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HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)

 DPB1_HUMAN              Reviewed;         258 AA.
P04440; A0PFJ7; A5I886; A8YPB3; B5U8B4; B7VF80; B7VF87; B8ZX68;
B8ZYT0; B9W5S8; B9W6F7; B9W6F9; C0MPP5; C0MPQ2; C0MPQ3; C0MPQ5;
C0MPQ6; C0MPQ7; C4R9J5; C5IZL1; O00259; O19698; O19700; O19702;
O19749; O46884; O77952; O98215; O98216; O98217; O98218; O98219;
O98222; O98223; P01916; P04232; P13763; P79493; P79608; Q0P0L4;
Q0ZFN3; Q14279; Q27S71; Q29682; Q29684; Q29698; Q29714; Q29775;
Q29776; Q29778; Q29779; Q29781; Q29827; Q29828; Q29879; Q29880;
Q29898; Q29977; Q2MGW3; Q30015; Q30031; Q30032; Q30033; Q30034;
Q30050; Q30051; Q30052; Q30053; Q30054; Q30055; Q30174; Q4GY31;
Q4JHD8; Q5ENE0; Q5ENE1; Q5ENW3; Q5EP46; Q5EP47; Q5EP49; Q5EP51;
Q5EP52; Q5EP53; Q5EP56; Q5I4H8; Q5I4H9; Q5ISH4; Q5ISH5; Q5SQ73;
Q5STP2; Q5YLA6; Q6IVX1; Q6LBX2; Q6LBX3; Q6LBX4; Q6LBX5; Q6LBX6;
Q6LBX7; Q6PWX6; Q6TAS4; Q714U1; Q714U2; Q7YQ10; Q860Z7; Q8HWL7;
Q8HWT5; Q8SNC4; Q95HC1; Q95IT7; Q95IT8; Q9BD13; Q9GIM2; Q9GIM4;
Q9GIX6; Q9GJ41; Q9MY67; Q9TNT7; Q9TQE2; Q9XS11; Q9XS12;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
25-OCT-2017, entry version 164.
RecName: Full=HLA class II histocompatibility antigen, DP beta 1 chain;
AltName: Full=HLA class II histocompatibility antigen, DP(W4) beta chain;
AltName: Full=MHC class II antigen DPB1;
Flags: Precursor;
Name=HLA-DPB1; Synonyms=HLA-DP1B;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*02:01), AND NUCLEOTIDE
SEQUENCE [GENOMIC DNA] (ALLELES DPB1*03:01 AND DPB1*04:01).
PubMed=6098459;
Kappes D.J., Arnot D., Okada K., Strominger J.L.;
"Structure and polymorphism of the HLA class II SB light chain
genes.";
EMBO J. 3:2985-2993(1984).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*02:01).
PubMed=2998758;
Tonnelle C., Demars R., Long E.O.;
"DO beta: a new beta chain gene in HLA-D with a distinct regulation of
expression.";
EMBO J. 4:2839-2847(1985).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPB1*04:01).
PubMed=2987832; DOI=10.1093/nar/13.5.1607;
Kelly A., Trowsdale J.;
"Complete nucleotide sequence of a functional HLA-DP beta gene and the
region between the DP beta 1 and DP alpha 1 genes: comparison of the
5' ends of HLA class II genes.";
Nucleic Acids Res. 13:1607-1621(1985).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPB1*04:01).
PubMed=3036829;
Gustafsson K., Widmark E., Jonsson A.-K., Servenius B., Sachs D.H.,
Larhammar D., Rask L., Peterson P.A.;
"Class II genes of the human major histocompatibility complex.
Evolution of the DP region as deduced from nucleotide sequences of the
four genes.";
J. Biol. Chem. 262:8778-8786(1987).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*04:01).
PubMed=2838415; DOI=10.1016/0888-7543(88)90103-6;
Compagnone-Post P., Turco E., Robinson C., Trucco M.;
"The beta-chains of DP4 molecules from different haplotypes are
encoded by the same gene.";
Genomics 2:8-13(1988).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*01:01).
PubMed=1529429; DOI=10.1111/j.1399-0039.1992.tb01938.x;
Korioth F., Hartung K., Deicher H., Frey J.;
"A new HLA-DPB1 allele from a patient with systemic lupus
erythematosus.";
Tissue Antigens 39:216-219(1992).
[7]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DPB1*01:01; DPB1*02:02;
DPB1*04:01; DPB1*04:02; DPB1*05:01; DPB1*05:02; DPB1*06:02;
DPB1*08:02; DPB1*09:01; DPB1*09:02; DPB1*13:01; DPB1*15:01 AND
DPB1*19:01).
PubMed=16189666; DOI=10.1007/s00251-005-0043-8;
Reinders J., Rozemuller E.H., van Gent R., Arts-Hilkes Y.H.,
van den Tweel J.G., Tilanus M.G.J.;
"Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1
typing.";
Immunogenetics 57:790-794(2005).
[8]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DPB1*02:02; DPB1*05:01 AND
DPB1*13:01).
Lee E., Kim E., Kwack K.;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DPB1*04:01).
TISSUE=Spleen;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DPB1*01:01).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DPB1*02:02;
DPB1*03:01; DPB1*04:01 AND DPB1*04:02).
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[12]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DPB1*04:01).
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[13]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DPB1*01:01 AND
DPB1*04:01).
TISSUE=B-cell, and Lymph;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[14]
NUCLEOTIDE SEQUENCE [MRNA] OF 9-258 (ALLELE DPB1*04:01).
PubMed=2714855; DOI=10.1007/BF00352845;
Lee J.S., Sartoris S., Briata P., Choi E., Cullen C., Lepaslier D.,
Yunis I.;
"Sequence polymorphism of HLA-DP beta chains.";
Immunogenetics 29:346-349(1989).
[15]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-114 (ALLELE DPB1*75:01).
Louie L., Ginther C., Francisco A.M., van der Zwan A.W.,
Katongole-Mbidde E., Tilanus M.G.J., Klitz W.;
"HLA and mtDNA variation among the Baganda in Uganda.";
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
[16]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-122 (ALLELE DPB1*56:01).
PubMed=7638863; DOI=10.1111/j.1399-0039.1995.tb02450.x;
Rani R., Fernandez-Vina M.A., Zhang S., Stastny P.;
"HLA-DPB1 alleles in a population from north India and description of
a new variant (DPB1*5601).";
Tissue Antigens 45:264-269(1995).
[17]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*39:01).
PubMed=1481203; DOI=10.1111/j.1399-0039.1992.tb02055.x;
Hessner M.J., Baxter-Lowe L.A.;
"Characterization of novel HLA-DPB1 alleles by oligotyping and
nucleotide sequencing.";
Tissue Antigens 40:261-263(1992).
[18]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*67:01).
PubMed=8896187; DOI=10.1111/j.1399-0039.1996.tb02637.x;
Meyer C.G., May J., Simon C., Bohm B.O., Loeliger C.C.;
"DPB1*TF, a novel HLA class II DPB1 allele (DPB1*6701) identified in a
Turkish family.";
Tissue Antigens 48:231-232(1996).
[19]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (DPB1*77:01 AND
DPB1*78:01).
PubMed=9756410; DOI=10.1111/j.1399-0039.1998.tb02285.x;
Voorter C., Richeldi L., Gervais T., van den Berg-Loonen E.;
"Identification of two new DPB1 alleles, DPB1*7701 and *7801, by
sequence-based typing.";
Tissue Antigens 52:190-192(1998).
[20]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*79:01).
PubMed=9756411; DOI=10.1111/j.1399-0039.1998.tb02286.x;
Voorter C., Chatelain B., Sintnicolaas K., Tilanus M.G.J., Hidajat M.,
van den Berg-Loonen E.;
"Identification of a new DPB1 allele (DPB1*7901) by sequence-based
typing.";
Tissue Antigens 52:193-195(1998).
[21]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*04:03).
PubMed=16147881; DOI=10.1080/10425170500061442;
Weston A., Ensey J.S., Frye B.L.;
"DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA-
DPB1*0403.";
DNA Seq. 16:235-236(2005).
[22]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*98:01).
TISSUE=Blood;
Cox S.T., Wallis-Jones S.;
"Two new HLA DP alleles.";
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[23]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*20:02), AND
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*14:02).
Cox S.T.;
"Sequence of DPB1*0301 allele, and sequence of HLA-DPB1*66new.";
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[24]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*21:02).
Casanova A.A.;
"Sequence of DPB1*0101 variant.";
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
[25]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELES DPB1*30:01;
DPB1*32:01; DPB1*33:01; DPB1*34:01 AND DPB1*35:01), AND NUCLEOTIDE
SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*27:01).
PubMed=1440570; DOI=10.1111/j.1399-0039.1992.tb02109.x;
Moonsamy P.V., Suraj V.C., Bugawan T.L., Saiki R.K., Stoneking M.,
Roudier J., Magzoub M.M., Hill A.V., Begovich A.B.;
"Genetic diversity within the HLA class II region: ten new DPB1
alleles and their population distribution.";
Tissue Antigens 40:153-157(1992).
[26]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELE DPB1*58:01).
PubMed=7806296; DOI=10.1007/BF00182337;
Versluis L.F., van der Zwan A.W., Tilanus M.G.J., Daly L.N.,
Degli-Eposti M.A., Dawkins R.L.;
"Identification of the novel HLA-DPB1*5801 allele detected by
sequenced based typing.";
Immunogenetics 41:173-173(1995).
[27]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELES DPB1*60:01 AND
DPB1*62:01).
PubMed=8773318; DOI=10.1111/j.1399-0039.1996.tb02556.x;
Zimmerman P.A., Steiner L.L., Titanji V.P., Nde P.N., Bradley J.E.,
Pogonka T., Begovich A.B.;
"Three new DPB1 alleles identified in a Bantu-speaking population from
central Cameroon.";
Tissue Antigens 47:293-299(1996).
[28]
NUCLEOTIDE SEQUENCE [MRNA] OF 35-258, AND VARIANTS LEU-94; VAL-105;
ASP-113; GLU-114; ALA-115; VAL-116; LYS-125 AND ILE-199.
PubMed=6330724; DOI=10.1073/pnas.81.13.3934;
Gorski J., Rollini P., Long E., Mach B.;
"Molecular organization of the HLA-SB region of the human major
histocompatibility complex and evidence for two SB beta-chain genes.";
Proc. Natl. Acad. Sci. U.S.A. 81:3934-3938(1984).
[29]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-215 (ALLELE DPB1*24:02).
PubMed=19775376; DOI=10.1111/j.1399-0039.2009.01325.x;
Witter K., Kirchner E., Borelli C., Messer G., Albert T., Zahn R.,
Kauke T.;
"In a study for acne vulgaris, sequence-based HLA typing showed a
novel DPB1 allele, DPB1*2402.";
Tissue Antigens 74:354-356(2009).
[30]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-215 (ALLELES DPB1*06:01;
DPB1*16:01; DPB1*17:01; DPB1*18:01; DPB1*20:01; DPB1*23:01;
DPB1*26:01; DPB1*26:02; DPB1*28:01; DPB1*45:01; DPB1*55:01; DPB1*85:01
AND DPB1*88:01).
Witter K., Tran H., Sabine S.;
"Confirmation of several HLA-DPB1 alleles including exon 3.";
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[31]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*04:01).
PubMed=2460556;
Bugawan T.L., Horn G.T., Long C.M., Mickelson E., Hansen J.A.,
Ferrara G.B., Angelini G., Erlich H.A.;
"Analysis of HLA-DP allelic sequence polymorphism using the in vitro
enzymatic DNA amplification of DP-alpha and DP-beta loci.";
J. Immunol. 141:4024-4030(1988).
[32]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*04:01), AND
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DPB1*08:01).
PubMed=2242906; DOI=10.1007/BF00187094;
Bugawan T.L., Begovich A.B., Erlich H.A.;
"Rapid HLA-DPB typing using enzymatically amplified DNA and
nonradioactive sequence-specific oligonucleotide probes.";
Immunogenetics 32:231-241(1990).
[33]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*46:01).
TISSUE=Leukocyte;
PubMed=8344726; DOI=10.1007/BF00210483;
Buyse I., Emonds M.P., Bouillon R., Marynen P., Cassiman J.J.;
"Novel class II HLA-DRB4 and DPB1 alleles found in the Belgian
population.";
Immunogenetics 38:380-380(1993).
[34]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*41:01).
PubMed=7901923; DOI=10.1111/j.1399-0039.1993.tb02016.x;
Mizuki N., Ohno S., Sugimura K., Seki T., Ishioka M., Inoko H.,
Geng L.;
"Identification of a new HLA-DPB1 allele detected by PCR-RFLP and its
nucleotide sequence determination by direct sequencing after PCR
amplification.";
Tissue Antigens 41:259-262(1993).
[35]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*47:01).
TISSUE=Blood;
PubMed=7912859; DOI=10.1111/j.1399-0039.1994.tb02297.x;
Koshizaka T., Taguchi M., Onishi H., Kobayashi S., Inoko H.;
"A new HLA-DPB1 allele, DPB1*SUT (DPB1*4701).";
Tissue Antigens 43:50-53(1994).
[36]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*51:01).
TISSUE=Blood;
PubMed=7839356; DOI=10.1111/j.1399-0039.1994.tb02382.x;
Kaneshige T., Kinoshita T., Hashimoto M., Matsumoto Y., Moribe T.,
Ichikawa Y., Fukunishi T., Uchida K.;
"Direct sequencing of a novel DPB1 allele (DPB1*5101) of the
heterozygote from the membrane of reverse dot blot analysis.";
Tissue Antigens 44:204-207(1994).
[37]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*66:01).
TISSUE=Blood;
PubMed=8781129; DOI=10.1007/BF02602788;
Schnittger L., May J., Kretschmer C., Kremsner P.G., Meyer C.G.;
"DPB1*BR: an Mhc class II DPB1 allele (DPB1*6601) of negroid origin.";
Immunogenetics 44:405-406(1996).
[38]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*65:01).
PubMed=8824162; DOI=10.1007/BF02602812;
Versluis L.F., Philippe M., Van der Zwan A., Thonnard J., Tongio M.M.,
Tilanus M.G.J.;
"Identification of a new HLA-DPB1*6501 allele in a Caucasian
individual.";
Immunogenetics 44:483-484(1996).
[39]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*82:01 AND
DPB1*83:01).
PubMed=11169249; DOI=10.1034/j.1399-0039.2000.560613.x;
Voorter C., Tilanus M.G.J., van den Berg-Loonen E.;
"Two new HLA DPB1 alleles identified by sequence-based typing:
DPB1*8201 and DPB1*8301.";
Tissue Antigens 56:560-562(2000).
[40]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*86:01).
PubMed=11556983; DOI=10.1034/j.1399-0039.2001.057006536.x;
Bengtsson M.;
"DPB1*8601, a previously unrecognized DPB1 variant in the Caucasoid
population.";
Tissue Antigens 57:536-539(2001).
[41]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*87:01).
PubMed=11782281; DOI=10.1034/j.1399-0039.2001.580410.x;
Grams S.E., Wu J., Noreen H.J., Mangaccat J., Cognato M.A.,
Johnson S., Segall M., Williams T.M., Begovich A.B.;
"Three new DP alleles identified in a study of 800 unrelated bone
marrow donor-recipient pairs.";
Tissue Antigens 58:272-275(2001).
[42]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*90:01).
PubMed=12135440; DOI=10.1034/j.1399-0039.2002.590419.x;
Bengtsson M., Danielsson F., Jansson I.E., Johansson U.;
"Identification of a new HLA-DPB1 allele,HLA-DPB1*9001.";
Tissue Antigens 59:344-346(2002).
[43]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*93:01).
PubMed=12694578; DOI=10.1046/j.0001-2815.2002.00143.x;
Liu Z.-H., Fan X., Lin J., Fu Y., Liu X., Xu A.;
"Identification of a novel DPB1 allele, DPB1*9301, by sequence-based
typing in a Lahu ethnic minority of China.";
Tissue Antigens 61:261-262(2003).
[44]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*94:01 AND
DPB1*95:01).
PubMed=12890000; DOI=10.1034/j.1399-0039.2003.00066.x;
Luo M., Ramdahin S., Iqbal S., Pan Y., Jacobson K., Narayansingh M.J.,
Schroeder M., Brunham R.C., Embree J., Plummer F.A.;
"High resolution sequence-based DPB1 typing identified two novel DPB1
alleles, DPB1*9401 and DPB1*9501, from a Kenyan population.";
Tissue Antigens 62:182-184(2003).
[45]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (DPB1*96:01).
PubMed=12890001; DOI=10.1034/j.1399-0039.2003.00081.x;
Witter K., Gervais T., Dunn P.P., Voorter C., Muramoto J.,
Albert E.D.;
"Sequence-based typing identifies a novel HLA-DPB1 allele,
DPB1*9601.";
Tissue Antigens 62:185-187(2003).
[46]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*01:02).
PubMed=15361132; DOI=10.1111/j.1399-0039.2004.00276.x;
Lv F., Lin J., Liu Z.-H., Gao J., Fu Y., Xu A.;
"Identification of a novel HLA-DPB1 allele--DPB1*0102.";
Tissue Antigens 64:512-514(2004).
[47]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*17:02).
TISSUE=Blood;
PubMed=16866899; DOI=10.1111/j.1399-0039.2006.00630.x;
Li M., Nie J., Xu Y., Xu A., Yu X.;
"Identification of a novel HLA-DPB1 allele, DPB1*1702.";
Tissue Antigens 68:187-188(2006).
[48]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*21:01;
DPB1*22:01; DPB1*24:01; DPB1*25:01; DPB1*29:01 AND DPB1*31:01).
Kimura A.;
Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases.
[49]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*89:01).
Dormoy A., Routoulp M., Froelich N., Tongio M.M.;
"A new HLA-DPB1* allele identical to the DPB1*0101 allele except for
the polymorphic positions 226 and 228 where G and A are found
respectively in place of A and G.";
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
[50]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*91:01 AND
DPB1*92:01).
Varney M.D., Rossi V.;
"A novel DPB1 allele.";
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
[51]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*10:01).
Luo M., Mao X., Shehzad I., Jacobson K., Kwan L., Shroeder M.,
Plummer F.A.;
"Sequence-based DPB typing fills the missing exon 2 sequences of
multiple HLA-DPB1 alleles.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[52]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*99:01).
Edelshtein D., Sidebottom D., Chen D.-F., Baxter-Lowe L.A.;
"A novel DPB1 allele identified by sequence-based typing and Confirmed
by SSP.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[53]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*02:03).
Wu J., Williams T.M., Cognato M.A.;
"Novel human HLA-DPB1 allele identified in potential bone marrow
donors.";
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[54]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*10:02 AND
DPB1*11:02).
Garbarino L., Chiesa A., Pastori F., Sacchi N., Cusano R., Bottero F.,
Bossi R.;
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
[55]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*13:02).
Moonsamy P.V., Bonella P.L., Sali P.J., Bentley L.G., Post J.L.,
Goodwin G., Erlich H.E.;
"The identification of a new DPB1 allele in a type 1 diabetes genetics
consortium family.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
[56]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*16:02).
Kashiwase K., Ichihara T., Shimizu M., Satake M.;
"HLA-DPB1*8601V1.";
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
[57]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*18:02).
Cordovado S.K., Hancock L.N., Mueller P.W.;
"Identification of a novel DPB1 allele by sequence-based typing in the
GoKinD population.";
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
[58]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*19:02).
Monos D.S.;
"A New HLA-DPB1 allele.";
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
[59]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*11:01).
TISSUE=Peripheral blood;
Vilches C.;
"Complete exon 2 sequence of the HLA-DPB1*110101 allele.";
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
[60]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*22:02).
TISSUE=Peripheral blood;
McWhinnie A.J.M., Wallis-Jones S., Little A.M.;
"Exon 2 sequence of a new HLA-DPB1 allele DPB1*XX exhibiting single
nucleotide difference G337A from HLA-DPB1*1401.";
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
[61]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*25:02).
Lazaro A.M., Xiao Y., Nehlsen-Cannarella S.L., Fagoaga O.R.,
Hurley C.K.;
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
[62]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELES DPB1*40:01;
DPB1*48:01; DPB1*49:01; DPB1*50:01; DPB1*51:01; DPB1*52:01 AND
DPB1*53:01).
PubMed=8085260; DOI=10.1111/j.1399-0039.1994.tb02333.x;
Moonsamy P.V., Aldrich C.L., Petersdorf E.W., Hill A.V.,
Begovich A.B.;
"Seven new DPB1 alleles and their population distribution.";
Tissue Antigens 43:249-252(1994).
[63]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELES DPB1*59:01;
DPB1*68:01; DPB1*70:01; DPB1*71:01; DPB1*72:01 AND DPB1*73:01).
PubMed=9174146; DOI=10.1111/j.1399-0039.1997.tb02788.x;
Noreen H.J., Steiner L.L., Davidson M., Johnson S., Segall M.,
Begovich A.B.;
"Six new DPB1 alleles identified in a study of 1,302 unrelated bone
marrow donor-recipient pairs.";
Tissue Antigens 49:512-516(1997).
[64]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*80:01), AND
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPB1*81:01).
PubMed=10090623; DOI=10.1034/j.1399-0039.1999.530213.x;
Steiner L.L., Wu J., Noreen H.J., Moehlenkamp C., Cavalli A.S.,
Davidson M., Johnson S., Winden T., Segall M., Begovich A.B.,
Williams T.M.;
"Four new DP alleles identified in a study of 500 unrelated bone
marrow donor-recipient pairs.";
Tissue Antigens 53:201-206(1999).
[65]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*97:01).
PubMed=15140044; DOI=10.1111/j.0001-2815.2004.00198.x;
Lapi S., Curcio M., Fornaciari S., Mariotti M.L., Isola P., Bonci F.,
Pistello M., Scatena F.;
"Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence-
based typing.";
Tissue Antigens 63:606-608(2004).
[66]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*63:01).
Begovich A.B., Steiner L.L.;
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
[67]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*76:01).
Rozemuller E.H.;
"A new HLA-DPB1 allele: a variant of DPB1*1401.";
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
[68]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*44:01).
PubMed=7744621; DOI=10.1016/0198-8859(94)00100-5;
Versluis L.F., Tilanus M.G.J., Verduyn W., Abdulkadir J.,
Giphart M.J.;
"Novel HLA-DPB1 alleles detected in the Ethiopian population.";
Hum. Immunol. 42:181-183(1995).
[69]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-118 (ALLELE DPB1*59:01).
PubMed=8851734; DOI=10.1111/j.1399-0039.1996.tb02533.x;
Noble J.A., Cavalli A.S., Erlich H.A.;
"DPB1*5901a: a novel HLA-DPB1 allele from a Caucasian family with
insulin-dependent diabetes mellitus.";
Tissue Antigens 47:159-162(1996).
[70]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-118 (ALLELE DPB1*03:02).
PubMed=15982263; DOI=10.1111/j.1399-0039.2005.00429.x;
Sheldon M.H., Azzaro M.P., Sayer D., Bunce M., Sortino G.;
"Identification of a new allele in a Sicilian individual: HLA-
DPB1*0302.";
Tissue Antigens 66:64-66(2005).
[71]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPB1*69:01).
Varney M.D., Tait B.D.;
"Identification of a novel DPB allele.";
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
[72]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-114 (ALLELE DPB1*44:01).
TISSUE=Blood;
Easteal S., Croft L.;
"A new HLA-DPB1 alleles from Santa Cruz Island, Solomon Islands.";
Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases.
[73]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DPB1*37:01).
PubMed=1412421; DOI=10.1111/j.1399-0039.1992.tb01966.x;
Meyer C.G., Schnittger L., Begovich A.B., Erlich H.A., Horstmann R.D.;
"DPB1*WA4 - an additional HLA class II allele identified in west
Africa.";
Tissue Antigens 40:98-99(1992).
[74]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*38:01).
PubMed=1358867; DOI=10.1016/0198-8859(92)90113-2;
Mitsunaga S., Kuwata S., Tokunaga K., Uchikawa C., Takahashi K.,
Akaza T., Mitomi Y., Juji T.;
"Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-
DR/DQ and two 'new' alleles.";
Hum. Immunol. 34:203-211(1992).
[75]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*36:01).
PubMed=7817379; DOI=10.1111/j.1399-0039.1994.tb02370.x;
Ogawa K., Itho H., Nakajyo S., Kobayashi K., Sekiguchi S.,
Koshizaka T., Taguchi M., Onishi H., Kobayashi S., Inoko H.;
"A novel HLA-DPB1 allele, DPB1*3601 (DPB1*KT).";
Tissue Antigens 44:134-136(1994).
[76]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*74:01).
PubMed=9694359; DOI=10.1111/j.1399-0039.1998.tb03009.x;
Steiner L.L., Cavalli A., Zimmerman P.A., Boatin B.A., Titanji V.P.,
Bradley J.E., Lucius R., Nutman T.B., Begovich A.B.;
"Three new DP alleles identified in sub-Saharan Africa: DPB1*7401,
DPA1*02013, and DPA1*0302.";
Tissue Antigens 51:653-657(1998).
[77]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-115 (ALLELE DPB1*57:01).
TISSUE=Lymphocyte;
PubMed=8525482; DOI=10.1111/j.1399-0039.1995.tb03122.x;
Mersch G., Mytilineos J., De Canck I., Deufel A., Mijs W., Scherer S.,
Jannes G., Opelz G., Rossau R.;
"Characterization of a new DPB1 allele (DPB1*5701) isolated from a
Caucasian individual.";
Tissue Antigens 46:208-212(1995).
[78]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-121 (ALLELE DPB1*84:01).
PubMed=10958363; DOI=10.1034/j.1399-0039.2000.560114.x;
McTernan C.L., Mijovic C.H., Cockram C.S., Barnett A.H.;
"The nucleotide sequence of two new DP alleles, DPA1*02015 and
DPB1*8401, identified in a Chinese subject.";
Tissue Antigens 56:95-98(2000).
[79]
NUCLEOTIDE SEQUENCE [MRNA] OF 78-258 (ALLELE DPB1*02:01).
PubMed=6310612; DOI=10.1073/pnas.80.19.6036;
Roux-Dosseto M., Auffray C., Lillie J.W., Boss J.M., Cohen D.,
Demars R., Mawas C., Seidman J.G., Strominger J.L.;
"Genetic mapping of a human class II antigen beta-chain cDNA clone to
the SB region of the HLA complex.";
Proc. Natl. Acad. Sci. U.S.A. 80:6036-6040(1983).
[80]
REVIEW.
PubMed=8598037; DOI=10.1016/S0092-8674(00)81025-9;
Cresswell P.;
"Invariant chain structure and MHC class II function.";
Cell 84:505-507(1996).
[81]
REVIEW.
PubMed=11684289; DOI=10.1016/S0161-5890(01)00069-4;
Villadangos J.A.;
"Presentation of antigens by MHC class II molecules: getting the most
out of them.";
Mol. Immunol. 38:329-346(2001).
[82]
REVIEW.
PubMed=18046453; DOI=10.1038/sj.emboj.7601945;
Rocha N., Neefjes J.;
"MHC class II molecules on the move for successful antigen
presentation.";
EMBO J. 27:1-5(2008).
[83]
REVIEW.
PubMed=17241953; DOI=10.1016/j.immuni.2007.01.005;
Menendez-Benito V., Neefjes J.;
"Autophagy in MHC class II presentation: sampling from within.";
Immunity 26:1-3(2007).
[84]
REVIEW.
PubMed=19092054; DOI=10.1242/jcs.035089;
Berger A.C., Roche P.A.;
"MHC class II transport at a glance.";
J. Cell Sci. 122:1-4(2009).
[85]
REVIEW.
PubMed=19533806; DOI=10.3748/wjg.15.2855;
Beswick E.J., Reyes V.E.;
"CD74 in antigen presentation, inflammation, and cancers of the
gastrointestinal tract.";
World J. Gastroenterol. 15:2855-2861(2009).
-!- FUNCTION: Binds peptides derived from antigens that access the
endocytic route of antigen presenting cells (APC) and presents
them on the cell surface for recognition by the CD4 T-cells. The
peptide binding cleft accommodates peptides of 10-30 residues. The
peptides presented by MHC class II molecules are generated mostly
by degradation of proteins that access the endocytic route, where
they are processed by lysosomal proteases and other hydrolases.
Exogenous antigens that have been endocytosed by the APC are thus
readily available for presentation via MHC II molecules, and for
this reason this antigen presentation pathway is usually referred
to as exogenous. As membrane proteins on their way to degradation
in lysosomes as part of their normal turn-over are also contained
in the endosomal/lysosomal compartments, exogenous antigens must
compete with those derived from endogenous components. Autophagy
is also a source of endogenous peptides, autophagosomes
constitutively fuse with MHC class II loading compartments. In
addition to APCs, other cells of the gastrointestinal tract, such
as epithelial cells, express MHC class II molecules and CD74 and
act as APCs, which is an unusual trait of the GI tract. To produce
a MHC class II molecule that presents an antigen, three MHC class
II molecules (heterodimers of an alpha and a beta chain) associate
with a CD74 trimer in the ER to form a heterononamer. Soon after
the entry of this complex into the endosomal/lysosomal system
where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving
a small fragment termed CLIP (class-II-associated invariant chain
peptide). The removal of CLIP is facilitated by HLA-DM via direct
binding to the alpha-beta-CLIP complex so that CLIP is released.
HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound
to a peptide is then transported to the cell membrane surface. In
B-cells, the interaction between HLA-DM and MHC class II molecules
is regulated by HLA-DO. Primary dendritic cells (DCs) also to
express HLA-DO. Lysosomal microenvironment has been implicated in
the regulation of antigen loading into MHC II molecules, increased
acidification produces increased proteolysis and efficient peptide
loading.
-!- SUBUNIT: Heterodimer of an alpha and a beta subunit; also referred
as MHC class II molecule. In the endoplasmic reticulum (ER) it
forms a heterononamer; 3 MHC class II molecules bind to a CD74
homotrimer (also known as invariant chain or HLA class II
histocompatibility antigen gamma chain). In the
endosomal/lysosomal system; CD74 undergoes sequential degradation
by various proteases; leaving a small fragment termed CLIP on each
MHC class II molecule. MHC class II molecule interacts with
HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides.
-!- INTERACTION:
P50222:MEOX2; NbExp=4; IntAct=EBI-2802503, EBI-748397;
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein. Endoplasmic reticulum membrane; Single-pass type I
membrane protein. Golgi apparatus, trans-Golgi network membrane;
Single-pass type I membrane protein. Endosome membrane; Single-
pass type I membrane protein. Lysosome membrane; Single-pass type
I membrane protein. Note=The MHC class II complex transits through
a number of intracellular compartments in the endocytic pathway
until it reaches the cell membrane for antigen presentation.
-!- POLYMORPHISM: The following alleles of HLA-DPB1 are known:
DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03,
DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03,
DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02, DPB1*08:01,
DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02,
DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01,
DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02,
DPB1*17:01, DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01,
DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02,
DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02,
DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01,
DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01,
DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01,
DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01,
DPB1*45:01, DPB1*46:01, DPB1*47:01, DPB1*48:01, DPB1*49:01,
DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01,
DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01,
DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01,
DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01,
DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01,
DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01,
DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01, DPB1*86:01,
DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01,
DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01,
DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that
of DPB1*04:01.
-!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAQ12564.1; Type=Frameshift; Positions=39; Evidence={ECO:0000305};
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EMBL; X01426; CAA25672.1; -; mRNA.
EMBL; X02964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; X03023; CAE82008.1; -; Genomic_DNA.
EMBL; X03024; CAE82007.1; -; Genomic_DNA.
EMBL; X03022; CAA26823.1; -; Genomic_DNA.
EMBL; X03025; CAE82037.1; -; Genomic_DNA.
EMBL; X03026; CAE82042.1; -; Genomic_DNA.
EMBL; X03028; CAE82073.1; -; Genomic_DNA.
EMBL; X03027; CAE82043.1; -; Genomic_DNA.
EMBL; X03067; CAA26871.1; -; mRNA.
EMBL; X02228; CAA26147.1; -; Genomic_DNA.
EMBL; J03041; AAA35993.1; -; mRNA.
EMBL; M83664; AAA59837.1; -; mRNA.
EMBL; AY804132; AAW78737.1; -; mRNA.
EMBL; AY804133; AAW78738.1; -; mRNA.
EMBL; AY804135; AAW78740.1; -; mRNA.
EMBL; AY804136; AAW78741.1; -; mRNA.
EMBL; AY804137; AAW78742.1; -; mRNA.
EMBL; AY804138; AAW78743.1; -; mRNA.
EMBL; AY804139; AAW78744.1; -; mRNA.
EMBL; AY804141; AAW78746.1; -; mRNA.
EMBL; AY804142; AAW78747.1; -; mRNA.
EMBL; AY804143; AAW78748.1; -; mRNA.
EMBL; AY831401; AAW80919.1; -; mRNA.
EMBL; AY831402; AAW80920.1; -; mRNA.
EMBL; AY831403; AAW80921.1; -; mRNA.
EMBL; AY831404; AAW80922.1; -; mRNA.
EMBL; AY656678; AAV71025.1; -; mRNA.
EMBL; AY656679; AAV71026.1; -; mRNA.
EMBL; AY656680; AAV71027.1; -; mRNA.
EMBL; AK313305; BAG36110.1; -; mRNA.
EMBL; BT019780; AAV38583.1; -; mRNA.
EMBL; AL645931; CAI18042.1; -; Genomic_DNA.
EMBL; AL662824; CAI17602.1; -; Genomic_DNA.
EMBL; AL805913; CAI18551.1; -; Genomic_DNA.
EMBL; AL845446; CAI18551.1; JOINED; Genomic_DNA.
EMBL; AL845446; CAI95555.1; -; Genomic_DNA.
EMBL; AL805913; CAI95555.1; JOINED; Genomic_DNA.
EMBL; BX120009; CAM25984.1; -; Genomic_DNA.
EMBL; CR759795; CAQ07437.1; -; Genomic_DNA.
EMBL; CR759904; CAQ09869.1; -; Genomic_DNA.
EMBL; CR762479; CAQ10348.1; -; Genomic_DNA.
EMBL; CH471081; EAX03674.1; -; Genomic_DNA.
EMBL; BC007963; AAH07963.1; -; mRNA.
EMBL; BC013184; AAH13184.1; -; mRNA.
EMBL; M28202; AAA53197.1; -; mRNA.
EMBL; Y09327; CAA70507.1; -; Genomic_DNA.
EMBL; L31816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M97686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; X96985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; Y13900; CAA74199.1; -; Genomic_DNA.
EMBL; Y14230; CAA74608.1; -; Genomic_DNA.
EMBL; Y16095; CAA76060.1; -; Genomic_DNA.
EMBL; AY823995; AAW79272.1; -; Genomic_DNA.
EMBL; AJ563603; CAD91639.1; -; Genomic_DNA.
EMBL; AM039828; CAJ01690.1; -; Genomic_DNA.
EMBL; AM408787; CAL64063.1; -; Genomic_DNA.
EMBL; AM698036; CAM91695.1; -; Genomic_DNA.
EMBL; M84619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M84620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M84622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M84623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M84624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M84626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; X82123; CAA57635.1; -; Genomic_DNA.
EMBL; U22311; AAB60413.1; -; Genomic_DNA.
EMBL; U22313; AAB17108.1; -; Genomic_DNA.
EMBL; K01615; AAA36313.1; -; mRNA.
EMBL; FM883600; CAT04585.2; -; Genomic_DNA.
EMBL; FM882212; CAT03206.1; -; Genomic_DNA.
EMBL; FM956650; CAX11690.1; -; Genomic_DNA.
EMBL; FM991729; CAX20314.1; -; Genomic_DNA.
EMBL; FM992080; CAX21583.2; -; Genomic_DNA.
EMBL; FM992366; CAX30407.1; -; Genomic_DNA.
EMBL; FM992364; CAX30405.1; -; Genomic_DNA.
EMBL; FN252853; CAX53275.1; -; Genomic_DNA.
EMBL; FN256250; CAX53717.1; -; Genomic_DNA.
EMBL; FN256251; CAX53721.1; -; Genomic_DNA.
EMBL; FN256254; CAX53718.1; -; Genomic_DNA.
EMBL; FN256253; CAX53726.1; -; Genomic_DNA.
EMBL; FN256255; CAX53722.1; -; Genomic_DNA.
EMBL; FN393829; CAY85528.1; -; Genomic_DNA.
EMBL; M23675; AAA59740.1; -; Genomic_DNA.
EMBL; M62326; AAA59719.1; -; Genomic_DNA.
EMBL; M62331; AAA59724.1; -; Genomic_DNA.
EMBL; L07768; AAA59690.1; -; Genomic_DNA.
EMBL; D13174; BAA02465.1; -; Genomic_DNA.
EMBL; D10834; BAA01614.1; -; Genomic_DNA.
EMBL; D28809; BAA05970.1; -; Genomic_DNA.
EMBL; X96986; CAA65710.2; -; Genomic_DNA.
EMBL; X91886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; Y18498; CAC12860.1; -; Genomic_DNA.
EMBL; AJ238005; CAC12865.1; -; Genomic_DNA.
EMBL; AJ271373; CAB70605.2; -; Genomic_DNA.
EMBL; AF288354; AAG30143.1; -; Genomic_DNA.
EMBL; AJ292074; CAC27995.1; -; Genomic_DNA.
EMBL; AF536241; AAN33050.1; -; Genomic_DNA.
EMBL; AF549409; AAQ12563.1; -; Genomic_DNA.
EMBL; AF549410; AAQ12564.1; ALT_FRAME; Genomic_DNA.
EMBL; AJ514871; CAD55852.1; -; Genomic_DNA.
EMBL; AY374100; AAR21105.1; -; Genomic_DNA.
EMBL; DQ206450; ABB17974.1; -; Genomic_DNA.
EMBL; M83914; AAA36264.1; -; Genomic_DNA.
EMBL; M83915; AAA36259.1; -; Genomic_DNA.
EMBL; M83916; AAA36260.1; -; Genomic_DNA.
EMBL; M83917; AAA36261.1; -; Genomic_DNA.
EMBL; M83918; AAA36262.1; -; Genomic_DNA.
EMBL; M83919; AAA36263.1; -; Genomic_DNA.
EMBL; AJ297820; CAC14048.1; -; Genomic_DNA.
EMBL; AY029777; AAK40344.1; -; Genomic_DNA.
EMBL; AF489518; AAL92172.1; -; Genomic_DNA.
EMBL; AF492640; AAO84765.1; -; Genomic_DNA.
EMBL; AY425707; AAR29060.1; -; Genomic_DNA.
EMBL; AY572830; AAS77869.1; -; Genomic_DNA.
EMBL; AY855160; AAW33682.1; -; Genomic_DNA.
EMBL; AY855161; AAW33683.1; -; Genomic_DNA.
EMBL; DQ089022; AAY98352.1; -; Genomic_DNA.
EMBL; AB247517; BAE78492.1; -; Genomic_DNA.
EMBL; DQ386161; ABD36812.1; -; Genomic_DNA.
EMBL; DQ485789; ABF47047.1; -; Genomic_DNA.
EMBL; AM887530; CAP08783.1; -; Genomic_DNA.
EMBL; FM211032; CAR66500.1; -; Genomic_DNA.
EMBL; FJ976693; ACS12738.1; -; Genomic_DNA.
EMBL; L17310; AAA53479.1; -; Genomic_DNA.
EMBL; L17311; AAA53480.1; -; Genomic_DNA.
EMBL; L17313; AAA53481.1; -; Genomic_DNA.
EMBL; L17314; AAA53482.1; -; Genomic_DNA.
EMBL; L22076; AAA53476.1; -; Genomic_DNA.
EMBL; L22077; AAA53477.1; -; Genomic_DNA.
EMBL; L23400; AAA58441.1; -; Genomic_DNA.
EMBL; U59437; AAD09481.1; -; Genomic_DNA.
EMBL; U59438; AAD09482.1; -; Genomic_DNA.
EMBL; U59439; AAD09483.1; -; Genomic_DNA.
EMBL; U59440; AAD09484.1; -; Genomic_DNA.
EMBL; U59441; AAD09485.1; -; Genomic_DNA.
EMBL; U59442; AAD09486.1; -; Genomic_DNA.
EMBL; AF074845; AAD39682.1; -; Genomic_DNA.
EMBL; AF074846; AAD39683.1; -; Genomic_DNA.
EMBL; AY033075; AAK51161.1; -; Genomic_DNA.
EMBL; U34033; AAA81335.1; -; Genomic_DNA.
EMBL; Z92523; CAB06822.1; -; Genomic_DNA.
EMBL; X78042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; U29534; AAB52511.1; -; Genomic_DNA.
EMBL; AY618897; AAT40308.1; -; Genomic_DNA.
EMBL; X97406; CAA66059.1; -; Genomic_DNA.
EMBL; L01466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M87046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; D10478; BAA01281.1; -; Genomic_DNA.
EMBL; D10882; BAA01704.1; -; Genomic_DNA.
EMBL; U94839; AAC64232.1; -; Genomic_DNA.
EMBL; X80752; CAA56728.1; -; Genomic_DNA.
EMBL; AF077015; AAC26835.1; -; Genomic_DNA.
EMBL; K00409; AAA36312.1; -; mRNA.
CCDS; CCDS4765.1; -.
PIR; A02228; HLHUS1.
PIR; A02229; HLHUPB.
PIR; D30536; D30536.
PIR; D30537; D30537.
PIR; E30536; E30536.
PIR; I37298; I37298.
PIR; I37541; S49382.
PIR; I38195; HLHUS2.
PIR; I38197; I38197.
PIR; I59621; I59621.
PIR; I59637; I59637.
PIR; I59641; I59641.
PIR; I81234; I81234.
PIR; I81235; I81235.
PIR; I81236; I81236.
PIR; I81237; I81237.
PIR; I81238; I81238.
RefSeq; NP_002112.3; NM_002121.5.
UniGene; Hs.485130; -.
PDB; 3LQZ; X-ray; 3.25 A; B=33-218.
PDB; 4P4K; X-ray; 2.80 A; B/F=32-218.
PDB; 4P4R; X-ray; 3.00 A; B/D=32-218.
PDB; 4P57; X-ray; 2.60 A; B/D=33-218.
PDB; 4P5K; X-ray; 2.59 A; B/E=33-218.
PDB; 4P5M; X-ray; 1.70 A; B/D/F/H=33-218.
PDBsum; 3LQZ; -.
PDBsum; 4P4K; -.
PDBsum; 4P4R; -.
PDBsum; 4P57; -.
PDBsum; 4P5K; -.
PDBsum; 4P5M; -.
ProteinModelPortal; P04440; -.
SMR; P04440; -.
BioGrid; 109360; 40.
IntAct; P04440; 10.
STRING; 9606.ENSP00000408146; -.
iPTMnet; P04440; -.
PhosphoSitePlus; P04440; -.
SwissPalm; P04440; -.
BioMuta; HLA-DPB1; -.
DMDM; 122263; -.
MaxQB; P04440; -.
PaxDb; P04440; -.
PeptideAtlas; P04440; -.
PRIDE; P04440; -.
DNASU; 3115; -.
Ensembl; ENST00000399500; ENSP00000382422; ENSG00000215048.
Ensembl; ENST00000411749; ENSP00000414196; ENSG00000236693.
Ensembl; ENST00000418931; ENSP00000408146; ENSG00000223865.
Ensembl; ENST00000425130; ENSP00000396095; ENSG00000230763.
Ensembl; ENST00000433800; ENSP00000407674; ENSG00000226826.
Ensembl; ENST00000454006; ENSP00000389288; ENSG00000237710.
GeneID; 3115; -.
KEGG; hsa:3115; -.
UCSC; uc003ocu.3; human.
CTD; 3115; -.
DisGeNET; 3115; -.
EuPathDB; HostDB:ENSG00000223865.10; -.
GeneCards; HLA-DPB1; -.
HGNC; HGNC:4940; HLA-DPB1.
HPA; HPA011078; -.
HPA; HPA058509; -.
MalaCards; HLA-DPB1; -.
MIM; 142858; gene.
neXtProt; NX_P04440; -.
OpenTargets; ENSG00000223865; -.
Orphanet; 133; Chronic berylliosis.
Orphanet; 900; Granulomatosis with polyangiitis.
PharmGKB; PA35064; -.
eggNOG; ENOG410IWG3; Eukaryota.
eggNOG; ENOG410YI0S; LUCA.
GeneTree; ENSGT00900000140849; -.
HOVERGEN; HBG012730; -.
InParanoid; P04440; -.
KO; K06752; -.
OMA; ICQVEHT; -.
OrthoDB; EOG091G0W5S; -.
PhylomeDB; P04440; -.
TreeFam; TF336626; -.
Reactome; R-HSA-202424; Downstream TCR signaling.
Reactome; R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains.
Reactome; R-HSA-202430; Translocation of ZAP-70 to Immunological synapse.
Reactome; R-HSA-202433; Generation of second messenger molecules.
Reactome; R-HSA-2132295; MHC class II antigen presentation.
Reactome; R-HSA-389948; PD-1 signaling.
Reactome; R-HSA-877300; Interferon gamma signaling.
SIGNOR; P04440; -.
ChiTaRS; HLA-DPB1; human.
EvolutionaryTrace; P04440; -.
GeneWiki; HLA-DPB1; -.
GenomeRNAi; 3115; -.
PRO; PR:P04440; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000223865; -.
CleanEx; HS_HLA-DPB1; -.
ExpressionAtlas; P04440; baseline and differential.
Genevisible; P04440; HS.
GO; GO:0009986; C:cell surface; IMP:UniProtKB.
GO; GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome.
GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0005765; C:lysosomal membrane; TAS:Reactome.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0042613; C:MHC class II protein complex; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO; GO:0030658; C:transport vesicle membrane; TAS:Reactome.
GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IMP:UniProtKB.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IMP:UniProtKB.
GO; GO:0050870; P:positive regulation of T cell activation; IMP:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; IMP:UniProtKB.
GO; GO:0031295; P:T cell costimulation; TAS:Reactome.
GO; GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 3.10.320.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003006; Ig/MHC_CS.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR011162; MHC_I/II-like_Ag-recog.
InterPro; IPR014745; MHC_II_a/b_N.
InterPro; IPR000353; MHC_II_b_N.
Pfam; PF07654; C1-set; 1.
Pfam; PF00969; MHC_II_beta; 1.
ProDom; PD000328; MHC_II_b_N; 1.
SMART; SM00407; IGc1; 1.
SMART; SM00921; MHC_II_beta; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF54452; SSF54452; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00290; IG_MHC; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome; Disulfide bond;
Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus;
Immunity; Lysosome; Membrane; MHC II; Polymorphism;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 29
CHAIN 30 258 HLA class II histocompatibility antigen,
DP beta 1 chain.
/FTId=PRO_0000018984.
TOPO_DOM 30 225 Extracellular. {ECO:0000255}.
TRANSMEM 226 246 Helical. {ECO:0000255}.
TOPO_DOM 247 258 Cytoplasmic. {ECO:0000255}.
DOMAIN 124 212 Ig-like C1-type.
REGION 30 121 Beta-1.
REGION 122 215 Beta-2.
REGION 216 225 Connecting peptide.
CARBOHYD 48 48 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 44 106 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 144 200 {ECO:0000255|PROSITE-ProRule:PRU00114}.
VARIANT 16 16 T -> M (in allele DPB1*09:02;
dbSNP:rs41558014).
/FTId=VAR_060627.
VARIANT 24 24 T -> I (in dbSNP:rs11551416).
/FTId=VAR_060628.
VARIANT 30 30 R -> P (in allele DPB1*75:01).
/FTId=VAR_060629.
VARIANT 31 31 A -> L (in allele DPB1*75:01; requires 2
nucleotide substitutions).
/FTId=VAR_060630.
VARIANT 32 32 T -> P (in allele DPB1*75:01).
/FTId=VAR_060631.
VARIANT 33 33 P -> A (in allele DPB1*75:01).
/FTId=VAR_060632.
VARIANT 37 37 L -> V (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*05:02, allele
DPB1*06:01, allele DPB1*09:01, allele
DPB1*09:02, allele DPB1*10:01, allele
DPB1*11:01, allele DPB1*11:02, allele
DPB1*13:01, allele DPB1*13:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*15:01, allele DPB1*16:02, allele
DPB1*17:01, allele DPB1*17:02, allele
DPB1*18:01, allele DPB1*20:02, allele
DPB1*21:01, allele DPB1*21:02, allele
DPB1*20:01, allele DPB1*22:02, allele
DPB1*25:01, allele DPB1*25:02, allele
DPB1*26:01, allele DPB1*27:01, allele
DPB1*29:01, allele DPB1*30:01, allele
DPB1*35:01, allele DPB1*36:01, allele
DPB1*37:01, allele DPB1*44:01, allele
DPB1*45:01, allele DPB1*50:01, allele
DPB1*52:01, allele DPB1*54:01, allele
DPB1*55:01, allele DPB1*56:01, allele
DPB1*58:01, allele DPB1*66:01, allele
DPB1*67:01, allele DPB1*69:01, allele
DPB1*70:01, allele DPB1*74:01, allele
DPB1*76:01, allele DPB1*78:01, allele
DPB1*79:01, allele DPB1*85:01, allele
DPB1*86:01, allele DPB1*87:01, allele
DPB1*88:01, allele DPB1*89:01, allele
DPB1*90:01, allele DPB1*91:01, allele
DPB1*92:01, allele DPB1*93:01 and allele
DPB1*98:01; dbSNP:rs1126504).
/FTId=VAR_060633.
VARIANT 38 38 F -> D (in allele DPB1*70:01; requires 2
nucleotide substitutions).
/FTId=VAR_060635.
VARIANT 38 38 F -> H (in allele DPB1*09:01, allele
DPB1*10:01, allele DPB1*14:01, allele
DPB1*16:02, allele DPB1*17:01, allele
DPB1*22:02, allele DPB1*30:01, allele
DPB1*35:01, allele DPB1*45:01, allele
DPB1*54:01, allele DPB1*55:01, allele
DPB1*58:01, allele DPB1*66:01, allele
DPB1*67:01, allele DPB1*76:01, allele
DPB1*86:01, allele DPB1*91:01 and allele
DPB1*98:01; requires 2 nucleotide
substitutions).
/FTId=VAR_060634.
VARIANT 38 38 F -> L (in dbSNP:rs12722013).
/FTId=VAR_060636.
VARIANT 38 38 F -> Y (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*05:02, allele
DPB1*06:01, allele DPB1*09:02, allele
DPB1*11:01, allele DPB1*11:02, allele
DPB1*13:01, allele DPB1*13:02, allele
DPB1*14:02, allele DPB1*15:01, allele
DPB1*17:02, allele DPB1*18:01, allele
DPB1*20:02, allele DPB1*21:01, allele
DPB1*21:02, allele DPB1*20:01, allele
DPB1*25:01, allele DPB1*25:02, allele
DPB1*26:01, allele DPB1*27:01, allele
DPB1*29:01, allele DPB1*36:01, allele
DPB1*37:01, allele DPB1*44:01, allele
DPB1*50:01, allele DPB1*52:01, allele
DPB1*56:01, allele DPB1*69:01, allele
DPB1*74:01, allele DPB1*78:01, allele
DPB1*79:01, allele DPB1*85:01, allele
DPB1*87:01, allele DPB1*88:01, allele
DPB1*89:01, allele DPB1*90:01, allele
DPB1*92:01 and allele DPB1*93:01;
dbSNP:rs1126509).
/FTId=VAR_033433.
VARIANT 40 40 G -> L (in allele DPB1*03:01, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*09:01, allele DPB1*09:02, allele
DPB1*10:01, allele DPB1*11:01, allele
DPB1*11:02, allele DPB1*13:01, allele
DPB1*13:02, allele DPB1*14:01, allele
DPB1*14:02, allele DPB1*16:02, allele
DPB1*17:01, allele DPB1*17:02, allele
DPB1*20:02, allele DPB1*21:01, allele
DPB1*20:01, allele DPB1*22:02, allele
DPB1*25:01, allele DPB1*26:01, allele
DPB1*27:01, allele DPB1*29:01, allele
DPB1*30:01, allele DPB1*35:01, allele
DPB1*36:01, allele DPB1*37:01, allele
DPB1*44:01, allele DPB1*45:01, allele
DPB1*52:01, allele DPB1*54:01, allele
DPB1*55:01, allele DPB1*56:01, allele
DPB1*58:01, allele DPB1*66:01, allele
DPB1*67:01, allele DPB1*69:01, allele
DPB1*70:01, allele DPB1*74:01, allele
DPB1*76:01, allele DPB1*78:01, allele
DPB1*79:01, allele DPB1*85:01, allele
DPB1*86:01, allele DPB1*87:01, allele
DPB1*88:01, allele DPB1*91:01, allele
DPB1*92:01, allele DPB1*93:01 and allele
DPB1*98:01; requires 2 nucleotide
substitutions; dbSNP:rs386699869).
/FTId=VAR_060637.
VARIANT 40 40 G -> V (in dbSNP:rs1126513).
/FTId=VAR_033434.
VARIANT 41 41 R -> L (in allele DPB1*77:01;
dbSNP:rs41540313).
/FTId=VAR_060638.
VARIANT 44 44 C -> G (in allele DPB1*26:02).
/FTId=VAR_060639.
VARIANT 46 46 A -> P (in allele DPB1*38:01;
dbSNP:rs41555313).
/FTId=VAR_060640.
VARIANT 46 46 A -> T (in allele DPB1*18:02;
dbSNP:rs41555313).
/FTId=VAR_060641.
VARIANT 57 57 Y -> D (in allele DPB1*99:01;
dbSNP:rs41553416).
/FTId=VAR_060642.
VARIANT 61 61 R -> P (in allele DPB1*14:02 and allele
DPB1*21:02; dbSNP:rs41561114).
/FTId=VAR_060643.
VARIANT 62 62 E -> Q (ind allele DPB1*11:01, allele
DPB1*15:01 and allele DPB1*74:01;
dbSNP:rs12722018).
/FTId=VAR_033435.
VARIANT 64 64 F -> L (in allele DPB1*02:02, allele
DPB1*02:03, allele DPB1*05:01, allele
DPB1*15:02, allele DPB1*17:02, allele
DPB1*19:02, allele DPB1*21:01, allele
DPB1*21:01, allele DPB1*22:01, allele
DPB1*34:01, allele DPB1*36:01, allele
DPB1*38:01, allele DPB1*44:01, allele
DPB1*48:01, allele DPB1*58:01, allele
DPB1*62:01, allele DPB1*63:01, allele
DPB1*95:01 and allele DPB1*97:01;
dbSNP:rs9277348).
/FTId=VAR_060644.
VARIANT 64 64 F -> Y (in allele DPB1*01:01, allele
DPB1*01:02, allele DPB1*09:02, allele
DPB1*11:01, allele DPB1*13:01, allele
DPB1*15:01, allele DPB1*20:02, allele
DPB1*21:02, allele DPB1*25:02, allele
DPB1*26:01, allele DPB1*27:01, allele
DPB1*39:01, allele DPB1*40:01, allele
DPB1*49:01, allele DPB1*53:01, allele
DPB1*65:01, allele DPB1*74:01, allele
DPB1*85:01, allele DPB1*89:01 and allele
DPB1*96:01; dbSNP:rs1042117).
/FTId=VAR_033436.
VARIANT 65 65 A -> V (in allele DPB1*01:02, allele
DPB1*02:01, allele DPB1*02:02, allele
DPB1*02:03, allele DPB1*03:01, allele
DPB1*04:02, allele DPB1*04:03, allele
DPB1*05:01, allele DPB1*05:02, allele
DPB1*06:01, allele DPB1*06:02, allele
DPB1*08:01, allele DPB1*08:02, allele
DPB1*09:01, allele DPB1*10:01, allele
DPB1*10:02, allele DPB1*11:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*15:02, allele DPB1*16:01, allele
DPB1*16:02, allele DPB1*17:01, allele
DPB1*17:02, allele DPB1*18:01, allele
DPB1*18:02, allele DPB1*19:01, allele
DPB1*19:02, allele DPB1*21:01, allele
DPB1*20:01, allele DPB1*22:01, allele
DPB1*22:02, allele DPB1*23:01, allele
DPB1*25:01, allele DPB1*26:02, allele
DPB1*29:01, allele DPB1*30:01, allele
DPB1*32:01, allele DPB1*34:01, allele
DPB1*35:01, allele DPB1*36:01, allele
DPB1*37:01, allele DPB1*38:01, allele
DPB1*41:01, allele DPB1*44:01, allele
DPB1*45:01, allele DPB1*46:01, allele
DPB1*47:01, allele DPB1*48:01, allele
DPB1*50:01, allele DPB1*52:01, allele
DPB1*54:01, allele DPB1*55:01, allele
DPB1*57:01, allele DPB1*58:01, allele
DPB1*59:01, allele DPB1*60:01, allele
DPB1*62:01, allele DPB1*63:01, allele
DPB1*67:01, allele DPB1*68:01, allele
DPB1*69:01, allele DPB1*70:01, allele
DPB1*71:01, allele DPB1*73:01, allele
DPB1*75:01, allele DPB1*77:01, allele
DPB1*78:01, allele DPB1*79:01, allele
DPB1*80:01, allele DPB1*82:01, allele
DPB1*83:01, allele DPB1*84:01, allele
DPB1*86:01, allele DPB1*87:01, allele
DPB1*88:01, allele DPB1*91:01, allele
DPB1*93:01, allele DPB1*94:01, allele
DPB1*95:01, allele DPB1*97:01 and allele
DPB1*98:01; dbSNP:rs1042121).
/FTId=VAR_033437.
VARIANT 68 68 D -> Y (in allele DPB1*24:02;
dbSNP:rs77062860).
/FTId=VAR_060645.
VARIANT 72 72 G -> W (in allele DPB1*97:01;
dbSNP:rs41552915).
/FTId=VAR_060646.
VARIANT 84 84 A -> D (in allele DPB1*02:01, allele
DPB1*03:01, allele DPB1*04:02, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*06:02, allele DPB1*08:01, allele
DPB1*09:01, allele DPB1*10:01, allele
DPB1*10:02, allele DPB1*11:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*16:01, allele DPB1*16:02, allele
DPB1*17:01, allele DPB1*18:01, allele
DPB1*18:01, allele DPB1*18:02, allele
DPB1*19:02, allele DPB1*20:01, allele
DPB1*22:02, allele DPB1*25:01, allele
DPB1*25:02, allele DPB1*26:02, allele
DPB1*28:01, allele DPB1*29:01, allele
DPB1*32:01, allele DPB1*35:01, allele
DPB1*37:01, allele DPB1*41:01, allele
DPB1*44:01, allele DPB1*45:01, allele
DPB1*46:01, allele DPB1*48:01, allele
DPB1*49:01, allele DPB1*50:01, allele
DPB1*51:01, allele DPB1*53:01, allele
DPB1*57:01, allele DPB1*59:01, allele
DPB1*60:01, allele DPB1*68:01, allele
DPB1*69:01, allele DPB1*70:01, allele
DPB1*73:01, allele DPB1*75:01, allele
DPB1*76:01, allele DPB1*77:01, allele
DPB1*78:01, allele DPB1*79:01, allele
DPB1*80:01, allele DPB1*81:01, allele
DPB1*82:01, allele DPB1*83:01, allele
DPB1*86:01, allele DPB1*88:01, allele
DPB1*91:01, allele DPB1*92:01, allele
DPB1*93:01, allele DPB1*94:01 and allele
DPB1*98:01; dbSNP:rs707958).
/FTId=VAR_054662.
VARIANT 84 84 A -> E (in allele DPB1*01:02, allele
DPB1*02:02, allele DPB1*02:03, allele
DPB1*05:01, allele DPB1*08:02, allele
DPB1*17:02, allele DPB1*19:01, allele
DPB1*21:01, allele DPB1*22:01, allele
DPB1*24:01, allele DPB1*30:01, allele
DPB1*36:01, allele DPB1*38:01, allele
DPB1*47:01, allele DPB1*54:01, allele
DPB1*84:01 and allele DPB1*97:01;
dbSNP:rs386699870).
/FTId=VAR_060647.
VARIANT 84 84 A -> V (in dbSNP:rs707958).
/FTId=VAR_059511.
VARIANT 85 85 A -> E (in allele DPB1*02:01, allele
DPB1*03:01, allele DPB1*04:02, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*06:02, allele DPB1*08:01, allele
DPB1*09:01, allele DPB1*10:01, allele
DPB1*10:02, allele DPB1*11:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*16:01, allele DPB1*16:02, allele
DPB1*17:01, allele DPB1*18:01, allele
DPB1*18:02, allele DPB1*19:02, allele
DPB1*20:01, allele DPB1*22:02, allele
DPB1*25:01, allele DPB1*25:02, allele
DPB1*26:02, allele DPB1*28:01, allele
DPB1*29:01, allele DPB1*32:01, allele
DPB1*35:01, allele DPB1*37:01, allele
DPB1*41:01, allele DPB1*44:01, allele
DPB1*45:01, allele DPB1*46:01, allele
DPB1*48:01, allele DPB1*49:01, allele
DPB1*50:01, allele DPB1*51:01, allele
DPB1*53:01, allele DPB1*57:01, allele
DPB1*59:01, allele DPB1*60:01, allele
DPB1*68:01, allele DPB1*69:01, allele
DPB1*70:01, allele DPB1*73:01, allele
DPB1*75:01, allele DPB1*76:01, allele
DPB1*77:01, allele DPB1*78:01, allele
DPB1*79:01, allele DPB1*80:01, allele
DPB1*81:01, allele DPB1*82:01, allele
DPB1*83:01, allele DPB1*84:01, allele
DPB1*86:01, allele DPB1*88:01, allele
DPB1*91:01, allele DPB1*92:01, allele
DPB1*93:01, allele DPB1*94:01 and allele
DPB1*98:01; dbSNP:rs1042131).
/FTId=VAR_033438.
VARIANT 86 86 E -> D (in allele DPB1*03:01, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*09:01, allele DPB1*10:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*17:01, allele DPB1*20:01, allele
DPB1*22:02, allele DPB1*29:01, allele
DPB1*35:01, allele DPB1*44:01, allele
DPB1*46:01, allele DPB1*50:01, allele
DPB1*57:01, allele DPB1*69:01, allele
DPB1*70:01, allele DPB1*76:01, allele
DPB1*78:01, allele DPB1*80:01, allele
DPB1*86:01, allele DPB1*88:01, allele
DPB1*91:01, allele DPB1*92:01 and allele
DPB1*98:01; dbSNP:rs1042133).
/FTId=VAR_033439.
VARIANT 86 86 E -> V (in allele DPB1*32:01;
dbSNP:rs41545212).
/FTId=VAR_060648.
VARIANT 89 89 N -> H (in allele DPB1*02:03;
dbSNP:rs41550319).
/FTId=VAR_060649.
VARIANT 93 93 D -> H (in allele DPB1*96:01;
dbSNP:rs41560812).
/FTId=VAR_060650.
VARIANT 94 94 I -> F (allele DPB1*41:01 and allele
DPB1*83:01; dbSNP:rs1042136).
/FTId=VAR_059512.
VARIANT 94 94 I -> L (in allele DPB1*03:01, allele
DPB1*03:02, allele DPB1*05:02, allele
DPB1*06:01, allele DPB1*10:02, allele
DPB1*11:01, allele DPB1*14:01, allele
DPB1*14:02, allele DPB1*15:01, allele
DPB1*17:02, allele DPB1*20:01, allele
DPB1*22:02, allele DPB1*25:01, allele
DPB1*28:01, allele DPB1*29:01, allele
DPB1*31:01, allele DPB1*34:01, allele
DPB1*44:01, allele DPB1*45:01, allele
DPB1*50:01, allele DPB1*52:01, allele
DPB1*56:01, allele DPB1*57:01, allele
DPB1*59:01, allele DPB1*67:01, allele
DPB1*69:01, allele DPB1*70:01, allele
DPB1*72:01, allele DPB1*73:01, allele
DPB1*74:01, allele DPB1*76:01, allele
DPB1*78:01, allele DPB1*87:01, allele
DPB1*91:01, allele DPB1*92:01 and allele
DPB1*95:01; dbSNP:rs1042136).
{ECO:0000269|PubMed:6330724}.
/FTId=VAR_059513.
VARIANT 94 94 I -> N (in allele DPB1*60:01;
dbSNP:rs41547212).
/FTId=VAR_060651.
VARIANT 98 98 K -> E (in allele DPB1*02:01, allele
DPB1*02:02, allele DPB1*02:03, allele
DPB1*04:03, allele DPB1*06:01, allele
DPB1*08:01, allele DPB1*08:02, allele
DPB1*09:01, allele DPB1*09:02, allele
DPB1*10:01, allele DPB1*11:02, allele
DPB1*13:01, allele DPB1*13:02, allele
DPB1*16:01, allele DPB1*16:02, allele
DPB1*17:01, allele DPB1*18:02, allele
DPB1*19:01, allele DPB1*20:02, allele
DPB1*21:01, allele DPB1*22:01, allele
DPB1*26:02, allele DPB1*29:01, allele
DPB1*30:01, allele DPB1*32:01, allele
DPB1*33:01, allele DPB1*37:01, allele
DPB1*41:01, allele DPB1*44:01, allele
DPB1*46:01, allele DPB1*47:01, allele
DPB1*48:01, allele DPB1*54:01, allele
DPB1*55:01, allele DPB1*58:01, allele
DPB1*71:01, allele DPB1*81:01, allele
DPB1*86:01, allele DPB1*88:01, allele
DPB1*93:01 and allele DPB1*95:01;
dbSNP:rs1042140).
/FTId=VAR_033440.
VARIANT 98 98 K -> R (in allele DPB1*11:01, allele
DPB1*15:01, allele DPB1*69:01 and allele
DPB1*74:01; dbSNP:rs12722027).
/FTId=VAR_033441.
VARIANT 99 99 R -> W (in allele DPB1*94:01;
dbSNP:rs41554314).
/FTId=VAR_060652.
VARIANT 101 101 V -> L (in allele DPB1*31:01 and allele
DPB1*34:01; dbSNP:rs41546618).
/FTId=VAR_060653.
VARIANT 102 102 P -> L (in allele DPB1*78:01;
dbSNP:rs41551920).
/FTId=VAR_060654.
VARIANT 105 105 M -> I (in allele DPB1*08:02, allele
DPB1*09:02, allele DPB1*13:01, allele
DPB1*13:02 and allele DPB1*19:01;
dbSNP:rs1042153).
/FTId=VAR_033443.
VARIANT 105 105 M -> V (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*05:02, allele
DPB1*08:01, allele DPB1*09:01, allele
DPB1*10:01, allele DPB1*14:01, allele
DPB1*14:02, allele DPB1*17:02, allele
DPB1*21:02, allele DPB1*22:02, allele
DPB1*25:01, allele DPB1*25:02, allele
DPB1*26:01, allele DPB1*29:01, allele
DPB1*35:01, allele DPB1*37:01, allele
DPB1*44:01, allele DPB1*45:01, allele
DPB1*50:01, allele DPB1*52:01, allele
DPB1*54:01, allele DPB1*56:01, allele
DPB1*57:01, allele DPB1*65:01, allele
DPB1*67:01, allele DPB1*68:01, allele
DPB1*70:01, allele DPB1*73:01, allele
DPB1*75:01, allele DPB1*76:01, allele
DPB1*78:01, allele DPB1*79:01, allele
DPB1*84:01, allele DPB1*88:01, allele
DPB1*90:01 and allele DPB1*92:01;
dbSNP:rs1042151).
{ECO:0000269|PubMed:6330724}.
/FTId=VAR_033442.
VARIANT 113 113 G -> D (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*03:02, allele
DPB1*04:03, allele DPB1*05:01, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*08:01, allele DPB1*08:02, allele
DPB1*09:01, allele DPB1*09:02, allele
DPB1*10:01, allele DPB1*11:01, allele
DPB1*11:01, allele DPB1*13:01, allele
DPB1*13:02, allele DPB1*13:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*16:01, allele DPB1*17:01, allele
DPB1*17:02, allele DPB1*19:01, allele
DPB1*21:01, allele DPB1*21:01, allele
DPB1*21:02, allele DPB1*21:02, allele
DPB1*20:01, allele DPB1*22:01, allele
DPB1*25:01, allele DPB1*25:02, allele
DPB1*26:01, allele DPB1*27:01, allele
DPB1*29:01, allele DPB1*30:01, allele
DPB1*31:01, allele DPB1*35:01, allele
DPB1*36:01, allele DPB1*37:01, allele
DPB1*38:01, allele DPB1*44:01, allele
DPB1*45:01, allele DPB1*50:01, allele
DPB1*52:01, allele DPB1*54:01, allele
DPB1*55:01, allele DPB1*56:01, allele
DPB1*57:01, allele DPB1*58:01, allele
DPB1*63:01, allele DPB1*65:01, allele
DPB1*67:01, allele DPB1*68:01, allele
DPB1*69:01, allele DPB1*70:01, allele
DPB1*76:01, allele DPB1*78:01, allele
DPB1*79:01, allele DPB1*84:01, allele
DPB1*85:01, allele DPB1*87:01, allele
DPB1*88:01, allele DPB1*89:01, allele
DPB1*90:01, allele DPB1*91:01, allele
DPB1*92:01, allele DPB1*93:01, allele
DPB1*97:01 and allele DPB1*98:01;
dbSNP:rs1042169).
{ECO:0000269|PubMed:6330724}.
/FTId=VAR_060657.
VARIANT 113 113 G -> N (in allele DPB1*22:02; requires 2
nucleotide substitutions).
/FTId=VAR_060655.
VARIANT 113 113 G -> V (in allele DPB1*15:01, allele
DPB1*18:01, allele DPB1*28:01, allele
DPB1*34:01, allele DPB1*40:01, allele
DPB1*53:01, allele DPB1*62:01 and allele
DPB1*74:01; dbSNP:rs1042169).
/FTId=VAR_060656.
VARIANT 114 114 G -> E (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*03:02, allele
DPB1*04:03, allele DPB1*05:01, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*08:01, allele DPB1*08:02, allele
DPB1*09:01, allele DPB1*09:02, allele
DPB1*10:01, allele DPB1*11:01, allele
DPB1*13:01, allele DPB1*13:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*16:01, allele DPB1*17:01, allele
DPB1*17:02, allele DPB1*19:01, allele
DPB1*21:01, allele DPB1*21:02, allele
DPB1*20:01, allele DPB1*22:01, allele
DPB1*22:02, allele DPB1*25:01, allele
DPB1*25:02, allele DPB1*26:01, allele
DPB1*27:01, allele DPB1*29:01, allele
DPB1*30:01, allele DPB1*31:01, allele
DPB1*35:01, allele DPB1*36:01, allele
DPB1*37:01, allele DPB1*38:01, allele
DPB1*44:01, allele DPB1*45:01, allele
DPB1*50:01, allele DPB1*52:01, allele
DPB1*54:01, allele DPB1*55:01, allele
DPB1*56:01, allele DPB1*57:01, allele
DPB1*58:01, allele DPB1*63:01, allele
DPB1*65:01, allele DPB1*67:01, allele
DPB1*68:01, allele DPB1*69:01, allele
DPB1*70:01, allele DPB1*76:01, allele
DPB1*78:01, allele DPB1*79:01, allele
DPB1*84:01, allele DPB1*85:01, allele
DPB1*87:01, allele DPB1*88:01, allele
DPB1*89:01, allele DPB1*90:01, allele
DPB1*91:01, allele DPB1*92:01, allele
DPB1*93:01, allele DPB1*97:01 and allele
DPB1*98:01; dbSNP:rs9277354).
{ECO:0000269|PubMed:6330724}.
/FTId=VAR_033444.
VARIANT 115 115 P -> A (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*03:02, allele
DPB1*04:03, allele DPB1*05:01, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*08:01, allele DPB1*08:02, allele
DPB1*09:01, allele DPB1*09:02, allele
DPB1*10:01, allele DPB1*11:01, allele
DPB1*13:01, allele DPB1*13:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*16:01, allele DPB1*17:01, allele
DPB1*17:02, allele DPB1*19:01, allele
DPB1*21:01, allele DPB1*21:02, allele
DPB1*20:01, allele DPB1*22:01, allele
DPB1*22:02, allele DPB1*25:01, allele
DPB1*25:02, allele DPB1*26:01, allele
DPB1*27:01, allele DPB1*29:01, allele
DPB1*30:01, allele DPB1*31:01, allele
DPB1*35:01, allele DPB1*36:01, allele
DPB1*37:01, allele DPB1*38:01, allele
DPB1*44:01, allele DPB1*45:01, allele
DPB1*50:01, allele DPB1*52:01, allele
DPB1*54:01, allele DPB1*55:01, allele
DPB1*56:01, allele DPB1*57:01, allele
DPB1*58:01, allele DPB1*63:01, allele
DPB1*65:01, allele DPB1*67:01, allele
DPB1*68:01, allele DPB1*69:01, allele
DPB1*70:01, allele DPB1*76:01, allele
DPB1*78:01, allele DPB1*79:01, allele
DPB1*84:01, allele DPB1*85:01, allele
DPB1*87:01, allele DPB1*88:01, allele
DPB1*89:01, allele DPB1*90:01, allele
DPB1*91:01, allele DPB1*92:01, allele
DPB1*93:01, allele DPB1*97:01 and allele
DPB1*98:01; dbSNP:rs9277355).
{ECO:0000269|PubMed:6330724}.
/FTId=VAR_033445.
VARIANT 116 116 M -> V (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*03:02, allele
DPB1*04:03, allele DPB1*05:01, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*08:01, allele DPB1*08:02, allele
DPB1*09:01, allele DPB1*09:02, allele
DPB1*10:01, allele DPB1*11:01, allele
DPB1*13:01, allele DPB1*13:02, allele
DPB1*14:01, allele DPB1*14:02, allele
DPB1*16:01, allele DPB1*17:01, allele
DPB1*17:02, allele DPB1*19:01, allele
DPB1*21:01, allele DPB1*21:02, allele
DPB1*20:01, allele DPB1*22:01, allele
DPB1*22:02, allele DPB1*25:01, allele
DPB1*25:02, allele DPB1*26:01, allele
DPB1*27:01, allele DPB1*29:01, allele
DPB1*30:01, allele DPB1*31:01, allele
DPB1*35:01, allele DPB1*36:01, allele
DPB1*37:01, allele DPB1*38:01, allele
DPB1*44:01, allele DPB1*45:01, allele
DPB1*50:01, allele DPB1*52:01, allele
DPB1*54:01, allele DPB1*55:01, allele
DPB1*56:01, allele DPB1*58:01, allele
DPB1*63:01, allele DPB1*65:01, allele
DPB1*67:01, allele DPB1*68:01, allele
DPB1*69:01, allele DPB1*70:01, allele
DPB1*76:01, allele DPB1*78:01, allele
DPB1*79:01, allele DPB1*84:01, allele
DPB1*85:01, allele DPB1*87:01, allele
DPB1*88:01, allele DPB1*89:01, allele
DPB1*90:01, allele DPB1*91:01, allele
DPB1*92:01, allele DPB1*93:01, allele
DPB1*97:01 and allele DPB1*98:01;
dbSNP:rs9277356).
{ECO:0000269|PubMed:6330724}.
/FTId=VAR_033446.
VARIANT 120 120 R -> H (in allele DPB1*82:01 and allele
DPB1*85:01; dbSNP:rs41541915).
/FTId=VAR_060658.
VARIANT 125 125 R -> K (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*05:01, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*09:01, allele DPB1*09:02, allele
DPB1*13:01, allele DPB1*14:01, allele
DPB1*15:01, allele DPB1*18:01, allele
DPB1*19:01, allele DPB1*20:01, allele
DPB1*26:01, allele DPB1*45:01 and allele
DPB1*85:01; dbSNP:rs1126537).
{ECO:0000269|PubMed:6330724}.
/FTId=VAR_060659.
VARIANT 199 199 T -> I (in allele DPB1*01:01, allele
DPB1*03:01, allele DPB1*05:01, allele
DPB1*05:02, allele DPB1*06:01, allele
DPB1*09:01, allele DPB1*09:02, allele
DPB1*13:01, allele DPB1*14:01, allele
DPB1*15:01, allele DPB1*18:01, allele
DPB1*19:01, allele DPB1*20:01, allele
DPB1*26:01, allele DPB1*45:01 and allele
DPB1*85:01; dbSNP:rs1042335).
{ECO:0000269|PubMed:6330724}.
/FTId=VAR_060660.
VARIANT 207 207 L -> M (in allele DPB1*04:02;
dbSNP:rs14362).
/FTId=VAR_033447.
VARIANT 223 223 R -> Q (in allele DPB1*01:01;
dbSNP:rs9276).
/FTId=VAR_050393.
VARIANT 234 234 V -> M (in allele DPB1*05:01 and allele
DPB1*19:01; dbSNP:rs11551421).
/FTId=VAR_050394.
VARIANT 244 244 I -> T (in allele DPB1*15:01;
dbSNP:rs3097675).
/FTId=VAR_033448.
STRAND 37 47 {ECO:0000244|PDB:4P5M}.
STRAND 50 59 {ECO:0000244|PDB:4P5M}.
STRAND 62 68 {ECO:0000244|PDB:4P5M}.
TURN 69 71 {ECO:0000244|PDB:4P5M}.
STRAND 73 78 {ECO:0000244|PDB:4P5M}.
HELIX 79 81 {ECO:0000244|PDB:4P5M}.
HELIX 82 89 {ECO:0000244|PDB:4P5M}.
HELIX 92 99 {ECO:0000244|PDB:4P5M}.
TURN 100 104 {ECO:0000244|PDB:4P5M}.
HELIX 105 112 {ECO:0000244|PDB:4P5M}.
HELIX 114 118 {ECO:0000244|PDB:4P5M}.
STRAND 125 130 {ECO:0000244|PDB:4P5M}.
HELIX 134 137 {ECO:0000244|PDB:4P5M}.
STRAND 141 152 {ECO:0000244|PDB:4P5M}.
STRAND 155 160 {ECO:0000244|PDB:4P5M}.
STRAND 163 165 {ECO:0000244|PDB:4P5M}.
STRAND 167 171 {ECO:0000244|PDB:4P5M}.
STRAND 178 180 {ECO:0000244|PDB:4P5M}.
STRAND 182 189 {ECO:0000244|PDB:4P5M}.
STRAND 197 203 {ECO:0000244|PDB:4P5M}.
STRAND 211 216 {ECO:0000244|PDB:4P5M}.
SEQUENCE 258 AA; 29159 MW; E74777D438DE9C41 CRC64;
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN
REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA VPDRMCRHNY ELGGPMTLQR
RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW
TFQILVMLEM TPQQGDVYTC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC
GVGIFMHRRS KKVQRGSA


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