alpha 2 helix of MHC class I is revealed
by the crystal structure of HLA-B*3501.";
Immunity 4:203-214(1996).
[13]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
PubMed=9878435; DOI=10.1006/jmbi.1998.2363;
Menssen R., Orth P., Ziegler A., Saenger W.;
"Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due
to non-standard positioning of the C-terminus.";
J. Mol. Biol. 285:645-653(1999).
[14]
VARIANT [LARGE SCALE ANALYSIS] TYR-140, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[15]
VARIANT [LARGE SCALE ANALYSIS] GLU-87, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
-!- FUNCTION: Involved in the presentation of foreign antigens to the
immune system.
-!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
microglobulin). Interacts with human herpesvirus 8 MIR1 protein
(By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- PTM: Polyubiquitinated in a post ER compartment by interaction
with human herpesvirus 8 MIR1 protein. This targets the protein
for rapid degradation via the ubiquitin system (By similarity).
{ECO:0000250}.
-!- POLYMORPHISM: The following alleles of B-35 are known: B*35:01,
B*35:02, B*35:03, B*35:04, B*35:05 (B35-G), B*35:06 (B35-K),
B*35:07, B*35:08, B*35:25, B*35:28, B*35:29 (B*KG), B*35:30,
B*35:32 (B*TMUL) and B*35:36. The sequence shown is that of
B*35:01.
-!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
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EMBL; M28115; AAA59617.1; -; Genomic_DNA.
EMBL; M28109; AAA59617.1; JOINED; Genomic_DNA.
EMBL; M28110; AAA59617.1; JOINED; Genomic_DNA.
EMBL; M28111; AAA59617.1; JOINED; Genomic_DNA.
EMBL; M28112; AAA59617.1; JOINED; Genomic_DNA.
EMBL; M28113; AAA59617.1; JOINED; Genomic_DNA.
EMBL; M28114; AAA59617.1; JOINED; Genomic_DNA.
EMBL; M63454; AAA59682.1; -; Genomic_DNA.
EMBL; M81798; AAA59684.1; -; mRNA.
EMBL; D50299; BAA08828.1; -; mRNA.
EMBL; M84385; AAA59635.1; -; mRNA.
EMBL; M84381; AAA59631.1; -; mRNA.
EMBL; L04695; AAA59694.1; -; mRNA.
EMBL; L04696; AAA52674.1; -; mRNA.
EMBL; Z22651; CAA80366.1; -; mRNA.
EMBL; M86403; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AH007565; AAD23460.1; -; Genomic_DNA.
EMBL; AH007706; AAD30277.1; -; Genomic_DNA.
EMBL; AH006372; AAC32570.1; -; Genomic_DNA.
EMBL; AH007604; AAD27538.1; -; Genomic_DNA.
EMBL; AH008126; AAD51745.1; -; Genomic_DNA.
EMBL; AH007584; AAD26151.1; -; Genomic_DNA.
EMBL; AH009759; AAG01819.1; -; Genomic_DNA.
PIR; A45880; A45880.
PIR; I54298; I54298.
PIR; I56133; I56133.
PIR; I61904; I61904.
PIR; I61907; I61907.
PIR; I81233; I81233.
UniGene; Hs.654404; -.
UniGene; Hs.726974; -.
UniGene; Hs.77961; -.
PDB; 1A1N; X-ray; 2.00 A; A=25-300.
PDB; 1A9B; X-ray; 3.20 A; A/D=25-301.
PDB; 1A9E; X-ray; 2.50 A; A=25-301.
PDB; 1CG9; X-ray; 2.70 A; A=25-301.
PDB; 1XH3; X-ray; 1.48 A; A=25-300.
PDB; 1ZHK; X-ray; 1.60 A; A=25-300.
PDB; 1ZHL; X-ray; 1.50 A; A=25-300.
PDB; 1ZSD; X-ray; 1.70 A; A=25-300.
PDB; 2AK4; X-ray; 2.50 A; A/F/K/Q=25-300.
PDB; 2AXF; X-ray; 1.80 A; A=25-300.
PDB; 2AXG; X-ray; 2.00 A; A=25-300.
PDB; 2CIK; X-ray; 1.75 A; A=25-300.
PDB; 2FYY; X-ray; 1.50 A; A=25-300.
PDB; 2FZ3; X-ray; 1.90 A; A=25-300.
PDB; 2H6P; X-ray; 1.90 A; A=25-300.
PDB; 2NW3; X-ray; 1.70 A; A=25-300.
PDB; 2NX5; X-ray; 2.70 A; A/F/K/Q=25-300.
PDB; 3BW9; X-ray; 1.75 A; A=25-300.
PDB; 3BWA; X-ray; 1.30 A; A=25-300.
PDB; 3KWW; X-ray; 2.18 A; A=25-300.
PDB; 3KXF; X-ray; 3.10 A; A/C/I/K=25-300.
PDB; 3LKN; X-ray; 2.00 A; A=25-300.
PDB; 3LKO; X-ray; 1.80 A; A=25-300.
PDB; 3LKP; X-ray; 1.80 A; A=25-300.
PDB; 3LKQ; X-ray; 1.80 A; A=25-300.
PDB; 3LKR; X-ray; 2.00 A; A=25-300.
PDB; 3LKS; X-ray; 1.90 A; A=25-300.
PDB; 3MV7; X-ray; 2.00 A; A=25-300.
PDB; 3MV8; X-ray; 2.10 A; A=25-300.
PDB; 3MV9; X-ray; 2.70 A; A=25-300.
PDB; 3VFS; X-ray; 1.85 A; A=25-300.
PDB; 3VFT; X-ray; 1.95 A; A=25-300.
PDB; 3VFU; X-ray; 1.65 A; A=25-300.
PDB; 3VFV; X-ray; 1.55 A; A=25-300.
PDB; 3VFW; X-ray; 2.30 A; A=25-300.
PDB; 4LNR; X-ray; 2.00 A; A=25-300.
PDB; 4PR5; X-ray; 1.80 A; A=25-300.
PDB; 4PRN; X-ray; 1.65 A; A=25-300.
PDB; 4QRR; X-ray; 3.00 A; A=25-300.
PDB; 5XOS; X-ray; 1.70 A; A=25-300.
PDB; 5XOT; X-ray; 2.79 A; A=25-300.
PDBsum; 1A1N; -.
PDBsum; 1A9B; -.
PDBsum; 1A9E; -.
PDBsum; 1CG9; -.
PDBsum; 1XH3; -.
PDBsum; 1ZHK; -.
PDBsum; 1ZHL; -.
PDBsum; 1ZSD; -.
PDBsum; 2AK4; -.
PDBsum; 2AXF; -.
PDBsum; 2AXG; -.
PDBsum; 2CIK; -.
PDBsum; 2FYY; -.
PDBsum; 2FZ3; -.
PDBsum; 2H6P; -.
PDBsum; 2NW3; -.
PDBsum; 2NX5; -.
PDBsum; 3BW9; -.
PDBsum; 3BWA; -.
PDBsum; 3KWW; -.
PDBsum; 3KXF; -.
PDBsum; 3LKN; -.
PDBsum; 3LKO; -.
PDBsum; 3LKP; -.
PDBsum; 3LKQ; -.
PDBsum; 3LKR; -.
PDBsum; 3LKS; -.
PDBsum; 3MV7; -.
PDBsum; 3MV8; -.
PDBsum; 3MV9; -.
PDBsum; 3VFS; -.
PDBsum; 3VFT; -.
PDBsum; 3VFU; -.
PDBsum; 3VFV; -.
PDBsum; 3VFW; -.
PDBsum; 4LNR; -.
PDBsum; 4PR5; -.
PDBsum; 4PRN; -.
PDBsum; 4QRR; -.
PDBsum; 5XOS; -.
PDBsum; 5XOT; -.
ProteinModelPortal; P30685; -.
SMR; P30685; -.
IntAct; P30685; 2.
MINT; MINT-1516663; -.
SwissPalm; P30685; -.
DMDM; 231390; -.
EPD; P30685; -.
PeptideAtlas; P30685; -.
PRIDE; P30685; -.
Ensembl; ENST00000359635; ENSP00000352656; ENSG00000206450.
DisGeNET; 3106; -.
GeneCards; HLA-B; -.
H-InvDB; HIX0167180; -.
HGNC; HGNC:4932; HLA-B.
MalaCards; HLA-B; -.
MIM; 142830; gene.
neXtProt; NX_P30685; -.
HOVERGEN; HBG016709; -.
OrthoDB; EOG091G09OH; -.
Reactome; R-HSA-1236974; ER-Phagosome pathway.
Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway.
Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-HSA-877300; Interferon gamma signaling.
Reactome; R-HSA-909733; Interferon alpha/beta signaling.
Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
ChiTaRS; HLA-B; human.
EvolutionaryTrace; P30685; -.
Proteomes; UP000005640; Chromosome 6.
CleanEx; HS_HLA-B; -.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0031901; C:early endosome membrane; TAS:Reactome.
GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0042612; C:MHC class I protein complex; ISS:UniProtKB.
GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome.
GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB.
GO; GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
GO; GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome.
GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 3.30.500.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003006; Ig/MHC_CS.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR011161; MHC_I-like_Ag-recog.
InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
InterPro; IPR011162; MHC_I/II-like_Ag-recog.
InterPro; IPR001039; MHC_I_a_a1/a2.
InterPro; IPR010579; MHC_I_a_C.
Pfam; PF07654; C1-set; 1.
Pfam; PF00129; MHC_I; 1.
Pfam; PF06623; MHC_I_C; 1.
PRINTS; PR01638; MHCCLASSI.
SMART; SM00407; IGc1; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF54452; SSF54452; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00290; IG_MHC; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Disulfide bond; Glycoprotein;
Host-virus interaction; Immunity; Membrane; MHC I; Polymorphism;
Reference proteome; Signal; Transmembrane; Transmembrane helix;
Ubl conjugation.
SIGNAL 1 24
CHAIN 25 362 HLA class I histocompatibility antigen,
B-35 alpha chain.
/FTId=PRO_0000018840.
TOPO_DOM 25 308 Extracellular. {ECO:0000255}.
TRANSMEM 309 332 Helical. {ECO:0000255}.
TOPO_DOM 333 362 Cytoplasmic. {ECO:0000255}.
DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
CARBOHYD 110 110 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
DISULFID 125 188
DISULFID 227 283
VARIANT 40 40 G -> V (in allele B*35:07).
/FTId=VAR_016393.
VARIANT 48 48 A -> S (in allele B*35:25).
/FTId=VAR_016394.
VARIANT 69 69 T -> E (in allele B*35:25; requires 2
nucleotide substitutions).
/FTId=VAR_016395.
VARIANT 87 87 N -> E (in allele B*35:28; requires 2
nucleotide substitutions).
{ECO:0000244|PubMed:24275569}.
/FTId=VAR_016396.
VARIANT 91 91 F -> S (in allele B*35:28).
/FTId=VAR_016397.
VARIANT 98 98 Y -> D (in allele B*35:29).
/FTId=VAR_016398.
VARIANT 107 107 G -> D (in allele B*35:36).
/FTId=VAR_016399.
VARIANT 118 119 II -> TL (in allele B*35:05 and allele
B*35:32).
/FTId=VAR_016400.
VARIANT 121 121 R -> S (in allele B*35:05 and allele
B*35:30).
/FTId=VAR_016401.
VARIANT 127 127 L -> V (in allele B*35:32).
/FTId=VAR_016402.
VARIANT 133 133 L -> F (in allele B*35:02).
/FTId=VAR_016403.
VARIANT 138 138 D -> N (in allele B*35:02, allele B*35:04
and allele B*35:06).
/FTId=VAR_016404.
VARIANT 140 140 S -> F (in allele B*35:06 and allele
B*35:36).
/FTId=VAR_016405.
VARIANT 140 140 S -> Y (in allele B*35:02, allele B*35:03
and allele B*35:04).
{ECO:0000244|PubMed:21269460}.
/FTId=VAR_016406.
VARIANT 180 180 L -> R (in allele B*35:08).
/FTId=VAR_016407.
STRAND 27 36 {ECO:0000244|PDB:3BWA}.
STRAND 41 43 {ECO:0000244|PDB:3BWA}.
STRAND 45 52 {ECO:0000244|PDB:3BWA}.
STRAND 55 61 {ECO:0000244|PDB:3BWA}.
STRAND 64 66 {ECO:0000244|PDB:3BWA}.
STRAND 69 71 {ECO:0000244|PDB:3KXF}.
HELIX 74 76 {ECO:0000244|PDB:3BWA}.
HELIX 81 108 {ECO:0000244|PDB:3BWA}.
STRAND 113 115 {ECO:0000244|PDB:3BW9}.
STRAND 118 127 {ECO:0000244|PDB:3BWA}.
STRAND 133 142 {ECO:0000244|PDB:3BWA}.
STRAND 145 150 {ECO:0000244|PDB:3BWA}.
STRAND 157 161 {ECO:0000244|PDB:3BWA}.
HELIX 162 173 {ECO:0000244|PDB:3BWA}.
HELIX 176 185 {ECO:0000244|PDB:3BWA}.
HELIX 187 198 {ECO:0000244|PDB:3BWA}.
HELIX 200 203 {ECO:0000244|PDB:3BWA}.
STRAND 210 217 {ECO:0000244|PDB:3BWA}.
STRAND 219 235 {ECO:0000244|PDB:3BWA}.
STRAND 238 243 {ECO:0000244|PDB:3BWA}.
HELIX 249 251 {ECO:0000244|PDB:3BWA}.
STRAND 252 254 {ECO:0000244|PDB:1ZHL}.
STRAND 261 263 {ECO:0000244|PDB:3BWA}.
STRAND 265 274 {ECO:0000244|PDB:3BWA}.
HELIX 278 280 {ECO:0000244|PDB:3BWA}.
STRAND 281 286 {ECO:0000244|PDB:3BWA}.
STRAND 290 292 {ECO:0000244|PDB:1ZHK}.
STRAND 294 296 {ECO:0000244|PDB:3BWA}.
SEQUENCE 362 AA; 40455 MW; 52906854FC43E7A6 CRC64;
MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE SLRNLRGYYN QSEAGSHIIQ
RMYGCDLGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL
RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL
TA


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Catalog number Product name Quantity
EIAAB11884 DX alpha chain,HLA class II histocompatibility antigen, DQ alpha 2 chain,HLA class II histocompatibility antigen, DQ(6) alpha chain,HLA-DQA1,HLA-DQA2,HLA-DXA,Homo sapiens,Human,MHC class II DQA2
U1386h CLIA HLA class I histocompatibility antigen, alpha chain G,HLA G antigen,HLA-6.0,HLAG,HLA-G,Homo sapiens,Human,MHC class I antigen G 96T
E1386h ELISA kit HLA class I histocompatibility antigen, alpha chain G,HLA G antigen,HLA-6.0,HLAG,HLA-G,Homo sapiens,Human,MHC class I antigen G 96T
E1386h ELISA HLA class I histocompatibility antigen, alpha chain G,HLA G antigen,HLA-6.0,HLAG,HLA-G,Homo sapiens,Human,MHC class I antigen G 96T
U1752h CLIA HLA class I histocompatibility antigen, alpha chain E,HLA-6.2,HLAE,HLA-E,Homo sapiens,Human,MHC class I antigen E 96T
E1752h ELISA kit HLA class I histocompatibility antigen, alpha chain E,HLA-6.2,HLAE,HLA-E,Homo sapiens,Human,MHC class I antigen E 96T
E1752h ELISA HLA class I histocompatibility antigen, alpha chain E,HLA-6.2,HLAE,HLA-E,Homo sapiens,Human,MHC class I antigen E 96T
EIAAB11895 HLA class II histocompatibility antigen, DR alpha chain,HLA-DRA,HLA-DRA1,Homo sapiens,Human,MHC class II antigen DRA
EIAAB11449 DMA,HLA class II histocompatibility antigen, DM alpha chain,HLA-DMA,Homo sapiens,Human,MHC class II antigen DMA,Really interesting new gene 6 protein,RING6
EIAAB11639 HLA class II histocompatibility antigen, DO alpha chain,HLA-DNA,HLA-DOA,HLA-DZA,Homo sapiens,Human,MHC class II antigen DOA,MHC DN-alpha,MHC DZ alpha
EIAAB11729 HLA class II histocompatibility antigen, DP beta 1 chain,HLA class II histocompatibility antigen, DP(W4) beta chain,HLA-DP1B,HLA-DPB1,Homo sapiens,Human,MHC class II antigen DPB1
EIAAB11726 DP(W3),DP(W4),HLA class II histocompatibility antigen, DP alpha 1 chain,HLA-DP1A,HLA-DPA1,HLASB,HLA-SB alpha chain,Homo sapiens,Human,MHC class II DP3-alpha,MHC class II DPA1
EIAAB11886 HLA class II histocompatibility antigen, DQ beta 2 chain,HLA class II histocompatibility antigen, DX beta chain,HLA-DQB2,HLA-DXB,Homo sapiens,Human,MHC class II antigen DQB2
EIAAB11453 DMB,HLA class II histocompatibility antigen, DM beta chain,HLA-DMB,Homo sapiens,Human,MHC class II antigen DMB,Really interesting new gene 7 protein,RING7
EIAAB11640 HLA class II histocompatibility antigen, DO beta chain,HLA-DOB,Homo sapiens,Human,MHC class II antigen DOB
EIAAB11883 DC-1 alpha chain,DC-alpha,HLA class II histocompatibility antigen, DQ alpha 1 chain,HLA-DCA,HLA-DQA1,Homo sapiens,Human,MHC class II DQA1
U1702m CLIA H-2 class I histocompatibility antigen, Q7 alpha chain,H2-Q7,Mouse,Mus musculus,QA-2 antigen 96T
E1702m ELISA H-2 class I histocompatibility antigen, Q7 alpha chain,H2-Q7,Mouse,Mus musculus,QA-2 antigen 96T
E1702m ELISA kit H-2 class I histocompatibility antigen, Q7 alpha chain,H2-Q7,Mouse,Mus musculus,QA-2 antigen 96T
U1555m CLIA H-2 class I histocompatibility antigen, TLA(B) alpha chain,H2-T3,MHC thymus leukemia antigen,Mouse,Mus musculus 96T
E1555m ELISA H-2 class I histocompatibility antigen, TLA(B) alpha chain,H2-T3,MHC thymus leukemia antigen,Mouse,Mus musculus 96T
E1555m ELISA kit H-2 class I histocompatibility antigen, TLA(B) alpha chain,H2-T3,MHC thymus leukemia antigen,Mouse,Mus musculus 96T
EIAAB11903 HLA class II histocompatibility antigen, DR beta 3 chain,HLA-DRB3,Homo sapiens,Human,MHC class II antigen DRB3
EIAAB11885 HLA class II histocompatibility antigen, DQ beta 1 chain,HLA-DQB,HLA-DQB1,Homo sapiens,Human,MHC class II antigen DQB1
EIAAB11904 HLA class II histocompatibility antigen, DR beta 4 chain,HLA-DRB4,Homo sapiens,Human,MHC class II antigen DRB4


 

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